Suzuki, Hirotsugu; Liao, Yumeng; Kawai, Yuya; Matsuda, Takanori published their research in European Journal of Organic Chemistry in 2021. The article was titled 《Rhodium-Catalyzed Additive-Free C-H Ethoxycarbonylation of (Hetero)Arenes with Diethyl Dicarbonate as a CO Surrogate》.Name: 2-Bromo-5-methylpyridine The article contains the following contents:
A rhodium-catalyzed C(sp2)-H ethoxycarbonylation of indoles and arylpyridines using di-Et dicarbonate to form indole-2-carboxylic acid esters such as I [X = CH, N; R1 = H, 4-Me, 5-Cl, etc.] and isophthalates II [R2 = H, 5-Me, 5-Ph, etc.; R3 = H, 5-Me, 4-Me] was developed. The catalytic process featured an additive-free ethoxycarbonylation reaction, in which only ethanol and CO2 were produced as byproducts, providing a CO-free and operationally simple protocol. The introduced ethoxycarbonyl group was easily transformed into other ester and amide functionalities in a single step. Moreover, the reaction could be successfully applied on gram scale, and allowed for the efficient synthesis of indole-2-carboxylic acid esters and isophthalates. The experimental part of the paper was very detailed, including the reaction process of 2-Bromo-5-methylpyridine(cas: 3510-66-5Name: 2-Bromo-5-methylpyridine)
2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Name: 2-Bromo-5-methylpyridine