Swanson, Devin M. published the artcileIdentification and biological evaluation of 4-(3-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid (5-trifluoromethylpyridin-2-yl)amide, a high affinity TRPV1 (VR1) vanilloid receptor antagonist, Computed Properties of 306934-70-3, the main research area is vanilloid receptor antagonist preparation analgesic.
High throughput screening using the recombinant human TRPV1 receptor was used to identify a series of pyridinylpiperazine ureas as TRPV1 vanilloid receptor ligands. Exploration of the structure-activity relationships by parallel synthesis identified the essential pharmacophoric elements for antagonism that permitted further optimization via targeted synthesis to provide a potent orally bioavailable and selective TRPV1 modulator 41 active in several in vivo models.
Journal of Medicinal Chemistry published new progress about Analgesics. 306934-70-3 belongs to class pyridine-derivatives, name is 1-(5-(Trifluoromethyl)pyridin-2-yl)-1,4-diazepane, and the molecular formula is C11H14F3N3, Computed Properties of 306934-70-3.