Transaminase-Mediated Amine Borrowing via Shuttle Biocatalysis was written by Taday, Freya;Ryan, James;O鈥睸ullivan, Rachel;O鈥睷eilly, Elaine. And the article was included in Organic Letters in 2022.Related Products of 54-47-7 The following contents are mentioned in the article:
Shuttle catalysis has emerged as a useful methodol. for the reversible transfer of small functional groups, such as CO and HCN, and goes far beyond transfer hydrogenation chem. While a biocatalytic hydrogen-borrowing methodol. is well established, the biocatalytic borrowing of alternative functional groups has not yet been realized. Herein, we present a new concept of amine borrowing via biocatalytic shuttle catalysis, which has no counterpart in chemo-shuttle catalysis and allows efficient intermol. amine shuttling to generate reactive intermediates in situ. By coupling this dynamic exchange with an irreversible downstream step to displace the reaction equilibrium in the forward direction, high conversion to target products can be achieved. We showcase the potential of this amine-borrowing methodol. using a biocatalytic equivalent of both the Knorr-pyrrole synthesis and Pictet-Spengler reaction. This study involved multiple reactions and reactants, such as (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7Related Products of 54-47-7).
(4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of 鈭?8.7 脳 10鈭? cm3路mol鈭?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ路mol鈭? in the liquid phase and 140.4 kJ路mol鈭? in the gas phase. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Related Products of 54-47-7