0-100 | Pyridine-derivatives

Gelis, Coralie et al. published their research in Chemistry – A European Journal in 2020 | CAS: 626-64-2

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Formula: C5H5NO

Catalytic Transfer Hydrogenation of Arenes and Heteroarenes was written by Gelis, Coralie;Heusler, Arne;Nairoukh, Zackaria;Glorius, Frank. And the article was included in Chemistry – A European Journal in 2020.Formula: C5H5NO This article mentions the following:

Transfer hydrogenation reactions are of great interest to reduce diverse mols. under mild reaction conditions. To date, this type of reaction has only been successfully applied to alkenes, alkynes and polarized unsaturated compounds such as ketones, imines, pyridines, etc. The reduction of benzene derivatives by transfer hydrogenation has never been described, which is likely due to the high energy barrier required to dearomatize these compounds In this context, a catalytic transfer hydrogenation reaction for the reduction of benzene derivatives and heteroarenes to form complex 3-dimensional scaffolds bearing various functional groups at room temperature without needing compressed hydrogen gas has been developed. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Formula: C5H5NO).

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Orsi, Douglas L. et al. published their research in Journal of Organic Chemistry in 2020 | CAS: 626-64-2

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the 闂?bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the 闂?bonds. Pyridine derivatives are also useful as small-molecule 婵?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Application In Synthesis of Pyridin-4-ol

Cobalt-Catalyzed Selective Unsymmetrical Dioxidation of gem-Difluoroalkenes was written by Orsi, Douglas L.;Douglas, Justin T.;Sorrentino, Jacob P.;Altman, Ryan A.. And the article was included in Journal of Organic Chemistry in 2020.Application In Synthesis of Pyridin-4-ol This article mentions the following:

Gem-Difluoroalkenes represent valuable synthetic handles for organofluorine chem.; however, most reactions of this substructure proceed through reactive intermediates prone to eliminate a fluorine atom and generate monofluorinated products. Taking advantage of the distinct reactivity of gem-difluoroalkenes, we present a cobalt-catalyzed regioselective unsym. dioxygenation of gem-difluoroalkenes using phenols and mol. oxygen, which retains both fluorine atoms and provides 闁?phenoxy-闁?闁?difluorobenzyl alcs. Mechanistic studies suggest that the reaction operates through a radical chain process initiated by Co(II)/O₂/phenol and quenched by the Co-based catalyst. This mechanism enables the retention of both fluorine atoms, which contrasts most transition-metal-catalyzed reactions of gem-difluoroalkenes that typically involve defluorination. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Application In Synthesis of Pyridin-4-ol).

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Vergara-Diaz, Omar et al. published their research in Plant Journal in 2020 | CAS: 626-64-2

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.SDS of cas: 626-64-2

Assessing durum wheat ear and leaf metabolomes in the field through hyperspectral data was written by Vergara-Diaz, Omar;Vatter, Thomas;Kefauver, Shawn Carlisle;Obata, Toshihiro;Fernie, Alisdair R.;Araus, Jose Luis. And the article was included in Plant Journal in 2020.SDS of cas: 626-64-2 This article mentions the following:

In this study, we explore the potential of field spectroscopy to predict the metabolite profiles in flag leaves and ear bracts in durum wheat. The full-range reflectance spectra (visible (VIS)-near-IR (NIR)-short wave IR (SWIR)) of flag leaves, ears and canopies were recorded in a collection of contrasting genotypes grown in four environments under different water regimes. GC-MS metabolite profiles were analyzed in the flag leaves, ear bracts, glumes, and lemmas. The results from regression models exceeded 50% of the explained variation (adj-R² in the validation sets) for at least 15 metabolites in each plant organ, whereas their errors were considerably low. The best regressions were obtained for malate (82%), glycerate and serine (63%) in leaves; myo-inositol (81%) in lemmas; glycolate (80%) in glumes; sucrose in leaves and glumes (68%); 缂?aminobutyric acid (GABA) in leaves and glumes (61% and 71%, resp.); proline and glucose in lemmas (74% and 71%, resp.) and glumes (72% and 69%, resp.). The selection of wavebands in the models and the performance of the models based on canopy and VIS organ spectra and yield prediction are discussed. We feel that this technique will likely to be of interest due to its broad applicability in ecophysiol. research, plant breeding programs, and the agri-food industry. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2SDS of cas: 626-64-2).

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Liao, Lieqiang et al. published their research in RSC Advances in 2021 | CAS: 626-64-2

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of 闂?8.7 闂?10闂? cm3闁荤姾娅ｅΛ纭俵闂?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ闁荤姾娅ｅΛ纭俵闂? in the liquid phase and 140.4 kJ闁荤姾娅ｅΛ纭俵闂? in the gas phase. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Product Details of 626-64-2

Supramolecular gel formation regulated by water content in organic solvents: self-assembly mechanism and biomedical applications was written by Liao, Lieqiang;Jia, Xinjian;Lou, Haoxiang;Zhong, Jinlian;Liu, Huijin;Ding, Shunming;Chen, Chao;Hong, Sanguo;Luo, Xuzhong. And the article was included in RSC Advances in 2021.Product Details of 626-64-2 This article mentions the following:

As one of the most important and fruitful methods, supramol. self-assembly has a significant advantage in designing and fabricating functional soft materials with various nanostructures. In this research, a low-mol.-weight gelator, N,N’-di(pyridin-4-yl)-pyridine-3,5-dicarboxamide (PDA-N4), was synthesized and used to construct self-assembled gels via a solvent-mediated strategy. It was found that PDA-N4 could form supramol. gels in mixed solvents of water and DMSO (or DMF) at high water fraction (greater than or equal to 50%). By decreasing the water fraction from 50% to 30%, the gel, suspension and solution phases appeared successively, indicating that self-assembled aggregates could be efficiently modulated via water content in organic solvents. Moreover, the as-prepared PDA-N4 supramol. gels not only displayed solid-like behavior, and pH- and thermo-reversible characteristics, but also showed a solution-gel-crystal transition with the extension of aging time. Further anal. suggested that both the crystal and gel had similar assembled structures. The intermol. hydrogen bonding between amide groups and the 闂?闂?stacking interactions between pyridine groups played key roles in gel formation. Addnl., the release behavior of vitamin B12 (VB₁₂) from PDA-N4 gel (H₂O/DMSO, volume/volume = 90/10) was evaluated, and the drug controlled release process was consistent with a first-order release mechanism. The human umbilical venous endothelial cell culture results showed that the PDA-N4 xerogel has good cytocompatibility, which implied that the gels have potential biol. application in tissue engineering and controlled drug release. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Product Details of 626-64-2).

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Jiang, Bin et al. published their research in Journal of Chemical & Engineering Data | CAS: 626-64-2

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the 闂?bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the 闂?bonds. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Related Products of 626-64-2

Intensification of High Boiling Point Organic Solvents on SO₂ Absorption in Deep Eutectic Solvents Formed by Hydroxypyridine and 1-Butyl-3-methylimidazolium Chloride was written by Jiang, Bin;Zhang, Congcong;Tantai, Xiaowei;Yang, Na;Zhang, Luhong;Sun, Yongli;Xiao, Xiaoming. And the article was included in Journal of Chemical & Engineering Data.Related Products of 626-64-2 This article mentions the following:

A series of hydrogen bond donors (HBDs) functionalized deep eutectic solvents (DESs) containing both phys. and chem. action sites were synthesized by hydroxypyridine with different structures and proportions plus 1-butyl-3-methylimidazolium chloride (BmimCl). The effects of temperature, partial pressure, HBDs structure, and water content on SO₂ absorption were investigated, and 4-hydroxypyridine (4-Op)/BmimCl (1:2) exhibited the highest SO₂ absorption capacity. In order to decrease the viscosity of absorbent and increase the applicability of 4-Op/BmimCl (1:2), the SO₂ absorption capacities in four hybrid absorbents based on 4-Op/BmimCl (1:2) and four high b.p. organic solvents [sulfone, DMSO, N-methylpyrrolidone (NMP), and 1-methylimidazole (NMI)] were further studied and compared. 4-Op/BmimCl (1:2)-(NMI) showed the best absorption performance; the addition of NMI significantly decreased the viscosity of the absorbent, and the absorption capacity of absorbent was also improved compared with that of pure 4-Op/BmimCl (1:2) absorbent. The SO₂ absorption capacity of hybrid absorbents (mass fraction of NMI 闂?= 0.3) could reach 1.23 g SO₂/g absorbent at 100 kPa SO₂ and 293.15 K, and the viscosity of the absorbent before absorption was only 12 mPa闁荤姾娅ｅ鈧?at 298.15 K. The gravimetric absorption capacity and desorption performance of hybrid absorbents did not change in the continuous absorption-desorption cycle experiments Furthermore, the results of quantum chem. calculation and spectral anal. showed that there were physicochem. mixing interactions between pure DESs and SO₂. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Related Products of 626-64-2).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the 闂?bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the 闂?bonds. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Related Products of 626-64-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wongsa, Prinya et al. published their research in Food Chemistry in 2019 | CAS: 626-64-2

Quality and bioactive compounds of blends of Arabica and Robusta spray-dried coffee was written by Wongsa, Prinya;Khampa, Nuttida;Horadee, Sineenat;Chaiwarith, Jeeranun;Rattanapanone, Nithiya. And the article was included in Food Chemistry in 2019.Recommanded Product: 626-64-2 This article mentions the following:

The objective of this study was to develop both a possible process and a spray-dried coffee product with a balanced content of bioactive compounds Spray-dried coffees were prepared by mixing different ratios of medium-roasted Coffea canephora (R) with green Coffea arabica (A) beans. Overall, quality characteristics of spray-dried coffees were not different. The dominant signals of 1D ¹H NMR were identified as trigonelline, caffeine and chlorogenic and organic acids. Principal component anal. explained 81.8% of the total variance. Roasted Robusta spray-dried coffee was clearly distinguished from blended coffees. Forty-two volatile compounds were identified. An increase in green Arabica mixed with roasted Robusta in the blends resulted in an increase in 5-caffeoylquinic acid but a decrease in caffeine contents. Spray-dried coffee prepared from a A35:R65 showed greater total phenolic content and antioxidant activity due to a balance in bioactive compounds In addition, its coffee brew obtained the highest overall liking score. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Recommanded Product: 626-64-2).

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Bettenhausen, Harmonie M. et al. published their research in Journal of the American Society of Brewing Chemists in 2021 | CAS: 626-64-2

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ璺痬ol閳? in pyridine vs. 150 kJ璺痬ol閳? in benzene). Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Category: pyridine-derivatives

Mass Spectrometry Metabolomics of Hot Steep Malt Extracts and Association to Sensory Traits was written by Bettenhausen, Harmonie M.;Barr, Lindsay;Omerigic, Heather;Yao, Linxing;Heuberger, Adam L.. And the article was included in Journal of the American Society of Brewing Chemists in 2021.Category: pyridine-derivatives This article mentions the following:

In the brewing industry, there is value in defining sensory attributes of malt, and recent protocols have been developed that enable anal. of aroma and taste. One method, the “hot steep” is a hot water extract that is highly reproducible and able to distinguish malt flavor. However, the chem. of the hot steep extracts has not been fully defined, and the links between specific metabolites of the hot steep and their resulting sensory attributes remains largely unknown. Here, a study was designed to describe the metabolite chem. of hot steep extracts, and to characterize variation in this chem. and corresponding sensory by comparative anal. of 12 com. pale malts. Metabolomics was performed on the 12 malt hot steep extracts using three mass spectrometry platforms to detect volatiles (HS/SPME-GC-MS) and non-volatiles (UHPLC-TOF-MS and GC-MS). The anal. detected a total of 1,026 compounds including lipids, organic acids, esters, and Maillard Reaction Products (MRPs), of which 162 compounds (15.7%) varied among the 12 hot steep extracts Sensory of the 12 hot steep extracts was performed using an integrated Check All That Apply and quant. anal. method for 14 traits, and the data revealed cereal, grassy, and dough aromas were the attributes that varied. The metabolomics and sensory data were integrated using OPLS anal. The anal. revealed 64 compounds strongly associated with cereal aroma and included MRPs. A total of 23 compounds were strongly associated with grassy aroma including alkane/alkenes, benzenoids, organic acids, lipids, and fatty acid esters. Taken together, these data highlight the utility of the hot steep extract to differentiate malt for flavor and chem. and indicate specific compounds that drive the most dominant flavors observed in this population of pale malts. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Category: pyridine-derivatives).

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Tupikina, Elena Yu. et al. published their research in Molecules in 2022 | CAS: 626-64-2

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ璺痬ol閳? in pyridine vs. 150 kJ璺痬ol閳? in benzene). Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Application of 626-64-2

Simultaneous Estimation of Two Coupled Hydrogen Bond Geometries from Pairs of Entangled NMR Parameters: The Test Case of 4-Hydroxypyridine Anion was written by Tupikina, Elena Yu.;Sigalov, Mark V.;Tolstoy, Peter M.. And the article was included in Molecules in 2022.Application of 626-64-2 This article mentions the following:

The computational method for estimating the geometry of two coupled hydrogen bonds with geometries close to linear using a pair of spectral NMR parameters was proposed. The method was developed based on the quantum-chem. investigation of 61 complexes with two hydrogen bonds formed by oxygen and nitrogen atoms of the 4-hydroxypyridine anion with OH groups of substituted methanols. The main idea of the method is as follows: from the NMR chem. shifts of nuclei of atoms forming the 4-hydroxylpyridine anion, we select such pairs, whose values can be used for simultaneous determination of the geometry of two hydrogen bonds, despite the fact that every NMR parameter is sensitive to the geometry of each of the hydrogen bonds. For these parameters, two-dimensional maps of dependencies of NMR chem. shifts on interat. distances in two hydrogen bonds were constructed. It is shown that, in addition to chem. shifts of the nitrogen atom and quaternary carbon, which are exptl. difficult to obtain, chem. shifts of the carbons and protons of the CH groups can be used. The performance of the proposed method was evaluated computationally as well on three addnl. complexes with substituted alcs. It was found that, for all considered cases, hydrogen bond geometries estimated using two-dimensional correlations differed from those directly calculated by quantum-chem. methods by not more than 0.04 鑴? In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Application of 626-64-2).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ璺痬ol閳? in pyridine vs. 150 kJ璺痬ol閳? in benzene). Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Application of 626-64-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Fotovic, Luka et al. published their research in Crystal Growth & Design in 2021 | CAS: 626-64-2

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. Pyridine has a conjugated system of six 锜?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H鐪塩kel criteria for aromatic systems. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Reference of 626-64-2

Evaluation of Halogenopyridinium Cations as Halogen Bond Donors was written by Fotovic, Luka;Bedekovic, Nikola;Stilinovic, Vladimir. And the article was included in Crystal Growth & Design in 2021.Reference of 626-64-2 This article mentions the following:

We have performed a database survey and a structural and computational study of the potential and the limitations of halogenopyridinium cations as halogen bond donors. The database survey demonstrated that adding a pos. charge on a halogenopyridine ring increases the probability that the halogen atom will participate in a halogen bond, although for chloropyridines it remains below 60%. Crystal structures of both protonated and N-methylated monohalogenated pyridinium cations revealed that the iodo- and bromopyridinium cations always form halogen-bonding contacts with the iodide anions shorter than the sum of the vdW radii, while chloropyridinium cations mostly participate in longer contacts or fail to form halogen bonds. Although a DFT study of the electrostatic potential has shown that both protonation and N-methylation of halogenopyridines leads to a considerable increase in the ESP of the halogen 锜?hole, it is generally not the most pos. site on the cation, allowing for alternate binding sites. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Reference of 626-64-2).

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Yang, Qing-Qing et al. published their research in iScience in 2020 | CAS: 626-64-2

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.COA of Formula: C5H5NO

Amphiphilic Oxo-Bridged Ruthenium “Green Dimer” for Water Oxidation was written by Yang, Qing-Qing;Jiang, Xin;Yang, Bing;Wang, Yang;Tung, Chen-Ho;Wu, Li-Zhu. And the article was included in iScience in 2020.COA of Formula: C5H5NO This article mentions the following:

In 1982, an oxo-bridged dinuclear ruthenium(III) complex, known as “blue dimer,” was discovered to be active for water oxidation In this work, a new amphiphilic ruthenium “green dimer” 2, obtained from an amphiphilic mononuclear Ru(bda) (N-OTEG) (L1) (1; N-OTEG = 4-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-pyridine; L1 = vinylpyridine) is reported. An array of mechanistic studies identifies “green dimer” 2 as a mixed valence of Ru^II-O-Ru^III oxo-bridged structure. Bearing the same bda2- and amphiphilic axial ligands, monomer 1 and green dimer 2 can be reversibly converted by ascorbic acid and oxygen, resp., in aqueous solution More importantly, the oxo-bridged “green dimer” 2 was found to take water nucleophilic attack for oxygen evolution, in contrast to monomer 1 via radical coupling pathway for O-O bond formation. This is the first report of an amphiphilic oxo-bridged catalyst, which possesses a new oxygen evolution pathway of Ru-bda catalysts. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2COA of Formula: C5H5NO).

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem