Tag: 0-100

A New waste-free integrated approach for sapropel processing using supercritical fluid extraction was written by Krivonos, Oksana I.;Belskaya, Olga B.. And the article was included in Journal of Supercritical Fluids in 2020.Formula: C5H5NO This article mentions the following:

An integrated approach to the processing of sapropel with the use of supercritical CO₂ extraction of bioactive substances with carbon dioxide at the first step of the process is discussed. The dependences of the yield and composition of extracts (8-35 MPa, 50°C) and features of sapropel are established. Further carbonization of the solid residue remaining after extraction results in organic-rich products (phenol and its mono, dialkyl and methoxy derivatives, hydrocarbons C14-C22) and carbon-mineral materials with a total pore volume of 0.681-1.211 cm³ g^-1. It was found that the introduction of the initial stage of treatment with supercritical CO₂ allows not only extracting valuable amino acids, but also affects the yield, composition and properties of liquid and solid sapropel transformation products at subsequent stages of heat treatment. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Formula: C5H5NO).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of âˆ?8.7 × 10âˆ? cm3·molâˆ?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·molâˆ? in the liquid phase and 140.4 kJ·molâˆ? in the gas phase. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Formula: C5H5NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Anchoring BODIPY photosensitizers enable pan-microbial photoinactivation was written by Gu, Kedan;Lin, Guangyu;Zhu, Yuanxing;Ji, Xin;Li, Jiyang;Dong, Xiaochun;Zhao, Weili. And the article was included in European Journal of Medicinal Chemistry in 2020.Application of 626-64-2 This article mentions the following:

Photodynamic antimicrobial chemotherapy (PACT) is an effective strategy to inactivate pathogenic and resistant microbes. However, pan-microbial photoinactivation has hardly achieved. In this manuscript, we built anti-microbial PSs based on 2,6-diiodo-1,3,5,7-tetramethyl BODIPY (2I-BDP) using anchoring strategy through modifications on boron atom with bis-cationic moieties. With appropriate bis-cationic anchoring, we could achieve effective PACT for pan-microbial photoinactivation via straight forward modifications. Our studies suggested that integration of an efficient photosensitizer, good amphiphilicity, as well as tight interaction with microbial membrane could be essential for effective PACT. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Application of 626-64-2).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Application of 626-64-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Visible-light-promoted aerobic oxidative hydroxylation of arylboronic acids in water by hydrophilic organic semiconductor was written by Yu, Kunyi;Zhang, Hanjie;Sheng, Yuqiang;Zhu, Yongfa. And the article was included in Tetrahedron Letters in 2020.Formula: C5H5NO This article mentions the following:

A green and sustainable catalytic system was developed based on perylenediimide (PDI) organic semiconductor for the aerobic oxidative hydroxylation of arylboronic acids in aqueous solution with visible light. By using PDI-SN, a hydrophilic organic semiconductor, which can activate oxygen to produce superoxide radicals in aqueous solution, this reaction proceeds under ambient conditions: water as the solvent and air as the oxidant, giving various phenols as products with high yields. In contrast to methods using organic solvents, this novel process has the potential of green industrial application. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Formula: C5H5NO).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of âˆ?8.7 × 10âˆ? cm3·molâˆ?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·molâˆ? in the liquid phase and 140.4 kJ·molâˆ? in the gas phase. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Formula: C5H5NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Importance of Hydrogen Bonding: Structure-Activity Relationships of Ruthenium(III) Complexes with Pyridine-Based Ligands for Alzheimer’s Disease Therapy was written by Wall, Brendan J.;Will, Mark F.;Yawson, Gideon K.;Bothwell, Paige J.;Platt, David C.;Apuzzo, C. Fiore;Jones, Marjorie A.;Ferrence, Gregory M.;Webb, Michael I.. And the article was included in Journal of Medicinal Chemistry in 2021.Electric Literature of C5H5NO This article mentions the following:

Alzheimer’s disease (AD) is the most common form of dementia, where one of the pathol. hallmarks of AD is extracellular protein deposits, the primary component of which is the peptide amyloid-β (Aβ). Recently, the soluble form of Aβ has been recognized as the primary neurotoxic species, making it an important target for therapeutic development. Metal-based drugs are promising candidates to target Aβ, as the interactions with the peptide can be tuned by ligand design. In the current study, 11 ruthenium complexes containing pyridine-based ligands were prepared, where the functional groups at the para position on the coordinated pyridine ligand were varied to determine structure-activity relationships. Overall, the complexes with terminal primary amines had the greatest impact on modulating the aggregation of Aβ and diminishing its cytotoxicity. These results identify the importance of specific intermol. interactions and are critical in the advancement of metal-based drugs for AD therapy. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Electric Literature of C5H5NO).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Electric Literature of C5H5NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Fullerene soot and a fullerene nanodispersion as recyclable heterogeneous off-the-shelf photocatalysts was written by Jozeliunaite, Augustina;Valceckas, Domantas;Orentas, Edvinas. And the article was included in RSC Advances in 2021.SDS of cas: 626-64-2 This article mentions the following:

In this report a comparative study which aims to evaluate the use of unmodified fullerene soot and a fullerene nanodispersion as non-soluble and quasi-soluble carbon-based photocatalysts, resp., for sulfide oxidation and other transformations using oxygen as an oxidant in ethanol was presented. A wide range of sulfoxides were successfully prepared with good yields and chemoselectivity using a very low catalyst loading. The fullerene soot photocatalyst was easily recovered and shows excellent stability of the catalytic properties. The reaction was shown to proceed via a singlet oxygen pathway and has a high selectivity for aliphatic sulfides, whereas the oxidation of thioanisoles can be accomplished using an amine mediated electron transfer mechanism. The applicability of the fullerene nanodispersion as a general purpose photocatalyst was demonstrated in radical cyclization, boronic acid oxidation and imine formation reactions. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2SDS of cas: 626-64-2).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.SDS of cas: 626-64-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Biological activities and synergistic effects of Elsholtzia stauntoni essential oil from flowers and leaves and their major constituents against Tribolium castaneum was written by Liang, Junyu;Ning, Anqi;Lu, Peiyu;An, Yue;Wang, Zuoliang;Zhang, Ji;He, Chunyu;Wang, Yongfeng. And the article was included in European Food Research and Technology in 2021.Product Details of 626-64-2 This article mentions the following:

Stored-product pests are a major problem in food production and storage. Essential oils (EOs) have been reported to have a wide range of insecticidal activities. In this study, the EOs of flowers and leaves from Elsholtzia stauntoni were analyzed for their chem. composition by GC-MS. The two EOs and their two common main components (cuminol and caryophyllene) were evaluated for their bioactivities against T. castaneum adults. Results of GC-MS anal. indicated that the chem. composition of EOs of flowers and leaves from E. stauntoni had certain similarity and diversity. The two same major components of EOs of flowers and leaves were cuminol (27.81% and 27.62%, resp.) and caryophyllene (5.78% and 10.95%, resp.). The results of bioassays indicated that the EOs of flowers and leaves possessed obvious contact toxicities (LD₅₀ = 19.05 and 18.75μg/Adult, resp.) and repellent activities against T. castaneum. In addition, the EOs of flowers (LC₅₀ = 16.26 mg/L Air) showed the higher fumigant toxicity than that of leaves (LC₅₀ = 44.42 mg/L Air). Cuminol and caryophyllene exhibited contact toxicity and repellency against T. castaneum, but showed no fumigant toxicity. In particular, cuminol was still significantly repellent to T. castaneum within the testing concentration range of 78.63-0.13 nL/cm² after 48 h. Furthermore, cuminol and caryophyllene exhibited synergistic contact activity against T. castaneum in all exptl. ratios. Altogether, it suggests that EOs of E. stauntoni and their two major monomers have promising potential to serve as bio-insecticides for controlling T. castaneum. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Product Details of 626-64-2).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Product Details of 626-64-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

An efficient one-pot synthesis of industrially valuable primary organic carbamates and N-substituted ureas by a reusable Merrifield anchored iron(II)-anthra catalyst [Fe^II(Anthra-Merf)] using urea as a sustainable carbonylation source was written by Basu, Priyanka;Dey, Tusar Kanto;Ghosh, Aniruddha;Biswas, Surajit;Khan, Aslam;Islam, Sk. Manirul. And the article was included in New Journal of Chemistry in 2020.Name: Pyridin-4-ol This article mentions the following:

An efficient synthesis of primary carbamates and N-substituted ureas is explored with a newly developed heterogeneous polymer supported iron catalyst in the presence of a sustainable carbonylation source. The Merrifield anchored iron(II)-anthra catalyst [FeII(Anthra-Merf)] was synthesized by functionalization of Merrifield polymer followed by grafting of iron metal. The catalyst [FeII(Anthra-Merf)] was characterized by several techniques, like SEM, EDAX, TGA, PXRD, XPS, FTIR, CHN, AAS and UV-Vis anal. The designed polymer embedded [FeII(Anthra-Merf)] complex is a remarkably successful catalyst for the synthesis of primary organic carbamates and N-substituted ureas by using safe carbonylation agent urea with different derivatives of alcs. and amines, resp. The reported catalyst is a potential candidate towards contributing a satisfactory yield of isolated products under suitable reaction conditions. The catalyst is recyclable and almost non-leaching in nature after six runs with an insignificant drop in catalytic activity. Thus we found an economical and viable catalyst [FeII(Anthra-Merf)] for primary carbamates and N-substituted urea synthesis under moderate reaction conditions. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Name: Pyridin-4-ol).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Name: Pyridin-4-ol

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Selective C-H trifluoromethoxylation of (hetero)arenes as limiting reagent was written by Deng, Zhijie;Zhao, Mingxin;Wang, Feng;Tang, Pingping. And the article was included in Nature Communications in 2020.Product Details of 626-64-2 This article mentions the following:

A general late-stage C-H trifluoromethoxylation of arenes and heteroarenes RH (R = 4-methoxypyridin-2-yl, 4-t-butylphenyl, 3-acetylbenzothien-2-yl, etc.) as limiting reagent with trifluoromethoxide anion was described. The reaction is mediated by silver salts under mild reaction conditions, exhibiting broad substrate scope and wide functional-group compatibility. In addition, ortho-position selective C-H trifluoromethoxylation of pyridines is observed The method is not only applicable to the gram-scale synthesis of trifluoromethoxylated products ROCF₃ but also allows efficient late-stage C-H trifluoromethoxylation of marketed small-mol. drugs, common pharmacophores and natural products. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Product Details of 626-64-2).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Product Details of 626-64-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Meso-pyridinium substituted BODIPY dyes as mitochondria-targeted probes for the detection of cysteine in living cells and in vivo was written by Ji, Xin;Wang, Nannan;Zhang, Jian;Xu, Shuang;Si, Yubing;Zhao, Weili. And the article was included in Dyes and Pigments in 2021.Synthetic Route of C5H5NO This article mentions the following:

Cysteine (Cys) is a crucial bio-thiol attributing to its significant role in many physiol. and pathol. processes and maintaining redox dynamic balance. In mitochondria, ROS can cause oxidative damage, and Cys can solve this problem by acting as an antioxidant. Herein, we designed and synthesized a series of meso-pyridin and meso-pyridinium substituted BODIPY dyes as fluorescent probes to distinguish Cys. Through screening the responsive behaviors of the all probes toward biothiols, we obtained an appropriate mitochondria-targeted probe BDP-S-o-Py⁺ for Cys-specific detection. D. functional theory (DFT) calculations were used to demonstrate the different reactivity of the probes. BDP-S-o-Py⁺ could detect Cys with fast response under biol. environment. The probe BDP-S-o-Py⁺ had a low limit of detection (LOD, 72 nM) at the linear dynamic range from 0 to 50 μM. In particularly, BDP-S-o-Py⁺ could be used for imaging of mitochondrial Cys in living cells, and was capable of monitoring endogenous Cys in vivo, successfully. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Synthetic Route of C5H5NO).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Synthetic Route of C5H5NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Quantitative structure-property relationship of standard enthalpies of nitrogen oxides based on a MSR and LS-SVR algorithm predictions was written by Wan, Zhongyu. And the article was included in Journal of Molecular Structure in 2020.Electric Literature of C5H5NO This article mentions the following:

Quantum chem. method is used to calculate 1444 descriptors of each N oxide mol. Variables are screened by using multiple stepwise regression (MSR). The optimal 10-element regression equation is derived, its R² = 0.934 and Q² = 0.927. The support vector regression (SVR) model between 10 mol descriptors and standard formation enthalpy is established, and the support vector machine is optimized by using the least squares method (LS). The training set consisting of 78 compounds have R² = 0.969 and Q² = 0.954. The other 22 compounds constitute the test set to verify the external prediction ability of the model, and its R² = 0.958. It demonstrates that the LS-SVR model has good stability and prediction ability, and overcomes the problem of over-fitting. The conclusion of quant. structural property relation (QSPR) shows that the mol. descriptor and the standard enthalpy of formation are nonlinear 2nd-order functions. The authors speculate that the electronegativity of atoms is the key to determine the standard enthalpy of formation of compounds In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Electric Literature of C5H5NO).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Electric Literature of C5H5NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem