Tag: 0-100

A thermochemical computational study on hydroxyquinolines and their azulene analogues was written by Meshhal, Moyassar M.;El-Demerdash, Safinaz H.;El-Nahas, Ahmed M.. And the article was included in Journal of Molecular Structure in 2019.Related Products of 626-64-2 This article mentions the following:

Ab initio CBS-QB3 method has been used to determine gas-phase enthalpies of formation for 34 compounds including a number of hydroxyquinoline isomers, the corresponding azulene analogs and their parent systems. The mean absolute deviation of 4.43 kJ/mol reveals good agreement between our results and the available exptl. data. Relative thermodn. stabilities of hydroxyquinoline isomers and related analogs were discussed and several isomerization reactions enthalpies were derived. The same level of theory has also been utilized to calculate adiabatic ionization energies and electron affinities for the mols. with known exptl. values and the agreement between theory and experiment was found to be within 8 kJ/mol. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Related Products of 626-64-2).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Related Products of 626-64-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

4-Hydroxy Pyridinium Triflate@SiO₂ Nanoparticles as a Novel Efficient Catalyst for Fries Rearrangement of Aryl Esters with High Selectivity was written by Ghalehbandi, Shermineh Sadat;Ghazanfari, Dadkhoda;Ahmadi, Sayed Ali;Sheikhhosseini, Enayatollah. And the article was included in Current Organic Synthesis in 2020.SDS of cas: 626-64-2 This article mentions the following:

A simple, fast and new method for the Fries rearrangement of aryl esters was developed. 4-Hydroxy pyridinium triflate functionalized silica was a very efficient, reusable and economically available catalyst for the Fries rearrangement in solvent-free condition and under microwave irradiation Also, a notable selectivity was observed in the presence of 4-hydroxy pyridinium triflate functionalized silica. Selectivity, shorter reaction time, high yield and easy work-up are advantages of this synthetic method. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2SDS of cas: 626-64-2).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. SDS of cas: 626-64-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hierarchical nanostructures of a liquid crystalline block copolymer with a hydrogen-bonded calamitic mesogen was written by Pan, Hongbing;Xiao, Anqi;Zhang, Wei;Luo, Longfei;Shen, Zhihao;Fan, Xinghe. And the article was included in Polymer in 2019.HPLC of Formula: 626-64-2 This article mentions the following:

With a pyridine derivative containing a calamitic mesogen 4-((6-((4′-((4-hexylphenyl)ethynyl)-[1,1′-biphenyl]-4-yl)oxy)hexyl)oxy)pyridine (HEBC6) used as the hydrogen-bonding acceptor and polydimethylsiloxane-b-poly(2,5-bis(4-carboxy phenyl)styrene) (PDMS-b-PM3H) as the hydrogen-bonding donor, a series of supramol. liquid crystalline block copolymers (SLCBCPs) were prepared through hydrogen bonding. In the supramol. block, the calamitic mesogen was decoupled from the motion of PM3H chains by using a flexible spacer. Different microphase-separated nanostructures and liquid crystalline (LC) structures were obtained by varying the d.p. of the PM3H block and the molar ratio of HEBC6 to PDMS-b-PM3H. The SLCBCPs can self-assemble into hexagonally packed cylinders (HEX), lamellae (LAM), and inverted HEX. Smectic A phase and parallel packing of the calamitic mesogens were also observed on a smaller length scale, and these two ordered structures are synergistic and promotional. Therefore, hierarchically ordered structures can be obtained from these SLCBCPs. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2HPLC of Formula: 626-64-2).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. HPLC of Formula: 626-64-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Design, synthesis and antitumor activities of thiazole-containing mitochondrial targeting agents was written by Zhang, Dongdong;Hu, Yixin;Hao, Zhiqiang;Zhang, Yang;Luo, Shuhua;Dang, Xin;Sun, Ran;Duan, Shixin;Lv, Dan;Jiang, Faqin;Fu, Lei. And the article was included in Bioorganic Chemistry in 2021.SDS of cas: 626-64-2 This article mentions the following:

In this study, a novel batch of thiazole-containing mitochondrial targeting agents e.g., I were designed and synthesized. Four kinds of mitochondrial targeting moieties and six kinds of linkers were designed. The screening of antiproliferative activity revealed that most compounds displayed cytotoxicity on HeLa cancer cell. In particular, II has an IC₅₀ value of 35.32μmol·L^-1 against HeLa cell. In addition, cellular respiratory activities were also tested on HeLa cancer cells. The II had a basal oxygen consumption rate of 8.84 pmol·s^-1·mL^-1. Also, II inhibited the mitochondrial respiration of HeLa cell significantly at 5μmol·L^-1, as well as a complete inhibitory of oxygen consumption for cellular ATP coupling. Furthermore, the pKa, logP, and logD under different pH conditions of all the compounds were calculated by the ACD/Percepta-PhysChem Suite, and the results manifested the correlation between physicochem. properties and chem. activity of compounds The results identify II as a promising mitochondria inhibitor and anticancer agent with appropriate physicochem. properties. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2SDS of cas: 626-64-2).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. SDS of cas: 626-64-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Metabolomic investigation of ultraviolet ray-inactivated white spot syndrome virus-induced trained immunity in Marsupenaeus japonicus was written by Zang, Shaoqing;Lv, Li-Xia;Liu, Chen-Fei;Zhang, Peng;Li, Cang;Wang, Jin-Xing. And the article was included in Frontiers in Immunology in 2022.Formula: C5H5NO This article mentions the following:

Trained immunity is driven by metabolism and epigenetics in innate immune cells in mammals. The phenomenon of trained immunity has been identified in invertebrates, including shrimp, but the underlying mechanisms remain unclear. To elucidate mechanisms of trained immunity in shrimp, the metabolomic changes in hemolymph of Marsupenaeus japonicus trained by the UV-inactivated white spot syndrome virus (UVWSSV) were analyzed using tandem gas chromatog.-mass/mass spectrometry. The metabolomic profiles of shrimp trained with UV-WSSV followed WSSV infection showed significant differences comparison with the control groups, PBS injection followed WSSV infection. 16 differential metabolites in total of 154 metabolites were identified, including Dfructose-6-phosphate, D-glucose-6-phosphate, and D-fructose-6-phosphate, and metabolic pathways, glycolysis, pentose phosphate pathway, and AMPK signaling pathway were enriched in the UV-WSSV trained groups. Further study found that histone monomethylation and trimethylation at H3K4 (H3K4me1 and H3K4me3) were involved in the trained immunity. Our data suggest that the UV-WSSV induced trained immunity leads to metabolism reprogramming in the shrimp and provide insights for WSSV control in shrimp aquaculture. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Formula: C5H5NO).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Formula: C5H5NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Supramolecular liquid crystals displaying competitive hydrogen bonding: Mesogenic associative chain structures using rigid and flexible pyridyl groups was written by John, Eric A.;Heltne, Michael D.;Bornowski, Evan C.;Lindberg, David J.;Carli, Joshua D.;Legare, Seth B.;Carli, John T.;Wiegel, Kurt N.. And the article was included in Molecular Crystals and Liquid Crystals in 2019.Reference of 626-64-2 This article mentions the following:

A series of liquid-crystalline supramol. copolymers formed through hydrogen bonding has been created. These polymers are composed of a bis-benzoic acid and two different pyridyl species – a small rigid bispyridyl capable of forming a mesophase when assembled and one of a pair of flexible bis pyridyl non-mesogenic “disruptor” species. The latter set of mols. consist of the pyridyl functionality separated by six or ten methylene units (6BPD and 10BPD, resp.). It was found that the associative chain polymers display monotropic characteristics depending upon the length of the methylene spacer group. The hexamethylene chain produced smectic phases up to 15% composition and cleared nematic characteristics at 70% loading. The decamethylene species eliminated smectic phases at 5% loading and displayed nematic phases up to 40% inclusion. It is believed that the increased length and flexibility of the alkyl chain allows for too much conformational mobility and freedom to efficiently form liquid-crystalline phases at high concentrations In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Reference of 626-64-2).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Reference of 626-64-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Efficient Phosphorus-Free Chlorination of Hydroxy Aza-Arenes and Their Application in One-Pot Pharmaceutical Synthesis was written by Wang, Jian;Li, Yan-Hui;Pan, Song-Cheng;Li, Ming-Fang;Du, Wenting;Yin, Hong;Li, Jing-Hua. And the article was included in Organic Process Research & Development in 2020.Application In Synthesis of Pyridin-4-ol This article mentions the following:

The chlorination of hydroxy aza-arenes with bis(trichloromethyl) carbonate (BTC) and SOCl₂ has been effectively performed by refluxing with 5 weight % 4-(dimethylamino)pyridine (DMAP) as a catalyst. Various substrates are chlorinated with high yields. The obtained chlorinated aza-arenes can be used directly with simple workup for succedent one-pot synthesis on a large scale. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Application In Synthesis of Pyridin-4-ol).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Application In Synthesis of Pyridin-4-ol

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Light-promoted synthesis of surface-grafted polymers bearing pyridine groups by metal-free ATRP in microliter volumes was written by Slowikowska, Monika;Wojcik, Artur J.;Wolski, Karol;Hatalak, Anna;Zapotoczny, Szczepan. And the article was included in Polymer in 2021.Synthetic Route of C5H5NO This article mentions the following:

Polymers with pendant pyridine groups (PPPGs) are pH responsive weak polyelectrolytes potentially attractive for many applications such as sensors, antibacterial coatings, and ion gating systems. Synthesis of PPPGs by classical atom transfer radical polymerization (ATRP) is challenging due to highly probable formation of monomer/metal complexes. In response to that, we report here a facile synthetic strategy to obtain surface-grafted PPPGs that utilizes light-mediated ATRP. Metal-free surface-initiated ATRP catalyzed by 10-phenylphenothiazine is used to polymerize three isomeric monomers with methacrylate groups attached at various positions of a pyridine ring. The reactivity of the isomers is compared for selection of optimal monomer structure leading to thick brushes. The polymerizations are conducted under visible light, at ambient conditions, and using only microliter volumes of the reaction mixture that is important for reducing the complexity and costs of the process and limiting chem. waste. The observed linear dependency of the brush thickness vs. polymerization time for poly(pyridin-3-yl methacrylate) (PP3M) grafted from indium tin oxide or silicon wafers indicated the controlled characteristics of the developed method. The obtained PP3M brush demonstrated pH responsive behavior associated with protonation of pyridine groups in acidic solution and adoption of highly stretched conformation below pK_a. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Synthetic Route of C5H5NO).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Synthetic Route of C5H5NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

A Predictive Strategy Based on Volatile Profile and Chemometric Analysis for Traceability and Authenticity of Sugarcane Honey on the Global Market was written by Silva, Pedro;Freitas, Jorge;Nunes, Fernando M.;Camara, Jose S.. And the article was included in Foods in 2021.Electric Literature of C5H5NO This article mentions the following:

Sugarcane honey (SCH) is a syrup produced on Madeira Island and recognized by its unique aroma, a complex attribute of quality with an important influence on the final consumer’s acceptance of the product, and determined by a complex mixture of a large number of volatile organic compounds (VOCs) generated during its traditional making process and storage. Therefore, the purpose of this study was to establish the volatile profile of genuine SCH produced by a regional certified producer for seven years and compare it with syrups from non-certified regional producers and with producers from different geog. regions (Spain, Egypt, Brazil and Australia), as a powerful strategy to define the volat. fingerprint of SCH. Different volatile profiles were recognized for all samples, with 166 VOCs being identified belonging to different chem. classes, including furans, ketones, carboxylic acids, aldehydes and alcs. Chemometric anal. allowed (i) the differentiation between all syrups, being more pronounced between SCH and other syrups; and (ii) the identification of 32 VOCs as potential markers for the traceability and authenticity of SCH on the global market. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Electric Literature of C5H5NO).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Electric Literature of C5H5NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The roles of metabolic pathways in maintaining primary dormancy of Pinus koraiensis seeds was written by Song, Yuan;Zhu, Jiaojun. And the article was included in BMC Plant Biology in 2019.Quality Control of Pyridin-4-ol This article mentions the following:

Background: Korean pine seeds have primary dormancy following dispersal, leading to poor seed germination and seedling establishment. Metabolic homeostasis determines whether the seeds are dormant or non-dormant. However, the specific metabolic pathways that maintain the primary dormancy of pine seeds are poorly understood. Results: Metabolic anal. was employed on the embryos of PDRS (seeds released from primary dormancy) and PDS (primary dormant seeds) on days 0, 5 and 11 after incubation under a germination-inductive temperature A larger metabolic switch occurred in PDRS embryos from days 0 to 11. The contents of ninety metabolites were significantly changed from days 0 to 5, 83% of which (including most sugars, organic acids and amino acids) increased, reflecting that biosynthetic metabolism processes are initiated. The contents of ninety-two metabolites showed distinct variations from days 5 to 11, 71% of which (including most organic acids and almost all amino acids) reduced substantially. Fructose 6-phosphate, inositol-3-phosphate, 3-phosphoglyceric and D-glucose-6-phosphate contents showed the most decrease with decreasing 409-, 75-, 58- and 41-fold, indicating that the glycolysis and tricarboxylic acid (TCA) cycle strongly slowed down. The contents of the most metabolites in PDS embryos also displayed a relatively larger alteration only from days 0 to 5. Although 64% of metabolites increased from days 0 to 5, their levels were still lower compared with PDRS embryos. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Quality Control of Pyridin-4-ol).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Quality Control of Pyridin-4-ol

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem