Tag: 0-100

A unique nickel-base nitrogen-oxygen bidentate ligand catalyst for carbonylation of acetylene to acrylic acid was written by Cui, Long;Yang, Xiangui;Zeng, Yi;Chen, Yuntang;Wang, Gongying. And the article was included in Molecular Catalysis in 2019.Safety of Pyridin-4-ol This article mentions the following:

A nickel-base nitrogen-oxygen bidentate ligand catalyst was prepared in-situ via the complexation method. Our results show that the ligand with nickel can form a chelate catalyst possessing a ring structure, which exhibits good catalytic performance in the carbonylation reaction of acetylene to acrylic acid (AA). Furthermore, we discovered that, under our optimized conditions, when 8-hydroxyquinoline (HQ) is used as the ligand [c(Ni(OAc)₂·4H₂O) = 15 X 10-6 mol L^-1, n(HQ):n(Ni(OAc)₂·4H₂O) = 1:1, V(H₂O) = 7 mL], 70.1% conversion of acetylene and 92.4% the selectivity of AA is achieved at 200 °C with 8.0 MPa pressure for 30 min. Compared to traditional acetylene carbonylation catalysts and nickel-base phosphine ligand homogeneous complex catalysts, our catalytic system has unique advantages, including no copper, no halogen and no carbon deposition generated during the reaction process. It displays high selectivity and no corrosion of equipment, suggesting that this catalytic system possesses future industrial applications. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Safety of Pyridin-4-ol).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Safety of Pyridin-4-ol

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Discovery of IACS-9439, a Potent, Exquisitely Selective, and Orally Bioavailable Inhibitor of CSF1R was written by Czako, Barbara;Marszalek, Joseph. R.;Burke, Jason P.;Mandal, Pijus;Leonard, Paul G.;Cross, Jason B.;Mseeh, Faika;Jiang, Yongying;Chang, Edward Q.;Suzuki, Erika;Kovacs, Jeffrey J.;Feng, Ningping;Gera, Sonal;Harris, Angela L.;Liu, Zhen;Mullinax, Robert A.;Pang, Jihai;Parker, Connor A.;Spencer, Nakia D.;Yu, Simon S.;Wu, Qi;Tremblay, Martin R.;Mikule, Keith;Wilcoxen, Keith;Heffernan, Timothy P.;Draetta, Giulio F.;Jones, Philip. And the article was included in Journal of Medicinal Chemistry in 2020.Application of 626-64-2 This article mentions the following:

Tumor-associated macrophages (TAMs) have a significant presence in the tumor stroma across multiple human malignancies and are believed to be beneficial to tumor growth. Targeting CSF1R has been proposed as a potential therapy to reduce TAMs, especially the protumor, immune-suppressive M2 TAMs. Addnl., the high expression of CSF1R on tumor cells has been associated with poor survival in certain cancers, suggesting tumor dependency and therefore a potential therapeutic target. The CSF1-CSF1R signaling pathway modulates the production, differentiation, and function of TAMs; however, the discovery of selective CSF1R inhibitors devoid of type III kinase activity has proven to be challenging. We discovered a potent, highly selective, and orally bioavailable CSF1R inhibitor, IACS-9439 (I). Treatment with I led to a dose-dependent reduction in macrophages, promoted macrophage polarization toward the M1 phenotype, and led to tumor growth inhibition in MC38 and PANC02 syngeneic tumor models. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Application of 626-64-2).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Application of 626-64-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kinetic study on pyridinolysis of aryl benzenesulfonates: factors governing regioselectivity and reaction mechanism was written by Um, Ik-Hwan;Jung, Yoon Jae;Dust, Julian M.. And the article was included in Canadian Journal of Chemistry in 2022.Safety of Pyridin-4-ol This article mentions the following:

A kinetic study is reported for reactions of 2,4-dinitrophenyl X-substituted-benzenesulfonates (1a-1f) and Y-substituted-Ph benzenesulfonates (2a-2f) with Z-substituted-pyridines. The reactions proceed through S-O and C-O bond scissions competitively. The Yukawa-Tsuno plot for the reactions of 1a-1f with 4-oxypyridine (S-O bond fission) exhibits an excellent linearity. The Bronsted-type plot for the reactions of 2,4-dinitrophenyl benzenesulfonate (1d) with pyridines (S-O bond fission) is also linear with β_nuc = 0.62. The Bronsted-type plot for the reactions of 2a-2f with 4-oxypyridines (S-O bond fission) is linear with β_lg = -1.17. Thus, the reactions have been concluded to proceed through a concerted mechanism, in which leaving-group expulsion is significantly more advanced than bond formation between the electrophilic center and nucleophile at the transition state. The Hammett plot for the reactions of 1a-1f with 4-oxypyridine (C-O bond fission) exhibits scattered points with ρ_X = 0.98. The Bronsted-type plot for the reactions of 1d with Z-substituted-pyridines (C-O bond fission) results in an excellent linear correlation with β_nuc = 0.38. Thus, the reactions (C-O bond fission) have been concluded to proceed through a stepwise mechanism with a Meisenheimer complex, in which expulsion of the leaving group occurs after the rate-determining step. Factors governing regioselectivity and reaction mechanism are discussed. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Safety of Pyridin-4-ol).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Safety of Pyridin-4-ol

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Metal-Free Difunctionalization of Pyridines: Selective Construction of N-CF₂H and N-CHO Dihydropyridines was written by Zhou, Sen;Sun, Ze-Ying;Zhu, Kongying;Zhao, Wentao;Tang, Xiangyang;Guo, Minjie;Wang, Guangwei. And the article was included in Organic Letters in 2021.HPLC of Formula: 626-64-2 This article mentions the following:

A novel nucleophilic addition of N-difluoromethylpyridinium salts with nitroalkanes to synthesize N-CF₂H-dihydropyridines and N-CHO-dihydropyridines in a highly efficient and regioselective pathway was reported. This protocol exhibited good functional group tolerance and good to excellent yields. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2HPLC of Formula: 626-64-2).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.HPLC of Formula: 626-64-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Endogenous bioethanol production by solid-state prefermentation for enhanced crude bio-oil recovery through integrated hydrothermal liquefaction of seaweeds was written by El-Hefnawy, Mohamed E.;Alhayyani, Sultan;El-Sherbiny, Mohsen M.;Abomohra, Abd El-Fatah;Al-Harbi, Mamdouh. And the article was included in Journal of Cleaner Production in 2022.Recommanded Product: 626-64-2 This article mentions the following:

The present study evaluated the action of endogenous bioethanol produced during solid-state fermentation of Ulva spp. on subsequent hydrothermal liquefaction (HTL). HTL of raw biomass (RB) was compared with HTL of the fermented biomass after bioethanol separation (F-Aqua) and HTL of the whole fermentation broth containing the bioethanol (F-Eth). Optimization of fermentation conditions increased the ethanol yield efficiency (Y_eff) and specific ethanol yield (SEY) from 23.55% and 0.120 g g^-1 sugar consumed to 43.97% and 0.224 g g^-1 sugar consumed, resp. TGA and FTIR anal. confirmed noticeable changes in the thermal profile and functional groups of the fermented residue with increased volatiles and lower ash content. Among different HTL treatments, F-Eth showed the highest bio-oil yield of 24.96% at 250°C, which was 37.7% and 39.0% higher than that of RB and F-Aqua, resp. In addition, hydrocarbons and esters in the bio-oil represented the dominant compounds in F-Aqua and F-Eth, altogether 28.28% and 68.58%, resp., compared to 17.96% in RB. Economic anal. for a proposed 100 ton year^-1 plant confirmed that HTL of the whole fermentation broth containing endogenous bioethanol enhanced the gross energy output to 8.152 GJ ton^-1, which represented 4.2-time, 51.1%, and 23.3% higher than individual bioethanol production, individual bio-oil production, and sequential bioethanol/bio-oil recovery, with the highest net annual profit of 29553 US$ compared to 23391 US$ for the sequential production In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Recommanded Product: 626-64-2).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Recommanded Product: 626-64-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Peat burning – An important source of pyridines in the earth atmosphere was written by Kosyakov, Dmitry S.;Ul’yanovskii, Nikolay V.;Latkin, Tomas B.;Pokryshkin, Sergey A.;Berzhonskis, Valeria R.;Polyakova, Olga V.;Lebedev, Albert T.. And the article was included in Environmental Pollution (Oxford, United Kingdom) in 2020.Related Products of 626-64-2 This article mentions the following:

Studies of the chem. composition of atm. aerosols, rain water and snow in various regions of the globe quite often show the presence of pyridine and a number of its low mass derivatives Nevertheless, the sources of those compounds in the environment have not yet been established and definitely require elucidation, supported by reliable exptl. results. In the present work the chem. composition of peat combustion products as one of the important sources of atm. aerosol emission is studied by two-dimensional gas chromatog. – high-resolution mass spectrometry with a focus on the detection of pyridine derivatives Twenty-five compounds of this class were reliably identified and quantified in laboratory experiments on peat burning. Among them 3-hydroxypyridine predominates, while the rest analytes are mostly represented by alkyl derivatives: pyridine, 2-methylpyridine, 3-methylpyridine, 2,5-dimethylpyridine, 2,6-dimethylpyridine, 2-ethylpyridine, lutidines (in order of decreasing concentration). The experiments on peat thermal decomposition by pyrolysis GC-MS demonstrated that the maximum concentrations as well as the number of detected analytes were found under conditions of oxygen lack and a temperature of about 500°C, i.e. characteristic conditions of peat wildfires. The observed levels of pyridines’ emission recalculated on the peat dry weight exceeded 200 mg kg^-1. The obtained results allow concluding that peat burning may be the major and still underestimated source of pyridine and lower alkylpyridines in the Earth atm. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Related Products of 626-64-2).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Related Products of 626-64-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

High-Precision Automated Workflow for Urinary Untargeted Metabolomic Epidemiology was written by Meister, Isabel;Zhang, Pei;Sinha, Anirban;Skold, C. Magnus;Wheelock, Asa M.;Izumi, Takashi;Chaleckis, Romanas;Wheelock, Craig E.. And the article was included in Analytical Chemistry (Washington, DC, United States) in 2021.Electric Literature of C5H5NO This article mentions the following:

Urine is a noninvasive biofluid that is rich in polar metabolites and well suited for metabolomic epidemiol. However, because of individual variability in health and hydration status, the physiol. concentration of urine can differ >15-fold, which can pose major challenges in untargeted liquid chromatog.-mass spectrometry (LC-MS) metabolomics. Although numerous urine normalization methods have been implemented (e.g., creatinine, sp. gr.-SG), most are manual and, therefore, not practical for population-based studies. To address this issue, we developed a method to measure SG in 96-well-plates using a refractive index detector (RID), which exhibited accuracy within 85-115% and <3.4% precision. Bland-Altman statistics showed a mean deviation of -0.0001 SG units (limits of agreement: -0.0014 to 0.0011) relative to a hand-held refractometer. Using this RID-based SG normalization, we developed an automated LC-MS workflow for untargeted urinary metabolomics in a 96-well-plate format. The workflow uses pos. and neg. ionization HILIC chromatog. and acquires mass spectra in data-independent acquisition (DIA) mode at three collision energies. Five tech. internal standards (tISs) were used to monitor data quality in each method, all of which demonstrated raw coefficients of variation (CVs) < 10% in the quality controls (QCs) and < 20% in the samples for a small cohort (n = 87 urine samples, n = 22 QCs). Application in a large cohort (n = 842 urine samples, n = 248 QCs) demonstrated CV_QC < 5% and CV_samples < 16% for 4/5 tISs after signal drift correction by cubic spline regression. The workflow identified >540 urinary metabolites including endogenous and exogenous compounds This platform is suitable for performing urinary untargeted metabolomic epidemiol. and will be useful for applications in population-based mol. phenotyping. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Electric Literature of C5H5NO).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Electric Literature of C5H5NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Effect of processing and storage on the volatile profile of sugarcane honey: A four-year study was written by Silva, Pedro;Freitas, Jorge;Nunes, Fernando M.;Camara, Jose S.. And the article was included in Food Chemistry in 2021.COA of Formula: C5H5NO This article mentions the following:

Sugarcane honey (SCH) is a syrup from Madeira Island recognized by its unique and excellent aroma, associated to volatile organic compounds (VOCs) generated during the well-defined five stages of its traditional making process. The establishment of volatile profile throughout all SCH-making stages during four years, allowed the evaluation of the influence of each stage in the typical characterisitcs of SCH. One hundred eighthy seven VOCs were identified, being associated to several origins and formation pathways. VOCs formed during stage 1 and 2 were originate from raw material, and its oxidation (i.e. enzymic browning) and thermal degradation (i.e. lipid oxidation, Maillard reactions, Strecker degradation). In stage 3 and 4, the caramelization and melanoidin degradation also occurred, while in stage 5, the thermal degradation continues, followed by microbial activity. Chemometric anal. allowed to identify 35 VOCs as potential markers for processing control by the producers and as guarantee of the typicality and authenticity of SCH. Based on the obtained results, we propose for the first time an innovative schematic diagram explaining the potential reactions and pathways for VOCs formation during the different steps of the SCH production In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2COA of Formula: C5H5NO).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.COA of Formula: C5H5NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Copper-Mediated Selective Mono- and Sequential Organochalcogenation of C-H Bonds: Synthesis of Hybrid Unsymmetrical Aryl Ferrocene Chalcogenides was written by Sattar, Moh.;Patidar, Krishna;Thorat, Raviraj Ananda;Kumar, Sangit. And the article was included in Journal of Organic Chemistry in 2019.Quality Control of Pyridin-4-ol This article mentions the following:

A 8-aminoquinoline directed Cu/1,10-phenanthroline-mediated selective mono-organothiolation of C-H bond in ferroceneamide was developed using aryl/alkyl-disulfide substrates. The sequential ferrocene C-H organochalcogenation (chalcogen = S, Se, and Te) also was established for the synthesis of novel hybrid unsym. aryl chalcogenides with the aid of a catalytic amount of Cu(OAc)2 under ambient reaction conditions. The developed protocol exhibits a broad functional group tolerance to allow alkyl, aryl, hetero-aryl, bromo, chloro, and nitro containing diorgano dichalcogenides as a coupling partner. Further, the 8-aminoquinoline directing group is easily removed to afford the aldehyde functionality after C-H organochalcogenation. A mechanistic understanding of the Cu-mediated selective mono-organothiolation reaction suggests that rigid bi-coordinated 1,10-phenanthroline ligand and freshly generated Cu(II) from Cu(I) in the less polar solvent MeCN seem crucial for the selective mono-C-H functionalization of ferroceneamide. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Quality Control of Pyridin-4-ol).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Quality Control of Pyridin-4-ol

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Structure-activity relationship toward electrocatalytic nitrogen reduction of MoS₂ growing on polypyrrole/graphene oxide affected by pyridinium-type ionic liquids was written by Mao, Hui;Fu, Yuanlin;Yang, Haoran;Zhang, Shuai;Liu, Jinchi;Wu, Shuyao;Wu, Qiong;Ma, Tianyi;Song, Xi-Ming. And the article was included in Chemical Engineering Journal (Amsterdam, Netherlands) in 2021.Quality Control of Pyridin-4-ol This article mentions the following:

MoS₂ with different crystal structures and phase compositions have in-situ grown on the surface of pyridinium-type ionic liquids functionalized polypyrrole/graphene oxide (pyridinium-ILs/PPy/GO) and exhibited different electocatalytic performance towards Nitrogen reduction reaction (NRR), affected by the difference of crystal structure and phase compositions of MoS₂ resulting from the induction of substituent groups in pyridinium. Combining the results of NRR performance tests with material characterizations determined by XRD, XPS and Raman spectra to explore the structure-activity relationship toward NRR of MoS₂/pyridinium-ILs/PPy/GO, pyridinium-ILs with a group containing amino in the para- or ortho-position can be beneficial to induce 1T-MoS₂ with good crystallinity, resulting in the satisfying NH₃ yield, but poor stability, while the hydroxyl group at the para-position in pyridinium-ILs only induce 2H-MoS₂ indexed to JCPDS file number 75-1539, not conducive to nitrogen fixation. Surprisingly, the most excellent NRR electroactivity is achieved by MoS₂/pyridinium-ILs/PPy/GO synthesized using 2-amino-3-hydroxypyridine with the excellent lamellar hierarchical inorganic/organic micro-/nanostructures. It may be attributed to the confinement effect caused by the stereo hindrance composed of amino group at the ortho-position and hydroxyl group at the meta-position in pyridinium-ILs, resulting in 1T/2H-MoS₂ nanoplates with rich defects indexed to JCPDS file number 37-1492 growing on pyridinium-ILs/PPy/GO. Therefore, the kind and position of substituent groups in pyridinium played an essential role for the crystal structure and phase compositions of MoS₂ growing on pyridinium-ILs/PPy/GO, and further affected the NRR performance, which would provide a new thought and method for the reasonable design and performance optimization of electrocatalysts based on transition metal dichalcogenides for electrocatalysis. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Quality Control of Pyridin-4-ol).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Quality Control of Pyridin-4-ol

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem