Tag: 0-100

Rapid determination of chemical composition in the particulate matter of cigarette mainstream smoke was written by Wang, Xinxin;Jiang, Qing;Li, Hongli;Chen, David D. Y.. And the article was included in Talanta in 2020.Quality Control of Pyridin-4-ol This article mentions the following:

Particulate matter from mainstream smoke (MSS) is significantly hazardous when inhaled into the human body. An ambient ionization mass spectrometric method, direct anal. in real time mass spectrometry (DART-MS), was applied to rapidly and simultaneously measure multiple particulate components in MSS. A variety of compounds were obtained in seconds, where different types of cigarettes and different solvent extracts generated distinct chem. constituents as validated by principle component anal. Chem. formula assignment and compound identification were based on accurate m/z values with mass errors <10 ppm. Quantitation of nicotine was achieved using an isotope internal standard with DART-MS. Method validation with chromatog.-MS anal. further proved the advantages of DART-MS with respect to anal. speed and operational simplicity for the direct evaluation of complex samples. DART-MS is feasible for the rapid acquisition of cigarette fingerprints for quality control as well as for quant. assessment of carcinogens for harm reduction In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Quality Control of Pyridin-4-ol).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Quality Control of Pyridin-4-ol

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Discovery and Development of 3-(6-Chloropyridine-3-yloxymethyl)-2-azabicyclo[3.1.0]hexane Hydrochloride (SUVN-911): A Novel, Potent, Selective, and Orally Active Neuronal Nicotinic Acetylcholine α4β2 Receptor Antagonist for the Treatment of Depression was written by Nirogi, Ramakrishna;Mohammed, Abdul Rasheed;Shinde, Anil K.;Ravella, Srinivasa Rao;Bogaraju, Narsimha;Subramanian, Ramkumar;Mekala, Venkat Reddy;Palacharla, Raghava Choudary;Muddana, Nageswararao;Thentu, Jagadeesh Babu;Bhyrapuneni, Gopinadh;Abraham, Renny;Jasti, Venkat. And the article was included in Journal of Medicinal Chemistry in 2020.Electric Literature of C5H5NO This article mentions the following:

A series of chem. optimizations guided by in vitro affinity at the α4β2 receptor in combination with selectivity against the α3β4 receptor, pharmacokinetic evaluation, and in vivo efficacy in a forced swim test resulted in identification of 3-(6-chloropyridine-3-yloxymethyl)-2-azabicyclo[3.1.0]hexane hydrochloride, I, (SUVN-911) as a clin. candidate. Compound I is a potent α4β2 receptor ligand with a K_i value of 1.5 nM. It showed >10μM binding affinity toward the ganglionic α3β4 receptor apart from showing selectivity over 70 other targets. It is orally bio-available and showed good brain penetration in rats. Marked antidepressant activity and dose-dependent receptor occupancy in rats support its potential therapeutic utility in the treatment of depression. It does not affect the locomotor activity at doses several folds higher than its efficacy dose. It is devoid of cardiovascular and gastrointestinal side effects. Successful long-term safety studies in animals and phase-1 evaluation in healthy humans for safety, tolerability, and pharmacokinetics paved the way for its further development. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Electric Literature of C5H5NO).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Electric Literature of C5H5NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Doping engineering of single-walled carbon nanotubes by nitrogen compounds using basicity and alignment was written by Kumanek, Bogumila;Milowska, Karolina Z.;Przypis, Lukasz;Stando, Grzegorz;Matuszek, Karolina;MacFarlane, Douglas;Payne, Mike C.;Janas, Dawid. And the article was included in ACS Applied Materials & Interfaces in 2022.Safety of Pyridin-4-ol This article mentions the following:

Charge transport properties in single-walled carbon nanotubes (SWCNTs) can be significantly modified through doping, tuning their elec. and thermoelec. properties. In our study, we used more than 40 nitrogen-bearing compounds as dopants and determined their impact on the material’s elec. conductivity The application of nitrogen compounds of diverse structures and electronic configurations enabled us to determine how the dopant nature affects the SWCNTs. The results reveal that the impact of these dopants can often be anticipated by considering their Hammett’s constants and pK_a values. Furthermore, the empirical observations supported by first-principles calculations indicate that the doping level can be tuned not only by changing the type and the concentration of dopants but also by varying the orientation of nitrogen compounds around SWCNTs. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Safety of Pyridin-4-ol).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Safety of Pyridin-4-ol

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis, Antifungal Activity, and 3D-QASR of Novel 1,2,3,4-Tetrahydroquinoline Derivatives Containing a Pyrimidine Ether Scaffold as Chitin Synthase Inhibitors was written by Zhang, Xiaoming;Yang, Zhaokai;Xu, Huan;Liu, Yuansheng;Yang, Xinling;Sun, Tengda;Lu, Xingxing;Shi, Fasheng;Yang, Qing;Chen, Wei;Duan, Hongxia;Ling, Yun. And the article was included in Journal of Agricultural and Food Chemistry in 2022.Application In Synthesis of Pyridin-4-ol This article mentions the following:

The introduction of active groups of natural products into the framework of pesticide mols. is an effective approach for discovering active lead compounds, and thus has been widely used in the development of new agrochems. In this work, a novel series of 1,2,3,4-tetrahydroquinoline derivatives containing a pyrimidine ether scaffold were designed and synthesized by the active substructure splicing method. The new compounds showed good antifungal activities against several fungi. Especially, compound (I) displayed excellent in vitro activity against Valsa mali and Sclerotinia sclerotiorum with EC₅₀ values of 0.71 and 2.47 μg/mL, resp. I had slightly stronger inhibitory activity (68.08% at 50 μM) against chitin synthase (CHS) than that of polyoxin D (63.84% at 50 μM) and exhibited obvious curative and protective effects on S. sclerotiorumin vivo. Thus, I can be considered as a new candidate fungicide as a chitin synthase inhibitor. An accurate and reliable three-dimensional quant. structure-activity relationship (3D-QSAR) model presented a useful direction for the further excogitation of more highly active fungicides. Mol. docking revealed that the conventional hydrogen bond mainly affected the binding affinity of I with chitin synthase. The present results will provide a guidance to discover potential CHS-based fungicides for plant disease control in agriculture. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Application In Synthesis of Pyridin-4-ol).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Application In Synthesis of Pyridin-4-ol

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Bamboo pyroligneous acid as a novel insecticide, its mosquito repellency activity, chemical components and safety towards animals was written by Li, Zhikun;Maliang, Huidong;Liu, Qing;Chen, Anliang;Liu, Hongbo;Lin, Haiping;Ma, Jianyi;Wang, Pinwewi. And the article was included in Fresenius Environmental Bulletin in 2022.Reference of 626-64-2 This article mentions the following:

Mosquitoes transmit pathogens which cause human and mammalian diseases. We employed several practical and multidisciplinary approaches to discover a new natural mosquito repellent. The active ingredient tests revealed that bamboo vinegar (BV) showed 91% protective efficacy. The forearm skin landing test showed that 9% acetic acid water solution (AAWS) and BV had strong protective efficacy against Aedes albopictus. The limb skin landing test also showed that BV and AAWS had protective efficacy. The sugar-feeding behavioral bioassay showed that mosquitoes were repelled by the smell of AAWS. There was no significant difference between the number of mosquitoes that landed on the two Petri dishes treated with BV (6.6% acetic acid (AA)), 4.5% AAWS, 9% AAWS, and 4.5% DEBT, but a significant difference was found among BV (6.6% AA), 4.5% AAWS, 9.0% AAWS, DEBT, and distilled water. The arm-in-cage tests showed that there was a descending order for the duration of complete protection was DEBT (75-90 min) = BV (75-90 min) > formic acid (60-75 min) > AA (45-60 min) > propanoic acid (30-45 min) > butanoic acid (15-30 min) > water (0 min). The safety tests showed that the acute oral toxicity (LD50) of BV (6.6% AA) was > 5000 mg/kg for mice and produced no red spots or edema symptoms. Furthermore, the dermal sensitization rate was zero for rabbits, and the marrow micronucleus rates for mice were neg. In summary, BV can be safely used for volatilization and skin applications. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Reference of 626-64-2).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Reference of 626-64-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis and Characterization of Poly(m-tolyloxy-co-4-pyridinoxy phosphazene)s and their Application as Proton Exchange Membranes was written by Yigen, Burak;Kassim Ali, Mariamu;Karatas, Betul;Alkan Guersel, Selmiye;Karatas, Yunus. And the article was included in ChemistrySelect in 2022.COA of Formula: C5H5NO This article mentions the following:

A novel set of polyphosphazenes are synthesized to produce three polymers with varying side group ratios for proton exchange membranes. The designed heterosubstituted polymers here are the rare examples of polyphosphazenes of this kind to serve as proton exchange membranes with optimized structural stability and high temperature ionic conductivity High quality polyphosphazenes with narrow polydispersity and rather low Tg values were prepared These poly(m-tolyloxy-co-4-pyridinoxy phosphazene)s are sulfonated under a range of conditions and characterized in order to investigate the synergetic effect of the heteroatom on the proton conductivity of the proton exchange membranes. The effect of sulfonation temperature and time on the fuel cell relevant properties is also investigated. Hydrolytically stable proton exchange membranes with high thermal and chem. stabilities are achieved. Addnl., resultant membranes exhibit proton conductivity, IEC and water uptake values comparable with com. Nafion membranes. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2COA of Formula: C5H5NO).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. COA of Formula: C5H5NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Structural considerations for charge-enhanced Bronsted acid catalysts was written by Payne, Curtis;Kass, Steven R.. And the article was included in Journal of Physical Organic Chemistry in 2020.SDS of cas: 626-64-2 This article mentions the following:

All three N-methylated and N-protonated hydroxypyridinium BAr^F₄^– salt isomers were synthesized and their hydrogen bond donating abilities were investigated. DFT and G4 theory computations along with IR spectroscopic measurements were found to be effective methods for predicting the catalytic activities of these O-H and N-H Bronsted acids. A UV-vis titration approach for rapidly quantifying hydrogen bond donating ability revealed that carbon-hydrogen bonds also can participate in electrostatic interactions, but the presence of multiple equilibrium complexes results in a limitation of this method. In the methylated series of hydroxypyridines, the ortho and para isomers displayed modest rate enhancements relative to the meta derivative Protonation introduces a new acidic site and the ortho hydroxypyridinium ion salt is a significantly more active catalyst than all of the other species examined This is indicative of bidentate activation by the N-H and O-H acidic sites, and suggests a new design strategy for improving charge-enhanced catalysts. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2SDS of cas: 626-64-2).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.SDS of cas: 626-64-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

How Hydrogen Bonding Amplifies Isomeric Differences in Pyridones toward Strong Changes in Acidity and Tautomerism was written by Buechner, Robby;Fondell, Mattis;Mascarenhas, Eric J.;Pietzsch, Annette;Vaz da Cruz, Vinicius;Foehlisch, Alexander. And the article was included in Journal of Physical Chemistry B in 2021.Product Details of 626-64-2 This article mentions the following:

Steric hindrance of hydration and hydrogen bond enhancement by localized charges have been identified as key factors for the massive chem. differences between the hydroxypyridine/pyridone isomers in aqueous solution While all isomers occur mainly in the hydroxypyridine form in the gas phase, they differ by more than 3 orders of magnitude both in their acidity and tautomeric equilibrium constants upon hydration. By monitoring the electronic and solvation structures as a function of the protonation state and the O^– substitution position on the pyridine ring, the amplification of the isomeric differences in aqueous solution has been investigated. Near-edge X-ray absorption fine structure (NEXAFS) measurements at the N K-edge served as the probe of the chem. state. The combination of mol. dynamics simulations, complete active space SCF (CASSCF), and time-dependent d. functional theory (TD-DFT) spectral calculations contributes to unraveling the principles of tautomerism and acidity in multiple biochem. systems based on tautomerism. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Product Details of 626-64-2).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Product Details of 626-64-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Isotruxene-based porous polymers as efficient and recyclable photocatalysts for visible-light induced metal-free oxidative organic transformations was written by Zhang, Haowen;Zhou, Cen;Zheng, Ying;Zhang, Xiao. And the article was included in Green Chemistry in 2021.Application In Synthesis of Pyridin-4-ol This article mentions the following:

Two new isotruxene-based porous polymers were prepared and demonstrated to be highly efficient, metal-free heterogeneous photocatalysts for oxidative transformations using air as the mild oxidant under visible-light irradiation Both catalysts show excellent recyclability. In addition, the reactions can be performed in water, further indicating the greenness of this method. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Application In Synthesis of Pyridin-4-ol).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Application In Synthesis of Pyridin-4-ol

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Magnetic properties of a quantum spin ladder in proximity to the isotropic limit was written by Zvyagin, S. A.;Ponomaryov, A. N.;Ozerov, M.;Schulze, E.;Skourski, Y.;Beyer, R.;Reimann, T.;Zviagina, L. I.;Green, E. L.;Wosnitza, J.;Sheikin, I.;Bouillot, P.;Giamarchi, T.;Wikara, J. L.;Turnbull, M. M.;Landee, C. P.. And the article was included in Physical Review B in 2021.HPLC of Formula: 626-64-2 This article mentions the following:

We report on the synthesis, crystal structure, magnetic, thermodn., and electron-spin-resonance properties of the coordination complex [Cu₂(pz)₃(4-HOpy)₄](ClO₄)₄ (pz=pyrazine; 4-HOpy=4-hydroxypyridine). This material is identified as a spin-1/2 Heisenberg ladder system with exchange-coupling parameters J_rung/k_B = 12.1(1)K and J_leg/k_B = 10.5(3)K[J_rung/J_leg = 1.15(4)]. For single crystals our measurements revealed two critical fields, Μ₀H_c1=4.63(5)T and Μ₀H_c2=22.78(5)T (for H||a*), separating the gapped spin-liquid, gapless Tomonaga-Luttinger-liquid, and fully spin-polarized phase. No signature of a field-induced transition into a magnetically ordered phase was found at temperatures down to 450 mK. The material bridges an important gap by providing an excellent phys. realization of an almost isotropic spin-1/2 strong-rung Heisenberg ladder system with modest exchange-coupling energy and critical-field scales. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2HPLC of Formula: 626-64-2).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. HPLC of Formula: 626-64-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem