Tag: 100-200

Directed Lithiation of 3-[(tert-Butoxycarbonyl)amino]-2-methoxypyridines: Synthetic Route to Nevirapine and Its 4-Substituted Derivatives was written by Kelly, Terence A.;Patel, Usha R.. And the article was included in Journal of Organic Chemistry in 1995.Synthetic Route of C7H10N2O This article mentions the following:

The directed lithiation of 3-[(tert-butoxycarbonyl)amino]-2-methoxypyridines produces a variety of 4-substituted derivatives A general route to 4-substituted dipyridodiazepinones, culminating in the synthesis of the antiviral nevirapine (I) is demonstrated. In the experiment, the researchers used many compounds, for example, 2-Methoxy-4-methylpyridin-3-amine (cas: 76005-99-7Synthetic Route of C7H10N2O).

2-Methoxy-4-methylpyridin-3-amine (cas: 76005-99-7) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of 閳?8.7 鑴?10閳? cm3璺痬ol閳?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ璺痬ol閳? in the liquid phase and 140.4 kJ璺痬ol閳? in the gas phase. Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Synthetic Route of C7H10N2O

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reaction of aromatic N-oxides with dipolarophiles. XVI. Cycloaddition behavior of aromatic N-oxides toward electron-deficient allenes and x-ray structure of the 1,4-dipolar cycloadduct was written by Hisano, Takuzo;Harano, Kazunobu;Matsuoka, Toshikazu;Matsuzaki, Tatsuya;Eto, Masashi. And the article was included in Chemical & Pharmaceutical Bulletin in 1991.Computed Properties of C7H9NO This article mentions the following:

In connection with the pericyclic reaction of pyridine N-oxides with dipolarophiles, the cycloaddition behavior of some aromatic N-oxides toward electron-deficient allenes was investigated. In the reaction of 2-phenylpyridine N-oxide with di-Me 2,3-pentadienedioate, the 2,3-dihydropyridine type 1:1 cycloadducts I, which resulted from 1,5-sigmatropic rearrangement of the primary cycloadduct, were isolated. The reaction of 3,5-dihalopyridine N-oxides with the allene gave the dehydrohalogenated cycloadducts II (R = Cl, Br). The reaction of 3,5-dimethylpyridine N-oxide with the allene caused deoxygenation to give 3,5-dimethylpyridine, which in turn reacted with two mols. of the allene to give 1:2 cycloadduct (1,4-dipolar cycloaddition product) III. The mol. structure of III was determined by single crystal x-ray anal. The observed reaction behaviors are discussed in terms of frontier MO considerations. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Computed Properties of C7H9NO).

3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of 閳?8.7 鑴?10閳? cm3璺痬ol閳?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ璺痬ol閳? in the liquid phase and 140.4 kJ璺痬ol閳? in the gas phase. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Computed Properties of C7H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reaction of aromatic N-oxides with dipolarophiles. VI. Further studies on the 1,3-dipolar cycloaddition reaction of pyridine N-oxides with phenyl isocyanates was written by Harano, Kazunobu;Suematsu, Fumihiro;Matsuoka, Toshikazu;Hisano, Takuzo. And the article was included in Chemical & Pharmaceutical Bulletin in 1984.Related Products of 3718-65-8 This article mentions the following:

To provide addnl. evidence for the concerted mechanism postulated for the 1,3-dipolar cycloaddition reaction of pyridine N-oxides with Ph isocyanates, kinetic studies on the cycloaddition reactions were conducted in a variety of solvents. The cycloaddition showed low sensitivity to the ionizing power of the medium, indicating that it proceeds by a mechanism which involves very little change in charge separation between the ground state and the transition state. The observed cycloadditivity and site selectivity are discussed in terms of the following controlling factors based on MINDO/3 calculations: HOMO-LUMO control, secondary orbital interaction, steric interaction, dipole-dipole interaction, and charge-transfer complexation. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Related Products of 3718-65-8).

3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. Pyridine has a conjugated system of six 锜?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H鐪塩kel criteria for aromatic systems. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Related Products of 3718-65-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Cyclometalated Iron and Ruthenium Complexes Supported by a Tetradentate Ligand Scaffold with Mixed O, N, and C Donor Atoms: Synthesis, Structures, and Excited-State Properties was written by Law, Kwok-Chung;Tang, Zhou;Wu, Liangliang;Wan, Qingyun;To, Wai-Pong;Chang, Xiaoyong;Low, Kam-Hung;Liu, Yungen;Che, Chi-Ming. And the article was included in Organometallics in 2022.Name: Pyridinehydrochloride This article mentions the following:

Cyclometalated Fe(II/III) and Ru(II/III) complexes bearing a tetradentate dianionic [O-N-C-N] ligand (H₂[O-N-C-N] = 2-(6-(3-(pyridin-2-yl)phenyl)pyridin-2-yl)phenol) were synthesized and structurally characterized. The strong-field dianionic [O-N-C-N] ligand enforces all of these complexes in low-spin state at 298 K as revealed by ¹H NMR, magnetic susceptibility, and EPR measurements. A 77 K 2-MeTHF glassy solution of the bis(arylisocyanide) Ru(II) complex [Ru^II(O-N-C-N)(XylNC)₂] displays a weak and broad emission band (浣?sub>em: 680 nm; 锜? 0.27娓璼) while the others are nonemissive. DFT/TDDFT calculations revealed that ¹dd excited states of the d⁶ [M(II)(O-N-C-N)(PMe₃)₂] (M = Fe, Ru) are strongly destabilized. The [Fe(II)(O-N-C-N)(PMe₃)₂] exhibits panchromatic absorption up to 850 nm. A combined study of fs-TA, spectroelectrochem., and theor. calculation revealed that the possible ³MLCT excited state (锜? 14 ps) of [Fe(II)(O-N-C-N)(PMe₃)₂] decays via a lower-lying ³dd excited state. For the d⁵ [M(III)(O-N-C-N)(PMe₃)₂]⁺ (M = Fe, Ru), the presence of low-lying ²dd excited states and ²LMCT states with short lifetimes (锜? 11.7-12.6 ps) is suggested. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Name: Pyridinehydrochloride).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Name: Pyridinehydrochloride

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Powerful peracetic acid-ionic liquid pretreatment process for the efficient chemical hydrolysis of lignocellulosic biomass was written by Uju;Goto, Masahiro;Kamiya, Noriho. And the article was included in Bioresource Technology in 2016.Category: pyridine-derivatives This article mentions the following:

The aim of this work was to design a new method for the efficient saccharification of lignocellulosic biomass (LB) using a combination of peracetic acid (PAA) pretreatment with ionic liquid (IL)-HCl hydrolysis. The pretreatment of LBs with PAA disrupted the lignin fractions, enhanced the dissolution of LB and led to a significant increase in the initial rate of the IL-HCl hydrolysis. The pretreatment of Bagasse with PAA prior to its 1-butyl-3-methylimidazolium chloride ([Bmim][Cl])-HCl hydrolysis, led to an improvement in the cellulose conversion from 20% to 70% in 1.5 h. Interestingly, the 1-butyl-3-methylpyridium chloride ([Bmpy][Cl])-HCl hydrolysis of Bagasse gave a cellulose conversion greater than 80%, with or without the PAA pretreatment. For LB derived from seaweed waste, the cellulose conversion reached 98% in 1 h. The strong hydrolysis power of [Bmpy][Cl] was attributed to its ability to transform cellulose I to II, and lowering the d.p. of cellulose. In the experiment, the researchers used many compounds, for example, 1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3Category: pyridine-derivatives).

1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Decarboxylative Arylation of Pyridine 1-Oxides and Anilides with Benzoic Acid via Palladium-Catalyzed C-H Functionalization was written by Dabiri, Minoo;Alavioon, Seyed Iman;Movahed, Siyavash Kazemi. And the article was included in European Journal of Organic Chemistry in 2019.Product Details of 3718-65-8 This article mentions the following:

A novel method for the palladium-catalyzed decarboxylative ortho C-H bond arylation of pyridine 1-oxides I [R¹ = H, 3-Cl, 3-C(O)OCH₂CH₃, 4-CN, etc.] and anilides R²NHC(O)R³ [R² = C₆H₅, 4-BrC₆H₄, 3,4-(H₃CO)₂C₆H₃, etc.; R³ = C(CH₃)₃, C₆H₅] with benzoic acids R⁴C₆H₄C(O)OH [R⁴ = 4-CF₃, 4-F, 4-NO₂, 2-Br, 3-CH₃, etc.] as aryl sources is described. The established methodol. provides a direct approach for the synthesis of 2-arylpyridine 1-oxides II and 2-aryl anilides 4-R⁵-5-R⁶-2-(R⁴C₆H₄)C₆H₂NHC(O)R³ (R⁵ = H, Br, Me, CF₃, F, Cl, MeO; R⁶ = H, Cl, Me, MeO) in good isolated yields. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Product Details of 3718-65-8).

3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of 閳?8.7 鑴?10閳? cm3璺痬ol閳?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ璺痬ol閳? in the liquid phase and 140.4 kJ璺痬ol閳? in the gas phase. Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Product Details of 3718-65-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reaction of 2-pyridones with benzyne was written by Bauer, Ludwig;Bell, Charles Leighton;Wright, George Edward. And the article was included in Journal of Heterocyclic Chemistry in 1966.Recommanded Product: 4783-68-0 This article mentions the following:

When 1-methyl-2-pyridone (I) was allowed to react with diazotized anthranilic acid (II) under conditions which generate benzyne (Friedman and Logullo, CA 59, 1556a), the adduct (III) was obtained in 10% yield, with acridone as a by product, which also forms from II under identical conditions even in the absence of I. On pyrolysis at 200鎺? III forms naphthalene. When benzyne was generated from PhCl and NaNH2 (Leake and Levine, CA 53, 16048f), the reaction with I gave 1-methyl-3-phenyl-2-pyridone in 5.4% yield, with 1,1′-dimethyl-2,2′-bipyridine-6,6′-dioneas by-product [which was also synthesized from 2,2′-bipyridine by quaternizing it with Me2SO4 to the bis(methosulfate), followed by the Decker oxidation with K3Fe(CN)6]. It also forms in small amounts in the reaction of I with NaNH2 in liquid NH3 in the absence of PhCl. In liquid NH3, ring opening of I was observed to give MeNHCH:CHCH:CHCONH2 in 6% yield. In the reaction of 2-pyridone with benzyne (from II) no Diels-Alder adduct could be isolated, the products found being 2-phenoxypyridine (3.9%), 1-phenyl-2-pyridone, and a little acridone. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0Recommanded Product: 4783-68-0).

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Recommanded Product: 4783-68-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Rhodium(I)-catalysed decarbonylative direct C-H vinylation and dienylation of arenes was written by Xu, Jianbin;Chen, Changjun;Zhao, Haoqiang;Xu, Conghui;Pan, Yixiao;Xu, Xin;Li, Huanrong;Xu, Lijin;Fan, Baomin. And the article was included in Organic Chemistry Frontiers in 2018.Formula: C12H11N This article mentions the following:

Rh(I)-catalyzed decarbonylative direct C-H bond vinylation and dienylation of arenes with readily available acrylic acid and (E)-penta-2,4-dienoic acid under chelation assistance were developed for the first time. A significant effect of the ligand on the reactivity was observed with the bidentate phosphine ligand being optimal. This protocol was efficient under oxidant-free conditions to access synthetically valuable styrenes and 1-aryl-1,3-butadienes in high yields with a broad substrate scope and good functionality tolerance. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Formula: C12H11N).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Formula: C12H11N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Rh(III)-Catalyzed C-C coupling of unactivated C(sp³)-H bonds with iodonium ylides for accessing all-carbon quaternary centers was written by Xie, Pengfei;Gao, Huixing;Li, Xingwei;Jiang, Yuqin;Liu, Bingxian. And the article was included in Organic Chemistry Frontiers in 2022.Formula: C8H11N This article mentions the following:

Rhodium-catalyzed inert C(sp³)-H activation/carbene insertion, which enables the construction of all-carbon quaternary centers, has been realized. Iodonium ylides are used as C1 synthons for efficient C-C bond formation with PhI being the only byproduct. A rhodacycle has been synthesized and proved to be the active intermediate. In the experiment, the researchers used many compounds, for example, 2-Isopropylpyridine (cas: 644-98-4Formula: C8H11N).

2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the 锜?bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the 锜?bonds. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Formula: C8H11N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem