Tag: 100-200

Cao, Dawei et al. published their research in Nature Communications in 2022 | CAS: 91-02-1

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the 锜?bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the 锜?bonds. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Application of 91-02-1

Light-driven transition-metal-free direct decarbonylation of unstrained diaryl ketones via a dual C-C bond cleavage was written by Cao, Dawei;Ataya, Mohamad;Chen, Zhangpei;Zeng, Huiying;Peng, Yong;Khaliullin, Rustam Z.;Li, Chao-Jun. And the article was included in Nature Communications in 2022.Application of 91-02-1 This article mentions the following:

An efficient light-driven transition-metal-free strategy for decarbonylation of unstrained diaryl ketones R1C(O)R2 (R1 = Ph, 2H-1,3-benzodioxol-5-yl, thiophen-2-yl, etc.; R2 = Ph, 4-methoxyphenyl, pyridin-2-yl, etc.) to construct biaryl compounds R1R2 through dual inert C – C bonds cleavage was reported. This reaction featured mild reaction conditions, easy-to-handle reactants and reagents, and excellent functional groups tolerance. The mechanistic investigation and DFT calculation suggest that this strategy proceeds through the formation of dioxy radical intermediate via a single-electron-transfer (SET) process between photo-excited diaryl ketone and DBU mediated by DMSO, followed by removal of CO2 to construct biaryl compounds In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Application of 91-02-1).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the 锜?bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the 锜?bonds. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Application of 91-02-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Shu, Shiqi et al. published their research in Journal of Organic Chemistry in 2016 | CAS: 4373-61-9

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C閳ユ弻 in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Name: 2-(m-Tolyl)pyridine

Ru(II)-Catalyzed Direct C(sp2)-H Activation/Selenylation of Arenes with Selenyl Chlorides was written by Shu, Shiqi;Fan, Zhoulong;Yao, Qizheng;Zhang, Ao. And the article was included in Journal of Organic Chemistry in 2016.Name: 2-(m-Tolyl)pyridine This article mentions the following:

A new ruthenium catalytic system was developed for the construction of a C(sp2)-Se bond with the assistance of directing groups. This protocol features mild reaction conditions, wider substrate scope, and convenient late-stage selenylation of bioactive mols. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Name: 2-(m-Tolyl)pyridine).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C閳ユ弻 in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Name: 2-(m-Tolyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wasserscheid, P. et al. published their research in Catalysis Today in 2001 | CAS: 125652-55-3

1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ璺痬ol閳? in pyridine vs. 150 kJ璺痬ol閳? in benzene). Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Formula: C10H16ClN

Selective dimerization of 1-butene in biphasic mode using buffered chloroaluminate ionic liquid solvents – design and application of a continuous loop reactor was written by Wasserscheid, P.;Eichmann, M.. And the article was included in Catalysis Today in 2001.Formula: C10H16ClN This article mentions the following:

The dimerization of 1-butene using (cod)Ni(hfacac) 1 as catalyst has been investigated in different chloroaluminate ionic liquids Systems prepared by buffering an acidic ionic liquid with weak organic bases proved to be very suitable solvents for the reaction. The reaction takes place in biphasic reaction mode with facile catalyst separation and catalyst recycling. The high intrinsic dimer linearity of catalyst 1 is maintained, but with significant enhancement of catalyst activity and of the selectivity to the dimer product over that observed in toluene solvent. For further investigation, a continuous reactor was designed. Our results in continuous mode show the general tech. applicability of the selective Ni-catalyzed dimerization in chloroaluminate ionic liquids using a loop reactor concept. In the experiment, the researchers used many compounds, for example, 1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3Formula: C10H16ClN).

1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ璺痬ol閳? in pyridine vs. 150 kJ璺痬ol閳? in benzene). Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Formula: C10H16ClN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Morisawa, Yasuhiro et al. published their research in Journal of Medicinal Chemistry in 1978 | CAS: 65169-38-2

2-Chloro-4-methylpyridine-3-carbonitrile (cas: 65169-38-2) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ璺痬ol閳? in pyridine vs. 150 kJ璺痬ol閳? in benzene). Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Product Details of 65169-38-2

Studies on anticoccidial agents. 12. Synthesis and anticoccidial activity of methyl-2(6)-nitro- and -3(5)-nitropyridinecarboxamides was written by Morisawa, Yasuhiro;Kataoka, Mitsuru;Sakamoto, Toshiaki;Nagahori, Hitoshi;Kitano, Noritoshi;Kusano, Kenichi. And the article was included in Journal of Medicinal Chemistry in 1978.Product Details of 65169-38-2 This article mentions the following:

Twelve methyl-2-nitro- and 9 methyl-3-nitropyridinecarboxamides were prepared and tested in vivo for anticoccidial activity against Eimeria鑱?em>tenella. Almost all the compounds were active, with optimal activity shown by 5-methyl- (I) [65169-65-5] and 6-methyl-2-nitroisonicotinamide (II) [60780-18-9], which were as potent as 2-nitroisonicotinamide. At least 1 H atom adjacent to the NO2 group is important for anticoccidial activity and a Me group adjacent to the CONH2 function sometimes enhances activity. In the experiment, the researchers used many compounds, for example, 2-Chloro-4-methylpyridine-3-carbonitrile (cas: 65169-38-2Product Details of 65169-38-2).

2-Chloro-4-methylpyridine-3-carbonitrile (cas: 65169-38-2) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ璺痬ol閳? in pyridine vs. 150 kJ璺痬ol閳? in benzene). Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Product Details of 65169-38-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Andersen, Claire et al. published their research in Organic Letters in 2020 | CAS: 85838-94-4

tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Computed Properties of C10H17NO2

Copper-Catalyzed Cross-Coupling between Alkyl (Pseudo)halides and Bicyclopentyl Grignard Reagents was written by Andersen, Claire;Ferey, Vincent;Daumas, Marc;Bernardelli, Patrick;Guerinot, Amandine;Cossy, Janine. And the article was included in Organic Letters in 2020.Computed Properties of C10H17NO2 This article mentions the following:

The development of a copper-catalyzed cross-coupling between primary and secondary (pseudo)halides and bicyclopentyl Grignard reagents is reported. Highly strained bicyclopentanes can be cross-coupled with a large panel of primary alkyl mesylates and secondary alkyliodides. The catalytic system is simple and cheap, and the reaction is general and chemoselective. In the experiment, the researchers used many compounds, for example, tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4Computed Properties of C10H17NO2).

tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Computed Properties of C10H17NO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hondo, Takeshi et al. published their research in Journal of Medicinal Chemistry in 2013 | CAS: 34206-49-0

5-Bromopyridine-2,3-diol (cas: 34206-49-0) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.HPLC of Formula: 34206-49-0

4-Hydroxypyridazin-3(2H)-one Derivatives as Novel d-Amino Acid Oxidase Inhibitors was written by Hondo, Takeshi;Warizaya, Masaichi;Niimi, Tatsuya;Namatame, Ichiji;Yamaguchi, Tomohiko;Nakanishi, Keita;Hamajima, Toshihiro;Harada, Katsuya;Sakashita, Hitoshi;Matsumoto, Yuzo;Orita, Masaya;Takeuchi, Makoto. And the article was included in Journal of Medicinal Chemistry in 2013.HPLC of Formula: 34206-49-0 This article mentions the following:

4-Hydroxypyridazin-3(2H)-ones such as I [R = Ph, PhCH2, cyclohexylmethyl, 4-ClC6H4, Me3C, 2-FC6H4, 2-F3CC6H4, 3-FC6H4, 3-F3CC6H4, 3-MeOC6H4, 4-FC6H4, 4-F3CC6H4, 4-MeOC6H4, 3,4-F2C6H3, 3,5-(F3C)2C6H3, 3,5-(MeO)2C6H3; X = N] were prepared as inhibitors of human D-amino acid oxidase (hDAAO) for potential use as treatments for schizophrenia based on the binding of smaller fragments such as benzoic acid and 3-hydroxy-2-pyridinone to hDAAO. Based on the crystal structure of the complex of 3-hydroxy-2-pyridinone and hDAAO, compounds such as I (R = Ph; X = CH) with the ability to fill an adjacent ligand-dependent binding pocket of hDAAO were designed and prepared; I (R = Ph; X = CH) inhibited hDAAO with IC50 values of 3.9 nM and 20 nM in enzyme- and cell-based assays, resp. but was toxic at high concentrations Pyridazinone analogs of I (R = Ph; X = CH) were prepared as analogs with potentially reduced toxicities. In particular, I (R = 3,5-F2C6H3; X = N) inhibited DAAO in vitro, and in human, rat, and murine cells with IC50 values of 1.5-16 nM, entered the brains of mice within 30 min after oral dosage (brain concentration = 460 ng/mL), and improved cognitive function in a mouse model of schizophrenia. The structures of I (R = Ph; X = CH, N) and of 3-hydroxy-2-pyridinone bound to hDAAO were determined by X-ray crystallog. In the experiment, the researchers used many compounds, for example, 5-Bromopyridine-2,3-diol (cas: 34206-49-0HPLC of Formula: 34206-49-0).

5-Bromopyridine-2,3-diol (cas: 34206-49-0) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.HPLC of Formula: 34206-49-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Viswanadhan, Vellarkad N. et al. published their research in Journal of Chemical Information and Computer Sciences in 1989 | CAS: 27876-24-0

4-Hexylpyridine (cas: 27876-24-0) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Safety of 4-Hexylpyridine

Atomic physicochemical parameters for three dimensional structure directed quantitative structure-activity relationships. 4. Additional parameters for hydrophobic and dispersive interactions and their application for an automated superposition of certain naturally occurring nucleoside antibiotics was written by Viswanadhan, Vellarkad N.;Ghose, Arup K.;Revankar, Ganapathi R.;Robins, Roland K.. And the article was included in Journal of Chemical Information and Computer Sciences in 1989.Safety of 4-Hexylpyridine This article mentions the following:

At. values for physicochem. properties are an important guide for correlating the observed biol. activity of the ligands to their chem. structure. The objective of the present work was to (i) report the hydrophobicity and the molar refractivity for P and Se atoms at different structural environments that are ubiquitous in biol. active systems, (ii) refine the at. values of the various elements reported earlier to satisfy the largely extended data set, and (iii) suggest a method for selecting the best superposition of different mols. on a reference structure using these at. physicochem. properties. The octanol-water partition coefficient was used to scale the at. hydrophobicity. The hydrophobicity values of 120 atom types were evaluated from 893 compounds The observed and calculated octanol-water partition coefficient showed a correlation coefficient of 0.926 and a standard deviation of 0.496. The at. refractivity values were evaluated from the molar refractivities of 538 compounds; the corresponding correlation coefficient and standard deviation were 0.999 and 0.774, resp. The at. values were tested by predicting the resp. properties for a large number of compounds The superposition methods was applied to certain naturally occurring nucleoside antibiotics. The algorithm presented showed various important superpositions of 閳? mols. with min. phys. assistance to avoid any personal bias. In the experiment, the researchers used many compounds, for example, 4-Hexylpyridine (cas: 27876-24-0Safety of 4-Hexylpyridine).

4-Hexylpyridine (cas: 27876-24-0) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Safety of 4-Hexylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lougiakis, Nikolaos et al. published their research in Chemical & Pharmaceutical Bulletin in 2008 | CAS: 24103-75-1

4-Methoxy-2-methylpyridine (cas: 24103-75-1) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Application In Synthesis of 4-Methoxy-2-methylpyridine

Synthesis and antiviral activity evaluation of some novel acyclic C-nucleosides was written by Lougiakis, Nikolaos;Marakos, Panagiotis;Poul, Nicole;Balzarini, Jan. And the article was included in Chemical & Pharmaceutical Bulletin in 2008.Application In Synthesis of 4-Methoxy-2-methylpyridine This article mentions the following:

The preparation of novel 5-amino or 7-hydroxy substituted pyrazolo[4,3-b]pyridine and pyrazolo[3,4-c]pyridine acyclic C-nucleosides is described. Their synthesis was carried out by condensation of suitably substituted lithiated picolines with 2-benzyloxyethoxymethylchloride followed by pyrazole ring annulation. The compounds were evaluated for their antiviral activity against a wide panel of viruses, but were found inactive at subtoxic concentrations In the experiment, the researchers used many compounds, for example, 4-Methoxy-2-methylpyridine (cas: 24103-75-1Application In Synthesis of 4-Methoxy-2-methylpyridine).

4-Methoxy-2-methylpyridine (cas: 24103-75-1) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Application In Synthesis of 4-Methoxy-2-methylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Singh, Yogendra Pratap et al. published their research in Journal of Molecular Structure in 2021 | CAS: 91-02-1

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. Pyridine has a conjugated system of six 锜?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H鐪塩kel criteria for aromatic systems. Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Quality Control of Phenyl(pyridin-2-yl)methanone

Molecular structures, spectral, electrochemical, DFT and antioxidant activities of copper(II) complexes with NNO donor Schiff base ligand was written by Singh, Yogendra Pratap;Patel, Satish Kumar. And the article was included in Journal of Molecular Structure in 2021.Quality Control of Phenyl(pyridin-2-yl)methanone This article mentions the following:

The synthesis and solid state structural, spectral and electrochem. solution characterization of [Cu(L)(acpy)]ClO4鑱?strong>1 and [Cu(L)(NO3)] 2 [where L = N’-[(E)-phenyl(pyridin-2-yl)methylidene]thiophene-2-carbohydrazide and acpy = 2,6-Diacetylpyridine] were done by elemental anal., UV-visible, FTIR, electrochem. techniques (CV and DPV) and EPR spectroscopy. The single crystal structures were solved by the x-ray diffraction technique. In complex 1, copper ion is in a distorted octahedral environment. The geometry of copper(II) in complex 2 is distorted square pyramidal (锜?= 0.201). The mono deprotonated, HL ligand act as a tridentate to a copper(II) ion. On the basis of d. functional theory (DFT) calculation, the electronic excitations involve transitions mainly from metal ligand bonding mostly the 浼?LUMO within the dominant Cu dxy character and to 浼?LUMO+1. EPR spectra for polycrystalline samples showed the copper(II) hyperfine features as well as half-field signal which are appropriate for 铻朚s = 鍗? of dimers. Presence of half-field signal in 1 is due to solid-solid interaction (intra-mol.) where as in 2 the nature of interaction is intra-mol. The antioxidant superoxide measurements show that the both complexes 1 and 2 behave as superoxide mimic in alk. nitro blue tetrazolium chloride assay. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Quality Control of Phenyl(pyridin-2-yl)methanone).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. Pyridine has a conjugated system of six 锜?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H鐪塩kel criteria for aromatic systems. Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Quality Control of Phenyl(pyridin-2-yl)methanone

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Shin, Eun-Jae et al. published their research in Synlett in 2019 | CAS: 51834-97-0

5-Hydroxy-2-methoxylpyridine (cas: 51834-97-0) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ璺痬ol閳? in pyridine vs. 150 kJ璺痬ol閳? in benzene). Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C閳ユ弻 in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Application In Synthesis of 5-Hydroxy-2-methoxylpyridine

Room-Temperature Ionic Liquids (RTILs) as Green Media for Metal- and Base-Free ipso -Hydroxylation of Arylboronic Acids was written by Shin, Eun-Jae;Kwon, Gyu-Tae;Kim, Seung-Hoi. And the article was included in Synlett in 2019.Application In Synthesis of 5-Hydroxy-2-methoxylpyridine This article mentions the following:

The oxidative hydroxylation of arylboronic acids to the corresponding phenolic compounds under metal- and base-free aerobic conditions is successfully demonstrated on a greener media. Hydrogen peroxide, as an eco-friendly oxidant, is compatible with room-temperature ionic liquids (RTIL)s, providing hydroxylation products of arylboronic acids in an efficient manner. The RTIL support is particularly interesting for its reusability. In the experiment, the researchers used many compounds, for example, 5-Hydroxy-2-methoxylpyridine (cas: 51834-97-0Application In Synthesis of 5-Hydroxy-2-methoxylpyridine).

5-Hydroxy-2-methoxylpyridine (cas: 51834-97-0) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ璺痬ol閳? in pyridine vs. 150 kJ璺痬ol閳? in benzene). Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C閳ユ弻 in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Application In Synthesis of 5-Hydroxy-2-methoxylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem