Tag: 100-200

Gulledge, Zachary Z. et al. published their research in Organic & Biomolecular Chemistry in 2022 | CAS: 91-02-1

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Product Details of 91-02-1

Chemoselective, osmium-free, dihydroxylation/oxidative cleavage of heteroaryl isoprenes by a contemporary Malaprade reaction was written by Gulledge, Zachary Z.;Pinson, Connor C.;Stovall, Alexander M.;Dzeagu, Fortune O.;Carrick, Jesse D.. And the article was included in Organic & Biomolecular Chemistry in 2022.Product Details of 91-02-1 This article mentions the following:

In this work authors present the development and application of an oxidative cleavage reaction of various pyridinyl isoprenes towards accessing the downstream Me ketone for utilization in advanced cyclizations for the preparation of soft-N-donor complexant scaffolds. This efficient protocol parallels the principles of Green chem. by exchanging KMnO4 for the toxic OsO4 and offers the end-user an efficient, more environmentally friendly option for accessing heteroaryl Me ketones in one hour of reaction time using potassium permanganate and sodium paraperiodate as a synergistically potent oxidative cleavage system. The wide substrate scope defined access to simple, as well as advanced heteroaryl Me ketones. Method development, optimization, substrate scope, preliminary mechanistic observations, and a scale up reaction are delineated herein. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Product Details of 91-02-1).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Product Details of 91-02-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Saher, Saliha et al. published their research in Journal of Molecular Liquids in 2018 | CAS: 125652-55-3

1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Recommanded Product: 1-Butyl-3-methylpyridinium Chloride

Pyridinium based ionic liquid: A pretreatment solvent and reaction medium for catalytic conversion of cellulose to total reducing sugars (TRS) was written by Saher, Saliha;Saleem, Haris;Asim, Azmat Mehmood;Uroos, Maliha;Muhammad, Nawshad. And the article was included in Journal of Molecular Liquids in 2018.Recommanded Product: 1-Butyl-3-methylpyridinium Chloride This article mentions the following:

In the last decade, the transformation of lignocellulosic biomass into biofuel through a sugar platform has been an active research subject due to depletion of fossil fuel sources. Total reducing sugars (TRS) obtained from lignocellulosic materials are considered intermediates for the preparation of various valuable chem. compounds In this work, pyridinium based ionic liquids were synthesized and utilized for the dissolution of cellulose and further conversion to TRS in the presence of metal salts as catalysts. The prepared ILs were characterized using 1H NMR and evaluated for the dissolution of cellulose and found that [C4C1Py][Cl] is the best solvent to dissolve it up to 28% at 110 鎺矯. Optical microscopy in conjunction with FTIR, SEM, XRD and TGA analyzes were employed to monitor dissolution phenomenon and ascertain structural changes in regenerated cellulose. SEM results showed disrupted flaky construction for regenerated cellulose. The thermal stability decreased for regenerated cellulose as observed by TGA anal. This desirable change in cellulose after IL pretreatment was utilized to facilitate metal salts based on the catalytic conversion of cellulose to TRS. Among metal salts, CoCl2 was identified as the best one to generate the highest yield of TRS i.e. 78% at 110 鎺矯 for 4 h. Various reaction conditions like time, temperature, and catalyst loading were optimized for catalytic conversion. The optimum conditions were observed at 4 h treatment time, 120 鎺矯 and 12% catalyst loading. In the experiment, the researchers used many compounds, for example, 1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3Recommanded Product: 1-Butyl-3-methylpyridinium Chloride).

1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Recommanded Product: 1-Butyl-3-methylpyridinium Chloride

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Venu, Boosa et al. published their research in Catalysis Science & Technology in 2016 | CAS: 4373-61-9

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridine has a conjugated system of six 锜?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H鐪塩kel criteria for aromatic systems. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.HPLC of Formula: 4373-61-9

C-H bond cyanation of arenes using N,N-dimethylformamide and NH4HCO3 as a CN source over a hydroxyapatite supported copper catalyst was written by Venu, Boosa;Vishali, Bilakanti;Naresh, Gutta;Kumar, Velisoju Vijay;Sudhakar, Medak;Kishore, Ramineni;Beltramini, Jorge;Konarova, Muxina;Venugopal, Akula. And the article was included in Catalysis Science & Technology in 2016.HPLC of Formula: 4373-61-9 This article mentions the following:

A hydroxyapatite supported Cu catalyst [HAP:Ca5(PO4)3(OH)] has been found to be an efficient and reusable heterogeneous catalyst for safe cyanation of C-H bonds of heteroaryl compounds The combination of NH4HCO3 and DMF is identified as a CN source under mild reaction conditions. 10 wt% Cu/HAP offered good to excellent yields compared to Ru/HAP and Pd/HAP catalysts. The surface basicity and Cu metal surface area of the catalysts played a significant role in the cyanation reaction through C-H bond activation. The catalyst was recovered and reused for five cycles showing consistent activity and selectivity. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9HPLC of Formula: 4373-61-9).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridine has a conjugated system of six 锜?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H鐪塩kel criteria for aromatic systems. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.HPLC of Formula: 4373-61-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ronson, Tanya K. et al. published their research in Dalton Transactions in 2007 | CAS: 122637-39-2

6-Acetylpicolinic acid (cas: 122637-39-2) belongs to pyridine derivatives. Pyridine has a conjugated system of six 锜?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H鐪塩kel criteria for aromatic systems. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Quality Control of 6-Acetylpicolinic acid

Polynuclear lanthanide complexes of a series of bridging ligands containing two tridentate N,N’,O-donor units: structures and luminescence properties was written by Ronson, Tanya K.;Adams, Harry;Harding, Lindsay P.;Pope, Simon J. A.;Sykes, Daniel;Faulkner, Stephen;Ward, Michael D.. And the article was included in Dalton Transactions in 2007.Quality Control of 6-Acetylpicolinic acid This article mentions the following:

A set of three potentially bridging ligands containing two tridentate chelating N,N’,O-donor (pyrazole-pyridine-amide) donors separated by an o- (I = L2), m- (L3), or p-phenylene (L1) spacer has been prepared and their coordination chem. with lanthanide(III) ions investigated. Ligand L1 forms complexes with a 2:3 M:L ratio according to the proportions used in the reaction mixture The Ln2(L1)3 complexes contain two 9-coordinate Ln(III) centers with all three bridging ligands spanning both metal ions and have a cylindrical (non-helical) ‘mesocate’ architecture. The 1:1 complexes display a range of structural types depending on the conditions used including a cyclic Ln4(L1)4 tetranuclear helicate, a Ln2(L1)2 dinuclear mesocate and an infinite one-dimensional coordination polymer in which metal ions and bridging ligands alternate along the sequence. ESMS studies indicate that the 1:1 complexes form a mixture of oligonuclear species {Ln(L1)}n in solution (n up to 5) which are likely to be cyclic helicates. In contrast, ligands L2 and L3 generally form dinuclear Ln2L2 Ln(III) complexes in which the two ligands may be arranged in a helical or non-helical architecture about the two metal ions. These complexes also contain an addnl. exogenous bidentate bridging ligand, either acetate or formate, which has arisen from hydrolysis of solvent mols. promoted by the Lewis-acidity of the Ln(III) ions. Luminescence studies on some of the Nd(III) complexes showed that excitation into ligand-centered 锜?锜? transitions result in the characteristic near-IR luminescence from Nd(III) at 1060 nm. In the experiment, the researchers used many compounds, for example, 6-Acetylpicolinic acid (cas: 122637-39-2Quality Control of 6-Acetylpicolinic acid).

6-Acetylpicolinic acid (cas: 122637-39-2) belongs to pyridine derivatives. Pyridine has a conjugated system of six 锜?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H鐪塩kel criteria for aromatic systems. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Quality Control of 6-Acetylpicolinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Cingolani, G. M. et al. published their research in European Journal of Medicinal Chemistry in 1990 | CAS: 24103-75-1

4-Methoxy-2-methylpyridine (cas: 24103-75-1) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the 锜?bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the 锜?bonds. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Computed Properties of C7H9NO

Indolizine derivatives with biological activity. VI. 1-(2-Aminoethyl)-3-benzyl-7-methoxy-2-methylindolizine, benanserine structural analog was written by Cingolani, G. M.;Claudi, F.;Massi, M.;Venturi, F.. And the article was included in European Journal of Medicinal Chemistry in 1990.Computed Properties of C7H9NO This article mentions the following:

The title compound (I) was prepared from 3-(4-methoxy-2-pyridyl)propionate. In comparison with benanserine I showed greatly reduced antihistaminic activity and somewhat reduced antiserotonin activity whereas the anticholinergic activity remained unaffected. In the experiment, the researchers used many compounds, for example, 4-Methoxy-2-methylpyridine (cas: 24103-75-1Computed Properties of C7H9NO).

4-Methoxy-2-methylpyridine (cas: 24103-75-1) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the 锜?bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the 锜?bonds. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Computed Properties of C7H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Liu, Jiahui et al. published their research in Biomaterials in 2021 | CAS: 3718-65-8

3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. Pyridine has a conjugated system of six 锜?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H鐪塩kel criteria for aromatic systems. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Formula: C7H9NO

Multifunctional SGQDs-CORM@HA nanosheets for bacterial eradication through cascade-activated “nanoknife” effect and photodynamic/CO gas therapy was written by Liu, Jiahui;Li, Rong Sheng;He, Mengting;Xu, Zhigang;Xu, Li Qun;Kang, Yuejun;Xue, Peng. And the article was included in Biomaterials in 2021.Formula: C7H9NO This article mentions the following:

Infection associated with multidrug-resistant (MDR) bacteria has become a serious threat to public health, and there is an urgent demand of developing new antibiotics that offer combinatorial therapy to effectively combat MDR. Herein, a multifunctional two-dimensional nanoantibiotic was facilely designed and established on the basis of the covalent conjugation of CO-releasing mol. (CORM-401) and electrostatic adsorption of hyaluronic acid (HA) onto single-layered graphene quantum dots (SGQDs) to assemble SGQDs-CORM@HA nanosheets, abbreviated as SCH. Upon the enrichment of as-prepared nanoantibiotics in the community of targeted microbe, bacterial-secreted hyaluronidase (HAase) would cleave HA on SCH, and the sharp edges as well as the reactive sites on SGQDs-CORM nanosheets were exposed for cascade activation of synergistic antibacterial effects. Specifically, ultrathin SGQDs-CORM nanosheets can penetrate into bacterial cells deemed as the unique “nanoknife” effect. Under white light irradiation, SGQDs-CORM nanosheets can act as a high-efficient photosensitizer to generate cytotoxic singlet oxygen (1O2), as a well-recognized reactive oxygen species (ROS), to produce high oxidative stress and damage bacteria. As a complementary to photodynamic therapy (PDT), the accumulation of local ROS further triggered the release of CO to hinder the bacterial growth via causing plasma membrane damage and inducing metabolic disorders. Such synergistic treatment regimen arising from cascade-activated “nanoknife” effect and photodynamic/CO gas therapy, was devoted to outstanding on-demand antibacterial performance both in vitro and in vivo. Fascinatingly, the nanoplatform showed good biocompatibility toward both normal somatic cells and non-targeted bacteria. The remarkable antibacterial capability and admirable biocompatibility endow SCH with great potential to fight against MDR pathogens for in-coming clin. translations. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Formula: C7H9NO).

3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. Pyridine has a conjugated system of six 锜?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H鐪塩kel criteria for aromatic systems. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Formula: C7H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Dix, Stefan et al. published their research in Chemistry – A European Journal in 2021 | CAS: 3939-12-6

6-Fluoronicotinonitrile (cas: 3939-12-6) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the 锜?bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the 锜?bonds. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Name: 6-Fluoronicotinonitrile

Radical C-H Trifluoromethoxylation of (Hetero)arenes with Bis(trifluoromethyl)peroxide was written by Dix, Stefan;Golz, Paul;Schmid, Jonas R.;Riedel, Sebastian;Hopkinson, Matthew N.. And the article was included in Chemistry – A European Journal in 2021.Name: 6-Fluoronicotinonitrile This article mentions the following:

Herein, bis(trifluoromethyl)peroxide (BTMP, CF3OOCF3) as a practical and efficient trifluoromethoxylating reagent, which easily accessible from inexpensive bulk chems. was introduced. Using either visible light photoredox or TEMPO catalysis, trifluoromethoxylated arenes could be prepared in good yields under mild conditions directly from unactivated aromatics Moreover, TEMPO catalysis allowed for the one-step synthesis of valuable pyridine derivatives, which was previously prepared via multi-step approaches. In the experiment, the researchers used many compounds, for example, 6-Fluoronicotinonitrile (cas: 3939-12-6Name: 6-Fluoronicotinonitrile).

6-Fluoronicotinonitrile (cas: 3939-12-6) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the 锜?bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the 锜?bonds. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Name: 6-Fluoronicotinonitrile

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Czyz, Milena L. et al. published their research in ACS Catalysis in 2021 | CAS: 91-02-1

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Application In Synthesis of Phenyl(pyridin-2-yl)methanone

Reductive Activation and Hydrofunctionalization of Olefins by Multiphoton Tandem Photoredox Catalysis was written by Czyz, Milena L.;Taylor, Mitchell S.;Horngren, Tyra H.;Polyzos, Anastasios. And the article was included in ACS Catalysis in 2021.Application In Synthesis of Phenyl(pyridin-2-yl)methanone This article mentions the following:

The conversion of olefin feedstocks to architecturally complex alkanes represents an important strategy in the expedient generation of valuable mols. for the chem. and life sciences. Synthetic approaches are reliant on the electrophilic activation of unactivated olefins, necessitating functionalization with nucleophiles. However, the reductive functionalization of unactivated and less activated olefins with electrophiles remains an ongoing challenge in synthetic chem. Here, we report the nucleophilic activation of inert styrenes through a photoinduced direct single electron reduction to the corresponding nucleophilic radical anion. Central to this approach is the multiphoton tandem photoredox cycle of the iridium photocatalyst [Ir(ppy)2(dtb-bpy)]PF6, which triggers in situ formation of a high-energy photoreductant that selectively reduces styrene olefinic 锜?bonds to radical anions without stoichiometric reductants or dissolving metals. This mild strategy enables the chemoselective reduction and hydrofunctionalization of styrenes to furnish valuable alkane and tertiary alc. derivatives Mechanistic studies support the formation of a styrene olefinic radical anion intermediate and a Birch-type reduction involving two sequential single electron transfers. Overall, this complementary mode of olefin activation achieves the hydrofunctionalization of less activated alkenes with electrophiles, adding value to abundant olefins as valuable building blocks in modern synthetic protocols. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Application In Synthesis of Phenyl(pyridin-2-yl)methanone).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Application In Synthesis of Phenyl(pyridin-2-yl)methanone

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kim, Yu-Yon et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2019 | CAS: 315180-16-6

2-(Chloromethyl)-6-fluoropyridine (cas: 315180-16-6) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of 閳?8.7 鑴?10閳? cm3璺痬ol閳?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ璺痬ol閳? in the liquid phase and 140.4 kJ璺痬ol閳? in the gas phase. Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Application of 315180-16-6

Synthesis and evaluation of thieno[3,2-d]pyrimidine derivatives as novel FMS inhibitors was written by Kim, Yu-Yon;Choi, Jaeyul;Choi, Kyungjin;Park, Changhee;Kim, Young Hoon;Suh, Kwee Hyun;Ham, Young Jin;Jang, Sun Young;Lee, Kyu-Hang;Hwang, Kwang Woo. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2019.Application of 315180-16-6 This article mentions the following:

Colony stimulating factor-1 receptor (CSF-1R or FMS) and it ligand, CSF-1, signaling regulates the differentiation and function of tumor-associated macrophages (TAMs) that play an important role in tumor progression. Derivatives of thieno[3,2-d]pyrimidine were synthesized and evaluated as kinase inhibitors of FMS. The most representative compound I showed strong activity (IC50 = 2 nM) against FMS kinase and served as candidate for proof of concept. Anti-tumor activity alone and/or in combination with paclitaxel was examined via a tumor cell growth inhibition assay and via an in vitro tumor invasion assay using human breast adenocarcinoma cells. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-6-fluoropyridine (cas: 315180-16-6Application of 315180-16-6).

2-(Chloromethyl)-6-fluoropyridine (cas: 315180-16-6) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of 閳?8.7 鑴?10閳? cm3璺痬ol閳?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ璺痬ol閳? in the liquid phase and 140.4 kJ璺痬ol閳? in the gas phase. Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Application of 315180-16-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chatterjea, J. N. et al. published their research in Journal of the Indian Chemical Society in 1978 | CAS: 17281-59-3

1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the 锜?bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the 锜?bonds. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Application In Synthesis of 1-(Cyanomethyl)pyridin-1-ium chloride

Synthesis in the 4-azafluorene group. Part III was written by Chatterjea, J. N.;Shaw, S. C.;Singh, S. N.. And the article was included in Journal of the Indian Chemical Society in 1978.Application In Synthesis of 1-(Cyanomethyl)pyridin-1-ium chloride This article mentions the following:

Cyclocondensation of benzylideneindandiones I (R = H, Me, MeO, NO2) with NH4OAc in the presence of 1-phenacylpyridinium bromide gave the diindenopyridines II. Hantzsch cyclization of 2-benzylidene-1-indanone with PhC(NH2):CCN gave the dihydroazafluorenone III, which was aromatized by chromic acid, hydrolyzed, and decarboxylated to give the azafluorenone IV (Z = O). Wolff-Kishner reduction of IV (Z = O) gave IV (Z = H2). Treatment of 2-benzylideneindan-1-one with NH4OAc and 1-acetonylpyridinium bromide gave 3-methyl-1-phenyl-4-azafluorene, which was also obtained from Et 3-methyl-1-phenyl-4-azafluorenone-2-carboxylate by successive hydrolysis, decarboxylation, and Wolff-Kishner reduction 1-Benzylidene-2-indanone was prepared from Et 3-benzylidene-2-oxo-1-indancarboxylate by hydrolysis-decarboxylation. In the experiment, the researchers used many compounds, for example, 1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3Application In Synthesis of 1-(Cyanomethyl)pyridin-1-ium chloride).

1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the 锜?bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the 锜?bonds. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Application In Synthesis of 1-(Cyanomethyl)pyridin-1-ium chloride

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem