Tag: 100-200

Nevskaya, Alisa A. et al. published their research in Tetrahedron Letters in 2021 | CAS: 91-02-1

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of 閳?8.7 鑴?10閳? cm3璺痬ol閳?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ璺痬ol閳? in the liquid phase and 140.4 kJ璺痬ol閳? in the gas phase. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Reference of 91-02-1

Synthesis and cytotoxicity of novel 1-arylindolizines and 1-arylpyrrolo[2,1-a]isoquinolines was written by Nevskaya, Alisa A.;Miftyakhova, Almira R.;Anikina, Lada V.;Borisova, Tatiana N.;Varlamov, Aleksey V.;Voskressensky, Leonid G.. And the article was included in Tetrahedron Letters in 2021.Reference of 91-02-1 This article mentions the following:

An efficient approach to the synthesis of indolizines and pyrrolo[2,1-a]isoquinolines based on a domino reaction was described. The reactivity of the derivatives and the structure-activity anal. are carried out in a number of the obtained compounds A hit was found showing high cytotoxicity on tumor cells whose cytotoxic effect was comparable to that of the known topoisomerase I inhibitor camptothecin. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Reference of 91-02-1).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of 閳?8.7 鑴?10閳? cm3璺痬ol閳?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ璺痬ol閳? in the liquid phase and 140.4 kJ璺痬ol閳? in the gas phase. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Reference of 91-02-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hansen, Helge-Boj et al. published their research in Chemistry – A European Journal in 2021 | CAS: 24103-75-1

4-Methoxy-2-methylpyridine (cas: 24103-75-1) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Quality Control of 4-Methoxy-2-methylpyridine

The Stronger the Better: Donor Substituents Push Catalytic Activity of Molecular Chromium Olefin Polymerization Catalysts was written by Hansen, Helge-Boj;Wadepohl, Hubert;Enders, Markus. And the article was included in Chemistry – A European Journal in 2021.Quality Control of 4-Methoxy-2-methylpyridine This article mentions the following:

The donor strength of bifunctional pyridine-cyclopentadienyl ligands was altered systematically by the introduction of donating groups in the para-position of the pyridine. In the resulting chromium complexes an almost linear correlation between donor strength and the nitrogen-chromium distance as well as the electronic absorption maximum is exptl. observed The connection of electron-donating groups in the ligand backbone leads to an efficient transfer of the electronic influences to the catalytically active metal center without restricting it through steric effects. Therefore, catalytic olefin polymerization activity, which is already very high for the previously studied catalysts, increase considerably by attaching para-amino groups to the chelating pyridine or quinoline, resp. Combining electron-rich indenyl ligands with para-amino substituted pyridines lead to the highest catalytic activities observed so far for this class of organo chromium olefin polymerization catalysts. The resulting polymers are of ultra-high mol. weight and the ability of the catalysts to incorporate co-monomers is also very high. In the experiment, the researchers used many compounds, for example, 4-Methoxy-2-methylpyridine (cas: 24103-75-1Quality Control of 4-Methoxy-2-methylpyridine).

4-Methoxy-2-methylpyridine (cas: 24103-75-1) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Quality Control of 4-Methoxy-2-methylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Nakano, Yuji et al. published their research in Angewandte Chemie, International Edition in 2020 | CAS: 91-02-1

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Quality Control of Phenyl(pyridin-2-yl)methanone

Photoenzymatic Hydrogenation of Heteroaromatic Olefins Using 閳ョ潷ne閳?Reductases with Photoredox Catalysts was written by Nakano, Yuji;Black, Michael J.;Meichan, Andrew J.;Sandoval, Braddock A.;Chung, Megan M.;Biegasiewicz, Kyle F.;Zhu, Tianyu;Hyster, Todd K.. And the article was included in Angewandte Chemie, International Edition in 2020.Quality Control of Phenyl(pyridin-2-yl)methanone This article mentions the following:

Flavin-dependent 閳ョ灃ne閳?reductases (EREDs) are highly selective catalysts for the asym. reduction of activated alkenes. This function is, however, limited to enones, enoates, and nitroalkenes using the native hydride transfer mechanism. Here we demonstrate that EREDs can reduce vinyl pyridines when irradiated with visible light in the presence of a photoredox catalyst. Exptl. evidence suggests the reaction proceeds via a radical mechanism where the vinyl pyridine is reduced to the corresponding neutral benzylic radical in solution DFT calculations reveal this radical to be “dynamically stable”, suggesting it is sufficiently long-lived to diffuse into the enzyme active site for stereoselective hydrogen atom transfer. This reduction mechanism is distinct from the native one, highlighting the opportunity to expand the synthetic capabilities of existing enzyme platforms by exploiting new mechanistic models. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Quality Control of Phenyl(pyridin-2-yl)methanone).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Quality Control of Phenyl(pyridin-2-yl)methanone

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Dega-Szafran, Zofia et al. published their research in Bulletin of the Polish Academy of Sciences, Chemistry in 1996 | CAS: 27876-24-0

4-Hexylpyridine (cas: 27876-24-0) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ璺痬ol閳? in pyridine vs. 150 kJ璺痬ol閳? in benzene). Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Recommanded Product: 27876-24-0

A versatile synthesis of carboxypyridine betaines and their 1H and 13C NMR spectra was written by Dega-Szafran, Zofia;Kowalczyk, Iwona;Szafran, Miroslaw. And the article was included in Bulletin of the Polish Academy of Sciences, Chemistry in 1996.Recommanded Product: 27876-24-0 This article mentions the following:

Pyridine betaine and 15 substituted betaines, I (R = 2-, 3-, 4-Me, 4-Et, 4-CMe3, 3,4-Me2, etc.), were prepared by alkylation of the corresponding R-substituted pyridines with Et chloroacetate. The ester group was removed by acid hydrolysis and the obtained hydrochlorides were subsequently reacted with propylene oxide in order to obtain pure, free R-pyridine betaines I. The 1H and 13C NMR spectra of free betaines and their hydrochlorides were analyzed with respect to interaction of the ring substituents with the N+CH2COO group. In the experiment, the researchers used many compounds, for example, 4-Hexylpyridine (cas: 27876-24-0Recommanded Product: 27876-24-0).

4-Hexylpyridine (cas: 27876-24-0) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ璺痬ol閳? in pyridine vs. 150 kJ璺痬ol閳? in benzene). Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Recommanded Product: 27876-24-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Fagan, Paul J. et al. published their research in Journal of the American Chemical Society in 2000 | CAS: 15128-90-2

3-Hydroxy-6-methyl-2-nitropyridine (cas: 15128-90-2) belongs to pyridine derivatives. Pyridine has a conjugated system of six 锜?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H鐪塩kel criteria for aromatic systems. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Related Products of 15128-90-2

Using Intelligent/Random Library Screening To Design Focused Libraries for the Optimization of Homogeneous Catalysts: Ullmann Ether Formation was written by Fagan, Paul J.;Hauptman, Elisabeth;Shapiro, Rafael;Casalnuovo, Albert. And the article was included in Journal of the American Chemical Society in 2000.Related Products of 15128-90-2 This article mentions the following:

A 96-member pyridine library consisting of both rationally chosen and random members was used to screen Ullmann ether forming reactions. The reaction of 2-bromo-4,6-dimethylaniline and other substrates with a variety of alkoxides was studied under different conditions with the aid of an automated liquid handler. From the results of the 96-member library screening, a structure activity profile was determined which led to the design of smaller focused ligand libraries. The focused libraries produced a higher frequency of hits compared to the original 96-member library. Some of the more effective ligands discovered in this work are generally useful for alkoxylation of a variety of substrates, and also functioned in intramol. ether forming reactions. This work demonstrates for homogeneous catalysis the analogy to the pharmacol. model of drug discovery. By using a large library to screen for a lead compound followed by screening the diversity space closest to the lead, a larger fraction of increased performance ligands was discovered. In the experiment, the researchers used many compounds, for example, 3-Hydroxy-6-methyl-2-nitropyridine (cas: 15128-90-2Related Products of 15128-90-2).

3-Hydroxy-6-methyl-2-nitropyridine (cas: 15128-90-2) belongs to pyridine derivatives. Pyridine has a conjugated system of six 锜?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H鐪塩kel criteria for aromatic systems. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Related Products of 15128-90-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Purc, Anna et al. published their research in Journal of Materials Chemistry C: Materials for Optical and Electronic Devices in 2016 | CAS: 3939-14-8

2-Fluoroisonicotinonitrile (cas: 3939-14-8) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.COA of Formula: C6H3FN2

Modulation of the fluorescence properties of diketopyrrolopyrroles via various electron-rich substituents was written by Purc, Anna;Banasiewicz, Marzena;Glodkowska-Mrowka, Eliza;Gryko, Daniel T.. And the article was included in Journal of Materials Chemistry C: Materials for Optical and Electronic Devices in 2016.COA of Formula: C6H3FN2 This article mentions the following:

Four diketopyrrolopyrroles have been synthesized starting from heterocyclic aromatic nitriles. It was found that the neg. influence of electron-donating groups on the reactivity of nitriles can be overcome by the presence of an electron-deficient pyridine ring. The absorption and emission properties of the diketopyrrolopyrroles and their N-substituted derivatives were evaluated in a range of solvents revealing that the exact position of the electron-donating substituents significantly modulated their fluorescence response. The presence of a dialkylamino moiety at position 3 of the aryl substituents led to the occurrence of very fast nonradiative deactivation processes. Formation of both the anion (located on the core) and cation (located on the pyridine ring) changes the relative energy of the excited states leading to strong red fluorescence. On the other hand, the presence of a pyrrole moiety at position 4 of the aryl substituents resulted in a record high fluorescence quantum yield (0.88). The combination of the two dialkylamino-pyridine moieties and the oligoethylene glycol substituent made it possible to obtain a compound possessing reasonable water-solubility, which was applied in fluorescence microscopy for the selective staining of mitochondria in living cells. In the experiment, the researchers used many compounds, for example, 2-Fluoroisonicotinonitrile (cas: 3939-14-8COA of Formula: C6H3FN2).

2-Fluoroisonicotinonitrile (cas: 3939-14-8) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.COA of Formula: C6H3FN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lu, Yan et al. published their research in Journal of Medicinal Chemistry in 2014 | CAS: 189230-41-9

2-Bromopyridine-3,4-diamine (cas: 189230-41-9) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ璺痬ol閳? in pyridine vs. 150 kJ璺痬ol閳? in benzene). Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Application of 189230-41-9

Design, Synthesis, and Biological Evaluation of Stable Colchicine Binding Site Tubulin Inhibitors as Potential Anticancer Agents was written by Lu, Yan;Chen, Jianjun;Wang, Jin;Li, Chien-Ming;Ahn, Sunjoo;Barrett, Christina M.;Dalton, James T.;Li, Wei;Miller, Duane D.. And the article was included in Journal of Medicinal Chemistry in 2014.Application of 189230-41-9 This article mentions the following:

To block the metabolically labile sites of novel tubulin inhibitors targeting the colchicine binding site based on SMART, ABI, and PAT templates, we have designed, synthesized, and biol. tested three focused sets of new derivatives with modifications at the carbonyl linker, the para-position in the C ring of SMART template, and modification of A ring of the PAT template. Structure-activity relationships of these compounds led to the identification of new benzimidazole and imidazo[4,5-c]pyridine-fused ring templates, represented by compounds I(X = N, CH), resp., which showed enhanced antitumor activity and substantially improved the metabolic stability in liver microsomes compared to SMART. MOM group replaced TMP C ring and generated a potent analog 15, which showed comparable potency to the parent SMART compound Further modification of PAT template yielded another potent analog 33 with 5-indolyl substituent at A ring. In the experiment, the researchers used many compounds, for example, 2-Bromopyridine-3,4-diamine (cas: 189230-41-9Application of 189230-41-9).

2-Bromopyridine-3,4-diamine (cas: 189230-41-9) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ璺痬ol閳? in pyridine vs. 150 kJ璺痬ol閳? in benzene). Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Application of 189230-41-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Khan, Imran et al. published their research in Fluid Phase Equilibria in 2016 | CAS: 125652-55-3

1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C閳ユ弻 in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Category: pyridine-derivatives

Interactions of pyridinium, pyrrolidinium or piperidinium based ionic liquids with water: Measurements and COSMO-RS modelling was written by Khan, Imran;Taha, Mohamed;Pinho, Simao P.;Coutinho, Joao A. P.. And the article was included in Fluid Phase Equilibria in 2016.Category: pyridine-derivatives This article mentions the following:

Looking for a better knowledge concerning water and ionic liquids (ILs) interactions, a systematic study of the activity coefficients of water in pyridinium, pyrrolidinium and piperidinium-based ILs at 298.2 K is here presented based on water activity measurements. Addnl., the study of the structural effects of the pyridinium-based cation is also pursued. The results show that non-aromatic ILs are interacting more with water than aromatic ones, and among the ortho, meta and para isomers of 1-butyl-methylpyridinium chloride, the ortho position confers a more hydrophilic character to that specific IL. The phys.-chem. of the solutions was interpreted based on dissociation constants, natural bond orbitals and excess enthalpies providing a sound basis for the interpretation of the exptl. observations. These results show that hydrogen bonding controls the behavior of these systems, being the anion-water one of the most relevant interactions, but modulated by the anion-cation interactions. In the experiment, the researchers used many compounds, for example, 1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3Category: pyridine-derivatives).

1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C閳ユ弻 in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Ying et al. published their research in Journal of Fluorine Chemistry in 2009 | CAS: 1072951-54-2

(2,6-Dichloropyridin-4-yl)boronic acid (cas: 1072951-54-2) belongs to pyridine derivatives. Pyridine has a conjugated system of six 锜?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H鐪塩kel criteria for aromatic systems. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Application of 1072951-54-2

Hydrolytic stability of nitrogenous-heteroaryltrifluoroborates under aqueous conditions at near neutral pH was written by Li, Ying;Asadi, Ali;Perrin, David M.. And the article was included in Journal of Fluorine Chemistry in 2009.Application of 1072951-54-2 This article mentions the following:

The hydrolytic stability of heteroaryltrifluoroborates under physiol. conditions has been analyzed by 19F NMR spectroscopy and is found to be greatly enhanced by the presence of endocyclic ring nitrogens. Stability is further enhanced by the presence of exocyclic electron withdrawing substituents. As with aryltrifluoroborates, NMR anal. suggests that the hydrolysis proceeds via single rate-determining step reflecting loss of the first fluoride atom. The stability of these complexes is significant both in terms of metal catalyzed cross-coupling reactions as well as the potential for generating boronic acid based 18F-PET imaging agents. In the experiment, the researchers used many compounds, for example, (2,6-Dichloropyridin-4-yl)boronic acid (cas: 1072951-54-2Application of 1072951-54-2).

(2,6-Dichloropyridin-4-yl)boronic acid (cas: 1072951-54-2) belongs to pyridine derivatives. Pyridine has a conjugated system of six 锜?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H鐪塩kel criteria for aromatic systems. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Application of 1072951-54-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lei, Yingjie et al. published their research in Chemical Communications (Cambridge, United Kingdom) in 2018 | CAS: 3939-14-8

2-Fluoroisonicotinonitrile (cas: 3939-14-8) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the 锜?bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the 锜?bonds. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Recommanded Product: 3939-14-8

Arylation of benzyl amines with aromatic nitriles was written by Lei, Yingjie;Yang, Ju;Qi, Rupeng;Wang, Shan;Wang, Rui;Xu, Zhaoqing. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2018.Recommanded Product: 3939-14-8 This article mentions the following:

Radical arylations using aromatic nitriles without the assistance of photoirradn was developed. Importantly, with this method, the direct arylation of C(sp3)-H in benzyl amines provided a practical method for the synthesis of diarylmethylamines I [R = H, CN; R1 = H, F, 4-MeOC6H4, etc.; Ar = Ph, 4-ClC6H4, 2-furyl, etc.; X = C-R, N; R = H, CN] without the use of precious transition metal catalysts. In the experiment, the researchers used many compounds, for example, 2-Fluoroisonicotinonitrile (cas: 3939-14-8Recommanded Product: 3939-14-8).

2-Fluoroisonicotinonitrile (cas: 3939-14-8) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the 锜?bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the 锜?bonds. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Recommanded Product: 3939-14-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem