Tag: 100-200

Bondar, Olena et al. published their research in Chemistry & Chemical Technology in 2017 | CAS: 628-13-7

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of 閳?8.7 鑴?10閳? cm3璺痬ol閳?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ璺痬ol閳? in the liquid phase and 140.4 kJ璺痬ol閳? in the gas phase. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C閳ユ弻 in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Category: pyridine-derivatives

Biocorrosion of metal sewage treatment constructions and its inhibition with pyridinium chlorides was written by Bondar, Olena;Kurmakova, Iryna;Polevichenko, Sergey;Demchenko, Nataliya. And the article was included in Chemistry & Chemical Technology in 2017.Category: pyridine-derivatives This article mentions the following:

On the metal sewage treatment constructions (Chernihiv, Ukraine) a biofilm is formed, which is corrosive because of the number of sulfate-reducing bacteria (107 cell/cm2). By affecting sulfate-reducing activity of microorganisms, pyridinium chlorides at the concentration of 0.5 g/l were revealed to provide St3ps steel inhibition efficiency of up to 98.7% under the corrosion caused by biofilm bacteria. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Category: pyridine-derivatives).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of 閳?8.7 鑴?10閳? cm3璺痬ol閳?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ璺痬ol閳? in the liquid phase and 140.4 kJ璺痬ol閳? in the gas phase. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C閳ユ弻 in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Du, Kaifeng et al. published their research in RSC Advances in 2020 | CAS: 4373-61-9

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Application of 4373-61-9

The C-H activated controlled mono- and di-olefination of arenes in ionic liquids at room temperature was written by Du, Kaifeng;Yao, Tian. And the article was included in RSC Advances in 2020.Application of 4373-61-9 This article mentions the following:

The controlled mono and di-olefination of arenes was first realized at room temperature via the C-H bond activation in ionic liquids, probably due to the pos. effects of ionic liquids was reported. It was an energy-saving routes in industrial production without the need for heating equipment. Different catalysts were screened, and it was found that [Ru(p-cymene)Cl2]2 generated mono-olefinated products predominantly while [Cp*RhCl2]2 selectively gave di-olefinated products. These catalysts ([BMIM]NTf2 and [BMIM]PF6) as green and recyclable reaction media were highly efficient under mild conditions. This reaction process was avoid any volatile and environmentally toxic organic solvents, and was much safer without the need for pressure-tight equipment. A wide substrate scope with good yields and satisfactory selectivity was achieved. The reactions was scaled up to gram-scale. Furthermore, an expensive rhodium/ruthenium catalytic system was recycled for at least 6 times with consistently high catalytic activity, which was economical and environmental friendly from an industrial point of view. According to the mechanistic study, the C-H bond cleavage was probably achieved via the concerted metalation-deprotonation. This technique was applied in the synthesis of various valuable unsaturated aromatic compounds and showed a great potential for industrial production In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Application of 4373-61-9).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Application of 4373-61-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gou, Yi et al. published their research in Journal of Medicinal Chemistry in 2022 | CAS: 91-02-1

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. Pyridine has a conjugated system of six 锜?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H鐪塩kel criteria for aromatic systems. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Quality Control of Phenyl(pyridin-2-yl)methanone

Dithiocarbazate-FeIII, -CoIII, -NiII, and -ZnII Complexes: Design, Synthesis, Structure, and Anticancer Evaluation was written by Gou, Yi;Jia, Xiaoying;Hou, Li Xia;Deng, Jun Gang;Huang, Guo Jin;Jiang, Hao Wen;Yang, Feng. And the article was included in Journal of Medicinal Chemistry in 2022.Quality Control of Phenyl(pyridin-2-yl)methanone This article mentions the following:

Non-platinum-metal complexes show great potential as anticancer agents. Herein, a series of dithiocarbazate non-Pt-metal complexes, including [FeIII(L)2]璺疌l璺?H2O 1, [CoIII(L)2]璺疦O3璺?.5H2O 2, [NiII(L)2] 3, and [ZnII(L)2] 4, have been designed and evaluated for their efficacy as antineoplastic agents. Among them, complex 2 exhibited higher anticancer efficacy than complexes 1, 3, 4, and cisplatin against several cancer cell lines. Hemolysis assays revealed that complex 2 showed comparable hemolysis with cisplatin. In vivo anticancer evaluations showed that complex 2 could retard tumor xenograft growth effectively with low systemic toxicity. Further studies revealed that complex 2 suppressed cancer cells by triggering multiple mechanisms involving the simultaneous inhibition of mitochondria and glycolytic bioenergetics. Overall, our study provides new insights into the anticancer mechanism of Co complexes, which can be used as a good strategy to overcome the flexibility of cancer cells to chemotherapy adaptation. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Quality Control of Phenyl(pyridin-2-yl)methanone).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. Pyridine has a conjugated system of six 锜?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H鐪塩kel criteria for aromatic systems. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Quality Control of Phenyl(pyridin-2-yl)methanone

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chatterjee, Arnab et al. published their research in Inorganica Chimica Acta in 2020 | CAS: 91-02-1

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of 閳?8.7 鑴?10閳? cm3璺痬ol閳?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ璺痬ol閳? in the liquid phase and 140.4 kJ璺痬ol閳? in the gas phase. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. COA of Formula: C12H9NO

pH dependent catecholase activity of Fe(II) complexes of type [Fe(L)]X2 [L = N-(phenyl-pyridin-2-yl-methylene)-ethane-1,2-diamine; X = ClO–4 (1), PF–6 (2)]: Role of counter anion on turnover number was written by Chatterjee, Arnab;Kaur, Gurpreet;Joshi, Mayank;Choudhury, Angshuman Roy;Ghosh, Rajarshi. And the article was included in Inorganica Chimica Acta in 2020.COA of Formula: C12H9NO This article mentions the following:

Two mononuclear Fe(II) complexes having same ligand framework, coordination geometry but different counter anions [Fe(L)]X2 [L = N-(phenyl-pyridin-2-yl-methylene)-ethane-1,2-diamine; X = ClO–4 (1), PF–6 (2)] have been synthesized and crystallog. characterized. Both the complexes catalyzed catechol-quinone oxidation pH dependently. In the pH range 8.3-8.5 the suitable activity of both the complexes were found. Counter anions in the complexes played a significant role in controlling the turn over numbers of the catalytic reactions. In acetonitrile (MeCN), the turn over number for 1 was 4.99 h-1 and for 2, it was 42.75 h-1. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1COA of Formula: C12H9NO).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of 閳?8.7 鑴?10閳? cm3璺痬ol閳?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ璺痬ol閳? in the liquid phase and 140.4 kJ璺痬ol閳? in the gas phase. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. COA of Formula: C12H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Simeone, Joseph P. et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2002 | CAS: 156761-88-5

4-Bromo-2-ethylpyridine (cas: 156761-88-5) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C閳ユ弻 in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Computed Properties of C7H8BrN

Modification of the pyridine moiety of non-peptidyl indole GnRH receptor antagonists was written by Simeone, Joseph P.;Bugianesi, Robert L.;Ponpipom, Mitree M.;Yang, Yi Tien;Lo, Jane-Ling;Yudkovitz, Joel B.;Cui, Jisong;Mount, George R.;Ren, Rena Ning;Creighton, Mellissa;Mao, An-Hua;Vincent, Stella H.;Cheng, Kang;Goulet, Mark T.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2002.Computed Properties of C7H8BrN This article mentions the following:

The synthesis of a number of indole GnRH antagonists is described. Oxidation of the pyridine ring nitrogen, combined with alkylation at the two position, led to a compound with an excellent in vitro activity profile as well as oral bioavailability in both rats and dogs. In the experiment, the researchers used many compounds, for example, 4-Bromo-2-ethylpyridine (cas: 156761-88-5Computed Properties of C7H8BrN).

4-Bromo-2-ethylpyridine (cas: 156761-88-5) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C閳ユ弻 in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Computed Properties of C7H8BrN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reisenbauer, Julia C. et al. published their research in Organic Process Research & Development in 2022 | CAS: 91-02-1

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. Pyridine has a conjugated system of six 锜?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H鐪塩kel criteria for aromatic systems. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C閳ユ弻 in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Product Details of 91-02-1

Development of an Operationally Simple, Scalable, and HCN-Free Transfer Hydrocyanation Protocol Using an Air-Stable Nickel Precatalyst was written by Reisenbauer, Julia C.;Bhawal, Benjamin N.;Jelmini, Nicola;Morandi, Bill. And the article was included in Organic Process Research & Development in 2022.Product Details of 91-02-1 This article mentions the following:

Herein, HCN-free transfer hydrocyanation of alkenes and alkynes that employed com. available aliphatic nitriles R1CC(CN)R1 [R1 = Ph, 2-MeC6H4, 4-PhC6H4, etc.; R2 = H; R1R2 = (CH2)6] and alkenyl nitriles R1C=C(CN)R1 [R1 = nPr, nBu, SiMe3 R2 = nPr, nBu, Ph] as sacrificial HCN donors in combination with a catalytic amount of air-stable and inexpensive NiCl2 as a precatalyst and a cocatalytic Lewis acid was reported. The scalability and robustness of the catalytic process were demonstrated by the hydrocyanation of 浼?methylstyrene on a 100 mmol scale (11.4 g of product obtained) using 1 mol % of the Ni catalyst. In addition, the feasibility of the dehydrocyanation protocol using the air-stable Ni(II) precatalyst and norbornadiene as a sacrificial acceptor was showcased by the selective conversion of an aliphatic nitrile into the corresponding alkene. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Product Details of 91-02-1).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. Pyridine has a conjugated system of six 锜?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H鐪塩kel criteria for aromatic systems. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C閳ユ弻 in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Product Details of 91-02-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhou, P. et al. published their research in European Journal of Soil Science in 2010 | CAS: 28020-37-3

3-Amino-2,6-dimethoxypyridine (cas: 28020-37-3) belongs to pyridine derivatives. Pyridine has a conjugated system of six 锜?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H鐪塩kel criteria for aromatic systems. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. SDS of cas: 28020-37-3

Molecular changes in particulate organic matter (POM) in a typical Chinese paddy soil under different long-term fertilizer treatments was written by Zhou, P.;Pan, G. X.;Spacclni, R.;Piccolo, A.. And the article was included in European Journal of Soil Science in 2010.SDS of cas: 28020-37-3 This article mentions the following:

A combination of solid-state CPMAS-13C-NMR and TMAH thermochemolysis-GC/MS was applied to investigate the mol. composition of particulate organic matter (POM) separated from a Chinese paddy soil, from the Tai Lake region, under a long-term field experiment with different fertilizer treatments. The treatments were: (i) no fertilizer application (NF), (ii) chem. fertilizers only (CF), (iii) chem. fertilizer plus pig manure (CFM) and (iv) chem. fertilizer plus crop straw (CFS). CPMAS-13C-NMR spectra showed that POM from all treated plots was rich in O-alkyl-C compounds, followed by alkyl-C and aromatic-C compounds However, as compared with a control (NF), POM under CFM and CFS treatments exhibited a smaller relative O-alkyl-C content and a larger contribution of aromatic-C and alkyl-C, thus increasing both aromaticity and hydrophobicity and, hence, recalcitrance of POM samples. Thermochemolysis of POM from all treatments demonstrated a dominance of aliphatic and lignin-derived compounds However, the distribution of lignin monomers (p-hydroxyphenyl, P, guaiacyl, G, and syringyl, S) revealed significant differences among the treatments. The relative distribution of lignin P, G and S monomers in NF, CF and CFS indicated a preferential contribution of annual crops and maize straw, as compared with that found for CFM. Concomitantly, a larger content of aliphatic thermochemolysis derivatives was found for CFS and CFM. The relative increase of aliphatic mols. in CFS was attributed to hydrophobic polyesters from higher plants. In the CF and CFM systems, the presence of aliphatic components of microbial origin suggested a greater microbial activity in comparison with NF and CFS. The combined application of solid state CPMAS-13C-NMR and TMAH thermochemolysis-GC/MS can be used to assess effectively the accumulation of recalcitrant organic compounds in soil POM under long-term fertilizer application with organic biomass. It is thus inferred that soil organic matter stabilization by mol. recalcitrance contributes to carbon sequestration in Chinese paddy soils under long-term managements. In the experiment, the researchers used many compounds, for example, 3-Amino-2,6-dimethoxypyridine (cas: 28020-37-3SDS of cas: 28020-37-3).

3-Amino-2,6-dimethoxypyridine (cas: 28020-37-3) belongs to pyridine derivatives. Pyridine has a conjugated system of six 锜?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H鐪塩kel criteria for aromatic systems. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. SDS of cas: 28020-37-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhu, Weibo et al. published their research in European Journal of Medicinal Chemistry in 2016 | CAS: 4373-61-9

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the 锜?bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the 锜?bonds. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.HPLC of Formula: 4373-61-9

N-Phenyl indole derivatives as AT1 antagonists with anti-hypertension activities: Design, synthesis and biological evaluation was written by Zhu, Weibo;Bao, Xiaolu;Ren, He;Da, Yajing;Wu, Dan;Li, Fuming;Yan, Yijia;Wang, Li;Chen, Zhilong. And the article was included in European Journal of Medicinal Chemistry in 2016.HPLC of Formula: 4373-61-9 This article mentions the following:

The design, synthesis, in vitro and in vivo evaluation of 6-substituted benzimidazole with 1, 4-disubstituted or 1, 5-disubstituted indole derivatives as novel angiotensin II receptor antagonists are outlined. Radioligand binding assays showed that several 6-substituted benzimidazole derivatives displayed high affinities binding to the angiotensin II type 1 receptor at the same order of magnitude to telmisartan. The biol. evaluation on spontaneously hypertensive rats showed that 2-[4-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole-1-yl]methyl]-1H-indol-1-yl]benzoic acid, I, could cause significant decrease on MBP in a dose dependent manner. Its maximal response lowered 53 mmHg of MBP at 5 mg/kg and 64 mmHg of MBP at 10 mg/kg after oral administration, and the significant antihypertensive effect lasted beyond 24 h, which was better than both losartan and telmisartan. A study designed to determine acute toxicity showed that I had low acute toxicity with no significant changes in the weight and no obvious untoward reactions. The encouraging results make I an effective and durable anti-hypertension drug candidate and deserve further investigation for therapeutic application. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9HPLC of Formula: 4373-61-9).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the 锜?bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the 锜?bonds. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.HPLC of Formula: 4373-61-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kwok, Russell et al. published their research in Journal of Heterocyclic Chemistry in 1978 | CAS: 52583-87-6

2-(Methylamino)nicotinonitrile (cas: 52583-87-6) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Quality Control of 2-(Methylamino)nicotinonitrile

Preparation of some tricyclic fused ring iminopyrido[3,2-e]pyrimidines was written by Kwok, Russell. And the article was included in Journal of Heterocyclic Chemistry in 1978.Quality Control of 2-(Methylamino)nicotinonitrile This article mentions the following:

Iminopyridopyrimidines I [R = Me, PhCH2, Ph, m-(F3C)C6H4; n = 2, 3] were prepared Thus, treatment of 2-chloronicotinonitrile with primary amines gave 2-(alkylamino)-3-pyridinecarbonitriles which condensed with H2N(CH2)nNH2 to give cyclic amidines II. Treatment of II with BrCN gave I. The preparation of diaminopyrido[2,3-d]pyrimidines and tricyclic quinazolines by related procedures was discussed. In the experiment, the researchers used many compounds, for example, 2-(Methylamino)nicotinonitrile (cas: 52583-87-6Quality Control of 2-(Methylamino)nicotinonitrile).

2-(Methylamino)nicotinonitrile (cas: 52583-87-6) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Quality Control of 2-(Methylamino)nicotinonitrile

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Esposito, Anna et al. published their research in RSC Advances in 2019 | CAS: 628-13-7

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Application In Synthesis of Pyridinehydrochloride

Expeditious synthesis and preliminary antimicrobial activity of deflazacort and its precursors was written by Esposito, Anna;De Gregorio, Eliana;De Fenza, Maria;D’Alonzo, Daniele;Satawani, Anil;Guaragna, Annalisa. And the article was included in RSC Advances in 2019.Application In Synthesis of Pyridinehydrochloride This article mentions the following:

The synthesis of deflazacort (DFZ) and a preliminary evaluation of its microbial activity against the human pathogens Acinetobacter baumannii and Staphylococcus aureus is herein reported. While DFZ is inactive, one of its synthetic precursors showed a strong antibacterial activity against both Gram-neg. and -pos. bacteria. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Application In Synthesis of Pyridinehydrochloride).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Application In Synthesis of Pyridinehydrochloride

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem