Tag: 100-200

Schrader, Thomas O. et al. published their research in ACS Medicinal Chemistry Letters in 2021 | CAS: 3939-12-6

6-Fluoronicotinonitrile (cas: 3939-12-6) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Synthetic Route of C6H3FN2

Discovery of PIPE-359, a Brain-Penetrant, Selective M1 Receptor Antagonist with Robust Efficacy in Murine MOG-EAE was written by Schrader, Thomas O.;Xiong, Yifeng;Lorenzana, Ariana O.;Broadhead, Alexander;Stebbins, Karin J.;Poon, Michael M.;Baccei, Christopher;Lorrain, Daniel S.. And the article was included in ACS Medicinal Chemistry Letters in 2021.Synthetic Route of C6H3FN2 This article mentions the following:

The discovery of PIPE-359, a brain-penetrant and selective antagonist of the muscarinic acetylcholine receptor subtype 1 is described. Starting from a literature-reported M1 antagonist, linker replacement and structure-activity relationship investigations of the eastern 1-(pyridinyl)piperazine led to the identification of a novel, potent, and selective antagonist with good MDCKII-MDR1 permeability. Continued semi-iterative positional scanning facilitated improvements in the metabolic and hERG profiles, which ultimately delivered PIPE-359. This advanced drug candidate exhibited robust efficacy in mouse myelin oligodendrocyte glycoprotein (MOG)-induced exptl. autoimmune encephalitis (EAE), a preclin. model for multiple sclerosis. In the experiment, the researchers used many compounds, for example, 6-Fluoronicotinonitrile (cas: 3939-12-6Synthetic Route of C6H3FN2).

6-Fluoronicotinonitrile (cas: 3939-12-6) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Synthetic Route of C6H3FN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhang, Jin et al. published their research in Organic Letters in 2022 | CAS: 91-02-1

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Related Products of 91-02-1

Selective Oxidation of Alkylarenes to the Aromatic Ketones or Benzaldehydes with Water was written by Zhang, Jin;Du, Jihong;Zhang, Chenyang;Liu, Kun;Yu, Feifei;Yuan, Yongkun;Duan, Baogen;Liu, Renhua. And the article was included in Organic Letters in 2022.Related Products of 91-02-1 This article mentions the following:

Here a palladium-catalyzed oxidation method for converting alkylarenes into the aromatic ketones or benzaldehydes ArC(O)R1 [Ar = Ph, 4-MeC6H4, 4-HOC6H4, etc.; R1 = H, Ph, 4-ClC6H4, etc.] with water as the only oxygen donor was reported. This C-H bond oxidation functionalization did not require other oxidants and hydrogen acceptors, and H2 was the only byproduct. The oxygen atom introduced into the products was confirmed to be from water by the MS anal. on the product of the 18O-labeled water reaction. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Related Products of 91-02-1).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Related Products of 91-02-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Morikawa, Atsushi et al. published their research in High Performance Polymers in 2016 | CAS: 628-13-7

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Recommanded Product: Pyridinehydrochloride

Synthesis and properties of polyimides containing tetraphenylnaphthalene units was written by Morikawa, Atsushi;Karube, Chihiro;Sakaki, Yu. And the article was included in High Performance Polymers in 2016.Recommanded Product: Pyridinehydrochloride This article mentions the following:

Aromatic polyimides (PI1x) with a tetraphenylnaphthalene unit between ether linkages were synthesized from 1,4-bis[4-(aminophenoxy)phenyl]-2,3-diphenylnaphthalene (1) and various tetracarboxylic dianhydrides by a conventional two-step procedure that included ring-opening polymerization in N-methyl-2-pyrrolidone and subsequent thermal cyclic dehydration. PI1x were characterized by X-ray diffraction, differential scanning calorimetry, thermogravimetry, and dynamic mech. anal. PI1x had glass transition temperatures in the range of 270 to 315鎺?and all PI1x were amorphous. The structure-property relationships of these PIs were examined and compared with those of polyimides (PI2x) from 4,4′-bis(4-aminophenoxy)biphenyl (2) and polyimides (PI3x) from 1,4-bis(4-aminophenyl)-2,3-diphenylnaphthalene (3). Water absorption and dielec. constants (钄? of the PIs were also compared and discussed on the basis of imide content per repeating unit. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Recommanded Product: Pyridinehydrochloride).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Recommanded Product: Pyridinehydrochloride

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Xu, Pengcheng et al. published their research in Organic & Biomolecular Chemistry in 2021 | CAS: 91-02-1

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Product Details of 91-02-1

Palladium-catalyzed dearomative cyclocarbonylation of allyl alcohol for the synthesis of quinolizinones was written by Xu, Pengcheng;Qian, Bo;Qi, Zaojuan;Gao, Bao;Hu, Bin;Huang, Hanmin. And the article was included in Organic & Biomolecular Chemistry in 2021.Product Details of 91-02-1 This article mentions the following:

An approach for the synthesis of quinolizinone I (R = H, 6-Me, 7-F, etc.; R1 = H, Me, Ph; R2 = H, Me, pentyl; R3 = H, Me; X = N, CH) with potential bioactivity has been developed via palladium-catalytic dearomative cyclocarbonylation of allyl alc. R4C(R1)=C(R2)CH(R3)OH (R4 = pyridin-2-yl, 5-fluoropyridin-2-yl, pyrazin-2-yl, etc.). Diverse quinolizinone compounds I could be attained with good efficiencies. A feasible reaction pathway could be a successive procedure of allylation, dearomatization, CO insertion and the Heck reaction. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Product Details of 91-02-1).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Product Details of 91-02-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hirano, Tomohiro et al. published their research in Journal of Polymer Science, Part A: Polymer Chemistry in 2012 | CAS: 3718-65-8

3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Quality Control of 3,5-Dimethylpyridine 1-oxide

Syndiotactic- and heterotactic-specific radical polymerizations of N-n-propyl-浼?fluoroacrylamide and phase-transition behaviors of aqueous solutions of poly(N-n-propyl-浼?fluoroacrylamide) was written by Hirano, Tomohiro;Furutani, Takahiro;Oshimura, Miyuki;Ute, Koichi. And the article was included in Journal of Polymer Science, Part A: Polymer Chemistry in 2012.Quality Control of 3,5-Dimethylpyridine 1-oxide This article mentions the following:

Radical polymerization of N-n-propyl-浼?fluoroacrylamide (NNPFAAm) was studied in several solvents at low temperatures in the presence or absence of Lewis bases, Lewis acids, alkyl alcs., silyl alcs., or fluorinated alcs. Different effects of solvents and additives on stereospecificity were observed in the radical polymerizations of NNPFAAm and its hydrocarbon analogs such as N-isopropylacrylamide (NIPAAm) and N-n-propylacrylamide (NNPAAm); for instance, syndiotactic (and heterotactic) specificities were induced in radical polymerization of NNPFAAm in polar solvents (and in toluene in the presence of alkyl and silyl alcs.), whereas isotactic (and syndiotactic) specificities were induced in radical polymerizations of the hydrocarbon analogs under the corresponding conditions. In contrast, heterotactic specificity induced by fluorinated alcs. was further enhanced in radical polymerization of NNPFAAm. The effects of stereoregularity on the phase-transition behaviors of aqueous solutions of poly(NNPFAAm) were also studied. Different tendencies in stereoregularity were observed in aqueous solutions of poly(NNPFAAm)s from those in solutions of the hydrocarbon analogs such as poly(NIPAAm) and poly (NNPAAm). The polymerization behavior of NNPFAAm and the phase-transition behavior of aqueous poly(NNPFAAm) are discussed based on possible fluorine-fluorine repulsion between the monomer and propagating chain-end, and neighboring monomeric units. 婕?2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Quality Control of 3,5-Dimethylpyridine 1-oxide).

3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Quality Control of 3,5-Dimethylpyridine 1-oxide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Vakuliuk, Olena et al. published their research in ChemPhotoChem in 2017 | CAS: 1620-76-4

4-Methylpicolinonitrile (cas: 1620-76-4) belongs to pyridine derivatives. Pyridine has a conjugated system of six 锜?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H鐪塩kel criteria for aromatic systems. Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Reference of 1620-76-4

The Impact of the Interplay between Steric and Electronic Effects on the Synthesis and Optical Properties of Diketopyrrolopyrroles Bearing Pyridine Moieties was written by Vakuliuk, Olena;Purc, Anna;Clermont, Guillaume;Blanchard-Desce, Mireille;Gryko, Daniel T.. And the article was included in ChemPhotoChem in 2017.Reference of 1620-76-4 This article mentions the following:

The influence of a combination of steric and electronic factors on both the preparation and the optical properties of diketopyrrolopyrroles was investigated. The attachment of a cyano group to the electron-deficient pyridine ring overcame the neg. influence of the flanking Me group on the efficiency of the synthesis of diketopyrrolopyrroles. Diketopyrrolopyrroles possessing pyridine-N-oxide moieties were studied for the first time. We have also shown that reactions of cyanopyridines possessing an addnl. dialkylamino group were very capricious and depending on the relative position of all substituents, can lead to low yields of diketopyrrolopyrroles. The interplay between the dihedral angle between the diketopyrrolopyrrole core and the pyridyl substituents as well as the presence and position of electron-donating moieties made it possible to modulate the photophys. properties of N,N’-dialkyldiketopyrrolopyrroles. In particular, it was found that pyridine-N-oxides as the aryl moieties had a strong influence on the optical properties of diketopyrrolopyrroles, shifting both absorption and emission bands bathochromically. Two-photon absorption cross-sections had low values except for those dyes possessing a clear quadrupolar centrosym. nature. In the experiment, the researchers used many compounds, for example, 4-Methylpicolinonitrile (cas: 1620-76-4Reference of 1620-76-4).

4-Methylpicolinonitrile (cas: 1620-76-4) belongs to pyridine derivatives. Pyridine has a conjugated system of six 锜?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H鐪塩kel criteria for aromatic systems. Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Reference of 1620-76-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Mirshamsi, Sepideh et al. published their research in Journal of Chemical Thermodynamics in 2019 | CAS: 3718-65-8

3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Formula: C7H9NO

Thermal behaviour of nitrogen oxides relevant to oxidative denitrogenation was written by Mirshamsi, Sepideh;Yan, Yuwei;Kamal, Sidra;Yasemi, Amir-Arsalan;Gupta, Rajender;de Klerk, Arno;Prado, Glaucia H. C.. And the article was included in Journal of Chemical Thermodynamics in 2019.Formula: C7H9NO This article mentions the following:

Oxidative denitrogenation is an alternative method to hydro-treating, where the nitrogen compounds are oxidized to form nitrogen oxides, which can be separated from the oil by extraction with a polar solvent. During this separation process there is a loss of hydrocarbon material which can be between (10-20) wt% for an oil containing 1 wt% of N. The possibility to release nitrogen as NOx by thermal treatment and consequently recover the hydrocarbon portion from the N-oxide mol. is the topic explored in this work. The thermochem. of the N-oxides of pyridine, 3-picoline, 2-mercaptopyridine, quinoline, 4-nitropyridine, 3,5-dimethylpyridine, picolinic acid, 4-picoline, 3-hydroxypyridine, nicotinic acid, isonicotinic acid, and nicotinamide was studied. The results showed that the N-oxides of pyridine and 3-picoline evaporated at atm. pressure while the other compounds decomposed after or during melting or during evaporation Decomposition temperatures could be determined for all the N-oxides during thermal anal. at 5 MPa gauge. Infra-red spectroscopy of the residues after thermal treatment indicated that the compounds still contained nitrogen. The suggested chem. taking place upon thermal decomposition in the liquid phase was discussed. N-oxides may form an oxaziridine intermediate, which results in formation of polymeric structures that still contain the nitrogen. Therefore, pyrolysis of the N-oxides subsequent to oxidation seems to be inefficient to liberate the nitrogen as NOx. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Formula: C7H9NO).

3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Formula: C7H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Trovato, Salvatore et al. published their research in Gazzetta Chimica Italiana in 1973 | CAS: 4783-68-0

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Recommanded Product: 2-Phenoxypyridine

Particular applications of MIM [molecules in molecules] method. V. Electronic states and 锜?锜?transitions of diphenyl ether, phenoxypyridines, and dipyridyl ethers was written by Trovato, Salvatore;Zuccarello, Felice;Favini, Giorgio. And the article was included in Gazzetta Chimica Italiana in 1973.Recommanded Product: 2-Phenoxypyridine This article mentions the following:

The MIM method was used for comparison of the uv spectra of Ph2O, phenoxypyridines, and dipyridyl ethers. The compounds have a C-O-C angle of 120鎺?with both aromatic rings twisted by 30鎺?around the C-O bond. The absorption band at 閳?20 nm was due to a perturbed p-band and the absorption band at 270 nm was due to a perturbed 浼?band. A comparison of measured dipole moments with those calculated from ground-state wave functions was used to determine most probable mol. conformations. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0Recommanded Product: 2-Phenoxypyridine).

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Recommanded Product: 2-Phenoxypyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Al-Arnaout, A. et al. published their research in Journal of Organometallic Chemistry in 1987 | CAS: 3718-65-8

3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Safety of 3,5-Dimethylpyridine 1-oxide

Regioselective organometallic synthesis of pyridines, 4-picolines, and 3,5-lutidines substituted in the 2-position by an unsaturated and/or functional group was written by Al-Arnaout, A.;Courtois, G.;Miginiac, L.. And the article was included in Journal of Organometallic Chemistry in 1987.Safety of 3,5-Dimethylpyridine 1-oxide This article mentions the following:

[(Alkoxycarbonyl)oxy]pyridinium chlorides I (R1 = Et, CH2CHMe2; R2 = H, Me; R3 = H, Me) were treated with 2-alkenylzinc bromides to give pyridines II (R4 = 2-alkenyl). Similarly, II [R4 = C椤氬挵(CH:CH)nCH2OR5 (n = 0, 1; R5 = H, Me)] were prepared from I and R5OCH2(CH:CH)nC椤氬挵MgBr. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Safety of 3,5-Dimethylpyridine 1-oxide).

3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Safety of 3,5-Dimethylpyridine 1-oxide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Jing et al. published their research in Organic Letters in 2017 | CAS: 4783-68-0

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Application In Synthesis of 2-Phenoxypyridine

Nickel-Catalyzed Amination of Aryl 2-Pyridyl Ethers via Cleavage of the Carbon-Oxygen Bond was written by Li, Jing;Wang, Zhong-Xia. And the article was included in Organic Letters in 2017.Application In Synthesis of 2-Phenoxypyridine This article mentions the following:

Reaction of aryl 2-pyridyl ethers with amines was carried out via Ni-catalyzed C-OPy bond cleavage, giving aniline derivatives in reasonable to excellent yields. Both electron-rich and electron-poor aryl 2-pyridyl ethers and a wide range of amines can be used in the transformation. The method provides a conversion way for the 2-pyridyloxy directing group in the C-H bond functionalization reactions. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0Application In Synthesis of 2-Phenoxypyridine).

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Application In Synthesis of 2-Phenoxypyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem