Togo, Takaya’s team published research in Chemical & Pharmaceutical Bulletin in 2019 | CAS: 3510-66-5

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. COA of Formula: C6H6BrN

In 2019,Chemical & Pharmaceutical Bulletin included an article by Togo, Takaya; Sohma, Youhei; Kuninobu, Yoichiro; Kanai, Motomu. COA of Formula: C6H6BrN. The article was titled 《Palladium-catalyzed C-H heteroarylation of 2,5-disubstituted imidazoles》. The information in the text is summarized as follows:

A palladium-catalyzed C-H N-heteroarylation of N-protected-2,5-disubstituted imidazoles at the C4-position using N-heteroaryl halides as a coupling partner was developed. Intensive reaction condition screening led to identify fluorinated bathophenanthroline as the optimum ligand for the palladium catalyst. This reaction enhanced optimization of drug candidates by facilitating the synthesis of heterobiaryl compounds containing an imidazole ring. In the experimental materials used by the author, we found 2-Bromo-5-methylpyridine(cas: 3510-66-5COA of Formula: C6H6BrN)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. COA of Formula: C6H6BrN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

de Aguiar, Sara R. M. M.’s team published research in Monatshefte fuer Chemie in 2019 | CAS: 141-86-6

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Safety of 2,6-Diaminopyridine

In 2019,Monatshefte fuer Chemie included an article by de Aguiar, Sara R. M. M.; Schroeder-Holzhacker, Christian; Pecak, Jan; Stoeger, Berthold; Kirchner, Karl. Safety of 2,6-Diaminopyridine. The article was titled 《Synthesis and characterization of TADDOL-based chiral group six PNP pincer tricarbonyl complexes》. The information in the text is summarized as follows:

The new chiral PNP pincer ligand N2,N6-bis((3aR, 8aR)-2,2-dimethyl-4,4,8,8-tetraphenyltetrahydro[1,3]dioxolo[4,5-e][1,3,2]dioxaphosphepin-6-yl)pyridine-2,6-diamine (PNP-TADDOL) was synthesized in 80% isolated yield. [M(PNP-TADDOL)(CO)3] (M = Cr, Mo, and W) were prepared via a solvothermal approach. This methodol. constitutes a fast, simple, and practical synthetic method to obtain complexes of that type in high isolated yields. The x-ray structure of the Mo complex is presented. In the experimental materials used by the author, we found 2,6-Diaminopyridine(cas: 141-86-6Safety of 2,6-Diaminopyridine)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Safety of 2,6-Diaminopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Yan, Xiao-Wei’s team published research in Applied Organometallic Chemistry in 2018 | CAS: 13534-97-9

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Category: pyridine-derivatives

In 2018,Yan, Xiao-Wei; Xie, Yong-Rong; Jin, Zhi-Min; Hu, Mao-Lin; Zhou, Liang-Pu published 《Three Arene-Ru(II) compounds of 2-halogen-5-aminopyridine: Synthesis, characterization, and cytotoxicity》.Applied Organometallic Chemistry published the findings.Category: pyridine-derivatives The information in the text is summarized as follows:

Three novel compounds, (η6-p-cymene)RuCl2(2-fluoro-5-aminopyridine) (compound 1), (η6-p-cymene)RuCl2(5-amino-2-chloropyridine) (compound 2) and (η6-p-cymene)RuCl2(2-bromo- 5-aminopyridine) (compound 3), were synthesized and characterized. The structures of compound 1 and 3 were determined by x-ray diffraction, showing a distorted piano-stool type of geometry with similar bond lengths and angles around the Ru. Compound 2 exhibited moderate in vitro activity against A549 and MCF-7 human cancer cells, the other two lower activities. The UV-visible and fluorescent absorption titrations showed that the three compounds bonded with CT-DNA in a minor groove. The intrinsic binding constants (Kb) were calculated to be 2.13(±0.03) × 105 M-1, 2.89(±0.03) × 105 M-1 and 2.45(±0.03) × 105 M-1 for compound 1, 2 and 3, resp., by using UV-visible absorption titrations data. Among the three compound, the highest value of intrinsic binding constant of compound 2 was consistent with its high cytotoxicity against A549 and MCF-7 human cancer cells in vitro. The results came from multiple reactions, including the reaction of 6-Bromopyridin-3-amine(cas: 13534-97-9Category: pyridine-derivatives)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Faggyas, Reka J.’s team published research in Journal of Organic Chemistry in 2017 | CAS: 128071-75-0

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Electric Literature of C6H4BrNO

In 2017,Faggyas, Reka J.; Calder, Ewen D. D.; Wilson, Claire; Sutherland, Andrew published 《One-Pot Asymmetric Synthesis of Alkylidene 1-Alkylindan-1-ols Using Bronsted Acid and Palladium Catalysis》.Journal of Organic Chemistry published the findings.Electric Literature of C6H4BrNO The information in the text is summarized as follows:

A one-pot catalytic enantioselective allylboration/Mizoroki-Heck reaction of 2-bromoaryl ketones has been developed for the asym. synthesis of 3-methyleneindanes bearing a tertiary alc. center. Bronsted acid-catalyzed allylboration with a chiral BINOL derivative was followed by a palladium-catalyzed Mizoroki-Heck cyclization, resulting in selective formation of the exo-alkene. This novel protocol provides a concise and scalable approach to 1-alkyl-3-methyleneindan-1-ols in high enantiomeric ratios (up to 96:4 er). The potential of these compounds as chiral building blocks was demonstrated with efficient transformation to optically active diol and amino alc. scaffolds. In the experimental materials used by the author, we found 2-Bromonicotinaldehyde(cas: 128071-75-0Electric Literature of C6H4BrNO)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Electric Literature of C6H4BrNO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Jordan, John B.’s team published research in Journal of Medicinal Chemistry in 2016 | CAS: 13534-97-9

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Application In Synthesis of 6-Bromopyridin-3-amine

In 2016,Jordan, John B.; Whittington, Douglas A.; Bartberger, Michael D.; Sickmier, E. Allen; Chen, Kui; Cheng, Yuan; Judd, Ted published 《Fragment-Linking Approach Using 19F NMR Spectroscopy To Obtain Highly Potent and Selective Inhibitors of β-Secretase》.Journal of Medicinal Chemistry published the findings.Application In Synthesis of 6-Bromopyridin-3-amine The information in the text is summarized as follows:

Fragment-based drug discovery (FBDD) has become a widely used tool in small-mol. drug discovery efforts. One of the most commonly used biophys. methods in detecting weak binding of fragments is NMR (NMR) spectroscopy. In particular, FBDD performed with 19F NMR-based methods has been shown to provide several advantages over 1H NMR using traditional magnetization-transfer and/or two-dimensional methods. Here, we demonstrate the utility and power of 19F-based fragment screening by detailing the identification of a second-site fragment through 19F NMR screening that binds to a specific pocket of the aspartic acid protease, β-secretase (BACE-1). The identification of this second-site fragment allowed the undertaking of a fragment-linking approach, which ultimately yielded a mol. exhibiting a more than 360-fold increase in potency while maintaining reasonable ligand efficiency and gaining much improved selectivity over cathepsin-D (CatD). X-ray crystallog. studies of the mols. demonstrated that the linked fragments exhibited binding modes consistent with those predicted from the targeted screening approach, through-space NMR data, and mol. modeling.6-Bromopyridin-3-amine(cas: 13534-97-9Application In Synthesis of 6-Bromopyridin-3-amine) was used in this study.

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Application In Synthesis of 6-Bromopyridin-3-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Di Pompo, Gemma’s team published research in Journal of Medicinal Chemistry in 2015 | CAS: 13534-97-9

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Name: 6-Bromopyridin-3-amine

In 2015,Di Pompo, Gemma; Salerno, Manuela; Rotili, Dante; Valente, Sergio; Zwergel, Clemens; Avnet, Sofia; Lattanzi, Giovanna; Baldini, Nicola; Mai, Antonello published 《Novel Histone Deacetylase Inhibitors Induce Growth Arrest, Apoptosis, and Differentiation in Sarcoma Cancer Stem Cells》.Journal of Medicinal Chemistry published the findings.Name: 6-Bromopyridin-3-amine The information in the text is summarized as follows:

Musculoskeletal sarcomas are aggressive malignancies of bone and soft tissues often affecting children and adolescents. Histone deacetylase inhibitors (HDACi) have been proposed to counteract cancer stem cells (CSCs) in solid neoplasms. When tested in human osteosarcoma, rhabdomyosarcoma, and Ewing’s sarcoma stem cells, the new HDACi MC1742 I and MC2625 II increased acetyl-H3 and acetyl-tubulin levels and inhibited CSC growth by apoptosis induction. At nontoxic doses, I promoted osteogenic differentiation. Further investigation with I will be done in preclin. sarcoma models.6-Bromopyridin-3-amine(cas: 13534-97-9Name: 6-Bromopyridin-3-amine) was used in this study.

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Name: 6-Bromopyridin-3-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Dordahan, Fatemeh’s team published research in Canadian Journal of Chemistry in 2022 | CAS: 1539-42-0

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Reference of Bis(pyridin-2-ylmethyl)amine

《Lactide polymerization using sterically encumbered, flexible zinc complex》 was written by Dordahan, Fatemeh; Schaper, Frank. Reference of Bis(pyridin-2-ylmethyl)amineThis research focused onzinc complex catalyst preparation lactide polymerization. The article conveys some information:

4-(Tert-Butyl)-2-trityl-6-(di-(2-picolyl)amine)phenol, LH, was prepared from paraformaldehyde, 4-(tert-butyl)-2-tritylphenol, and di-(2-picolyl)amine. Reaction with Zn(N(SiMe3)2)2 gave LZnN(SiMe3)2. The complex was shown by X-ray diffraction study, variable temperature NMR, and DFT calculations to coordinate only one pyridine ligand, which allows for fast and facile complex isomerisation. LZnN(SiMe3)2 was active in rac-lactide polymerization, but in contrast to previous complexes of this type, it did not show any evidence for isotactic monomer enchainment via a catalytic-site mediated chain-end control mechanism. Addition of alc. led to increased activity, but the complex was unstable in the presence of free alc. In the experiment, the researchers used many compounds, for example, Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Reference of Bis(pyridin-2-ylmethyl)amine)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Reference of Bis(pyridin-2-ylmethyl)amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhang, Xinghao’s team published research in Journal of Solid State Chemistry in 2020 | CAS: 1134-35-6

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.Recommanded Product: 4,4′-Dimethyl-2,2′-bipyridine Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.

《Coordination polymers driven by 2,5-dibromoterephthalic acid and chelating co-ligands: Syntheses, structures and luminescent properties》 was written by Zhang, Xinghao; Zhang, Yaowen; Jiao, Shaoshao; Song, Xiuyan; Li, Shaoxiang; Liu, Kang; Wang, Lei. Recommanded Product: 4,4′-Dimethyl-2,2′-bipyridineThis research focused onzinc cobalt dibromoterephthalato bipyridine complex photoelectron crystal structure fluorescence. The article conveys some information:

Four coordination polymers, namely, [Zn(DBT)(4,4′-dmbpy)(H2O)]n (1), [Co(DBT)(2,2′-bpy)(H2O)]n (2), [Zn(DBT)(2,2′-bpy)]n (3), [Zn(DBT)0.5(2,2′-bpy)2·(HDBT-)]n (4) (H2DBT = 2,5-dibromoterephthalic acid, 4,4′-dmbpy = 4,4′-dimethyl-2,2′-bipyridyl and 2,2′-bpy = 2,2′-bipyridyl) were synthesized under solvothermal conditions and characterized by single crystal x-ray diffraction, powder x-ray diffraction, elemental anal., IR and thermogravimetric (TG) anal. These four compounds remained stable until 150°, and the major quality loss (83-90%) occurred between 150 and 700°. In mixed ligands system, the main ligand H2DBT exhibits monodentate or bidentate bridging coordination modes and the auxiliary ligands 4,4′-dmbpy and 2,2′-bpy both possess bidentate chelate coordination modes. An objective of this study was to investigate the pivotal role of chelating ligands in the formation of low dimensional structures. As the bipyridyl ligands occupy the coordination site, compounds 1-3 all display two dimensional structures and 4 shows 1-dimensional chains, of which compounds 1 and 2 are isomorphic. The hydrogen bonds and π-π stacking work together in the formation of 3-dimensional supramol. structure of these four compounds Besides, the authors investigated their photoluminescence properties in the solid state at room temperature 1, 3 And 4 exhibited good fluorescence performance, and their strong emission peaks were located at 447 nm (λex = 285 nm) for 1, 427 nm (λex = 330 nm) for 3, and 412 nm (λex = 310 nm) for 4. The results came from multiple reactions, including the reaction of 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Recommanded Product: 4,4′-Dimethyl-2,2′-bipyridine)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.Recommanded Product: 4,4′-Dimethyl-2,2′-bipyridine Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Fan, Jianfeng’s team published research in ACS Applied Materials & Interfaces in 2021 | CAS: 141-86-6

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Quality Control of 2,6-Diaminopyridine

Quality Control of 2,6-DiaminopyridineIn 2021 ,《Toward Robust, Tough, Self-Healable Supramolecular Elastomers for Potential Application in Flexible Substrates》 was published in ACS Applied Materials & Interfaces. The article was written by Fan, Jianfeng; Huang, Jiarong; Gong, Zhou; Cao, Liming; Chen, Yukun. The article contains the following contents:

A robust, tough, and self-healable elastomer is a promising candidate for substrate in flexible electronic devices, but there is often a trade-off between mech. properties (robustness and toughness) and self-healing. Here, a poly(dimethylsiloxane) (PDMS) supramol. elastomer is developed based on metal-coordinated bonds with relatively high activation energy. The strong metal-coordination complexes and their corresponding ionic clusters acting as the crosslinking points strengthen the resultant supramol. networks, which achieves superior mech. robustness (2.81 MPa), and their consecutive dynamic rupture and reconstruction efficiently dissipate strain energy during the stretching process, which leads to an impressive fracture toughness (32 MJ/m3). Addnl., the reversible intermol. interactions (weak hydrogen bonds and strong sacrificial coordination complexes/clusters) can break and re-form upon heating; thus, the elastomer self-heals at a moderate temperature with the highest healing efficiency of 95%. As such, the potential of the as-prepared supramol. elastomer for a substrate material of flexible electronic devices is discovered. The experimental part of the paper was very detailed, including the reaction process of 2,6-Diaminopyridine(cas: 141-86-6Quality Control of 2,6-Diaminopyridine)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Quality Control of 2,6-Diaminopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Nayal, Onkar S.’s team published research in Advanced Synthesis & Catalysis in 2018 | CAS: 13534-97-9

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Formula: C5H5BrN2

Formula: C5H5BrN2In 2018 ,《Ligand-free Iron(II)-Catalyzed N-Alkylation of Hindered Secondary Arylamines with Non-activated Secondary and Primary Alcohols via a Carbocationic Pathway》 was published in Advanced Synthesis & Catalysis. The article was written by Nayal, Onkar S.; Thakur, Maheshwar S.; Kumar, Manoranjan; Kumar, Neeraj; Maurya, Sushil K.. The article contains the following contents:

Secondary benzylic alcs. represent a challenging class of substrates for N-alkylation of amines. Herein, the authors describe an iron(II)-catalyzed eco-friendly protocol for N-alkylation of secondary arylamines with secondary benzyl alcs. through a carbocationic pathway instead of the known borrowing hydrogen transfer (BHT) approach. Transiently generated carbocations, produced from alcs. via self-condensation, were coupled with arylamines to provide highly functionalized amine products. The scope of this methodol. involves N-alkylation of primary, secondary and heterocyclic amines with primary/secondary benzylic, allylic and heterocyclic alcs., which are common key structures in numerous pharmaceuticals drugs. The method can also be easily adopted for the amination of various natural products. In the experimental materials used by the author, we found 6-Bromopyridin-3-amine(cas: 13534-97-9Formula: C5H5BrN2)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Formula: C5H5BrN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem