Tag: 100-200

In 2019,Journal of Molecular Structure included an article by Ben Moussa, Oumaima; Chebbi, Hammouda; Zid, Mohamed Faouzi. Application of 141-86-6. The article was titled 《Synthesis, crystal structure, vibrational study, optical properties and Hirshfeld surface analysis of bis(2,6-diaminopyridinium) tetrachloridocobaltate(II) monohydrate》. The information in the text is summarized as follows:

The title organic-inorganic hybrid compound, (C5H8N3)2 [CoCl4]·H2O, was synthesized by slow evaporation at room temperature Single-crystal x-ray diffraction anal. indicates that the asym. unit in this compound consists of one tetrahedral geometry [CoCl4]2-, two protonated organic cations (C5H8N3)+ and one water mol. of crystallization, all of which lie in general positions. In the crystal structure, the inorganic layers are built from tetrachloridocobaltate anions [CoCl4]2- and free water mols., linked together by O-H···Cl hydrogen bonds. The organic cations are intercalated between the inorganic layers via N-H···Cl hydrogen bonds and form chains through aromatic donor-acceptor interactions. Crystal cohesion is achieved through N-H···Cl, O-H···Cl, N-H···O and C-H···Cl hydrogen bonds between organic cations, inorganic anions and the water mols. building up a three-dimensional network. The functional groups present in the crystal were studied by FTIR spectroscopy. Investigation of the optical properties of the compound confirmed its semiconducting properties by revealing a direct optical band gap at 1.67 eV. Photoluminescence proprieties are also reported. The three-dimensional Hirshfeld surface (3-dimensional-HS) anal. and the two-dimensional fingerprint plots (2-dimensional-FP) reveal that the structure is dominated by H···Cl/Cl···H and H···H contacts. After reading the article, we found that the author used 2,6-Diaminopyridine(cas: 141-86-6Application of 141-86-6)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Application of 141-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Drug and Chemical Toxicology (1977) included an article by Varol, Mehmet; Benkli, Kadriye; Koparal, Ayse T.; Bostancioglu, Rakibe B.. Name: 4,4′-Dimethyl-2,2′-bipyridine. The article was titled 《Design and synthesis of novel organometallic complexes using boronated phenylalanine derivatives as potential anticancer agents》. The information in the text is summarized as follows:

Drug design and discovery studies are important because of the prevalence of diseases without available medical cures. New anticancer agents are particularly urgent because of the high mortality rate associated with cancer. A series of mononuclear gold (III) and platinum (II) complexes based on boronated phenylalanine (BPA) were designed and synthesized using 4,4′-dimethyl-2,2′-dipyridyl (L1) or 1,10-phenanthroline-5,6-dion (L2) ligands to obtain promising anticancer drug candidates. Proton NMR, IR, mass spectrometry, and elemental analyses were utilized for chem. characterizations. Cell viability, cancer cell colony formation, endothelial tube formation, and cytoskeleton staining assays were performed using A549 lung adenocarcinoma and human umbilical vein endothelial cells (HUVECs) to investigate preliminary pharmacol. activities. L1-based platinum (II) complex (BPA-L1-Pt) was the most promising complex, and has similar activity with the approved chemotherapy drug cis-platinum. Half maximal inhibitory concentration values for BPA-L1-Pt were 9.15 μM on A549s and 16.61 μM on HUVECs; the values for cis-platinum were 5.24 μM on A549s and 23.14 μM on HUVECs. Consequently, further synthesis studies should be performed to boost the cancer cell selectivity feature of BPA by varying metal and ligand types. The experimental part of the paper was very detailed, including the reaction process of 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Name: 4,4′-Dimethyl-2,2′-bipyridine)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.Name: 4,4′-Dimethyl-2,2′-bipyridine Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Letters in Organic Chemistry included an article by Gavhane, Dinesh S.; Sarkate, Aniket P.; Karnik, Kshipra S.; Jagtap, Shritesh D.; Ansari, Sajed H.; Izankar, Ashwini V.; Narula, Ishudeep K.; Jambhorkar, Vaishnavi S.; Rajhans, Aishwarya P.. Computed Properties of C5H6BNO2. The article was titled 《Nano Copper Catalyzed Microwave Assisted Coupling of Benzene Boronic Acids with Thiophenols》. The information in the text is summarized as follows:

A proficient, microwave mediated methodol. using CuFe2O4 nanoparticle as the catalyst for S-arylation of substituted benzene boronic acids with thiophenol was developed. In this method, the substituted thioethers were easily obtained through a C-S bond formation using microwave irradiation technique as well as conventional heating in the presence of CuFe2O4 nanoparticles with modest to excellent yields with the less reaction time. The ligand free microwave technique helped in the preparation of substituted thioethers in measurable amount within 10 mins. The same results were obtained with conventional heating in 12h. The reported method was economically efficient and an alternative to the initial existing method for the preparation of substituted thioethers. In the part of experimental materials, we found many familiar compounds, such as 2-Pyridinylboronic acid(cas: 197958-29-5Computed Properties of C5H6BNO2)

2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Computed Properties of C5H6BNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Lu, Te-Jui; Lin, Po-Han; Lee, Kun-Mu; Liu, Ching-Yuan published 《End-Capping Groups for Small-Molecule Organic Semiconducting Materials: Synthetic Investigation and Photovoltaic Applications through Direct C-H (Hetero)arylation》.European Journal of Organic Chemistry published the findings.Product Details of 53939-30-3 The information in the text is summarized as follows:

A Pd-catalyzed C-H (hetero)arylation methodol. has been optimized for the efficient synthesis of various useful end-capping groups that are widely applied in small-mol. optoelectronic materials. We report herein the synthesis of a broad scope of target mols. ranging from donor-type through acceptor-type to hybrid-type end-capping groups. To demonstrate their application in dye-sensitized solar cells, we have designed two new D-A-π-A’-type organic sensitizers (CYL-3 and CYL-4), which were synthesized in a step-economic manner by sequential C-H arylations using the facilely obtained end-capping groups. The devices based on CYL-3 and CYL-4 give Voc values of 0.67-0.71 V, Jsc values of 10.07-11.63 mA cm-2, and FF values of 70.6-72.9 %, which correspond to overall power conversion efficiencies of 4.76-6.02 %. This work is expected to become a practical synthetic alternative allowing materials scientists to access small-mol. organic materials in fewer synthetic transformations.5-Bromo-2-chloropyridine(cas: 53939-30-3Product Details of 53939-30-3) was used in this study.

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Product Details of 53939-30-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2011,Radeke, Heike S.; Purohit, Ajay; Harris, Thomas D.; Hanson, Kelley; Jones, Reinaldo; Hu, Carol; Yalamanchili, Padmaja; Hayes, Megan; Yu, Ming; Guaraldi, Mary; Kagan, Mikhail; Azure, Michael; Cdebaca, Michael; Robinson, Simon; Casebier, David published 《Synthesis and Cardiac Imaging of 18F-Ligands Selective for β1-Adrenoreceptors》.ACS Medicinal Chemistry Letters published the findings.Recommanded Product: 6-Bromopyridin-3-amine The information in the text is summarized as follows:

A series of potent and selective β1-adrenoreceptor ligands were identified (IC50 range, 0.04-0.25 nM; β1/β2 selectivity range, 65-450-fold), labeled with the PET radioisotope fluorine-18 and evaluated in normal Sprague-Dawley rats. Tissue distribution studies demonstrated uptake of each radiotracers from the blood pool into the myocardium (0.48-0.62% ID/g), lung (0.63-0.97% ID/g), and liver (1.03-1.14% ID/g). Dynamic μPET imaging confirmed the in vivo dissection studies. The experimental process involved the reaction of 6-Bromopyridin-3-amine(cas: 13534-97-9Recommanded Product: 6-Bromopyridin-3-amine)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Recommanded Product: 6-Bromopyridin-3-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2011,Kasparian, Annie J.; Savarin, Cecile; Allgeier, Alan M.; Walker, Shawn D. published 《Selective catalytic hydrogenation of nitro groups in the presence of activated heteroaryl halides》.Journal of Organic Chemistry published the findings.Category: pyridine-derivatives The information in the text is summarized as follows:

Chemoselective reduction of nitro groups in the presence of activated heteroaryl halides was achieved via catalytic hydrogenation with a com. available sulfided platinum catalyst. The optimized conditions employ low temperature, pressure, and catalyst loading (<0.1 mol % Pt) to afford heteroaromatic amines with minimal hydrodehalogenation byproducts. In addition to this study using 6-Bromopyridin-3-amine, there are many other studies that have used 6-Bromopyridin-3-amine(cas: 13534-97-9Category: pyridine-derivatives) was used in this study.

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2010,Young, Brandon M.; Hyatt, Janice L.; Bouck, David C.; Chen, Taosheng; Hanumesh, Parimala; Price, Jeanine; Boyd, Vincent A.; Potter, Philip M.; Webb, Thomas R. published 《Structure-Activity Relationships of Substituted 1-Pyridyl-2-phenyl-1,2-ethanediones: Potent, Selective Carboxylesterase Inhibitors》.Journal of Medicinal Chemistry published the findings.Synthetic Route of C5H5BrN2 The information in the text is summarized as follows:

Inhibition of intestinal carboxylesterases may allow modification of the pharmacokinetics/pharmacodynamic profile of existing drugs by altering half-life or toxicity. Since previously identified diarylethane-1,2-dione inhibitors are decidedly hydrophobic, a modified dione scaffold was designed and elaborated into a >300 member library, which was subsequently screened to establish the SAR for esterase inhibition. This allowed the identification of single digit nanomolar hiCE inhibitors that showed improvement in selectivity and measured solubility In the experiment, the researchers used 6-Bromopyridin-3-amine(cas: 13534-97-9Synthetic Route of C5H5BrN2)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Synthetic Route of C5H5BrN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of C9H12N2O2On September 28, 2017 ,《Discovery of Clinical Candidate N-((1S)-1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide (TAK-915): A Highly Potent, Selective, and Brain-Penetrating Phosphodiesterase 2A Inhibitor for the Treatment of Cognitive Disorders》 was published in Journal of Medicinal Chemistry. The article was written by Mikami, Satoshi; Nakamura, Shinji; Ashizawa, Tomoko; Nomura, Izumi; Kawasaki, Masanori; Sasaki, Shigekazu; Oki, Hideyuki; Kokubo, Hironori; Hoffman, Isaac D.; Zou, Hua; Uchiyama, Noriko; Nakashima, Kosuke; Kamiguchi, Naomi; Imada, Haruka; Suzuki, Noriko; Iwashita, Hiroki; Taniguchi, Takahiko. The article contains the following contents:

Phosphodiesterase (PDE) 2A inhibitors have emerged as a novel mechanism with potential therapeutic option to ameliorate cognitive dysfunction in schizophrenia or Alzheimer’s disease through upregulation of cyclic nucleotides in the brain, and thereby achieve potentiation of cyclic nucleotide signaling pathways. This article details the expedited optimization of the authors’ recently disclosed pyrazolo[1,5-a]pyrimidine lead compound 4b, leading to the discovery of clin. candidate 36 (I) (TAK-915), which demonstrates an appropriate combination of potency, PDE selectivity, and favorable pharmacokinetic (PK) properties, including brain penetration. Successful identification of 36 was realized through application of structure-based drug design (SBDD) to further improve potency and PDE selectivity, coupled with prospective design focused on physicochem. properties to deliver brain penetration. Oral administration of 36 demonstrated significant elevation of 3′,5′-cGMP levels in mouse brains, and improved cognitive performance in a novel object recognition task in rats. Consequently, compound 36 was advanced into human clin. trials. The experimental part of the paper was very detailed, including the reaction process of Ethyl 2-(3-aminopyridin-2-yl)acetate(cas: 295327-27-4Synthetic Route of C9H12N2O2)

Ethyl 2-(3-aminopyridin-2-yl)acetate(cas: 295327-27-4) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Synthetic Route of C9H12N2O2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of C6H6ClNO2SOn September 10, 2020 ,《Identification and Optimization of Pyrrolidine Derivatives as Highly Potent Ghrelin Receptor Full Agonists》 was published in Journal of Medicinal Chemistry. The article was written by Cooper, Martin; Llinas, Antonio; Hansen, Peter; Caffrey, Moya; Ray, Asim; Sjoedin, Stina; Shamovsky, Igor; Wada, Hiroki; Jellesmark Jensen, Tina; Sivars, Ulf; Hultin, Leif; Andersson, Ulf; Lundqvist, Sara; Gedda, Karin; Jinton, Lisa; Krutroek, Nina; Lewis, Richard; Jansson, Paul; Gardelli, Cristina. The article contains the following contents:

Muscle atrophy and cachexia are common comorbidities among patients suffering from cancer, chronic obstructive pulmonary disease, and several other chronic diseases. The peptide hormone ghrelin exerts pleiotropic effects including the stimulation of growth hormone secretion and subsequent increase of insulin-like growth factor-1 levels, an important mediator of muscle growth and repair. Ghrelin also acts on inflammation, appetite, and adipogenesis and therefore has been considered a promising therapeutic target for catabolic conditions. We previously reported on the synthesis and properties of an indane based series of ghrelin receptor full agonists which led to a sustained increase of insulin-like growth factor-1 in a dog pharmacodynamic study. Herein we report on the identification of a series of pyrrolidine or piperidine based full agonists and attempted optimization to give compounds with profiles suitable for progression as clin. candidates. In the part of experimental materials, we found many familiar compounds, such as 2-Methylpyridine-4-sulfonyl chloride(cas: 1025509-77-6Synthetic Route of C6H6ClNO2S)

2-Methylpyridine-4-sulfonyl chloride(cas: 1025509-77-6) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Synthetic Route of C6H6ClNO2S

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《One-Pot Direct Synthesis of Weinreb Amides From Aryl and Hetero Aryl Halides Using Co2(CO)8 as an Effective CO Source Under Conventional Thermal Heating》 was written by Baburajan, Poongavanam; Elango, Kuppanagounder P.. Safety of 5-Bromo-2-chloropyridineThis research focused onWeinreb amide cobalt carbonyl reaction; aminocarbonylation aryl halide cobalt carbonyl. The article conveys some information:

A successful protocol for the synthesis of Weinreb amides directly from aryl halides via aminocarbonylation with N,O-dimethylhydroxylamine using Co2(CO)8 as an in situ CO source has been demonstrated. The effects of various reaction parameters such as temperature, base, and CO source have also been investigated and optimized. In the experimental materials used by the author, we found 5-Bromo-2-chloropyridine(cas: 53939-30-3Safety of 5-Bromo-2-chloropyridine)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Safety of 5-Bromo-2-chloropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem