Tag: 100-200

Name: 4,4′-Dimethyl-2,2′-bipyridineIn 2020 ,《Hierarchical CoS2/N-Doped Carbon@MoS2 Nanosheets with Enhanced Sodium Storage Performance》 was published in ACS Applied Materials & Interfaces. The article was written by Xiao, Fengping; Yang, Xuming; Wang, Hongkang; Yu, Denis Y. W.; Rogach, Andrey L.. The article contains the following contents:

We introduce a hierarchical nanostructure of CoS2/N-doped carbon@MoS2 comprising two transition-metal sulfides CoS2 and MoS2, with enhanced sodium storage performance in sodium-ion batteries. A micron-sized Co metal-organic framework (MOF) is transformed into a CoS2/N-doped carbon composite, followed by a solvothermal growth of MoS2 nanosheets on the surface. The resulting composite material offers several specific advantages for sodium storage: (i) accelerated sodium-ion diffusion kinetics due to its heterogeneous interface; (ii) shortened ion diffusion path and exposed active sites for sodium storage due to its hierarchical nanosheet architecture; and (iii) homogeneous nitrogen doping of the MOF-derived carbon, which is beneficial for electronic conductivity Due to these merits, this composite exhibits excellent electrochem. performance with a specific capacity of 596 mAh g-1 after 100 cycles at 0.1 A g-1 and 395 mAh g-1 at 5.0 A g-1.4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Name: 4,4′-Dimethyl-2,2′-bipyridine) was used in this study.

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.Name: 4,4′-Dimethyl-2,2′-bipyridine Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

COA of Formula: C12H12N2In 2019 ,《A Ru(II) polypyridyl complex bearing aldehyde functions as a versatile synthetic precursor for long-wavelength absorbing photodynamic therapy photosensitizers》 was published in Bioorganic & Medicinal Chemistry. The article was written by Karges, Johannes; Heinemann, Franz; Maschietto, Federica; Patra, Malay; Blacque, Olivier; Ciofini, Ilaria; Spingler, Bernhard; Gasser, Gilles. The article contains the following contents:

The use of Photodynamic Therapy (PDT) for the treatment of several kinds of cancer as well as bacterial, fungal or viral infections has received increasing attention during the last decade. However, the currently clin. approved photosensitizers (PSs) have several drawbacks, including photobleaching, slow clearance from the organism and poor water solubility To overcome these shortcomings, many efforts have been made in the development of new types of PSs, such as Ru(II) polypyridyl complexes. Nevertheless, most studied Ru(II) polypyridyl complexes have a low absorbance in the spectral therapeutic window. In this work, we show that, by carefully selecting substituents on the polypyridyl complex, it is possible to prepare a complex absorbing at a much higher wavelength. Specifically, we report on the synthesis as well as in-depth exptl. and theor. characterization of a Ru(II) polypyridyl complex (complex 3) combining a shift in absorbance towards the spectral therapeutic window with a high 1O2 production To overcome the absence or poor selectivity of most approved PSs into targeted cells/bacteria, they can be linked to targeting moieties. In this line, compound 3 was designed with reactive aldehyde groups, which can be used as a highly versatile synthetic precursor for further conjugation. As a proof of concept, 3 was reacted with benzylamine and the stability of the resulting conjugate 4 was investigated in DMSO, PBS and cell media. 4 showed an impressive ability to act as a PDT PS with no measurable dark cytotoxicity and photocytotoxicity in the low micromolar range against cancerous HeLa cells from 450 nm up to 540 nm. In the experiment, the researchers used many compounds, for example, 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6COA of Formula: C12H12N2)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.COA of Formula: C12H12N2 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

HPLC of Formula: 53939-30-3In 2022 ,《Rigid α-diimine palladium complexes as direct C-H arylation precatalysts for thiophenes and heteroaryl bromides》 was published in Inorganic Chemistry Communications. The article was written by Gao, Tai-Heng; Ying Xiong; Guo, Pengfeng; Liu, Feng-Shou; Zhao, Limin. The article contains the following contents:

The direct C-H heteroarylation of thiophenes, promoted by rigid α-diimine palladium complexes is described. This approach exhibits broad substrate scopes with functional group tolerant, and proceeds with the formation of regioselective products. After reading the article, we found that the author used 5-Bromo-2-chloropyridine(cas: 53939-30-3HPLC of Formula: 53939-30-3)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. HPLC of Formula: 53939-30-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

COA of Formula: C7H9NOIn 2019 ,《Merging Photochemistry with Electrochemistry: Functional-Group Tolerant Electrochemical Amination of C(sp3)-H Bonds》 appeared in Angewandte Chemie, International Edition. The author of the article were Wang, Fei; Stahl, Shannon S.. The article conveys some information:

A combined electrochem./photochem. method for dehydrogenative C(sp3)-H/N-H coupling that exhibits good reactivity with both sp2 and sp3 N-H bonds has been reported. The results show how use of iodide as an electrochem. mediator, in combination with light-induced cleavage of intermediate N-I bonds, enables the electrochem. process to proceed at low electrode potentials. This approach significantly improves the functional-group compatibility of electrochem. C-H amination, for example, tolerating electron-rich aromatic groups that undergo deleterious side reactions in the presence of high electrode potentials. The experimental process involved the reaction of 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2COA of Formula: C7H9NO)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. COA of Formula: C7H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 1692-25-7In 2021 ,《Catalytic Enantioselective Synthesis of Pyridyl Sulfoximines》 appeared in Journal of the American Chemical Society. The author of the article were Tang, Yu; Miller, Scott J.. The article conveys some information:

The synthesis of chiral sulfoximines, e.g., I, through the desymmetrizing N-oxidation of pyridyl sulfoximines, e.g., II, using an aspartic-acid-containing peptide catalyst III (R = Ts, Boc) was reported. Various mono- and bis-pyridyl sulfoximine oxides, e.g., I and IV, are obtained with up to 99:1 er. The directing group introduced on the substrate highly enhances the enantioinduction and could be easily removed to give the free N-H sulfoximines V. Addnl., peptides with Me ester and the Me amide C-terminal protecting group give the opposite enantiomers of the product. A binding model is proposed to explain this phenomenon. The experimental process involved the reaction of Pyridin-3-ylboronic acid(cas: 1692-25-7Related Products of 1692-25-7)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Related Products of 1692-25-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: 3510-66-5In 2021 ,《A study of the structure-affinity relationship in SYA16263; is a D2 receptor interaction essential for inhibition of apormorphine-induced climbing behavior in mice?》 appeared in Bioorganic & Medicinal Chemistry. The author of the article were Onyameh, Edem K.; Bricker, Barbara A.; Eyunni, Suresh V. K.; Voshavar, Chandrashekhar; Gonela, Uma M.; Ofori, Edward; Jenkins, Andrea; Ablordeppey, Seth Y.. The article conveys some information:

Dopamine (DA) and serotonin (5-HT) receptors are prime targets for the development of antipsychotics. The specific role of each receptor subtype to the pharmacol. effects of antipsychotic drugs remains unclear. Understanding the relationship between antipsychotic drugs and their binding affinities at DA and 5-HT receptor subtypes is very important for antipsychotic drug discovery and could lead to new drugs with enhanced efficacies. We have previously disclosed SYA16263 (5) as an interesting compound with moderate radioligand binding affinity at the D2 & D3 receptors (Ki = 124 nM & 86 nM resp.) and high binding affinities towards D4 and 5-HT1A receptors (Ki = 3.5 nM & 1.1 nM resp.). Furthermore, we have demonstrated SYA16263 (5) is functionally selective and produces antipsychotic-like behavior but without inducing catalepsy in mice. Based on its pharmacol. profile, we selected SYA16263 (5) to study its structure-affinity relationship with a view to obtaining new analogs that display receptor subtype selectivity. In this study, we present the synthesis of structurally modified SYA16263 (5) analogs and their receptor binding affinities at the DA and 5-HT receptor subtypes associated with antipsychotic action. Furthermore, we have identified compound 21 with no significant binding affinity at the D2 receptor subtype but with moderate binding affinity at the D3 and D4 receptors subtypes. However, because 21 is able to demonstrate antipsychotic-like activity in a preliminary test, using the reversal of apomorphine-induced climbing behavior experiment in mice with SYA16263 and haloperidol as pos. controls, we question the essential need of the D2 receptor subtype in reversing apomorphine-induced climbing behavior. In the experiment, the researchers used many compounds, for example, 2-Bromo-5-methylpyridine(cas: 3510-66-5Recommanded Product: 3510-66-5)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Recommanded Product: 3510-66-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Patel, P. N.; Desai, D. H.; Patel, N. C. published an article in Russian Journal of Organic Chemistry. The title of the article was 《Novel Terpyridine Derivatives of Benzothiazole and Copper(II) Complex: Synthesis and Spectral Studies》.Synthetic Route of C7H7NO The author mentioned the following in the article:

Novel terpyridine derivatives of benzothiazole were synthesized by simple multicomponent 1-pot reaction of benzothiazole-2-carbaldehyde, ammonium hydroxide, and isomeric acetyl pyridines with isolated yields of 92-98%. All the prepared derivatives were characterized by NMR, IR, and high-resolution mass spectra. A Cu(II) complex was prepared selectively from the terpyridine derivative obtained from 2-acetylpyridine and was characterized by single-crystal x-ray anal. UV-visible spectra were recorded for all the synthesized compounds In the experiment, the researchers used 4-Acetylpyridine(cas: 1122-54-9Synthetic Route of C7H7NO)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Synthetic Route of C7H7NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,Tolmachova, Kateryna A.; Moroz, Yurii S.; Konovets, Angelika; Platonov, Maxim O.; Vasylchenko, Oleksandr V.; Borysko, Petro; Zozulya, Sergey; Gryniukova, Anastasia; Bogolubsky, Andrey V.; Pipko, Sergey; Mykhailiuk, Pavel K.; Brovarets, Volodymyr S.; Grygorenko, Oleksandr O. published 《(Chlorosulfonyl)benzenesulfonyl Fluorides-Versatile Building Blocks for Combinatorial Chemistry: Design, Synthesis and Evaluation of a Covalent Inhibitor Library》.ACS Combinatorial Science published the findings.Electric Literature of C5H5BrN2 The information in the text is summarized as follows:

Multigram synthesis of (chlorosulfonyl)benzenesulfonyl fluorides is described. Selective modification of these building blocks at the sulfonyl chloride function under parallel synthesis conditions is achieved. It is shown that the reaction scope includes the use of (hetero)aromatic and electron-poor aliphatic amines (e.g., amino nitriles). Utility of the method is demonstrated by preparation of the sulfonyl fluoride library for potential use as covalent fragments, which is demonstrated by a combination of in silico and in vitro screening against trypsin as a model enzyme. As a result, several inhibitors were identified with activity on par with that of the known inhibitor. In the part of experimental materials, we found many familiar compounds, such as 6-Bromopyridin-3-amine(cas: 13534-97-9Electric Literature of C5H5BrN2)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Electric Literature of C5H5BrN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Gunaga, Prashantha; Lloyd, John; Mummadi, Somanadham; Banerjee, Abhisek; Dhondi, Naveen Kumar; Hennan, James; Subray, Veena; Jayaram, Ramya; Rajugowda, Nagendra; Umamaheshwar Reddy, Kommuri; Kumaraguru, Duraimurugan; Mandal, Umasankar; Beldona, Dasthagiri; Adisechen, Ashok Kumar; Yadav, Navnath; Warrier, Jayakumar; Johnson, James A.; Sale, Harinath; Putlur, Siva Prasad; Saxena, Ajay; Chimalakonda, Anjaneya; Mandlekar, Sandhya; Conder, MaryLee; Xing, Dezhi; Gupta, Arun Kumar; Gupta, Anuradha; Rampulla, Richard; Mathur, Arvind; Levesque, Paul; Wexler, Ruth R.; Finlay, Heather J. published 《Selective IKur Inhibitors for the Potential Treatment of Atrial Fibrillation: Optimization of the Phenyl Quinazoline Series Leading to Clinical Candidate 5-[5-Phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl]pyridine-3-sulfonamide》.Journal of Medicinal Chemistry published the findings.Quality Control of 5-Bromo-2-chloropyridine The information in the text is summarized as follows:

We have recently disclosed 5-phenyl-N-(pyridin-2-ylmethyl)-2-(pyrimidin-5-yl)quinazolin-4-amine (I) as a potent IKur current blocker with selectivity vs. hERG, Na and Ca channels and an acceptable preclin. PK profile. On further characterization in vivo, Compound I demonstrated an unacceptable level of brain penetration. In an effort to reduce the level of brain penetration while maintaining the overall profile, SAR was developed at the C2′ position for a series of close analogs by employing hydrogen bond donors. As a result, 5-(5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl)pyridine-3-sulfonamide (II) was identified as the lead compound in this series. Compound II showed robust effects in rabbit and canine pharmacodynamic models and an acceptable cross-species pharmacokinetic profile and was advanced as the clin. candidate. Further optimization of II to mitigate pH dependent absorption resulted in identification of the corresponding phosphoramide prodrug (29) with an improved solubility and pharmacokinetic profile. In the part of experimental materials, we found many familiar compounds, such as 5-Bromo-2-chloropyridine(cas: 53939-30-3Quality Control of 5-Bromo-2-chloropyridine)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Quality Control of 5-Bromo-2-chloropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Robles, Andrew J.; McCowen, Shelby; Cai, Shengxin; Glassman, Michaels; Ruiz, Francisco; Cichewicz, Robert H.; McHardy, Stanton F.; Mooberry, Susan L. published 《Structure-Activity Relationships of New Natural Product-Based Diaryloxazoles with Selective Activity against Androgen Receptor-Positive Breast Cancer Cells》.Journal of Medicinal Chemistry published the findings.Safety of 2-Bromonicotinaldehyde The information in the text is summarized as follows:

Targeted therapies for ER+/PR+ and HER2-amplified breast cancers have improved patient survival, but there are no therapies for triple neg. breast cancers (TNBC) that lack expression of estrogen and progesterone receptors (ER/PR), or amplification or overexpression of HER2. Gene expression profiling of TNBC has identified mol. subtypes and representative cell lines. An extract of the Texas native plant Amyris texana was found to have selective activity against MDA-MB-453 cells, a model of the luminal androgen receptor (LAR) subtype of TNBC. Bioassay-guided fractionation identified two oxazole natural products with selective activity against this cell line. Conducted analog synthesis and structure-activity relationship studies provided analogs with more potent and selective activity against two LAR subtype cell line models, culminating in the discovery of compound I (CIDD-0067106). Lead compounds discovered have potent and selective antiproliferative activities, and mechanisms of action studies show they inhibit the activity of the mTORC1 pathway. The experimental process involved the reaction of 2-Bromonicotinaldehyde(cas: 128071-75-0Safety of 2-Bromonicotinaldehyde)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Safety of 2-Bromonicotinaldehyde

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem