Tag: 100-200

《Metal-Free, Redox-Neutral, Site-Selective Access to Heteroarylamine via Direct Radical-Radical Cross-Coupling Powered by Visible Light Photocatalysis》 was written by Zhou, Chao; Lei, Tao; Wei, Xiang-Zhu; Ye, Chen; Liu, Zan; Chen, Bin; Tung, Chen-Ho; Wu, Li-Zhu. Safety of 4-Cyanopyridine And the article was included in Journal of the American Chemical Society in 2020. The article conveys some information:

Transition-metal-catalyzed C-N bond-forming reactions have emerged as fundamental and powerful tools to construct arylamines, a common structure found in drug agents, natural products, and fine chems. Reported herein is an alternative access to heteroarylamine via radical-radical cross-coupling pathway, powered by visible light catalysis without any aid of external oxidant and reductant. Only by visible light irradiation of a photocatalyst, such as a metal-free photocatalyst, does the cascade single-electron transfer event for amines and heteroaryl nitriles occur, demonstrated by steady-state and transient spectroscopic studies, resulting in an amine radical cation and aryl radical anion in situ for C-N bond formation. The metal-free and redox economic nature, high efficiency, and site-selectivity of C-N cross-coupling of a range of available amines, hydroxylamines, and hydrazines with heteroaryl nitriles make this protocol promising in both academic and industrial settings. In the experiment, the researchers used many compounds, for example, 4-Cyanopyridine(cas: 100-48-1Safety of 4-Cyanopyridine)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Safety of 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Ditopic dithiocarbamate ligands for the production of trinuclear species》 was published in Arabian Journal of Chemistry in 2020. These research results belong to Marin-Carrillo, Edgar; Ruiz-Martinez, Adrian; Valdes, Hugo; Reyes-Martinez, Reyna; Hernandez-Ortega, Simon; Adriana Aguilar-Castillo, Bethsy; Morales-Morales, David. Application of 1539-42-0 The article mentions the following:

Reactions of group 10 transition metals with the ditopic ligand dipicolyldithiocarbamate (DPDTC) were performed. Thus, 1:2 reactions of [Ni(CH3COO)2], [Pd(COD)Cl2] or [Pt(COD)Cl2] with DPDTC produced monomeric complexes of the type [M(κ2-SCS-DPDTC)2, M = Ni (1), Pd (2) or Pt (3)] with the dithiocarbamate ligand (DTC) coordinated in a typical chelate κ2-SCS fashion. Interestingly, the reaction of [NiCl2] with DPDTC, under similar conditions, afforded the organic compound 2-(pyridin-2-ylmethyl)imidazo[1,5-a]pyri-dine-3(2 H)-thione (4) as unique product. In order to prove the ditopic nature of the ligand DPDTC, complex [Pd(κ2-SCS-DPDTC)2] (2) was further reacted with [ZnCl2] in a 1:2 M ratio to yield the trinuclear complex [Cl2Zn(κ2-NN-DPDTC-SCS-κ2)Pd(κ2-SCS-DPDTC-NN-κ2)ZnCl2] (5). The mol. structures of all compounds were determinate by typical anal. techniques including the unequivocal determination of all structures by single crystal x-ray diffraction anal. As expected, complexes 1-3 are isostructural, and the metal centers exhibiting slightly distorted square-planar geometries. While in 5, the trinuclear nature of the complex in confirmed exhibiting a nice combination of tetrahedral-square planar-tetrahedral geometries for the Zn-Pd-Zn centers resp. In the experiment, the researchers used many compounds, for example, Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Application of 1539-42-0)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Application of 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Efficient Phosphorus-Free Chlorination of Hydroxy Aza-Arenes and Their Application in One-Pot Pharmaceutical Synthesis》 was published in Organic Process Research & Development in 2020. These research results belong to Wang, Jian; Li, Yan-Hui; Pan, Song-Cheng; Li, Ming-Fang; Du, Wenting; Yin, Hong; Li, Jing-Hua. Name: 5-Bromo-2-chloropyridine The article mentions the following:

The chlorination of hydroxy aza-arenes with bis(trichloromethyl) carbonate (BTC) and SOCl2 has been effectively performed by refluxing with 5 weight % 4-(dimethylamino)pyridine (DMAP) as a catalyst. Various substrates are chlorinated with high yields. The obtained chlorinated aza-arenes can be used directly with simple workup for succedent one-pot synthesis on a large scale. In the experiment, the researchers used many compounds, for example, 5-Bromo-2-chloropyridine(cas: 53939-30-3Name: 5-Bromo-2-chloropyridine)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Name: 5-Bromo-2-chloropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Aryl-Diadamantyl Phosphine Ligands in Palladium-Catalyzed Cross-Coupling Reactions: Synthesis, Structural Analysis, and Application》 was published in European Journal of Organic Chemistry in 2020. These research results belong to Sinai, Adam; Simko, Daniel Cs.; Szabo, Fruzsina; Paczal, Attila; Gati, Tamas; Benyei, Attila; Novak, Zoltan; Kotschy, Andras. Computed Properties of C5H5BrN2 The article mentions the following:

Synthesis, temperature-dependent NMR structure study and use of a new, stable and easily accessible aryl-diadamantylphosphine ligand family is reported. The bulky and electron-rich phosphorus center of the ligand enhances the catalytic activity of palladium in cross-coupling reactions of sterically demanding ortho-substituted aryl halides. In the authors’ study, the authors demonstrated the synthetic applicability of the new phosphine ligands in Buchwald-Hartwig and tosyl hydrazone coupling reactions.6-Bromopyridin-3-amine(cas: 13534-97-9Computed Properties of C5H5BrN2) was used in this study.

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Computed Properties of C5H5BrN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Photoelectrochemical CO2 Reduction Using a Ru(II)-Re(I) Supramolecular Photocatalyst Connected to a Vinyl Polymer on a NiO Electrode》 were Kamata, Ryutaro; Kumagai, Hiromu; Yamazaki, Yasuomi; Sahara, Go; Ishitani, Osamu. And the article was published in ACS Applied Materials & Interfaces in 2019. SDS of cas: 1134-35-6 The author mentioned the following in the article:

A Ru(II)-Re(I) supramol. photocatalyst and a Ru(II) redox photosensitizer were both deposited successfully on a NiO electrode by using Me phosphonic acid anchoring groups and the electrochem. polymerization of the ligand vinyl groups of the complexes. This new mol. photocathode, poly-RuRe/NiO, adsorbed a larger amount of the metal complexes compared to one using only Me phosphonic acid anchor groups, and the stability of the complexes on the NiO electrode were much improved. The poly-RuRe/NiO acted as a photocathode for the photocatalytic reduction of CO2 at E = -0.7 V vs. Ag/AgCl under visible-light irradiation in an aqueous solution The poly-RuRe/NiO produced ∼2.5 times more CO, and its total faradaic efficiency of the reduction products improved from 57 to 85%. In the experiment, the researchers used many compounds, for example, 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6SDS of cas: 1134-35-6)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.SDS of cas: 1134-35-6 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《High in vitro and in vivo antitumor activities of Ln(III) complexes with mixed 5,7-dichloro-2-methyl-8-quinolinol and 4,4′-dimethyl-2,2′-bipyridyl chelating ligands》 were Meng, Ting; Qin, Qi-Pin; Chen, Zi-Lu; Zou, Hua-Hong; Wang, Kai; Liang, Fu-Pei. And the article was published in European Journal of Medicinal Chemistry in 2019. Recommanded Product: 4,4′-Dimethyl-2,2′-bipyridine The author mentioned the following in the article:

Three novel Ln(III) complexes, namely, [Pm(dmbpy)(ClQ)2NO3] (1), [Yb(dmbpy)(ClQ)2NO3] (2), and [Lu(dmbpy)(ClQ)2NO3] (3), with mixed 5,7-dichloro-2-methyl-8-quinolinol (H-ClQ) and 4,4′-dimethyl-2,2′-bipyridyl (dmbpy) chelating ligands were 1st synthesized. The cytotoxic activity of Ln(III) complexes 1-3, H-ClQ, and dmbpy against a panel of human normal and cancer cell lines, namely, human nonsmall cell lung cancer cells (NCI-H460), human cervical adenocarcinoma cancer cells, human ovarian cancer cells, and human normal hepatocyte cells, were evaluated by using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method. The three novel Ln(III) complexes showed a high in vitro antitumor activity toward the NCI-H460 with IC50 of 1.00 ± 0.25 nM for 1, 5.13 ± 0.44 μM for 2, and 11.87 ± 0.79 μM for 3, resp. Ln(III) complexes 1 and 2 exerted their in vitro antitumor activity/mechanism mainly via the mitochondrial death pathway and caused a G2/M phase arrest in the following order: 1 > 2. An NCI-H460 tumor xenograft mouse model was used to evaluate the Pm(III) complex 1 in vivo antitumor activity. Pm(III) complex 1 showed a high in vivo antitumor activity, and the tumor growth inhibition rate (IR) was 56.0% (p < 0.05). In summary, the authors' study on Pm(III) complex 1 revealed promising results in vitro and in vivo antitumor activity assays. In the experiment, the researchers used 4,4'-Dimethyl-2,2'-bipyridine(cas: 1134-35-6Recommanded Product: 4,4′-Dimethyl-2,2′-bipyridine)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.Recommanded Product: 4,4′-Dimethyl-2,2′-bipyridine Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Gas-phase structures of hemiporphyrazine and dicarbahemiporphyrazine: Key role of interactions inside coordination cavity》 were Otlyotov, Arseniy A.; Zhabanov, Yuriy A.; Pogonin, Alexander E.; Kuznetsova, Alexandra S.; Islyaikin, Mikhail K.; Girichev, Georgiy V.. And the article was published in Journal of Molecular Structure in 2019. HPLC of Formula: 141-86-6 The author mentioned the following in the article:

The structures of free hemiporphyrazine and dicarbahemiporphyrazine mols. were determined by gas-phase electron diffraction and DFT calculations Distance corrections (re – ra) were calculated using two different approaches: commonly applied Sipachev’s algorithm and a recently developed technique based on mol. dynamics simulations. Both approaches examined against each other for the first time in the refinement of a relatively large (52 atoms) structure were found to result in almost the same final structural parameters. Gas-phase structures of hemiporphyrazine and dicarbahemiporphyrazine are saddle distorted, in contrast to the planar structure previously found for the solid-state hemiporphyrazine. Doubly charged anionic form of hemiporphyrazine was calculated to be significantly saddle distorted, while the anion of dicarbahemiporphyrazine was determined to possess a planar equilibrium structure. Structural features of the mols. and their doubly charged anionic forms are discussed in terms of AIM and NBO analyses.2,6-Diaminopyridine(cas: 141-86-6HPLC of Formula: 141-86-6) was used in this study.

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.HPLC of Formula: 141-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Journal of Organometallic Chemistry included an article by Haque, Ashanul; Al Balushi, Rayya A.; Al-Busaidi, Idris Juma; Ilmi, Rashid; Al Rasbi, Nawal; Jayapal, Maharaja; Khan, Muhammad S.; Raithby, Paul R.. Safety of 4-Ethynylpyridine. The article was titled 《Synthesis, optical spectroscopy, structural, and DFT studies on dimeric iodo-bridged Copper(I) complexes》. The information in the text is summarized as follows:

Three new iodo-bridged Cu(I) complexes [CuI(PPh3)L]2, where L = ArC5H4N, Ar = Ph (C1), biphenyl (C2) and fluorenyl (C3) were synthesized via coordination-driven self-assembly processes. Two of the Cu(I) complexes, C2 and C3, were characterized by single-crystal x-ray diffraction studies. The complexes have two mols. of the P-donor ligand and two mols. of the N-donor ligand in trans configurations, supporting the central Cu2I2 unit. Absorption properties of the complexes were studied. Extensive DFT calculations were carried out to delineate the influence of the aromatic spacers on the optical properties and the nature of the excited states. The ease of synthesis of these Cu(I) dimers and the wide range of ethynylpyridine supporting ligands that can be incorporated highlight the potential for these materials to form polymers by linking through the ethynylpyridine ligands.4-Ethynylpyridine(cas: 2510-22-7Safety of 4-Ethynylpyridine) was used in this study.

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Safety of 4-Ethynylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Australian Journal of Chemistry included an article by Wegeberg, Christina; Nielsen, David; Mossin, Susanne; Abrahams, Brendan F.; McKee, Vickie; McKenzie, Christine J.. SDS of cas: 100-48-1. The article was titled 《Reversible and Vapochromic Chemisorption of Ammonia by a Copper(II) Coordination Polymer》. The information in the text is summarized as follows:

The single crystal x-ray structure determination of {[Cu(tpt)(o-phthalate)]·3 1/3(C2H2Cl4)}n (tpt = 2,4,6-tri-4-pyridyl-1,3,5-triazine, C2H2Cl4 = 1,1,2,2-tetrachloroethane = TCE) shows a 3-dimensional network in which Cu centers are linked by 3-connecting tpt ligands with the topol. of a 12,3 net. Cu centers are further linked by o-phthalate dianions. The copper coordination geometry is square pyramidal, with o-phthalate oxygen donors trans to each other in the basal plane and the remaining positions taken by the pyridines of three linking tpt units. The solvent accessible void space is ∼65%. The pale blue-green crystalline desolvate, obtained by heating to 200° or washing the TCE solvate with acetone is [Cu(tpt)(o-phthalate)]n. Powder x-ray diffraction and ESR spectroscopy show that the crystal structure and the Cu geometry changes upon desolvation. The crystalline desolvated phase sorbs two equivalent of ammonia per copper ion. The adduct, mauve [Cu(tpt)(o-phthalate)(NH3)2]n, shows reasonable crystallinity and is stable up to ∼150° under ambient conditions before the reversible desorption (min. 10 cycles) of the guest ammonia. The color change and high desorption temperature, along with changes in g values, is suggestive of chemisorption in two steps with Cu-ammine bonding in the loaded phase. In the experimental materials used by the author, we found 4-Cyanopyridine(cas: 100-48-1SDS of cas: 100-48-1)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. SDS of cas: 100-48-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Sensors and Actuators, B: Chemical included an article by Dugandzic, Vera; Kupfer, Stephan; Jahn, Martin; Henkel, Thomas; Weber, Karina; Cialla-May, Dana; Popp, Juergen. Related Products of 1539-42-0. The article was titled 《A SERS-based molecular sensor for selective detection and quantification of copper(II) ions》. The information in the text is summarized as follows:

A novel SERS-based mol. sensor for detection and quantification of copper(II) ions with very good specificity and selectivity is reported in this work. The sensing is enabled by the employment of a synthesized dipicolylamine-based ligand anchored onto plasmonic gold nanoparticles through the sulfur atom of the methylthio group. The interaction of the ligand with copper(II) ions is followed by changes in the spectral features associated with pyridine ring breathing, as indicated by quantum chem. calculations performed at the d. functional level of theory, which are proportional to the copper(II) concentration The detection of copper(II) was possible down to 5 × 10-8 M in water. The proposed mol. sensor was applied for the detection of copper(II) ions in white wine, with the ability to detect amounts of copper(II) in wine lower than the maximum recommended amount of 7.87 × 10-6 M (0.5μg/mL), indicating that the proposed mol. sensor is of potential interest as a routine test for the control of the copper(II) content in wine during wine production and in the final product. The experimental part of the paper was very detailed, including the reaction process of Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Related Products of 1539-42-0)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Related Products of 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem