Tag: 100-200

In 2019,Journal of the American Chemical Society included an article by Su, Lebin; Ren, Tianbing; Dong, Jianyu; Liu, Lixin; Xie, Shimin; Yuan, Lin; Zhou, Yongbo; Yin, Shuang-Feng. Electric Literature of C7H5N. The article was titled 《Cu(I)-Catalyzed 6-endo-dig Cyclization of Terminal Alkynes, 2-Bromoaryl Ketones, and Amides toward 1-Naphthylamines: Applications and Photophysical Properties》. The information in the text is summarized as follows:

Functional group substituted 1-naphthylamines, especially N-methylated ones, play important roles in numerous chem. and biol. processes. However, these compounds’ general and step-economic syntheses are highly limited, which seriously restricts efforts to improve the properties and develop new functions for this kind of compound In this report, we describe the development of an efficient, convenient, and general method for the synthesis of valuable functionalized 1-naphthylamines directly from readily available terminal alkynes, 2-bromoaryl ketones, and amides via Cu(I)-catalyzed benzannulation in a green solvent (i.e., water) under Pd- and ligand-free conditions. A total of 82 functionalized 1-naphthylamines, especially synthetically and biol. useful N-methylated compounds, are synthesized in isolated yields up to 95%. Some unique features of the reaction are as follows: (1) exclusive 6-endo-dig selectivity, (2) ready incorporation of a broad range of functional groups directly from easily available substrates, and (3) amides that can be used as aminating agents and that are excellent alternatives to toxic and/or odorous amines. Due to facile tuning of functional groups for the reaction, the products possess good electronic donor-acceptor structures and exhibit intriguing photophys. properties, such as tunable and polarity-sensitive fluorescence emission and large Stokes shifts (up to 258 nm). Utilizing the products’ unique polarity-sensitive fluorescence response, we successfully applied the 1-naphthylamine derivatives, such as compound 91, to image lipid droplets (LDs) and monitor cellular LDs growth. The previously mentioned advantages of this methodol., along with the mild conditions, simple operation, and scalable synthesis, may allow this novel reaction to be extended to varied applications in chem., biol., and materials science. The experimental part of the paper was very detailed, including the reaction process of 4-Ethynylpyridine(cas: 2510-22-7Electric Literature of C7H5N)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Electric Literature of C7H5N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Angewandte Chemie, International Edition included an article by Tu, Yujie; Liu, Junkai; Zhang, Haoke; Peng, Qian; Lam, Jacky W. Y.; Tang, Ben Zhong. SDS of cas: 1539-42-0. The article was titled 《Restriction of Access to the Dark State: A New Mechanistic Model for Heteroatom-Containing AIE Systems》. The information in the text is summarized as follows:

Restriction of intramol. motion (RIM), as the working mechanism of aggregation-induced emission (AIE), cannot fully explain some heteroatom-containing systems. Now, two excited states are taken into account and a mechanism, restriction of access to dark state (RADS), is specified to elaborate RIM and complete the picture of AIE mechanism. A nitrogen-containing mol. named APA is chosen as a model compound; its weak fluorescence in solution is ascribed to the easy access from the bright (π,π*) state to the close-lying dark (n,π*) state. By either metal complexation or aggregation, the dark state is less accessible due to restriction of the mol. motion leading to the dark state and elevation of the dark state energy, thus the bright state emission is restored. RADS is powerful in elucidating the AIE effect of mols. with excited states favoring non-radiative decay, including overlap-forbidden states such as (n,π*) and CT states, spin-forbidden triplet states, and so on. The experimental process involved the reaction of Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0SDS of cas: 1539-42-0)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. SDS of cas: 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Product Details of 3510-66-5In 2020 ,《Sulfur(IV)-Mediated Unsymmetrical Heterocycle Cross-Couplings》 was published in Angewandte Chemie, International Edition. The article was written by Zhou, Min; Tsien, Jet; Qin, Tian. The article contains the following contents:

Despite the tremendous utilities of metal-mediated cross-couplings in modern organic chem., coupling reactions involving nitrogenous heteroarenes remain a challenging undertaking – coordination of Lewis basic atoms into metal centers often necessitate elevated temperature, high catalyst loading, etc. Herein, the authors report a sulfur (IV) mediated cross-coupling amendable for the efficient synthesis of heteroaromatic substrates. Addition of heteroaryl nucleophiles to a simple, readily-accessible alkyl sulfinyl (IV) chloride gave a trigonal bipyramidal sulfurane intermediate. Reductive elimination therefrom provides bis-heteroaryl products in a practical and efficient fashion. The experimental process involved the reaction of 2-Bromo-5-methylpyridine(cas: 3510-66-5Product Details of 3510-66-5)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Product Details of 3510-66-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: 1539-42-0In 2021 ,《Going the dHis-tance: Site-Directed Cu2+ Labeling of Proteins and Nucleic Acids》 was published in Accounts of Chemical Research. The article was written by Gamble Jarvi, Austin; Bogetti, Xiaowei; Singewald, Kevin; Ghosh, Shreya; Saxena, Sunil. The article contains the following contents:

Conspectus: In this Account, we showcase site-directed Cu2+ labeling in proteins and DNA, which has opened new avenues for the measurement of the structure and dynamics of biomols. using ESR (EPR) spectroscopy. In proteins, the spin label is assembled in situ from natural amino acid residues and a metal complex and requires no post-expression synthetic modification or purification procedures. The labeling scheme exploits a double histidine (dHis) motif, which utilizes endogenous or site-specifically mutated histidine residues to coordinate a Cu2+ complex. Pulsed EPR measurements on such Cu2+-labeled proteins potentially yield distance distributions that are up to 5 times narrower than the common protein spin label-the approach, thus, overcomes the inherent limitation of the current technol., which relies on a spin label with a highly flexible side chain. This labeling scheme provides a straightforward method that elucidates biophys. information that is costly, complicated, or simply inaccessible by traditional EPR labels. Examples include the direct measurement of protein backbone dynamics at β-sheet sites, which are largely inaccessible through traditional spin labels, and rigid Cu2+-Cu2+ distance measurements that enable higher precision in the anal. of protein conformations, conformational changes, interactions with other biomols., and the relative orientations of two labeled protein subunits. Likewise, a Cu2+ label has been developed for use in DNA, which is small, is nucleotide independent, and is positioned within the DNA helix. The placement of the Cu2+ label directly reports on the biol. relevant backbone distance. Addnl., for both of these labeling techniques, we have developed models for interpretation of the EPR distance information, primarily utilizing mol. dynamics (MD) simulations. Initial results using force fields developed for both protein and DNA labels have agreed with exptl. results, which has been a major bottleneck for traditional spin labels. Looking ahead, we anticipate new combinations of MD and EPR to further our understanding of protein and DNA conformational changes, as well as working synergistically to investigate protein-DNA interactions. In addition to this study using Bis(pyridin-2-ylmethyl)amine, there are many other studies that have used Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Recommanded Product: 1539-42-0) was used in this study.

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Recommanded Product: 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

COA of Formula: C6H4BrNOIn 2018 ,《Synthetic Access to Functionalized Dipolarophiles of Lewis Basic Complexant Scaffolds through Sonogashira Cross-Coupling》 was published in Journal of Organic Chemistry. The article was written by Chaudhuri, Sauradip; Carrick, Jesse D.. The article contains the following contents:

Soft Lewis basic complexants that facilitate selective removal of discrete ions resident in spent nuclear fuel can decrease repository volume and radiotoxicity and are of significant interest. Optimization of chelation efficacy is predicated on modular access to synthons to rapidly evaluate structure-activity relationships. The following work highlights efficient access to functionalized synthons for use as potential dipolarophiles in subsequent cycloaddition processes via Sonogashira coupling of 3-(6-bromo-pyridin-2-yl)-[1,2,4]triazine scaffolds. The 41 examples explored during method development evaluated electrophile and nucleophile diversity affording the desired coupled products in 31-96% isolated yield. Method optimization, substrate scope, a scale-up reaction, and downstream product functionalization are reported herein. After reading the article, we found that the author used 2-Bromonicotinaldehyde(cas: 128071-75-0COA of Formula: C6H4BrNO)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. COA of Formula: C6H4BrNO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 141-86-6In 2019 ,《A new ratiometric, colorimetric and ”turn-on” fluorescent chemosensor for the detection of cyanide ions based on a phenol-bisthiazolopyridine hybrid》 appeared in New Journal of Chemistry. The author of the article were Assadollahnejad, Nazafarin; Kargar, Maryam; Darabi, Hossein Reza; Abouali, Negar; Jamshidi, Shadi; Sharifi, Ali; Aghapoor, Kioumars; Sayahi, Hani. The article conveys some information:

A novel C2-sym. ratiometric fluorescence and colorimetric cyanide (CN-) sensor 1 (I) based on a phenol-bisthiazolopyridine hybrid was synthesized and characterized. Among the various screened anions, this chromogenic receptor 1 showed only a distinct visible color change from colorless to yellow and blue to green fluorescence toward CN- in both pure methanol and aqueous methanol. The ”turn-on” ratiometric fluorescence (emission shift = 95 nm) and colorimetric (absorbance shift = 45 nm) detection of CN- can be attributed to the deprotonation of the OH groups of 1, as evidenced by OH- and 1H NMR experiments The binding mode of 1 with CN- was determined to be a 1 : 1 stoichiometry through a Job plot. Probe 1 was also highly sensitive (LOD = 75 nM) as measured by ratiometric fluorescence (I420/I515 nm) methods. Moreover, the reversibility of the deprotonated 1 by HCl in both solution and the solid state (TLC paper test strips) was successful. In general, probe 1 is a promising CN- indicator in terms of its ease-of-use, selectivity, sensitivity, rapid response (<1 s), reversibility and test kit application. In the experiment, the researchers used many compounds, for example, 2,6-Diaminopyridine(cas: 141-86-6Related Products of 141-86-6)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Related Products of 141-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: 2-BromonicotinaldehydeIn 2018 ,《Synthesis of Pyrimidine Fused Quinolines by Ligand-Free Copper-Catalyzed Domino Reactions》 appeared in Journal of Organic Chemistry. The author of the article were Panday, Anoop Kumar; Mishra, Richa; Jana, Asim; Parvin, Tasneem; Choudhury, Lokman H.. The article conveys some information:

Herein we report two novel methods for the synthesis of pyrimidine fused quinolines using one-pot C-C and C-N bond forming strategy from the reaction of 6-amino uracils with 2-bromo benzaldehydes or 2-bromobenzyl bromide derivatives in the presence of 10-mol% CuCl2 without using any ligand. The reaction of 2-bromobenzaldehyde or its derivatives with 6-amino-uracils in the presence K2CO3 as base and catalytic amount of CuCl2 in DMF medium under microwave heating conditions provide corresponding pyrimidine-fused quinoline derivatives in good yields within 30 min. Alternatively, pyrimidine fused quinoline derivatives have been synthesized from the reaction of 2-bromobenzyl bromides with 6-amino-uracil derivatives in the presence of mol. oxygen, CuCl2 (10-mol%) and K2CO3 as base in DMF under reflux conditions. Structures of all the products were unambiguously confirmed by spectroscopic techniques and by recording single crystal XRD of I. In addition to this study using 2-Bromonicotinaldehyde, there are many other studies that have used 2-Bromonicotinaldehyde(cas: 128071-75-0Recommanded Product: 2-Bromonicotinaldehyde) was used in this study.

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Recommanded Product: 2-Bromonicotinaldehyde

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

COA of Formula: C5H3BrClNIn 2015 ,《Iridium-Catalyzed Asymmetric Hydrogenation of 2-Pyridyl Cyclic Imines: A Highly Enantioselective Approach to Nicotine Derivatives》 appeared in Journal of the American Chemical Society. The author of the article were Guo, Cui; Sun, Dong-Wei; Yang, Shuang; Mao, Shen-Jie; Xu, Xiao-Hua; Zhu, Shou-Fei; Zhou, Qi-Lin. The article conveys some information:

A highly efficient asym. hydrogenation of cyclic imines containing a pyridyl moiety was established by using iridium catalysts with chiral spiro phosphine-oxazoline ligands. This process will facilitate the development of new nicotine-related pharmaceuticals I [R = 6-F, 6-Cl, 6-Me, etc; n = 1, 2, 3]. The introduction of a substituent at the ortho position of the pyridyl ring to reduce its coordinating ability ensures the success of the hydrogenation and excellent enantioselectivity. After reading the article, we found that the author used 5-Bromo-2-chloropyridine(cas: 53939-30-3COA of Formula: C5H3BrClN)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. COA of Formula: C5H3BrClN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Yang, Dongxu; Chen, Xiangyi; He, Dongsheng; Frommhold, Andreas; Shi, Xiaoqing; Boden, Stuart A.; Lebedeva, Maria A.; Ershova, Olga V.; Palmer, Richard E.; Li, Ziyou; Shi, Haofei; Gao, Jianzhi; Pan, Minghu; Khlobystov, Andrei N.; Chamberlain, Thomas W.; Robinson, Alex P. G. published an article in Journal of Physical Chemistry Letters. The title of the article was 《A Fullerene-Platinum Complex for Direct Functional Patterning of Single Metal Atom-Embedded Carbon Nanostructures》.Name: 4,4′-Dimethyl-2,2′-bipyridine The author mentioned the following in the article:

The development of patterning materials (“”resists””) at the nanoscale involves two distinct trends-one is toward high sensitivity and resolution for miniaturization, the other aims at functionalization of the resists to realize bottom-up construction of distinct nanoarchitectures. Patterning of carbon nanostructures, a seemingly ideal application for organic functional resists, has been highly reliant on complicated pattern transfer processes due to a lack of patternable precursors. Here we present a fullerene-metal coordination complex as a fabrication material for direct functional patterning of sub-10 nm metal-containing carbon structures. The attachment of one platinum atom per fullerene mol. not only leads to significant improvement of sensitivity and resolution, but also enables stable at. dispersion of the platinum ions within the carbon matrix, which may gain fundamentally new interest in functional patterning of hierarchical carbon nanostructures. In the part of experimental materials, we found many familiar compounds, such as 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Name: 4,4′-Dimethyl-2,2′-bipyridine)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.Name: 4,4′-Dimethyl-2,2′-bipyridine Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhang, Lei; Pfund, Bjorn; Wenger, Oliver S.; Hu, Xile published an article in 2022. The article was titled 《Oxidase-Type C-H/C-H Coupling Using an Isoquinoline-Derived Organic Photocatalyst》, and you may find the article in Angewandte Chemie, International Edition.Name: 4-Cyanopyridine The information in the text is summarized as follows:

Herein, an isoquinoline-derived diaryl ketone-type photocatalyst I, which has much enhanced absorption of blue and visible light compared to conventional diaryl ketones was reported. This photocatalyst enables dehydrogenative cross-coupling of heteroarenes e.g., II with inactivated and activated alkanes viz. cyclohexane, THF, adamantane, etc. as well as aldehydes viz. propanal, pentanal, 3-methylbutanal, cyclopropanecarbaldehyde, cyclopentanecarbaldehyde using air as the oxidant. A wide range of heterocycles with various functional groups are suitable substrates. Transient absorption and excited-state quenching experiments point to an unconventional mechanism that involves an excited state ”self-quenching” process to generate the N-radical cation form of the sensitizer, which subsequently abstracts a hydrogen atom from the alkane substrate to yield a reactive alkyl radical. After reading the article, we found that the author used 4-Cyanopyridine(cas: 100-48-1Name: 4-Cyanopyridine)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Name: 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem