Tag: 100-200

Recommanded Product: 141-86-6In 2020 ,《Supramolecular triblock copolymers through the formation of hydrogen bonds: synthesis, characterization, association effects in solvents of different polarity》 was published in Polymers (Basel, Switzerland). The article was written by Bitsi, Spyridoula-Lida; Droulia, Margarita; Pitsikalis, Marinos. The article contains the following contents:

Anionic polymerization techniques were employed for the synthesis of linear polystyrene (PS) and block copolymer of PS and polyisoprene (PI) PS-b-PI bearing end hydroxyl groups. Following suitable organic chem. transformation, the -OH end groups were converted to moieties able to form complementary hydrogen bonds including 2,6-diaminopurine (Dap), thymine (Thy), and the so-called Hamilton receptor, (Ham). The formation of hydrogen bonds was examined between the polymers PS-Dap and PS-b-PI-Thy, along with the polymers PS-Ham and PS-b-PI-Thy. The conditions under which supramol. triblock copolymers are formed and the possibility to form aggregates were examined both in solution and in the solid state using a variety of techniques such as 1H-NMR spectroscopy, size exclusion chromatog., dilute solution viscometry, dynamic light scattering, thermogravimetric anal., differential thermogravimetry, and differential scanning calorimetry. In addition to this study using 2,6-Diaminopyridine, there are many other studies that have used 2,6-Diaminopyridine(cas: 141-86-6Recommanded Product: 141-86-6) was used in this study.

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Recommanded Product: 141-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Name: Pyridin-3-ylboronic acidIn 2019 ,《A Mild and Direct Site-Selective sp2 C-H Silylation of (Poly)Azines》 was published in Journal of the American Chemical Society. The article was written by Gu, Yiting; Shen, Yangyang; Zarate, Cayetana; Martin, Ruben. The article contains the following contents:

A base-mediated protocol that allows for the site-selective sp2 C-H silylation of pyridines, pyrazines, pyridazines, pyrimidines and quinolines by Et3SiBpin is described. The substitution typically proceeds in 4- or 2-position of the pyridine ring. This method is distinguished by its mild conditions, simplicity and excellent site-selective modulation for a diverse set of azines, even in the context of late-stage functionalization, while exhibiting orthogonal reactivity with classical silylation reactions.Pyridin-3-ylboronic acid(cas: 1692-25-7Name: Pyridin-3-ylboronic acid) was used in this study.

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Name: Pyridin-3-ylboronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Computed Properties of C7H9NOIn 2019 ,《A biocatalytic synthesis of heteroaromatic N-oxides by whole cells of Escherichia coli expressing the multicomponent, soluble di-iron monooxygenase (SDIMO) PmlABCDEF》 was published in Advanced Synthesis & Catalysis. The article was written by Petkevicius, Vytautas; Vaitekunas, Justas; Tauraite, Daiva; Stankeviciute, Jonita; Sarlauskas, Jonas; Cenas, Narimantas; Meskys, Rolandas. The article contains the following contents:

Aromatic N-oxides (ArN-OX) are desirable biol. active compounds with a potential for application in pharmacy and agriculture industries. As biocatalysis is making a great impact in organic synthesis, there is still a lack of efficient and convenient enzyme-based techniques for the production of aromatic N-oxides. In this study, a recombinant soluble di-iron monooxygenase (SDIMO) PmlABCDEF overexpressed in Escherichia coli was showed to produce various aromatic N-oxides. Out of 98 tested N-heterocycles, seventy were converted to the corresponding N-oxides without any side oxidation products. This whole-cell biocatalyst showed a high activity towards pyridines, pyrazines, and pyrimidines. It was also capable of oxidizing bulky N-heterocycles with two or even three aromatic rings. Being entirely biocatalytic, our approach provides an environmentally friendly and mild method for the production of aromatic N-oxides avoiding the use of strong oxidants, organometallic catalysts, undesirable solvents, or other environment unfriendly reagents. The sequence of the p577A clone containing pmlABCDEF gene cluster was deposited in GenBank under the accession number MK037457. In the part of experimental materials, we found many familiar compounds, such as 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Computed Properties of C7H9NO)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Computed Properties of C7H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Category: pyridine-derivativesIn 2021 ,《Nickel-Copper bimetallic mesoporous nanoparticles: As an efficient heterogeneous catalyst for N-alkylation of amines with alcohols》 was published in Applied Organometallic Chemistry. The article was written by Nasresfahani, Zahra; Kassaee, Mohamad Z.. The article contains the following contents:

A bimetallic catalyst (Ni/Cu-MCM-41) is prepared via co-condensation method. Catalytic performance of Ni/Cu-MCM-41 is probed in N-alkylation of amines with alcs. through a hydrogen autotransfer process. Noteworthy, this catalytic system appears very efficient for synthesis of a range of secondary and tertiary amines in good to excellent isolated yields. Moreover, the catalyst is successfully recovered and reused four times without notable decrease in its activity. In the part of experimental materials, we found many familiar compounds, such as 2,6-Diaminopyridine(cas: 141-86-6Category: pyridine-derivatives)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application In Synthesis of 4,4′-Dimethyl-2,2′-bipyridineIn 2022 ,《Syntheses, characterizations and structures of ruthenium carbene and allenylidene complexes supported by 1,4,7-trimethyl-1,4,7-triazacyclononane (Me3tacn) ligands》 was published in Journal of Organometallic Chemistry. The article was written by Qian, Bing-Feng; Gao, Yang; Xu, Qian-Ya; Jia, Ai-Quan; Shi, Hua-Tian; Zhang, Qian-Feng. The article contains the following contents:

Treatment of ruthenium(II) precursor [(Me3tacn)Ru(dmso)Cl2] (Me3tacn = 1,4,7-trimethyl-1,4,7-triazacyclononane, dmso = dimethylsulfoxide) (1) with concentrated HCl in the presence of air afforded the ruthenium(III) complex [(Me3tacn)RuCl3·H2O] (2), from which a series of bipyridine-ruthenium(II) complexes [(Me3tacn)Ru(R-bpy)(H2O)](PF6)2 (bpy = 2,2′-bipyridine) was obtained according to our previous work. Reactions of [(Me3tacn)Ru(R-bpy)(H2O)](PF6)2 and 1,1-diphenylpropargyl alc. afforded ruthenium(II) methoxycarbene complexes [(Me3tacn)(R-bpy)Ru:C(OMe)CH:CPh2](PF6)2 (3, 5, 7, 9; R = H, 4,4′-Me2, 5,5′-Me2, 4,4′-tBu2) and ruthenium(II) allenylidene complexes [(Me3tacn)(R-bpy)Ru:C:C:CPh2](PF6)2 (4, 6, 8, 10; R = H, 4,4′-Me2, 5,5′-Me2, 4,4′-tBu2) under different solvent conditions. Complexes 3-10 were well characterized by IR, UV/Vis, mass spectrometry, and NMR spectroscopies. The mol. structures of complexes 5, 7, and 8 have been also established by single-crystal X-ray diffraction. In the experimental materials used by the author, we found 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Application In Synthesis of 4,4′-Dimethyl-2,2′-bipyridine)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.Application In Synthesis of 4,4′-Dimethyl-2,2′-bipyridine Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 2-Pyridinylboronic acidIn 2020 ,《Green-Synthesized Nickel Nanoparticles on Reduced Graphene Oxide as an Active and Selective Catalyst for Suzuki and Glaser-Hay Coupling Reactions》 appeared in Applied Organometallic Chemistry. The author of the article were Murugan, Karthik; Nainamalai, Devarajan; Kanagaraj, Pavithara; Nagappan, Saravana Ganesan; Palaniswamy, Suresh. The article conveys some information:

The present work disclosed the potential catalytic application of the as-prepared RGO-Ni nanocomposite in Csp2-Csp2 Suzuki type homocoupling and Csp-Csp Glaser-Hay coupling reactions. A mild and benign methodol. to synthesize biaryls Ar-Ar [Ar = Ph, 3-MeOC6H4, 2-pyridyl, etc.] and 1,3-diynes R-CC-CC-R [R = t-Bu, 3-FC6H4, 4-EtC6H4, etc.] was demonstrated using the nickel nanoparticles supported on reduced graphene oxide (RGO-Ni) as a heterogeneous catalyst which was prepared using green reagents. A series of substituted biaryls Ar-Ar and 1,3-diynes R-CC-CC-R was synthesized in good to excellent yields via reduced graphene oxide supported nickel nanoparticles catalyzed Suzuki coupling of arylboronic acids and Glaser-Hay coupling of terminal alkynes resp. using 1,4-dioxane as a benign solvent. The present ligand-free catalytic system proceeded smoothly under mild conditions, avoided noble and stoichiometric metal reagents and tolerated sensitive functional groups such as nitrogen and sulfur containing heteroaryl boronic acids. Hot filtration test unambiguously proved the true heterogeneity of the catalyst and which supported for the further reusability of the catalyst for several times without any change in the activity. The easy preparation and simple magnetic separation, stability and reusability revealed that as-prepared RGO-Ni as a versatile catalyst for the synthesis of polyaromatic compounds both in academia and industries. The results came from multiple reactions, including the reaction of 2-Pyridinylboronic acid(cas: 197958-29-5Reference of 2-Pyridinylboronic acid)

2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Reference of 2-Pyridinylboronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Safety of 4-CyanopyridineIn 2019 ,《Reactivity of Selected Mono- and Dimethylpyridines under Conditions of Oxidative Ammonolysis》 appeared in Russian Journal of General Chemistry. The author of the article were Vorobyev, P. B.; Serebryanskaya, A. P.. The article conveys some information:

The reactivity of 3-methyl-, 4-methyl-, 2,3-dimethyl-, and 3,4-dimethylpyridines under the oxidative ammonolysis on vanadium oxide catalysts has been studied. The yield of monocyanopyridines has been related to the simulated values of the deprotonation enthalpy of Me substituents being converted into the cyano group, both in the gas phase and under conditions simulating chemisorption at the acid center of the catalyst. Differences in the mechanism of conversion of the primary products of oxidative ammonolysis of 2,3- and 3,4-dimethylpyridines (2-cyano-3-methyl- and 4-cyano-3-methylpyridines) at elevated temperature have been revealed. In addition to this study using 4-Cyanopyridine, there are many other studies that have used 4-Cyanopyridine(cas: 100-48-1Safety of 4-Cyanopyridine) was used in this study.

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Safety of 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 3510-66-5In 2021 ,《Cobalt(III)-Catalyzed C-6 Alkenylation of 2-Pyridones by Using Terminal Alkyne with High Regioselectivity》 appeared in Journal of Organic Chemistry. The author of the article were Mohanty, Smruti Ranjan; Prusty, Namrata; Gupta, Lokesh; Biswal, Pragati; Ravikumar, Ponneri Chandrababu. The article conveys some information:

Co(III)-catalyzed alkenylation of 2-pyridones by using terminal alkyne as a reaction partner with high regioselectivity has been demonstrated for the first time. The reaction conditions are mild and compatible with a wide range of substrate combinations. It also shows good functional group tolerance. It proceeds through cyclometalation followed by alkyne insertion and protodemetalation steps. The formation of five- and seven-membered cobaltacycle intermediates was also detected through high-resolution mass spectrometry. The results came from multiple reactions, including the reaction of 2-Bromo-5-methylpyridine(cas: 3510-66-5Application of 3510-66-5)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Application of 3510-66-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

HPLC of Formula: 1122-54-9In 2022 ,《Synthesis, biological activities of chalcones and novel 4-acetylpyridine oximes, molecular docking of the synthesized products as acetylcholinesterase ligands》 appeared in Journal of Molecular Structure. The author of the article were Ould Lamara, Kamilia; Makhloufi-Chebli, Malika; Benazzouz-Touami, Amina; Terrachet-Bouaziz, Souhila; Robert, Anthony; Machado-Rodrigues, Carine; Behr, Jean-Bernard. The article conveys some information:

Heterocyclic chalcones I [X = O; R = C6H5, 4-MeOC6H4, 2-thienyl, etc.] were synthesized by reaction of 4-acetylpyridine with the corresponding aromatic aldehydes under Claisen Schmidt conditions. These chalcones I were used as starting material for the synthesis of oximes I [X = HON; R = 4-MeOC6H4, 4-ClC6H4, 2-thienyl, etc.] and II in the presence of hydroxylamine hydrochloride. The structures of the synthesized compounds I and II were confirmed by IR, 1H NMR, 13C NMR and ESI-MS, HRMS spectral analyses. All the synthesized compounds I and II were evaluated for their antioxidant activity by DPPH• method and their in-vitro antimicrobial activity by disk diffusion method against two Gram-neg. bacteria, one Gram-pos. bacteria and two fungal strains (C. albicans and A. niger). The results showed that the synthesized compounds I and II did not display significant antioxidant activity. However, I [X = O; R = 3-thienyl, C6H5, 4-O2NC6H4, 4-ClC6H4, 2,6-di-ClC6H3] showed excellent antibacterial activity better than the standard drug against the bacterial strain S. aureus (ATCC 25923). The two compounds I [X = O; R = (E)-styryl, C6H5] proved very active against the fungal strain A. niger (MIC= 7.81μg/ mL, 15.62μg/mL resp.) while the antifungal drug used as reference (Fluconazole) was inactive. Mol. docking and mol. dynamics results revealed that the synthesized compounds, I [X = HON; R = 4-MeOC6H4, (E)-styryl] and II were involved in a large number of favorable interactions with the active site residues of the acetylcholinesterase protein, which can stabilize the ligands in the active site and increase their affinities. In addition to this study using 4-Acetylpyridine, there are many other studies that have used 4-Acetylpyridine(cas: 1122-54-9HPLC of Formula: 1122-54-9) was used in this study.

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.HPLC of Formula: 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application In Synthesis of Bis(pyridin-2-ylmethyl)amineIn 2019 ,《High in vitro and in vivo antitumor activities of luminecent platinum(II) complexes with jatrorrhizine derivatives》 appeared in European Journal of Medicinal Chemistry. The author of the article were Qin, Qi-Pin; Zou, Bi-Qun; Wang, Zhen-Feng; Huang, Xiao-Ling; Zhang, Ye; Tan, Ming-Xiong; Wang, Shu-Long; Liang, Hong. The article conveys some information:

Two highly active anticancer Pt(II) complexes, [Pt(Jat1)Cl]Cl (Pt1) and [Pt(Jat2)Cl]Cl (Pt2), containing jatrorrhizine derivative ligands (Jat1 and Jat2) are described. Cell intake study showed high accumulation in cell nuclear fraction. Pt1 and Pt2 exhibited high selectivity for HeLa cancer cells (IC50 = 15.01 ± 1.05 nM and 1.00 ± 0.17 nM) comparing with HL-7702 normal cells (IC50 > 150μM), by targeting p53 and telomerase. Pt2 containing Jat2 ligand was more potent and showed high selectivity for telomerase. It also caused mitochondria and DNA damage, sub-G1 phase arrest, and a high rate of cell apoptosis at the low dose of 1.00 nM. The HeLa tumor inhibition rate (TIR) of Pt2 was 48.8%, which was even higher than cisplatin (35.2%). In addition, Pt2 displayed green luminescent property and potent telomerase inhibition. Our findings demonstrated the promising development of platinum(II) complexes containing jatrorrhizine derivatives as novel Pt-based anticancer agents. The results came from multiple reactions, including the reaction of Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Application In Synthesis of Bis(pyridin-2-ylmethyl)amine)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Application In Synthesis of Bis(pyridin-2-ylmethyl)amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem