Tag: 100-200

SDS of cas: 13534-97-9In 2020 ,《Discovery of CPI-1612: A Potent, Selective, and Orally Bioavailable EP300/CBP Histone Acetyltransferase Inhibitor》 appeared in ACS Medicinal Chemistry Letters. The author of the article were Wilson, Jonathan E.; Patel, Gaurav; Patel, Chirag; Brucelle, Francois; Huhn, Annissa; Gardberg, Anna S.; Poy, Florence; Cantone, Nico; Bommi-Reddy, Archana; Sims, Robert J.; Cummings, Richard T.; Levell, Julian R.. The article conveys some information:

The histone acetyltransferases, CREB binding protein (CBP) and EP300, are master transcriptional co-regulators that have been implicated in numerous diseases, such as cancer, inflammatory disorders, and neurodegeneration. A novel, highly potent, orally bioavailable EP300/CBP histone acetyltransferase (HAT) inhibitor, CPI-1612 or 17, was developed from the lead compound 3. Replacement of the indole scaffold of 3 with the aminopyridine scaffold of 17 led to improvements in potency, solubility, and bioavailability. These characteristics resulted in a 20-fold lower efficacious dose for 17 relative to lead 3 in a JEKO-1 tumor mouse xenograft study. The experimental process involved the reaction of 6-Bromopyridin-3-amine(cas: 13534-97-9SDS of cas: 13534-97-9)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.SDS of cas: 13534-97-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: 2-(2-Hydroxyethyl)pyridineIn 2018 ,《Coordination Chemistry of N-(2-Pyridylethyl)-Substituted Bulky Amidinates and Triazenides of Magnesium》 appeared in European Journal of Inorganic Chemistry. The author of the article were Kalden, Diana; Krieck, Sven; Goerls, Helmar; Westerhausen, Matthias. The article conveys some information:

The amidines Dipp-N:C(R)-NH(C2H4R’) [R = tBu, R’ = Ph (1a); R = Ph, R’ = Py (1b)] as well as 1-(2,4,6-triisopropylphenyl)-3-(2-pyridylethyl)triazene (1c) are magnesiated with com. available dibutylmagnesium yielding the complexes [(THF)Mg{Dipp-N:C(tBu)-N(C2H4Ph)}2] (3a), [Mg{Dipp-N:C(Ph)-N(C2H4Py)}2] (3b), and [Mg{Tripp-N:N-N(C2H4Py)}2] (3c). Handling and isolation of triazene 1c has been performed at room temperature or below to avoid elimination of dinitrogen and formation of 2-pyridylethyl-(2,4,6-triisopropylphenyl)amine (2). In the solid state, the compounds 1b and 1c form dimers via intermol. hydrogen bridges to the pyridyl groups of neighboring mols. The results came from multiple reactions, including the reaction of 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Recommanded Product: 2-(2-Hydroxyethyl)pyridine)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Recommanded Product: 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 100-48-1In 2021 ,《Mechanochemical Release of Non-Covalently Bound Guests from a Polymer-Decorated Supramolecular Cage》 appeared in Angewandte Chemie, International Edition. The author of the article were Kueng, Robin; Pausch, Tobias; Rasch, Dustin; Goestl, Robert; Schmidt, Bernd M.. The article conveys some information:

Supramol. coordination cages show a wide range of useful properties including, but not limited to, complex mol. machine-like operations, confined space catalysis, and rich host-guest chemistries. Here we report the uptake and release of non-covalently encapsulated, pharmaceutically-active cargo from an octahedral Pd cage bearing polymer chains on each vertex. Six poly(ethylene glycol)-decorated bipyridine ligands are used to assemble an octahedral PdII6(TPT)4 cage. The supramol. container encapsulates progesterone and ibuprofen within its hydrophobic nanocavity and is activated by shear force produced by ultrasonication in aqueous solution entailing complete cargo release upon rupture, as shown by NMR and GPC analyses. In the experiment, the researchers used many compounds, for example, 4-Cyanopyridine(cas: 100-48-1Related Products of 100-48-1)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Related Products of 100-48-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Wu, Terence; Tatton, Matthew R.; Greaney, Michael F. published an article in Angewandte Chemie, International Edition. The title of the article was 《NHC Catalysis for Umpolung Pyridinium Alkylation via Deoxy-Breslow Intermediates》.Safety of Pyridin-3-ylboronic acid The author mentioned the following in the article:

Umpolung N-heterocyclic carbene (NHC) catalysis of non-aldehyde substrates offers new pathways for CC bond formation, but has proven challenging to develop in terms of viable substrate classes. Here, the authors demonstrate that pyridinium ions can undergo NHC addition and subsequent intramol. C-C bond formation through a deoxy-Breslow intermediate. The alkylation demonstrates, for the first time, that deoxy-Breslow intermediates are viable for catalytic umpolung of areniums. In the part of experimental materials, we found many familiar compounds, such as Pyridin-3-ylboronic acid(cas: 1692-25-7Safety of Pyridin-3-ylboronic acid)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Safety of Pyridin-3-ylboronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Akishina, E. A.; Dikusar, E. A.; Stepin, S. G.; Alekseyev, R. S.; Bumagin, N. A.; Potkin, V. I. published an article in 2022. The article was titled 《Synthesis of 4-Acetyl- and 4-Benzoylpyridine Derivatives with 1,2-Azole Fragments》, and you may find the article in Russian Journal of General Chemistry.Safety of 4-Acetylpyridine The information in the text is summarized as follows:

A method for the synthesis of 5-arylisoxazole- and 4,5-dichloroisothiazole-3-carboxylic acids derivatives I (R1 = H, Me, Ph; R2 = H, Cl; R3 = Cl, Ph, 4-methylphenyl, 4-nitrophenyl; X = S, O) based on 4-acetyl- and 4-benzoylpyridine has been developed. Esters I and amides II were prepared by acylation of (pyridin-4-yl)methanols III (R4 = OH) and (pyridin-4-yl)methanamines III (R4 = NH2) with acid chlorides of substituted 1,2-azole-3-carboxylic acids IV in ether or methylene chloride in the presence of triethylamine. Quaternary ammonium salts V of synthesized pyridine derivatives were also obtained. In the experiment, the researchers used many compounds, for example, 4-Acetylpyridine(cas: 1122-54-9Safety of 4-Acetylpyridine)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Safety of 4-Acetylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Guo, Zhewen; Li, Guangfeng; Wang, Heng; Zhao, Jun; Liu, Yuhang; Tan, Hongwei; Li, Xiaopeng; Stang, Peter J.; Yan, Xuzhou published an article in 2021. The article was titled 《Drum-like Metallacages with Size-Dependent Fluorescence: Exploring the Photophysics of Tetraphenylethylene under Locked Conformations》, and you may find the article in Journal of the American Chemical Society.Electric Literature of C5H6BNO2 The information in the text is summarized as follows:

Materials with aggregation-induced emission (AIE) properties are of growing interest due to their widespread applications. AIEgens, such as tetraphenylethylene units, display varying emission behaviors during their conformational changes. However, the structure-property relationships of the intermediate conformations have rarely been explored. Herein, the authors show that the conformational restriction on TPE units can affect the structural relaxation in the excited state and the resulting photophys. behaviors. Specifically, three metallacages of different sizes were prepared via the coordination-driven self-assembly of a TPE-based tetrapyridyl donor with length-increasing Pt(II) acceptors. While the metallacages share similar scaffolds, they exhibit a trend of red-shifted fluorescence and attenuated quantum yield with the increase of their sizes. Furthermore, spectroscopic and computational studies together with a control experiment were conducted, revealing that the degree of cage tension imposed on the excited-state conformational relaxation of TPE moieties resulted in their distinct photophys. properties. The precise control of conformation holds promise as a strategy for understanding the AIE mechanism as well as optimizing the photophys. behaviors of materials on the platform of supramol. coordination complexes. After reading the article, we found that the author used Pyridin-3-ylboronic acid(cas: 1692-25-7Electric Literature of C5H6BNO2)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Electric Literature of C5H6BNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Fang, Zhen; Liu, Yang; Zhang, Rong; Chen, Qiang; Wang, Tianqi; Yang, Wei; Fan, Yan; Yu, Chundong; Xiang, Rong; Yang, Shengyong published an article in 2021. The article was titled 《Discovery of a potent and selective inhibitor of histone lysine demethylase KDM4D》, and you may find the article in European Journal of Medicinal Chemistry.Reference of 2-Pyridinylboronic acid The information in the text is summarized as follows:

Histone lysine demethylase 4D (KDM4D) plays an important role in the regulation of tumorigenesis, progression and drug resistance and has been considered a potential target for cancer treatment. However, there is still a lack of potent and selective KDM4D inhibitors. In this investigation, we report a new class of KDM4D inhibitors containing the 2-(aryl(pyrrolidine-1-yl)methyl)phenol scaffold, identified through AlphaLisa-based screening, structural optimization, and structure-activity relationship analyses. Among these inhibitors, 24s (I) was the most potent, with an IC50 value of 0.023 ± 0.004μM. This compound exhibited more than 1500-fold selectivity towards KDM4D vs. KDM4A as well as other JMJD subfamily members, indicating good selectivity for KDM4D. Kinetic anal. indicated that 24s did not occupy the 2-oxoglutarate binding pocket. In an in vitro assay, 24s significantly suppressed the proliferation and migration of colorectal cancer (CRC) cells. Overall, this study has identified a good tool compound to explore the biol. function of KDM4D and a good lead compound for drug discovery targeting KDM4D. After reading the article, we found that the author used 2-Pyridinylboronic acid(cas: 197958-29-5Reference of 2-Pyridinylboronic acid)

2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Reference of 2-Pyridinylboronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ishaq, Muhammad Waqas; Nawaz, Raziq; Jalil, Abdul; Hashmi, Muhammad Ali; Zheng, Tao; Li, Lianwei published their research in Journal of Molecular Structure in 2021. The article was titled 《Ligand Exchange Reaction in [Co4O4]-Cobalt Cubane: A Versatile Strategy Towards the Preparation of Cobalt Cubane-based Functional Small Molecules and Polymeric Materials》.SDS of cas: 2510-22-7 The article contains the following contents:

Herein, we report the mechanistic and application study of ligand exchange reaction in Co4O4-cobalt cubane, a well-known water oxidation catalyst (WOC). The ligand exchange reaction involves the instantaneous dissociation of attached pyridine ligand and replacement of target ligand in an appropriate solvent. The kinetic and thermodn. parameters were quantified for the ligand exchange reaction under mild conditions. Activation parameters revealed that the ligand exchange mechanism follows dissociative (D) or interchange-dissociative (Id) pathway in case of Co4O4, as it is evident by the high activation enthalpy (ΔH+) and the pos. activation entropy (ΔS+) values. The effects of ligand derivatization, reaction temperature and type of the solvent on the exchange kinetics and the product purity were also investigated in detail. Furthermore, our theor. studies disclosed the most probable ligand exchange pathway in case of Co4O4. Finally, this methodol. was successfully applied to the preparation of Co4O4-containning functional poly-4vinylpyridine (P4VP) and cross-linked heterogeneous polymeric catalysts. The present mechanistic study clearly demonstrates that the ligand exchange method is an efficient and versatile method for the preparation of Co4O4-based functional materials. In the experimental materials used by the author, we found 4-Ethynylpyridine(cas: 2510-22-7SDS of cas: 2510-22-7)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. SDS of cas: 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhang, Sheng; Li, Lijun; Li, Jingjing; Shi, Jianxue; Xu, Kun; Gao, Wenchao; Zong, Luyi; Li, Guigen; Findlater, Michael published their research in Angewandte Chemie, International Edition in 2021. The article was titled 《Electrochemical Arylation of Aldehydes, Ketones, and Alcohols: from Cathodic Reduction to Convergent Paired Electrolysis》.Electric Literature of C6H4N2 The article contains the following contents:

Arylation of carbonyls, one of the most common approaches toward alcs., has received tremendous attention, as alcs. are important feedstocks and building blocks in organic synthesis. Despite great progress, there is still a great gap to develop an ideal arylation method featuring mild conditions, good functional group tolerance, and readily available starting materials. We now show that electrochem. arylation can fill the gap. By taking advantage of synthetic electrochem., com. available aldehydes (ketones) and benzylic alcs. can be readily arylated to provide a general and scalable access to structurally diverse alcs. (97 examples, >10 g-scale). More importantly, convergent paired electrolysis, the ideal but challenging electrochem. technol., was employed to transform low-value alcs. into more useful alcs. Detailed mechanism study suggests that two plausible pathways are involved in the redox neutral α-arylation of benzylic alcs. After reading the article, we found that the author used 4-Cyanopyridine(cas: 100-48-1Electric Literature of C6H4N2)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Electric Literature of C6H4N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Peptide-Conjugated Long-Lived Theranostic Imaging for Targeting GRPr in Cancer and Immune Cells》 was written by Wang, Wanhe; Wu, Ke-Jia; Vellaisamy, Kasipandi; Leung, Chung-Hang; Ma, Dik-Lung. Category: pyridine-derivatives And the article was included in Angewandte Chemie, International Edition in 2020. The article conveys some information:

Gastrin-releasing peptide receptor (GRPr) plays proliferative and inflammatory roles in living systems. Here, the authors report a highly selective GRPr antagonist (JMV594)-tethered iridium(III) complex for probing GRPr in living cancer cells and immune cells. This probe exhibited desirable photophys. properties and also displayed negligible cytotoxicity, overcoming the inherent toxicity of the iridium(III) complex. Its long emission lifetime enabled its luminescence signal to be readily distinguished from the interfering fluorescence of organic dyes by using a time-resolved technique. This probe selectively visualized living cancer cells via specific binding to GRPr, while it also modulated the function of GRPr on TNF-α secretion in immune cells. To the authors′ knowledge, this is the first peptide-conjugated iridium(III) complex developed as a GRPr bioimaging probe and modulator of GRPr activity. This theranostic agent shows great potential at unmasking the diverse roles of GRPr in living systems. The results came from multiple reactions, including the reaction of 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Category: pyridine-derivatives)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.Category: pyridine-derivatives Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem