Tag: 100-200

Reference of 4-Amino-2-picolineOn October 24, 2019 ,《Development of Chemical Entities Endowed with Potent Fast-Killing Properties against Plasmodium falciparum Malaria Parasites》 was published in Journal of Medicinal Chemistry. The article was written by Matralis, Alexios N.; Malik, Adnan; Penzo, Maria; Moreno, Inmaculada; Almela, Maria J.; Camino, Isabel; Crespo, Benigno; Saadeddin, Anas; Ghidelli-Disse, Sonja; Rueda, Lourdes; Calderon, Felix; Osborne, Simon A.; Drewes, Gerard; Boesche, Markus; Fernandez-Alvaro, Elena; Martin Hernando, Jose Ignacio; Baker, David A.. The article contains the following contents:

One of the attractive properties of artemisinins is their extremely fast-killing capability, quickly relieving malaria symptoms. Nevertheless, the unique benefits of these medicines are now compromised by the prolonged parasite clearance times and the increasing frequency of treatment failures, attributed to the increased tolerance of Plasmodium falciparum to artemisinin. This emerging artemisinin resistance threatens to undermine the effectiveness of antimalarial combination therapies. Herein, we describe the medicinal chem. efforts focused on a cGMP-dependent protein kinase (PKG) inhibitor scaffold, leading to the identification of novel chem. entities with very potent, similar to artemisinins, fast-killing potency against asexual blood stages that cause disease, and activity against gametocyte activation that is required for transmission. Furthermore, we confirm that selective PKG inhibitors have a slow speed of kill, while chemoproteomic anal. suggests for the first time serine/arginine protein kinase 2 (SRPK2) targeting as a novel strategy for developing antimalarial compounds with extremely fast-killing properties. After reading the article, we found that the author used 4-Amino-2-picoline(cas: 18437-58-6Reference of 4-Amino-2-picoline)

4-Amino-2-picoline(cas: 18437-58-6) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Reference of 4-Amino-2-picoline

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《2D and 3D Zn(II) coordination polymers based on 4′-(Thiophen-2-yl)-4,2′:6′,4”-terpyridine: Structures and features of sorption behavior》 was written by Zaguzin, Alexander S.; Mahmoudi, Ghodrat; Sukhikh, Taisia S.; Sakhapov, Ilyas F.; Zherebtsov, Dmitry A.; Zubkov, Fedor I.; Valchuk, Karina S.; Sokolov, Maxim N.; Fedin, Vladimir P.; Adonin, Sergey A.. Application of 1122-54-9This research focused onzinc terephthalate iodoterephthalate thiophenylterpyridine coordination polymer preparation gas adsorption; crystal structure zinc terephthalate iodoterephthalate thiophenylterpyridine coordination polymer. The article conveys some information:

Reactions of Zn(II) nitrate, 4′-(thiophen-2-yl)-4,2′:6′,4”-terpyridine (ThioTerPy) and terephthalic (bdc) or 2-iodoterephthalic (2-I-bdc) acids result in 2D coordination polymer [Zn2bdc(ThioTerPy)2(OH)2] (1) or 3D metal-organic framework [Zn(2-I-bdc)(ThioTerPy)] (2), resp. Both compounds were characterized by X-ray diffractometry. For 2, I2 absorption, as well as selectivity of sorption of different organic substrates from mixtures was studied. In addition to this study using 4-Acetylpyridine, there are many other studies that have used 4-Acetylpyridine(cas: 1122-54-9Application of 1122-54-9) was used in this study.

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Application of 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

COA of Formula: C5H6BNO2In 2022 ,《Ornamenting of Blue Thermally Activated Delayed Fluorescence Emitters by Anchor Groups for the Minimization of Solid-State Solvation and Conformation Disorder Corollaries in Non-Doped and Doped Organic Light-Emitting Diodes》 was published in ACS Applied Materials & Interfaces. The article was written by Mahmoudi, Malek; Gudeika, Dalius; Kutsiy, Stepan; Simokaitiene, Jurate; Butkute, Rita; Skhirtladze, Levani; Woon, Kai Lin; Volyniuk, Dmytro; Grazulevicius, Juozas Vidas. The article contains the following contents:

Motivated to minimize the effects of solid-state solvation and conformation disorder on emission properties of donor-acceptor-type emitters, we developed five new asym. multiple donor-acceptor type derivatives of tert-Bu carbazole and trifluoromethyl benzene exploiting different electron-accepting anchoring groups. Using this design strategy, for a compound containing four di-tert-Bu carbazole units as donors as well as 5-Me pyrimidine and trifluoromethyl acceptor moieties, small singlet-triplet splitting of ca. 0.03 eV, reverse intersystem crossing rate of 1 x 106 s-1, and high photoluminescence quantum yield of neat film of ca. 75% were achieved. This compound was also characterized by the high value of hole and electron mobilities of 8.9 x 10-4 and 5.8 x 10-4 cm2 V-1 s-1 at an elec. field of 4.7 x 105 V/cm, showing relatively good hole/electron balance, resp. Due to the lowest conformational disorder and solid-state solvation effects, this compound demonstrated very similar emission properties (emission colors) in non-doped and differently doped organic light-emitting diodes (OLEDs). The lowest conformational disorder was observed for the compound with the addnl. accepting moiety inducing steric hindrance, limiting donor-acceptor dihedral rotational freedom. It can be exploited in the multi-donor-acceptor approach, increasing the efficiency. Using an emitter exhibiting the minimized solid-state solvation and conformation disorder effects, the sky blue OLED with the emitting layer of this compound dispersed in host 1,3-bis(N-carbazolyl)benzene displayed an emission peak at 477 nm, high brightness over 39 000 cd/m2, and external quantum efficiency up to 15.9% along with a maximum current efficiency of 42.6 cd/A and a maximum power efficiency of 24.1 lm/W. After reading the article, we found that the author used 2-Pyridinylboronic acid(cas: 197958-29-5COA of Formula: C5H6BNO2)

2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. COA of Formula: C5H6BNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: 4,4′-Dimethyl-2,2′-bipyridineIn 2019 ,《Synthesis, photophysics and the binding studies of rhenium(I) diimine surfactant complexes with serum albumins: A spectroscopic and docking study approach》 appeared in Journal of Luminescence. The author of the article were Balakrishnan, Gopalakrishnan; Rajendran, Thangamuthu; Murugan, Krishnan Senthil; Ganesan, Muniyandi; Sivasubramanian, Veluchamy Kamaraj; Rajagopal, Seenivasan. The article conveys some information:

Synthesis of the four rhenium(I) diimine surfactant complexes of the type fac-[Re(CO)3 (α-diimine){4-C11py}] CF3SO31a-1d (α-diimine = 2,2′-bipyridine) (a), 4,4′-di-methyl-2,2′-bipyridine (b), 4,4′-di-tert-butyl-2,2′-bipyridine (c) 4,4′-dinonyl-2,2′-bipyridine (d) and 4-C11py = (py-4-(CH2)10CH3) has been reported. In vitro protein (HSA and BSA) binding studies confirmed the binding affinity of the complexes toward the drug binding sites of subdomain IIA and IIIA, confirmed by spectral studies and mol. docking. The steady-state and time-resolved fluorescence spectra confirm that the static quenching, due to complex formation, is the dominant mechanism for fluorescence quenching. Mol. docking studies prove that hydrophobic interaction makes a predominant contribution even though hydrogen bonding does exist, and hence 1b, 1c and 1d exhibit stronger binding relative to 1a. The synchronous fluorescence and CD spectral studies show that these Re(I) complexes can induce conformational changes in the proteins. Finally, the distance, r, between donor (proteins) and acceptor (Re (I) complexes) obtained through FRET study is in the range 4.5-5.2 nm. The results came from multiple reactions, including the reaction of 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Recommanded Product: 4,4′-Dimethyl-2,2′-bipyridine)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.Recommanded Product: 4,4′-Dimethyl-2,2′-bipyridine Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

HPLC of Formula: 13534-97-9In 2012 ,《Discovery of 6,7-Dihydro-5H-pyrrolo[2,3-d]pyrimidines as Orally Available G Protein-Coupled Receptor 119 Agonists》 appeared in Journal of Medicinal Chemistry. The author of the article were Katamreddy, Subba R.; Carpenter, Andrew J.; Ammala, Carina E.; Boros, Eric E.; Brashear, Ron L.; Briscoe, Celia P.; Bullard, Sarah R.; Caldwell, Richard D.; Conlee, Christopher R.; Croom, Dallas K.; Hart, Shane M.; Heyer, Dennis O.; Johnson, Paul R.; Kashatus, Jennifer A.; Minick, Doug J.; Peckham, Gregory E.; Ross, Sean A.; Roller, Shane G.; Samano, Vicente A.; Sauls, Howard R.; Tadepalli, Sarva M.; Thompson, James B.; Xu, Yun; Way, James M.. The article conveys some information:

GPR119 is a 7-transmembrane receptor that is expressed in the enteroendocrine cells in the intestine and in the islets of Langerhans in the pancreas. Indolines and 6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidines were discovered as G protein-coupled receptor 119 (GPR119) agonists, and lead optimization efforts led to the identification of 1-methylethyl 4-({7-[2-fluoro-4-(methylsulfonyl)phenyl]-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)-1-piperidinecarboxylate (GSK1104252A) (3, I), a potent and selective GPR119 agonist. Compound 3 showed excellent pharmacokinetic properties and sufficient selectivity with in vivo studies supporting a role for GPR119 in glucose homeostasis in the rodent. Thus, 3 appeared to modulate the enteroinsular axis, improve glycemic control, and strengthen previous suggestions that GPR119 agonists may have utility in the treatment of type 2 diabetes. The experimental part of the paper was very detailed, including the reaction process of 6-Bromopyridin-3-amine(cas: 13534-97-9HPLC of Formula: 13534-97-9)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.HPLC of Formula: 13534-97-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 53939-30-3In 2019 ,《Scaffold Morphing Identifies 3-Pyridyl Azetidine Ureas as Inhibitors of Nicotinamide Phosphoribosyltransferase (NAMPT)》 appeared in ACS Medicinal Chemistry Letters. The author of the article were Palacios, Daniel S.; Meredith, Erik L.; Kawanami, Toshio; Adams, Christopher M.; Chen, Xin; Darsigny, Veronique; Palermo, Mark; Baird, Daniel; George, Elizabeth L.; Guy, Chantale; Hewett, Jeffrey; Tierney, Laryssa; Thigale, Sachin; Wang, Louis; Weihofen, Wilhelm A.. The article conveys some information:

Small mols. that inhibit the metabolic enzyme NAMPT have emerged as potential therapeutics in oncol. As part of our effort in this area, we took a scaffold morphing approach and identified 3-pyridyl azetidine ureas as a potent NAMPT inhibiting motif. We explored the SAR of this series, including 5 and 6 amino pyridines, using a convergent synthetic strategy. This lead optimization campaign yielded multiple compounds with excellent in vitro potency and good ADME properties that culminated in compound 27.5-Bromo-2-chloropyridine(cas: 53939-30-3Related Products of 53939-30-3) was used in this study.

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Related Products of 53939-30-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Jia, Pei-Pei; Xu, Lin; Hu, Yi-Xiong; Li, Wei-Jian; Wang, Xu-Qing; Ling, Qing-Hui; Shi, Xueliang; Yin, Guang-Qiang; Li, Xiaopeng; Sun, Haitao; Jiang, Yanrong; Yang, Hai-Bo published an article in 2021. The article was titled 《Orthogonal Self-Assembly of a Two-Step Fluorescence-Resonance Energy Transfer System with Improved Photosensitization Efficiency and Photooxidation Activity》, and you may find the article in Journal of the American Chemical Society.Recommanded Product: 4-Ethynylpyridine The information in the text is summarized as follows:

During the past few decades, fabrication of multistep fluorescence-resonance energy transfer (FRET) systems has become one of the most attractive topics within supramol. chem., chem. biol., and materials science. However, it is challenging to efficiently prepare multistep FRET systems with precise control of the distances between locations and the numbers of fluorophores. Herein we present the successful fabrication of a two-step FRET system bearing specific numbers of anthracene, coumarin, and BODIPY moieties at precise distances and locations through an efficient and controllable orthogonal self-assembly approach based on metal-ligand coordination and host-guest interactions. Notably, the photosensitization efficiency and photooxidation activity of the two-step FRET system gradually increased with the number of energy transfer steps. For example, the two-step FRET system exhibited 1.5-fold higher 1O2 generation efficiency and 1.2-fold higher photooxidation activity than that of its corresponding one-step FRET system. This research not only provides the first successful example of the efficient preparation of multistep FRET systems through orthogonal self-assembly involving coordination and host-guest interactions but also pushes multistep FRET systems toward the application of photosensitized oxidation of a sulfur mustard simulant. The experimental process involved the reaction of 4-Ethynylpyridine(cas: 2510-22-7Recommanded Product: 4-Ethynylpyridine)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Recommanded Product: 4-Ethynylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Afsharnadery, Fatemeh; Khosravi, Kaveh; Zolfigol, Mohammad Ali published their research in Applied Organometallic Chemistry in 2021. The article was titled 《A novel magnetically recyclable semi-dendrimer catalyst-based ethanolpyridole supported on ferrite nanoparticles (HNPs@Py) for the synthesis of biscoumarin and dihydropyrano[3,2-c]chromene derivatives》.Synthetic Route of C7H9NO The article contains the following contents:

The novel organic-inorganic nanohybrid magnetic nanoparticles (HNPs@Py) were prepared by a simple method and characterized by FT-IR, XRD, FE-SEM, TGA, VSM, EDX, and MAP. The catalytic activity of this new (HNPs@Py) was studied for green synthesis of biscoumarins I (R = 4-Br, 3-NO2, 2-OH, etc.) and 3,4-dihydropyrano[c]chromene derivatives II (Ar = 2,4-dichlorophenyl, naphthalen-2-yl, 3-hydroxyphenyl). The short reaction time, high yields, simple workup, and easy separation of catalyst from the reaction mixture by an external magnetic field are the main advantages of the present protocol. In the experiment, the researchers used 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Synthetic Route of C7H9NO)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Synthetic Route of C7H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Liu, Yan-Hua; Xie, Pei-Pei; Liu, Lei; Fan, Jun; Zhang, Zhuo-Zhuo; Hong, Xin; Shi, Bing-Feng published their research in Journal of the American Chemical Society in 2021. The article was titled 《Cp*Co(III)-Catalyzed Enantioselective Hydroarylation of Unactivated Terminal Alkenes via C-H Activation》.Application of 3510-66-5 The article contains the following contents:

Enantioselective hydroarylation of unactivated terminal alkenes RCH=CH2 (R = n-hexyl, benzyl, cyclohexylmethyl, etc.) constitutes a prominent challenge in organic chem. Synthesis of Cp*Co(III)-catalyzed asym. hydroarylation of unactivated aliphatic terminal alkenes assisted by a new type of tailor-made amino acid ligands. Critical to the chiral induction was the engaging of a novel noncovalent interaction (NCI), which has seldomly been disclosed in C-H activation area, arising from the mol. recognition among the organocobalt(III) intermediate, the coordinated alkene and the well-designed chiral ligand. A broad range of C2 alkylated indoles were obtained in high yields and excellent enantioselectivities. DFT calculations revealed the reaction mechanism and elucidated the origins of chiral induction in the stereodetermining alkene insertion step. The results came from multiple reactions, including the reaction of 2-Bromo-5-methylpyridine(cas: 3510-66-5Application of 3510-66-5)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Application of 3510-66-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Visible-Light-Induced ortho-Selective Migration on Pyridyl Ring: Trifluoromethylative Pyridylation of Unactivated Alkenes》 was written by Jeon, Jinwon; He, Yu-Tao; Shin, Sanghoon; Hong, Sungwoo. Category: pyridine-derivatives And the article was included in Angewandte Chemie, International Edition in 2020. The article conveys some information:

The photocatalyzed ortho-selective migration on a pyridyl ring has been achieved for the site-selective trifluoromethylative pyridylation of unactivated alkenes. The overall process was initiated by the selective addition of a CF3 radical to the alkene moiety of N-(alkenyloxy)pyridinium salts I [X = O, Z = (CH2)3, R1 = H, 2-Me, 3-MeO2C, 4-Ph, etc., R2 = H, Me; X = O, Z = CH2, CH2CH2, (CH2)4, R1 = 4-MeO2C, R2 = H; X = NTs, Z = CH2, CH2CH2, R1 = H, 4-MeO2C, R2 = H; etc.] to provide a nucleophilic alkyl radical intermediate, which enabled an intramol. endo addition exclusively to the ortho-position of the pyridinium salt to afford the corresponding functionalized pyridines II. Both secondary and tertiary alkyl radicals were well-suited for addition to the C2-position of pyridinium salts to ultimately provide synthetically valuable C2-fluoroalkyl functionalized pyridines. Moreover, the method was successfully applied to the reaction with P-centered radicals. The utility of this transformation was further demonstrated by the late-stage functionalization of complex bioactive mols. After reading the article, we found that the author used 4-Acetylpyridine(cas: 1122-54-9Category: pyridine-derivatives)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem