Tag: 100-200

In 2019,Angewandte Chemie, International Edition included an article by Guin, Srimanta; Dolui, Pravas; Zhang, Xinglong; Paul, Satyadip; Singh, Vikas Kumar; Pradhan, Sukumar; Chandrashekar, Hediyala B.; Anjana, S. S.; Paton, Robert S.; Maiti, Debabrata. Application In Synthesis of Picolinic acid. The article was titled 《Iterative Arylation of Amino Acids and Aliphatic Amines via δ-C(sp3)-H Activation: Experimental and Computational Exploration》. The information in the text is summarized as follows:

Directed C-H functionalization has been realized as a complementary tool to the traditional approaches for a straightforward access of non-proteinogenic amino acids; albeit such a process is restricted mostly up to the γ-position. In the present work, we demonstrate the diverse (hetero)arylation of amino acids and analogous aliphatic amines selectively at the remote δ-position by tuning the reactivity controlled by ligands. An organopalladium δ-C(sp3)-H activated intermediate has been isolated and crystallog. characterized. Mechanistic investigations carried out exptl. in conjunction with computational studies shed light on the difference in the mechanistic picture depending on the substrate structure. The experimental process involved the reaction of Picolinic acid(cas: 98-98-6Application In Synthesis of Picolinic acid)

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Application In Synthesis of Picolinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,Angewandte Chemie, International Edition included an article by Kim, Taehoon; McCarver, Stefan J.; Lee, Chulbom; MacMillan, David W. C.. Product Details of 53939-30-3. The article was titled 《Sulfonamidation of Aryl and Heteroaryl Halides through Photosensitized Nickel Catalysis》. The information in the text is summarized as follows:

Herein we report a highly efficient method for nickel-catalyzed C-N bond formation between sulfonamides and aryl electrophiles. This technol. provides generic access to a broad range of N-aryl and N-heteroaryl sulfonamide motifs, which are widely represented in drug discovery. Initial mechanistic studies suggest an energy-transfer mechanism wherein C-N bond reductive elimination occurs from a triplet excited NiII complex. Late-stage sulfonamidation in the synthesis of a pharmacol. relevant structure is also demonstrated. In the experiment, the researchers used many compounds, for example, 5-Bromo-2-chloropyridine(cas: 53939-30-3Product Details of 53939-30-3)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Product Details of 53939-30-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2015,Zhao, Huiping; Garg, Gaurav; Zhao, Jinbo; Moroni, Elisabetta; Girgis, Antwan; Franco, Lucas S.; Singh, Swapnil; Colombo, Giorgio; Blagg, Brian S. J. published 《Design, synthesis and biological evaluation of biphenylamide derivatives as Hsp90 C-terminal inhibitors》.European Journal of Medicinal Chemistry published the findings.Computed Properties of C5H5BrN2 The information in the text is summarized as follows:

Modulation of Hsp90 C-terminal function represents a promising therapeutic approach for the treatment of cancer and neurodegenerative diseases. Current drug discovery efforts toward Hsp90 C-terminal inhibition focus on novobiocin, an antibiotic that was transformed into an Hsp90 inhibitor. Based on structural information obtained during the development of novobiocin derivatives and mol. docking studies, scaffolds containing a biphenyl moiety in lieu of the coumarin ring present in novobiocin were identified as new Hsp90 C-terminal inhibitors. Structure-activity relationship studies produced new derivatives that inhibit the proliferation of breast cancer cell lines at nanomolar concentrations, which corresponded directly with Hsp90 inhibition. In the part of experimental materials, we found many familiar compounds, such as 6-Bromopyridin-3-amine(cas: 13534-97-9Computed Properties of C5H5BrN2)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Computed Properties of C5H5BrN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Design, synthesis, and biological evaluation of triazole-based heteroaromatic derivatives as Bcr-Abl kinase inhibitors》 was written by Pan, Xiaoyan; Liu, Nanxin; Liu, Yuying; Zhang, Qingqing; Wang, Kai; Liu, Xueying; Zhang, Jie. Application of 13534-97-9This research focused ontriazole heterocycle preparation kinase inhibitor antitumor apoptosis docking safety; Antileukemic activity; Aromatic heterocycles; Bcr-Abl kinases; In silico modeling study; Proline; Structure-activity relationship; Trizole. The article conveys some information:

A series of compounds with heteroaromatics-triazole scaffold as hinge binding moiety (HBM) were developed as Bcr-Abl inhibitors based on in silico modeling anal. Biol. results indicated that these compounds exhibited a significantly enhanced inhibition against Bcr-Abl WT and Bcr-Abl T315I in kinases assays, along with improved anti-proliferative activities in leukemia cell assays, compared with previous disclosed compounds Meanwhile, the inhibition of Bcr-Abl activity in Ba/F3 cells demonstrated that these compounds exerted effects mainly by acting on Bcr-Abl. Addnl., few compounds effectively induced apoptosis, arrested the cell cycle at S or G2/M phase, and inhibited phosphorylation of Bcr-Abl and STAT5 in a dose-dependent manner. Docking studies indicated that triazole indeed retained the hydrophobic interaction of aromatic heterocycles with hinge region, and ADME prediction suggested that tested compounds had a favorable safety profile. Therefore, aromatic heterocycles incorporated with triazole could serve as a promising HBM for Bcr-Abl inhibitors with proline as flexible linker.6-Bromopyridin-3-amine(cas: 13534-97-9Application of 13534-97-9) was used in this study.

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Application of 13534-97-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of C6H6BrNIn 2021 ,《Tetrahydroindazole inhibitors of CDK2/cyclin complexes》 was published in European Journal of Medicinal Chemistry. The article was written by Lee, Jae Chul; Hong, Kwon Ho; Becker, Andreas; Tash, Joseph S.; Schonbrunn, Ernst; Georg, Gunda I.. The article contains the following contents:

Over 50 tetrahydroindazoles I [R = 2-pyridyl, thiazol-2-yl, pyrimidin-4-yl, etc.] were synthesized after I [R = 2-pyridyl] was identified as a hit compound in a high throughput screen for inhibition of CDK2 in complex with cyclin A. The activity of the most promising analogs was evaluated by inhibition of CDK2 enzyme complexes with various cyclins. Analogs I [R = thiazol-2-yl, pyrimidin-4-yl] showed 3-fold better binding affinity for CDK2 and 2- to 10-fold improved inhibitory activity against CDK2/cyclin A1, E, and O compared to screening hit 3. The data from the enzyme and binding assays indicate that the binding of the analogs to a CDK2/cyclin complex is favored over binding to free CDK2. Computational anal. was used to predict a potential binding site at the CDK2/cyclin E1 interface. In the experiment, the researchers used 2-Bromo-5-methylpyridine(cas: 3510-66-5Electric Literature of C6H6BrN)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Electric Literature of C6H6BrN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 4-AcetylpyridineIn 2019 ,《Energy-efficient sonochemical approach for the preparation of nanohybrid composites from graphene oxide and metal-organic framework》 was published in Inorganic Chemistry Communications. The article was written by Tanhaei, Mahboobeh; Mahjoub, Ali Reza; Safarifard, Vahid. The article contains the following contents:

Two-fold interpenetration zinc-based metal-organic framework/graphene oxide (TMU-16-NH2/GO) nanohybrid materials were synthesized under a green, simple and large-scale sonochem. preparation method at room temperature and atm. pressure. The role of concentrations of graphene oxide on size and morphol. of nanostructures TMU-16-NH2/GO hybrid have been studied. The materials were characterized by SEM, powder x-ray diffraction (PXRD), FTIR spectroscopy and nitrogen adsorption. Both of the pure MOF and the nanohybrid MOF/GO composites exhibit microporous structure with a small number of mesopores. TMU-16-NH2 shows type IV isotherm with a H4 hysteresis loop, while the isotherm of TMU-16-NH2/GO appears to show normal Type II adsorption with a Type H3 hysteresis loop. The results obtained demonstrate this method to be applicable to the synthesis of other MOFs/GO nanohybrids and may possibly find various forthcoming industrial and technol. applications. In the experiment, the researchers used 4-Acetylpyridine(cas: 1122-54-9Reference of 4-Acetylpyridine)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Reference of 4-Acetylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: 3510-66-5In 2021 ,《Cobalt-Catalysed Asymmetric Addition and Alkylation of Secondary Phosphine Oxides for the Synthesis of P-Stereogenic Compounds》 appeared in Angewandte Chemie, International Edition. The author of the article were Wu, Zeng-Hua; Cheng, An-Qi; Yuan, Meng; Zhao, Ya-Xuan; Yang, Huai-Lan; Wei, Li-Hua; Wang, Huai-Yu; Wang, Tao; Zhang, Zunting; Duan, Wei-Liang. The article conveys some information:

Secondary pyridyl arylphosphine oxides undergo addition to activated double bonds and nucleophilic substitution with benzyl halides catalyzed by cobalt(II) complexes with chiral pincer isoindole-bis(oxazoline) ligands yielding P-chiral phosphine oxides ArPyP(O)R (Py = 2-pyridyl), which were converted into aryl and alkyl derivatives ArR1P(O)R by reaction with Grignard reagents R1MgX with minor loss of enantiopurity. The catalytic asym. synthesis of P-chiral phosphorus compounds is an important way to construct P-chiral ligands. Herein, we report a new strategy that adopts the pyridinyl moiety as the coordinating group in the cobalt-catalyzed asym. nucleophilic addition/alkylation of secondary phosphine oxides. A series of tertiary phosphine oxides were generated with up to 99% yield and 99.5% ee, and with broad functional-group tolerance. Mechanistic studies reveal that (R)-secondary phosphine oxides preferentially interact with the cobalt catalysts to produce P-stereogenic compounds In addition to this study using 2-Bromo-5-methylpyridine, there are many other studies that have used 2-Bromo-5-methylpyridine(cas: 3510-66-5Recommanded Product: 3510-66-5) was used in this study.

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Recommanded Product: 3510-66-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Category: pyridine-derivativesIn 2020 ,《The Covalent and Coordination Co-Driven Assembly of Supramolecular Octahedral Cages with Controllable Degree of Distortion》 appeared in Journal of the American Chemical Society. The author of the article were Bao, Shu-Jin; Xu, Ze-Ming; Ju, Yun; Song, Ying-Lin; Wang, Heng; Niu, Zheng; Li, Xiaopeng; Braunstein, Pierre; Lang, Jian-Ping. The article conveys some information:

Discovering and constructing novel and fancy structures is the goal of many supramol. chemists. In this work, authors propose an assembly strategy based on the synergistic effect of coordination and covalent interactions to construct a set of octahedral supramol. cages and adjust their degree of distortion. Their strategy innovatively utilizes the addition of sulfur atoms of a metal sulfide synthon, [Et4N][Tp*WS3] (A), to an alkynyl group of a pyridine-containing linker, resulting in a novel vertex with low symmetry, and of Cu(I) ions. By adjusting the length of the linker and the position of the reactive alkynyl group, the control of the deformation degree of the octahedral cages can be realized. These supramol. cages exhibit enhanced third-order nonlinear optical (NLO) responses. The results offer a powerful strategy to construct novel distorted cage structures as well as control the degree of distortion of supramol. geometries. In the experiment, the researchers used 4-Ethynylpyridine(cas: 2510-22-7Category: pyridine-derivatives)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Abednatanzi, Sara; Gohari Derakhshandeh, Parviz; Dalapati, Sasanka; Veerapandian, Savita K. P.; Froissart, Anne-Claire; Epping, Jan Dirk; Morent, Rino; De Geyter, Nathalie; Van Der Voort, Pascal published an article in ACS Applied Materials & Interfaces. The title of the article was 《Metal-Free Chemoselective Reduction of Nitroarenes Catalyzed by Covalent Triazine Frameworks: The Role of Embedded Heteroatoms》.Formula: C5H5BrN2 The author mentioned the following in the article:

Development of robust nanoporous covalent triazine frameworks (CTFs) as metal-free catalysts for the green chemoselective reduction of nitroarenes. The turnover frequency was found to be 43.03 h-1, exceeding activities of the heteroatom-doped carbon nanomaterials by a factor of 30. The XPS and control experiments provided further insights into the nature of active species for prompt catalysis. This report confirmed the importance of quaternary ‘N’ and ‘F’ atom functionalities to create active hydrogen species via charge delocalization as a critical step in improving the catalytic activity. In the part of experimental materials, we found many familiar compounds, such as 6-Bromopyridin-3-amine(cas: 13534-97-9Formula: C5H5BrN2)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Formula: C5H5BrN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Bodedla, Govardhana Babu; Tritton, Daniel Nnaemaka; Chen, Xi; Zhao, Jianzhang; Guo, Zeling; Leung, Ken Cham-Fai; Wong, Wai-Yeung; Zhu, Xunjin published an article in 2021. The article was titled 《Cocatalyst-free Photocatalytic Hydrogen Evolution with Simple Heteroleptic Iridium(III) Complexes》, and you may find the article in ACS Applied Energy Materials.Computed Properties of C12H12N2 The information in the text is summarized as follows:

A simple heteroleptic iridium(III) photosensitizer, Ir-1, containing two ligands 5-(trifluoromethyl)-2-phenylpyridine (ĈN-CF3) and bipyridine (N̂N) has for the first time been studied for cocatalyst-free photocatalytic hydrogen evolution (PHE). The complex Ir-1 produces a hydrogen production rate (ηH2) of 3.2 mmol g-1 h-1, which is over 3.6-fold higher than that of the control complex Ir-2 (0.9 mmol g-1 h-1) containing bipyridine and 2-phenylpyridine ligands without CF3 groups. The higher ηH2 of Ir-1 could be ascribed to the high light-harvesting property, longer triplet electron lifetime, and more appropriate driving force for accepting electrons from the sacrificial donor, which enable efficient charge separation and transfer of electrons for hydrogen evolution. Addnl., the photostability issues of Ir-1 and Ir-2 are addressed by the selection of suitable organic solvent/water photocatalytic systems. In the experiment, the researchers used 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Computed Properties of C12H12N2)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.Computed Properties of C12H12N2 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem