Tag: 100-200

Upadhyay, Rahul; Singh, Deepak; Maurya, Sushil K. published an article in 2021. The article was titled 《Highly efficient heterogeneous V2O5@TiO2 catalyzed the rapid transformation of boronic acids to phenols》, and you may find the article in European Journal of Organic Chemistry.Quality Control of Pyridin-3-ylboronic acid The information in the text is summarized as follows:

A V2O5@TiO2 catalyzed green and efficient protocol for hydroxylation of boronic acid into phenol was developed utilizing environmentally benign oxidant hydrogen peroxide. A wide range of electron-donating and electron-withdrawing group-containing (hetero)aryl boronic acids were transformed into their corresponding phenol. The methodol. was also applied successfully to transform various natural and bioactive mols. like tocopherol, amino acids, cinchonidine, vasicinone, menthol and pharmaceuticals such as ciprofloxacin, ibuprofen and paracetamol. The other feature of methodol. included gram-scale synthetic applicability, recyclability and short reaction time. The experimental process involved the reaction of Pyridin-3-ylboronic acid(cas: 1692-25-7Quality Control of Pyridin-3-ylboronic acid)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Quality Control of Pyridin-3-ylboronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ghosh, Pradip; Jacobi von Wangelin, Axel published an article in 2021. The article was titled 《Manganese-Catalyzed Hydroborations with Broad Scope》, and you may find the article in Angewandte Chemie, International Edition.Reference of 4-Cyanopyridine The information in the text is summarized as follows:

Reductive transformations of easily available oxidized matter are at the heart of synthetic manipulation and chem. valorization. The applications of catalytic hydrofunctionalization benefit from the use of liquid reducing agents and operationally facile setups. Metal-catalyzed hydroborations provide a highly prolific platform for reductive valorizations of stable C:X electrophiles. Here, the authors report an especially facile, broad-scope reduction of various functions including carbonyls, carboxylates, pyridines, carbodiimides, and carbonates under very mild conditions with the inexpensive pre-catalyst Mn(hmds)2. The reaction could be successfully applied to depolymerizations In the experiment, the researchers used 4-Cyanopyridine(cas: 100-48-1Reference of 4-Cyanopyridine)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Reference of 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Formula: C7H5NIn 2020 ,《Double Rotors with Fluxional Axles: Domino Rotation and Azide-Alkyne Huisgen Cycloaddition Catalysis》 appeared in Angewandte Chemie, International Edition. The author of the article were Goswami, Abir; Schmittel, Michael. The article conveys some information:

The simple preparation of the multicomponent devices [Cu4(A)2]4+ and [Cu2(A)(B)]2+, both rotors with fluxional axles undergoing domino rotation, highlights the potential of self-sorting. The concept of domino rotation requires the interconversion of axle and rotator, allowing the spatiotemporal decoupling of two degenerate exchange processes in [Cu4(A)2]4+ occurring at 142 kHz. Addition of two equiv of B to rotor [Cu4(A)2]4+ afforded the heteromeric two-axle rotor [Cu2(A)(B)]2+ with two distinct exchange processes (64.0 kHz and 0.55 Hz). The motion requiring a pyridine→zinc porphyrin bond cleavage is 1.2 × 105 times faster than that operating via a terpyridine→[Cu(phenAr2)]+ rupture. Finally, both rotors are catalysts due to their copper(I) content. The fast domino rotor (142 kHz) was shown to suppress product inhibition in the catalysis of the azide-alkyne Huisgen cycloaddition The experimental part of the paper was very detailed, including the reaction process of 4-Ethynylpyridine(cas: 2510-22-7Formula: C7H5N)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Formula: C7H5N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Komaba, Kyoka; Nimori, Shigeki; Miyashita, Ryo; Kumai, Reiji; Goto, Hiromasa published an article in Polymer-Plastics Technology and Materials. The title of the article was 《Hydroxypropyl cellulose/poly(aniline-co-pyridine-oxyl) as a liquid crystal polymer/polyradical blend with helical magnetic structure》.Computed Properties of C5H7N3 The author mentioned the following in the article:

A helical magnetic polymer was synthesized by blending a polyradical and hydroxypropyl cellulose (HPC), which is a helical liquid crystal. First, achiral m-linked poly(aniline-co-pyridine) was synthesized via Buchwald-Hartwig coupling, and poly(aniline-co-pyridine-oxyl) as a linear polyradical was then prepared by Tokumaru method. Helicity was induced in the linear polyradical simply by blending with HPC as a helical cholesteric liquid crystal. The magnetic properties of the polyradical and the HPC/polyradical blend composite were evaluated by performing ESR, superconducting quantum interference device, and vibrating sample magnetometer measurements, which revealed that the linear polyradical shows diamagnetism up to 5 K and the polymer bend exhibits weak diamagnetism at high temperature and paramagnetism at low temperature2,6-Diaminopyridine(cas: 141-86-6Computed Properties of C5H7N3) was used in this study.

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Computed Properties of C5H7N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Konda, Yesuraju; Ankireddy, Ashok Reddy; Velavalapalli, Vani Madhuri; Paidikondala, Kalyani; Pasula, Aparna; Gundla, Rambabu published an article in Russian Journal of General Chemistry. The title of the article was 《Synthesis, Alpha-Glucosidase Inhibition and Antibacterial Activities of the New Chiral (R)-3,3′-Disubstituted BINOL-Phosphates》.SDS of cas: 197958-29-5 The author mentioned the following in the article:

A new class of 3,3′-disubstituted chiral (R)-BINOL-derived phosphoric acid derivatives has been prepared The synthetic method has been optimized by involving Pd/C as a catalyst in the Suzuki-Miyaura cross coupling using a non-protected BINOL derivative The target compounds have been characterized and tested for their α-glucosidase inhibitory and antibacterial activities.2-Pyridinylboronic acid(cas: 197958-29-5SDS of cas: 197958-29-5) was used in this study.

2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.SDS of cas: 197958-29-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Matern, Jonas; Baeumer, Nils; Fernandez, Gustavo published an article in 2021. The article was titled 《Unraveling Halogen Effects in Supramolecular Polymerization》, and you may find the article in Journal of the American Chemical Society.SDS of cas: 2510-22-7 The information in the text is summarized as follows:

Halogens play a crucial role in numerous natural processes and synthetic materials due to their unique physicochem. properties and the diverse interactions they can engage in. In the field of supramol. polymerization, however, halogen effects remain poorly understood, and investigations were restricted to halogen bonding or the inclusion of polyfluorinated side groups. Recent contributions from our group revealed that chlorine ligands greatly influence mol. packing and pathway complexity phenomena of various metal complexes. These results prompted us to explore the role of the halogen nature on supramol. polymerization, a phenomenon that remained unexplored to date. To address this issue, the authors designed a series of archetypal bispyridyldihalogen PtII complexes bearing chlorine (1), bromine (2), or iodine (3) and systematically compared their supramol. polymerization in nonpolar media using various exptl. methods and theory. The studies reveal a remarkably different supramol. polymerization for the three compounds, which can undergo two competing pathways with either slipped (kinetic) or parallel (thermodn.) mol. packing. The halogen exerts an inverse effect on the energetic levels of the two self-assembled states, resulting in a single thermodn. pathway for 3, a transient kinetic species for 2, and a hidden thermodn. state for 1. This seesaw-like bias of the energy landscape can be traced back to the involvement of the halogens in weak N-H···X hydrogen-bonding interactions in the kinetic pathway, whereas in the thermodn. pathway the halogens are not engaged in the stabilizing interaction motif but rather amplify solvophobic effects. After reading the article, we found that the author used 4-Ethynylpyridine(cas: 2510-22-7SDS of cas: 2510-22-7)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. SDS of cas: 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Madide, Thobeka; Somboro, Anou M.; Amoako, Daniel G.; Khumalo, Hezekiel M.; Khan, Rene B. published an article in 2021. The article was titled 《Di-2-picolylamine triggers caspase-independent apoptosis by inducing oxidative stress in human liver hepatocellular carcinoma cells》, and you may find the article in Biotechnology and Applied Biochemistry.Application of 1539-42-0 The information in the text is summarized as follows:

The basis of this study was to determine the effects of DPA on the proliferation and apoptosis of human hepatocellular carcinoma cells and elucidate the possible mechanisms. The methylthiazol tetrazolium assay served to measure cell viability and generated an IC50 of 1591μM. Luminometry was used to investigate caspase activity and ATP concentration It was observed that the decreased cell viability was associated with reduced ATP levels. Despite increased Bax and caspase 9 activity, cell death was caspase independent as indicated by the reduction in caspase 3/7 activity. This was associated with the downregulation poly(ADP-ribose) polymerase cleavage (Western blotting). However, the Hoescht assay depicted nuclear condensation and apoptotic body formation with elevated DPA levels suggesting DNA damage in HepG2 cells. DNA damage assessed by the comet assay confirmed an increased comet tail formation. The presence of oxidative stress was investigated by quantifying reactive species (malondialdehyde and nitrates concentration) and Western blotting to confirm the expression of antioxidant proteins. The DPA increased lipid peroxidation (RNS), a marker of oxidative stress, consequently causing cell death. The accompanying upregulation of stress-associated proteins superoxide dismutase (SOD2), nuclear factor (erythroid-derived 2)-like 2 (Nrf2), and Hsp70 verifies oxidative stress. In addition to this study using Bis(pyridin-2-ylmethyl)amine, there are many other studies that have used Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Application of 1539-42-0) was used in this study.

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Application of 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kurose, Ayako; Ishida, Yuto; Hirata, Goki; Nishikata, Takashi published their research in Angewandte Chemie, International Edition in 2021. The article was titled 《Direct α-Tertiary Alkylations of Ketones in a Combined Copper-Organocatalyst System》.Product Details of 1122-54-9 The article contains the following contents:

Herein, we report an efficient method for the tertiary alkylation of a ketone by using an α-bromocarbonyl compound as the tertiary alkyl source in a combined Cu-organocatalyst system. This dual catalyst system enables the addition of a tertiary alkyl radical to an enamine. Mechanistic studies revealed that the catalytically generated enamine is a key intermediate in the catalytic cycle. The developed method can be used to synthesize substituted 1,4-dicarbonyl compounds containing quaternary carbons bearing various alkyl chains. The experimental process involved the reaction of 4-Acetylpyridine(cas: 1122-54-9Product Details of 1122-54-9)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Product Details of 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Yin, Chengyang; Liu, Shuang; Qin, Zhaoxian; Zhang, Yifei; Li, Gao; Zhao, Zhen published their research in European Journal of Inorganic Chemistry in 2021. The article was titled 《Butterfly-Like Tetranuclear Copper(I) Clusters for Efficient Alkyne Homocoupling Reactions》.Application of 2510-22-7 The article contains the following contents:

In this work, we here prepare a new tetranuclear CuI cluster with a precise configuration of Cu4(PPh3)4(bis(prop-2-ynyloxy)biphenyl)2. X-ray single-crystal diffraction shows that the bi-alkynyl ligands bind to two Cu atoms via a σ-bond and to the other two Cu atoms via a π-bond configuration, presenting a new alkynyl-Cu motif and a butterfly-like framework. Cu4(PPh3)4L2 clusters exhibit photoluminescence property at 410 and 505 nm. Cu4(PPh3)4L2 clusters also give good performances in the alkyne homocoupling reactions after its immobilization on different oxides. The copper(I) species is proved to be the catalytic active site during the homocoupling reactions. And the basic property of the oxides (e. g. NiO) can promote the coupling catalysis, and a side-group effect of the alkyne reactants is distinctly observed In all, this study extends the catalytic application of the copper clusters to the carbon-carbon coupling reactions and gives some cue to develop the potential exploitation of copper clusters in other organic transformations. In addition to this study using 4-Ethynylpyridine, there are many other studies that have used 4-Ethynylpyridine(cas: 2510-22-7Application of 2510-22-7) was used in this study.

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Application of 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Synthesis of Pd@graphene oxide framework nanocatalyst with enhanced activity in Heck-Mizoroki cross-coupling reaction》 was written by Shekarizadeh, Arezoo; Azadi, Roya. Computed Properties of C5H5BrN2 And the article was included in Applied Organometallic Chemistry in 2020. The article conveys some information:

A new method was developed for producing a catalyst involving a Pd nanoparticle (NP) embedded in a graphene oxide framework (Pd@GOF) with ordered macro- and mesoporous structures. First, 5,5′-diamino-2,2′-bipyridine was selected as crosslinking for covalent modification of GO nanosheets to prepare a 3-dimensional (3D) framework with interlayer spaces in which well-dispersed and ultra-small Pd NPs in situ grew and embedded the framework. The synthesized nanopores 3D Pd@GOF can act as nanoreactors to help the reaction substrates thoroughly come into contact with the surface of Pd NPs, thereby exhibiting high activity toward the Heck reaction, rarely reported concerning Pd NPs supported on 1-side functionalized graphene. The Pd@GOF catalyst can be used 10 times without any significant loss in the catalytic activity, confirming the long-term stability of this catalyst. The covalently assembled GOF was proposed as a universal platform for hosting noble metal NPs to construct the desired metal@GOF nanocatalyst with improved activity and stability that can be used in a broad range of practical applications. In the part of experimental materials, we found many familiar compounds, such as 6-Bromopyridin-3-amine(cas: 13534-97-9Computed Properties of C5H5BrN2)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Computed Properties of C5H5BrN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem