Tag: 100-200

Application of 53939-30-3In 2019 ,《Quaternary Centers by Nickel-Catalyzed Cross-Coupling of Tertiary Carboxylic Acids and (Hetero)Aryl Zinc Reagents》 was published in Angewandte Chemie, International Edition. The article was written by Chen, Tie-Gen; Zhang, Haolin; Mykhailiuk, Pavel K.; Merchant, Rohan R.; Smith, Courtney A.; Qin, Tian; Baran, Phil S.. The article contains the following contents:

This work bridges a gap in the cross-coupling of aliphatic redox-active esters with aryl zinc reagents. Previously limited to primary, secondary, and specialized tertiary centers, a new protocol has been devised to enable the coupling of general tertiary systems using nickel catalysis. The scope of this operationally simple method is broad, and it can be used to simplify the synthesis of medicinally relevant motifs bearing quaternary centers. In the experiment, the researchers used many compounds, for example, 5-Bromo-2-chloropyridine(cas: 53939-30-3Application of 53939-30-3)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Application of 53939-30-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

SDS of cas: 2510-22-7In 2019 ,《Sequentially Pd/Cu-Catalyzed Alkynylation-Oxidation Synthesis of 1,2-Diketones and Consecutive One-Pot Generation of Quinoxalines》 was published in European Journal of Organic Chemistry. The article was written by Niesobski, Patrik; Martinez, Ivette Santana; Kustosz, Sebastian; Mueller, Thomas J. J.. The article contains the following contents:

We report a simple and efficient one-pot synthesis of 1,2-diketones by concatenation of two Pd/Cu-catalyzed processes: Pd0/CuI-catalyzed Sonogashira coupling of terminal alkynes with aryl (pseudo)halides furnishes internal alkynes, which are directly transformed by PdII/CuII-catalyzed Wacker-type oxidation with DMSO and oxygen as dual oxidants to furnish 1,2-diketones. With this efficient, catalyst economical process, various aryl iodides and triflates are efficiently transformed in high yields into sym. and unsym. substituted 1,2-diketones with various functional groups. This process can be readily extended to a consecutive one-pot synthesis of quinoxalines in a diversity-oriented fashion. In the experiment, the researchers used many compounds, for example, 4-Ethynylpyridine(cas: 2510-22-7SDS of cas: 2510-22-7)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. SDS of cas: 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of C5H7N3In 2021 ,《Tris(oxalato)chromate(III) hybrid salts templated by pyridinium and mixed pyridinium-ammonium cations: synthesis, structures and magnetism》 was published in Journal of Coordination Chemistry. The article was written by Choubeu, Coustel M. N.; Ndosiri, Bridget N.; Vezin, Herve; Minaud, Claire; Orton, James B.; Coles, Simon J.; Nenwa, Justin. The article contains the following contents:

By modifying the stoichiometric ratio of starting materials, two tris(oxalato)chromate(III) salts, (C7H11N2)3[Cr(C2O4)3] and (C5H8N3)2(NH4)[Cr(C2O4)3]·2H2O {(C7H11N2)+ = 2-amino-4,6-dimethylpyridinium, (C5H8N3)+ = 2,6-diaminopyridinium}, were synthesized and characterized by elemental and thermal analyses, single-crystal x-ray diffraction, IR and UV – visible spectroscopies, EPR and SQUID measurements. Salt exhibits a 3-D supramol. framework based on [Cr(C2O4)3]3- and 2-amino-4,6-dimethylpyridinim cations, (C7H11N2)+, via N-H···O hydrogen bonds. π-π Stacking interactions between pyridine rings contribute to the stabilization of the crystal packing. In contrast to salt, no π-π stacking interactions are observed in the mixed-cation salt and its crystal packing is consolidated by N-H···O and O – H···O hydrogen bonds. EPR spectra of and are consistent with the oxidation state +3 of the chromium center in an octahedral environment. Temperature-dependence of the magnetic susceptibility data studied from 2 to 300 K revealed the existence of zero-field splitting effects (ZFS) for Cr(III) ions in both compounds In the experiment, the researchers used 2,6-Diaminopyridine(cas: 141-86-6Synthetic Route of C5H7N3)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Synthetic Route of C5H7N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Gottwald, Dominique; Geidel, Christian; Rueffer, Tobias; Schaarschmidt, Dieter; Lang, Heinrich published an article in Journal of Organometallic Chemistry. The title of the article was 《Heterodi-, -tri- and -tetrametallic Transition-Metal-Complexes》.Safety of 4-Ethynylpyridine The author mentioned the following in the article:

Complexes trans-[Pt(CCMc)2(PBu3)2] (Mc = Fc = Fe(n5-C5H4)(n5-C5H5) (3), [1,2] Mc = Rc = Ru(n5-C5H4)(n5-C5H5) (4)) were synthesized by treatment of cis-[PtCl2(PBu3)2] with McCCH (Mc = Fc (1), Rc (2)). The synthesis of trans-[Pt(PR3)2(CCFc)(CCR’)] (R = Bu: R’ = H (7a), R’ = PPh2 (7b), R’ = Rc (7c); R = Ph: R’ = 4-C5H4N (8a), R’ = C6H4-4-CN (8b), R’ = 2,2′-bipyridin-5-yl (8c), R’ = C6H4-4-CCH (8d)) was realized by the reaction of trans-[PtCl(PR3)2(CCFc)] (R = Bu (5), R = Ph (6)) with alkynes HCCR’. Treatment of 8a with [RuCl2(cymene)]2 (cymene = η6-1-Me-4-iPr-C6H4) or [Rh(η5-C5Me5)Cl2]2 and of 8c with [Mo(CO)4(2,5-norbornadiene)] or [Mn(CO)5Br] led to heterotrimetallic trans-[Pt(PPh3)2(CCFc)(CCR’-{M})] (R’ = 4-C5H4N: {M} = Ru(η6-cymene)Cl2 (10a), = Rh(η5-C5Me5)Cl2 (10b); R’ = 2,2′-bipyridin-5-yl: {M} = Mo(CO)4 (11a), = Mn(CO)3Br (11b)). When 8b,c were reacted with [{[Ti](μ-σ,π-CCSiMe3)2}Cu(MeCN)][PF6] ([Ti] = Ti(η5-C5H4SiMe3)2) then heterotetrametallic trans-[Pt(PPh3)2(CCFc)(CCR’-{M})][PF6] {M} = [Ti](μ-σ,π-CCSiMe3)2Cu: R’ = 2,2′-bipyridin-5-yl (11c), R’ = -C6H4-4-CN (11d) were produced. Compounds 3, 4 and 7c were characterized by single-crystal X-ray diffraction studies establishing the trans arrangement at Pt. The electrochem. behavior of all compounds was investigated by CV showing reversible redox events for Fc in 3, 7a,c, 8a-d, 10a,b, 11b,c in the range of E°1′ = -120 – -85 mV, while M feature irreversible redox processes between 745 and 1230 mV. In addition to this study using 4-Ethynylpyridine, there are many other studies that have used 4-Ethynylpyridine(cas: 2510-22-7Safety of 4-Ethynylpyridine) was used in this study.

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Safety of 4-Ethynylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Wang, Ze-Shu; Zhu, Lu-Jing; Li, Cui-Ting; Liu, Bin-Yang; Hong, Xin; Ye, Long-Wu published an article in Angewandte Chemie, International Edition. The title of the article was 《Synthesis of Axially Chiral N-Arylindoles via Atroposelective Cyclization of Ynamides Catalyzed by Chiral Broensted Acids》.Recommanded Product: 128071-75-0 The author mentioned the following in the article:

In recent years, asym. catalysis of ynamides has attracted much attention, but these reactions mostly constructed central chirality, except for a few examples on the synthesis of axially chiral compounds which exclusively relied on noble-metal catalysis. Herein, a facile access to axially chiral N-heterocycles enabled by chiral Broensted acid-catalyzed 5-endo-dig cyclization of ynamides is disclosed, which represents the first metal-free protocol for the construction of axially chiral compounds from ynamides. This method allows the practical and atom-economical synthesis of valuable N-arylindoles in excellent yields with generally excellent enantioselectivities. Moreover, organocatalysts and ligands based on such axially chiral N-arylindole skeletons are demonstrated to be applicable to asym. catalysis. The results came from multiple reactions, including the reaction of 2-Bromonicotinaldehyde(cas: 128071-75-0Recommanded Product: 128071-75-0)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Recommanded Product: 128071-75-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wang, Peng-Fei; Yu, Jiao; Guo, Kai-Xin; Jiang, Sheng-Peng; Chen, Ji-Jun; Gu, Qiang-Shuai; Liu, Ji-Ren; Hong, Xin; Li, Zhong-Liang; Liu, Xin-Yuan published an article in 2022. The article was titled 《Design of Hemilabile N,N,N-Ligands in Copper-Catalyzed Enantioconvergent Radical Cross-Coupling of Benzyl/Propargyl Halides with Alkenylboronate Esters》, and you may find the article in Journal of the American Chemical Society.Application of 2510-22-7 The information in the text is summarized as follows:

The enantioconvergent radical C(sp3)-C(sp2) cross-coupling of alkyl halides with alkenylboronate esters is an appealing tool in the assembly of synthetically valuable enantioenriched alkenes owing to the ready availability, low toxicity and air/moisture stability of alkenylboronate esters. A copper/chiral N,N,N-ligand catalytic system for the enantioconvergent cross-coupling of benzyl/propargyl halides with alkenylboronate esters (>80 examples) with good functional group tolerance was reported. The key to the success was the rational design of hemilabile N,N,N-ligands by mounting steric hindrance at the ortho position of one coordinating quinoline ring. Thus, the newly designed ligand not only promote the radical cross-coupling process in the tridentate form but also delivered enantiocontrol over highly reactive alkyl radicals in the bidentate form. Facile follow-up transformations highlight its potential utility in the synthesis of various enantioenriched building blocks as well as in the late-stage functionalization for drug discovery.4-Ethynylpyridine(cas: 2510-22-7Application of 2510-22-7) was used in this study.

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Application of 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Non-chelating p-phenylidene-linked bis-imidazoline analogs of known influenza virus endonuclease inhibitors: Synthesis and anti-influenza activity》 were Dar’in, Dmitry; Zarubaev, Vladimir; Galochkina, Anastasia; Gureev, Maxim; Krasavin, Mikhail. And the article was published in European Journal of Medicinal Chemistry in 2019. Electric Literature of C5H6BNO2 The author mentioned the following in the article:

A novel chemotype topol. similar to known influenza virus PA endonuclease inhibitors was designed. It was aimed to reproduce the extended topol. of the known metal-chelating ligands with a p-phenylidene-linked bis-imidazoline scaffold. It was envisioned that aromatic groups introduced to this scaffolds via metal-catalyzed N-arylation (Buchwald-Hartwig or Chan-Evans-Lam) would contribute to lipophilic binding to the target and one of the imidazoline nitrogen atoms would ensure non-chelating coordination to the prosthetic divalent metal ion. The compounds displayed appreciable anti-influenza activity in vitro and substantial concentration window from the general cytotoxicity range. Docking anal. of low-energy poses of the most active compound (as well as their comparison to the binding of an inactive compound) revealed that these compounds reproduced similar binding components to a known PA endonuclease inhibitor and displayed similar binding pose and desired monodentate metal coordination, as was initially envisioned. These findings warrant further study of the mechanism of action of the newly discovered series. In addition to this study using 2-Pyridinylboronic acid, there are many other studies that have used 2-Pyridinylboronic acid(cas: 197958-29-5Electric Literature of C5H6BNO2) was used in this study.

2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Electric Literature of C5H6BNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Graphene Oxide as a Carbocatalyst for Sustainable ipso-Hydroxylation of Arylboronic Acids: A Simple and Straightforward Strategy To Access Phenols》 were Karthik, Murugan; Suresh, Palaniswamy. And the article was published in ACS Sustainable Chemistry & Engineering in 2019. COA of Formula: C5H6BNO2 The author mentioned the following in the article:

A metal-free and straightforward protocol for the synthesis of phenols from aryl and heteroaryl boronic acids has been demonstrated using graphene oxide as a carbocatalyst. This sustainable ipso-hydroxylation takes place under mild conditions using aqueous H2O2 as an oxidant in a water medium in a short time under organocatalytic and base-free conditions. The control experiments reveal that the presence of carboxyl groups promotes ipso-hydroxylation. The developed methodol. offers GO as a benign solid-acid catalyst with good sustainability which can be reused several times without significant loss in its catalytic activities; this was proven by the Fourier transform IR and powder X-ray diffraction studies of the reused catalyst. In the experiment, the researchers used Pyridin-3-ylboronic acid(cas: 1692-25-7COA of Formula: C5H6BNO2)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. COA of Formula: C5H6BNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Structure characterization and antitumor activity of palladium pseudo halide complexes with 4-acetylpyridine》 were El-bendary, Mohamed M.; Arshad, Muhammad N.; Asiri, Abdullah M.. And the article was published in Journal of Coordination Chemistry in 2019. Related Products of 1122-54-9 The author mentioned the following in the article:

The addition of an aqueous solution of palladium chloride to an aqueous acetonitrile solution of 4-acetylpyridine (4-Acpy) and KSCN or NaN3 produces new complexes, [Pd(SCN)2(4-Acpy)2] (1) and [Pd(N3)2(4-Acpy)2] (2), at ambient conditions. Complexes 1 and 2 were characterized by elemental anal., FTIR, and UV-Visible spectra. The structures of 1 and 2 were determined by single crystal x-ray diffraction. The coordination geometry around the palladium center is distorted square planar in 1 and 2 as the palladium is coordinated with two 4-acetylpyridine and two thiocyanates in 1 or two azide groups in 2. The discrete units of 1 and 2 extend along the a-axis creating a 1 D-chain via noncovalent hydrogen bonds. The extensive noncovalent hydrogen bonds extend the structure of 1 and 2 to 3-dimensional-networks. Using MTT assay, the cytotoxic activities of 1 and 2 were screened against two cancer cell lines, HePG-2 (liver cancer) and MCF-7 (breast cancer). The MTT assay revealed that the cytotoxic activity of 1 is stronger than 2 for HePG-2 and MCF-7. Antioxidant and anti-hemolytic activities of 1 and 2 were examined Also, the luminescence spectra in the solid state of 1 and 2 are discussed. In the experiment, the researchers used 4-Acetylpyridine(cas: 1122-54-9Related Products of 1122-54-9)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Related Products of 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《A Single-Crystal Open-Capsule Metal-Organic Framework》 were Wei, Yong-Sheng; Zhang, Mei; Kitta, Mitsunori; Liu, Zheng; Horike, Satoshi; Xu, Qiang. And the article was published in Journal of the American Chemical Society in 2019. Application In Synthesis of 4-Acetylpyridine The author mentioned the following in the article:

Micro-/nanocapsules have received substantial attention due to various potential applications for storage, catalysis, and drug delivery. However, their conventional enclosed non-/polycrystalline walls pose huge obstacles for rapid loading and mass diffusion. Here, the authors present a new single-crystal capsular-MOF with openings on the wall, which is carefully designed at the mol. level and constructed from a crystal-structure transformation. This rare open-capsule MOF can easily load the largest amounts of S and I among known MOFs. Derived from capsular-MOF and melamine through pyrolysis-phosphidation, the authors fabricated a N-doped capsular C-based framework with Fe-Ni phosphide nanoparticles immobilized on capsular carbons interconnected by plentiful carbon nanotubes. Benefiting from synergistic effects between the C framework and highly surface-exposed phosphide sites, the material exhibits efficient multifunctional electrocatalysis for O evolution, H evolution, and O reduction, achieving well-qualified assemblies of an overall H2O splitting (low potential of 1.59 V at 10 mA cm-2) and a rechargeable Zn-air battery (high peak power d. of 250 mW cm-2 and excellent stability for 500 h), which afford remarkably practical prospects over previously known electrocatalysts. In the experimental materials used by the author, we found 4-Acetylpyridine(cas: 1122-54-9Application In Synthesis of 4-Acetylpyridine)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Application In Synthesis of 4-Acetylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem