Tag: 100-200

In 2018,Puttreddy, Rakesh; von Essen, Carolina; Rissanen, Kari published 《Halogen Bonds in Square Planar 2,5-Dihalopyridine-Copper(II) Bromide Complexes》.European Journal of Inorganic Chemistry published the findings.Recommanded Product: 53939-30-3 The information in the text is summarized as follows:

Halogen bonding in self-complementary 1:2 metal-ligand complexes obtained from copper(II) bromide (CuBr2) and seven 2,5-dihalopyridines were analyzed using single-crystal x-ray diffraction. All presented discrete complexes form 1D polymeric chains connected with C-X···Br-Cu halogen bonds (XB). In (2-chloro-5-X-pyridine)2·CuBr2 (X = Cl, Br, and I) only the C5-halogen and in (2-bromo-5-X-pyridine)2·CuBr2 (X = Cl, Br, and I) both C2- and C5-halogens form C-X···Br-Cu halogen bonds with the X acting as the XB donor and copper-coordinated bromide as the XB acceptor. The electron-withdrawing C2-chloride in (2-chloro-5-X-pyridine)2·CuBr2 complexes has only a minor effect on the C5-X5···Br-Cu XBs, and the X5···Br distances follow the expected order I5 < Br5 < Cl5 with RXB values of 0.91, 0.94, and 0.99, resp. In (2-bromo-5-X-pyridine)2·CuBr2 complexes, due to the polarization of both halogens, the C2-X2···Br-Cu and C5-X5···Br-Cu RXB values are very similar [0.92-0.99] as a result of the competition between C2- and C5-halogens for XB formation. In addition to the classical halogen bonds, the square-planar CuII complexes exhibit C2-X2···Cu(X = Cl and Br) contacts perpendicular to the Br-Cu-Br plane with shorter C2-Br2···Cu than C2-Cl2···Cu contacts. These interactions induce a pseudo-octahedral geometry for CuII ions. Notably, C2-X2···Br-Cu halogen bonds and the addnl. C2-X2···Cu contacts are slightly enhanced by the C5-halogen electronegativity. In the experiment, the researchers used many compounds, for example, 5-Bromo-2-chloropyridine(cas: 53939-30-3Recommanded Product: 53939-30-3)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Recommanded Product: 53939-30-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Pollice, Robert; Bot, Marek; Kobylianskii, Ilia J.; Shenderovich, Ilya; Chen, Peter published 《Attenuation of London Dispersion in Dichloromethane Solutions》.Journal of the American Chemical Society published the findings.Safety of 2-Bromonicotinaldehyde The information in the text is summarized as follows:

London dispersion constitutes one of the fundamental interaction forces between atoms and between mols. While modern computational methods have been developed to describe the strength of dispersive interactions in the gas phase properly, the importance of inter- and intramol. dispersion in solution remains yet to be fully understood because exptl. data are still sparse in that regard. We herein report a detailed exptl. and computational study of the contribution of London dispersion to the bond dissociation of proton-bound dimers, both in the gas phase and in dichloromethane solution, showing that attenuation of inter- and intramol. dispersive interaction by solvent is large (about 70% in dichloromethane), but not complete, and that current state-of-the-art implicit solvent models employed in quantum-mech. computational studies treat London dispersion poorly, at least for this model system. The results came from multiple reactions, including the reaction of 2-Bromonicotinaldehyde(cas: 128071-75-0Safety of 2-Bromonicotinaldehyde)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Safety of 2-Bromonicotinaldehyde

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2013,Majo, Vattoly J.; Arango, Victoria; Simpson, Norman R.; Prabhakaran, Jaya; Kassir, Suham A.; Underwood, Mark D.; Bakalian, Mihran; Canoll, Peter; John Mann, J.; Dileep Kumar, J. S. published 《Synthesis and in vitro evaluation of [18F]BMS-754807: A potential PET ligand for IGF-1R》.Bioorganic & Medicinal Chemistry Letters published the findings.Computed Properties of C5H5BrN2 The information in the text is summarized as follows:

Radiosynthesis and in vitro evaluation of [18F](S)-1-(4-((5-cyclopropyl-1H-pyrazol-3-yl)amino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)-N-(6-fluoropyridin-3-yl)-2-methylpyrrolidine-2-carboxamide ([18F]BMS-754807 or [18F] I) a specific IGF-1R inhibitor was performed. [18F]I demonstrated specific binding in vitro to human cancer tissues. Synthesis of reference standard II(X= F) and corresponding bromo derivative II(X = X = Br), the precursor for radiolabeling were achieved from 2,4-dichloropyrrolo[2,1-f][1,2,4]triazine in three steps with 50% overall yield. The radioproduct was obtained in 8% yield by reacting 1a with [18F]TBAF in DMSO at 170 °C at high radiochem. purity and specific activity (1-2 Ci/μmol, N = 10). The proof of concept of IGF-IR imaging with [18F]I was demonstrated by in vitro autoradiog. studies using pathol. identified surgically removed grade IV glioblastoma, breast cancer and pancreatic tumor tissues. These studies indicate that [18F]I can be a potential PET tracer for monitoring IGF-1R. In addition to this study using 6-Bromopyridin-3-amine, there are many other studies that have used 6-Bromopyridin-3-amine(cas: 13534-97-9Computed Properties of C5H5BrN2) was used in this study.

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Computed Properties of C5H5BrN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Investigating the effects of thickness on the performance of ZnO-based DSSC》 was written by Kouhestanian, E.; Ranjbar, M.; Mozaffari, S. A.; Salaramoli, H.. Category: pyridine-derivativesThis research focused onzinc oxide dye sensitized solar cell investigating effect. The article conveys some information:

Zinc oxide nanostructures exhibit unique properties which make them suitable for dye-sensitized solar cell applications. Their specific properties such as appropriate optical properties, proper energy band gap and high electron transfer characteristics have motivated researchers to use them in the fabrication of dye-sensitized solar cell photo-anodes. In the present study, the effect of thickness on the performance of a new ZnO photo-anode has been studied. All the photovoltaic parameters of the cells fabricated using N719 ruthenium dye were measured. SEM technique was utilized to determine the thickness and the UV-Visible method was used to study the transparent properties of the photo-anodes. Electrochem. impedance spectroscopy technique was employed to determine the appropriate equivalent circuit for studying the electron transfer mechanisms in all the fabricated cells. The results demonstrated that the ZnO thickness is a critical parameter for providing either sufficient resistance to suppress the charge recombination process or appropriate electron transferring properties. The optimized ZnO photo-anode was obtained at a thickness of 19μm, which resulted in an efficiency of 3.22%. In addition to this study using 2,6-Diaminopyridine, there are many other studies that have used 2,6-Diaminopyridine(cas: 141-86-6Category: pyridine-derivatives) was used in this study.

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Quality Control of Pyridin-3-ylboronic acidIn 2020 ,《Utilization of Multi-Heterodonors in Thermally Activated Delayed Fluorescence Molecules and Their High Performance Bluish-Green Organic Light-Emitting Diodes》 was published in ACS Applied Materials & Interfaces. The article was written by Balijapalli, Umamahesh; Tanaka, Masaki; Auffray, Morgan; Chan, Chin-Yiu; Lee, Yi-Ting; Tsuchiya, Youichi; Nakanotani, Hajime; Adachi, Chihaya. The article contains the following contents:

We report a series of pentacarbazolyl-benzonitrile derivatives such as 2,4,6-tri(9H-carbazol-9-yl)-3,5-bis(3,6-di(pyridin-3-yl)-9H-carbazol-9-yl)benzonitrile (mPyBN), 3,5-bis(3,6-bis(4-(trifluoromethyl)phenyl)-9H-carbazol-9-yl)-2,4,6-tri(9H-carbazol-9-yl)benzonitrile (pCF3BN), 2,4,6-tri(9H-carbazol-9-yl)-3-(3,6-di(pyridin-3-yl)-9H-carbazol-9-yl)-5-(3,6-diphenyl-9H-carbazol-9-yl)benzonitrile (PyPhBN), 3-(3,6-bis(4-(trifluoromethyl)phenyl)-9H-carbazol-9-yl)-2,4,6-tri(9H-carbazol-9-yl)-5-(3,6-di(pyridin-3-yl)-9H-carbazol-9-yl)benzonitrile (PyCF3BN), and 3-(3,6-bis(4-(trifluoromethyl)phenyl)-9H-carbazol-9-yl)-2,6-di(9H-carbazol-9-yl)-5-(3,6-di(pyridin-3-yl)-9H-carbazol-9-yl)-4-(9H-pyrido[3,4-b]indol-9-yl)benzonitrile (CbPyCF3BN) in which some of the carbazoles are substituted with modified 3,5-di-Ph carbazoles, exhibiting thermally activated delayed fluorescence (TADF) properties. These emitters comprised two, three, and four different types of donors, capable of bluish-green emission of around 480 nm with relatively high photoluminescence quantum yields over 90% in solution Emitters, namely, PyPhBN, PyCF3BN, and CbPyCF3BN, composed of three and four different types of donors endowed a rather short delayed lifetime (τd) of 4.25, 5.01, and 3.65μs in their film state, resp. Bluish-green organic light-emitting diodes based on PyPhBN, PyCF3BN, and CbPyCF3BN exhibit a high external quantum efficiency of 20.6, 19.5, and 19.6%, resp., with unsurpassed efficiency roll-off behavior. These results indicate that the TADF properties of multidonor type mols. can be manipulated by controlling the types and number of electron donor units.Pyridin-3-ylboronic acid(cas: 1692-25-7Quality Control of Pyridin-3-ylboronic acid) was used in this study.

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Quality Control of Pyridin-3-ylboronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Quality Control of Pyridin-3-ylboronic acidIn 2020 ,《Chan-Evans-Lam N1-(het)arylation and N1-alkenylation of 4-fluoroalkylpyrimidin-2(1H)-ones》 was published in Beilstein Journal of Organic Chemistry. The article was written by Tkachuk, Viktor M.; Lukianov, Oleh O.; Vovk, Mykhailo V.; Gillaizeau, Isabelle; Sukach, Volodymyr A.. The article contains the following contents:

The Chan-Evans-Lam reaction of 1-unsubstituted 4-fluoroalkylpyrimidin-2(1H)-ones with arylboronic acids was reported as a facile synthetic route to hitherto unavailable N1-(het)aryl and N1-alkenyl derivatives of the corresponding pyrimidines I [R = CH=CH2, Ph, 3-thienyl, etc.; R1 = CHF2, CF3, C2F5, CClF2; R2 = H, Br, CO2Me]. An efficient C-N bond-forming process was also observed by using boronic acid pinacol esters as coupling partners in the presence of Cu(II) acetate and boric acid. The 4-fluoroalkyl group on the pyrimidine ring significantly assists in the formation of the target N1-substituted products, in contrast to the 4-Me and 4-unsubstituted substrates which did not undergo N1-arylation under similar reaction conditions. In the experiment, the researchers used Pyridin-3-ylboronic acid(cas: 1692-25-7Quality Control of Pyridin-3-ylboronic acid)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Quality Control of Pyridin-3-ylboronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Name: 2-Bromo-5-methylpyridineIn 2019 ,《Anti-Markovnikov Hydroamination of Unactivated Alkenes with Primary Alkyl Amines》 was published in Journal of the American Chemical Society. The article was written by Miller, David C.; Ganley, Jacob M.; Musacchio, Andrew J.; Sherwood, Trevor C.; Ewing, William R.; Knowles, Robert R.. The article contains the following contents:

A photocatalytic method for the intermol. anti-Markovnikov hydroamination of unactivated olefins with primary alkyl amines to selectively furnish secondary amine products is reported. These reactions proceed through aminium radical cation (ARC) intermediates and occur at room temperature under visible light irradiation in the presence of an iridium photocatalyst and an aryl thiol hydrogen atom donor. Despite the presence of excess olefin, high selectivities are observed for secondary over tertiary amine products, even though the secondary amines are established substrates for ARC-based olefin amination under similar conditions.2-Bromo-5-methylpyridine(cas: 3510-66-5Name: 2-Bromo-5-methylpyridine) was used in this study.

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Name: 2-Bromo-5-methylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 5-Bromo-2-chloropyridineIn 2013 ,《Discovery of SAR184841, a potent and long-lasting inhibitor of 11β-hydroxysteroid dehydrogenase type 1, active in a physiopathological animal model of T2D》 was published in Bioorganic & Medicinal Chemistry Letters. The article was written by Venier, Olivier; Pascal, Cecile; Braun, Alain; Namane, Claudie; Mougenot, Patrick; Crespin, Olivier; Pacquet, Francois; Mougenot, Cecile; Monseau, Catherine; Onofri, Benedicte; Dadji-Faihun, Rommel; Leger, Celine; Ben-Hassine, Majdi; Van-Pham, Thao; Ragot, Jean-Luc; Philippo, Christophe; Farjot, Geraldine; Noah, Lionel; Maniani, Karima; Boutarfa, Asma; Nicolai, Eric; Guillot, Etienne; Pruniaux, Marie-Pierre; Gussregen, Stefan; Engel, Christian; Coutant, Anne-Laure; de Miguel, Beatriz; Castro, Antonio. The article contains the following contents:

Starting from 11β-HSD1 inhibitors that were active ex vivo but with Cyp 3A4 liability, we obtained a new series of adamantane ureas displaying potent inhibition of both human and rodent 11β-HSD1 enzymes, devoid of Cyp 3A4 interactions, and rationally designed to provide long-lasting inhibition in target tissues. Final optimizations lead to SAR184841 with good oral pharmacokinetic properties showing in vivo activity and improvement of metabolic parameters in a physiopathol. model of type 2 diabetes. After reading the article, we found that the author used 5-Bromo-2-chloropyridine(cas: 53939-30-3Reference of 5-Bromo-2-chloropyridine)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Reference of 5-Bromo-2-chloropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

SDS of cas: 1134-35-6In 2020 ,《Rationally Designed Long-Wavelength Absorbing Ru(II) Polypyridyl Complexes as Photosensitizers for Photodynamic Therapy》 was published in Journal of the American Chemical Society. The article was written by Karges, Johannes; Heinemann, Franz; Jakubaszek, Marta; Maschietto, Federica; Subecz, Chloe; Dotou, Mazzarine; Vinck, Robin; Blacque, Olivier; Tharaud, Mickael; Goud, Bruno; Vinuelas Zahinos, Emilio; Spingler, Bernhard; Ciofini, Ilaria; Gasser, Gilles. The article contains the following contents:

The utilization of photodynamic therapy (PDT) for the treatment of various types of cancer has gained increasing attention over the last decades. Despite the clin. success of approved photosensitizers (PSs), their application is sometimes limited due to poor water solubility, aggregation, photodegradation, and slow clearance from the body. To overcome these drawbacks, research efforts are devoted toward the development of metal complexes and especially Ru(II) polypyridine complexes based on their attractive photophys. and biol. properties. Despite the recent research developments, the vast majority of complexes utilize blue or UV-A light to obtain a PDT effect, limiting the penetration depth inside tissues and, therefore, the possibility to treat deep-seated or large tumors. To circumvent these drawbacks, we present the first example of a DFT guided search for efficient PDT PSs with a substantial spectral red shift toward the biol. spectral window. Thanks to this design, we have unveiled a Ru(II) polypyridine complex that causes phototoxicity in the very low micromolar to nanomolar range at clin. relevant 595 nm, in monolayer cells as well as in 3D multicellular tumor spheroids.4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6SDS of cas: 1134-35-6) was used in this study.

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.SDS of cas: 1134-35-6 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 4,4′-Dimethyl-2,2′-bipyridineIn 2020 ,《A Multi-action and Multi-target RuII-PtIV Conjugate Combining Cancer-Activated Chemotherapy and Photodynamic Therapy to Overcome Drug Resistant Cancers》 was published in Angewandte Chemie, International Edition. The article was written by Karges, Johannes; Yempala, Thirumal; Tharaud, Mickael; Gibson, Dan; Gasser, Gilles. The article contains the following contents:

PtII complexes are commonly used to treat cancer. To reduce their side effects and improve their pharmacol. properties, PtIV complexes are being developed as prodrug candidates that are activated by reduction in cancer cells. Concomitantly, RuII polypyridine complexes have gained much attention as photosensitizers for use in photodynamic therapy due to their attractive characteristics. In this article, a novel PtIV-RuII conjugate, which combines cancer activated chemotherapy with PDT, is presented. Upon entering the cancer cell, the PtIV center is reduced to PtII and the axial ligands including the RuII complex and phenylbutyrate are released. As each component has its individual targets, the conjugate exerts a multi-target and multi-action effect with (photo-)cytotoxicity values upon irradiation up to 595 nm in the low nanomolar range in various (drug resistant) 2D monolayer cancer cells and 3D multicellular tumor spheroids. In the experiment, the researchers used many compounds, for example, 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Reference of 4,4′-Dimethyl-2,2′-bipyridine)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.Reference of 4,4′-Dimethyl-2,2′-bipyridine Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem