Tag: 100-200

Watanabe, Hiroyuki; Tanaka, Kazuo; Chujo, Yoshiki published an article in 2021. The article was titled 《The Effect of the Substituent Positions on Self-Assembly Behaviors of Liquid-Crystalline 1,3,4,6,9b-Pentaazaphenalene Derivatives》, and you may find the article in Bulletin of the Chemical Society of Japan.Synthetic Route of C5H7N3 The information in the text is summarized as follows:

The syntheses and phase transition behaviors of liquid crystals composed of triangular π;-conjugated mols., 1,3,4,6,9b-pentaazaphenalene (5AP) was discussed. Three types of 5AP derivatives having 3,4,5-tris(dodecyloxy)phenyl ((OC12)3Ph) were prepared by changing substituent positions. From thermal and structural analyses, liquid crystalline phases were observed from all derivatives According to structural data and phase transition behaviors, it was suggested that the positions of the substituents significantly influence mol. alignments in liquid crystals as well as thermal properties. In particular, the columnar structures, which were favorable for expressing efficient carrier transportation, were observed in the 5AP derivative These results suggested that the 5AP scaffold could be a platform for constructing a variety of aggregated structures by slightly different patterns of the mol. structures. Plausible models for these transitions were discussed. The experimental process involved the reaction of 2,6-Diaminopyridine(cas: 141-86-6Synthetic Route of C5H7N3)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Synthetic Route of C5H7N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kassel, Vincent M.; Hanneman, Christopher M.; Delaney, Connor P.; Denmark, Scott E. published an article in 2021. The article was titled 《Heteroaryl-Heteroaryl Suzuki-Miyaura Anhydrous Cross-Coupling Reactions Enabled by Trimethyl Borate》, and you may find the article in Journal of the American Chemical Society.Product Details of 1692-25-7 The information in the text is summarized as follows:

Reaction conditions have been developed for refractory heteroaryl-heteroaryl Suzuki-Miyaura cross-couplings. The reported method employs neopentyl heteroarylboronic esters as nucleophiles, heteroaryl bromides and chlorides as the electrophiles, and the soluble base potassium trimethylsilanolate (TMSOK) under anhydrous conditions. The addition of tri-Me borate enhances reaction rates by several mechanisms, including (1) solubilization of in situ-generated boronate complexes, (2) preventing catalyst poisoning by the heteroat. units, and (3) buffering the inhibitory effect of excess TMSOK. The use of this method enables cross-coupling of diverse reaction partners including a broad range of π-rich and π-deficient heteroaryl boronic esters and heteroaryl bromides. Reactions proceed in good yields and short reaction times (3 h or less). The results came from multiple reactions, including the reaction of Pyridin-3-ylboronic acid(cas: 1692-25-7Product Details of 1692-25-7)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Product Details of 1692-25-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Bazin, Marc-Antoine; Cojean, Sandrine; Pagniez, Fabrice; Bernadat, Guillaume; Cave, Christian; Ourliac-Garnier, Isabelle; Nourrisson, Marie-Renee; Morgado, Cathy; Picot, Carine; Leclercq, Olivier; Baratte, Blandine; Robert, Thomas; Spath, Gerald F.; Rachidi, Najma; Bach, Stephane; Loiseau, Philippe M.; Le Pape, Patrice; Marchand, Pascal published their research in European Journal of Medicinal Chemistry in 2021. The article was titled 《In vitro identification of imidazo[1,2-a]pyrazine-based antileishmanial agents and evaluation of L. major casein kinase 1 inhibition》.Application of 1692-25-7 The article contains the following contents:

Leishmaniasis constitutes a severe public health problem, with an estimated prevalence of 12 million cases. This potentially fatal disease has a worldwide distribution and in 2012, the fatal Visceral Leishmaniasis (VL) was declared as new emerging disease in Europe, mainly due to global warming, with expected important public health impact. The available treatments are toxic, costly or lead to parasite resistance, thus there is an urgent need for new drugs with new mechanism of action. Previously, we reported the discovery of CTN1122, a potent imidazo[1,2-a]pyrazine-based antileishmanial hit compound targeting L-CK1.2 at low micromolar ranges. Here, we described structurally related, safe and selective compounds endowed with antiparasitic properties, better than miltefosine, the reference therapy by oral route. L-CK1.2 homol. model gave the first structural explanations of the role of 4-pyridyl (CTN1122) and 2-aminopyrimidin-4-yl (compound 21) moieties, at the position 3 of the central core, in the low micromolar to nanomolar L-CK1.2 inhibition, whereas N-methylpyrazole derivative 11 remained inactive against the parasite kinase. The experimental process involved the reaction of Pyridin-3-ylboronic acid(cas: 1692-25-7Application of 1692-25-7)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Application of 1692-25-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Fricke, Patrick J.; Dolewski, Ryan D.; McNally, Andrew published their research in Angewandte Chemie, International Edition in 2021. The article was titled 《Four-Selective Pyridine Alkylation via Wittig Olefination of Dearomatized Pyridylphosphonium Ylides》.Recommanded Product: 1692-25-7 The article contains the following contents:

Methods to synthesize alkylated pyridines are valuable because these structures are prevalent in pharmaceuticals and agrochems. A distinct approach to construct 4-alkylpyridines using dearomatized pyridylphosphonium ylide intermediates in a Wittig olefination-rearomatization sequence is reported. Pyridine N-activation is key to this strategy, and N-triazinylpyridinium salts enable coupling between a wide variety of substituted pyridines and aldehydes. The alkylation protocol is viable for late-stage functionalization, including methylation of pyridine-containing drugs. This approach represents an alternative to metal-catalyzed sp2-sp3 cross-coupling reactions and Minisci-type processes. In the experiment, the researchers used Pyridin-3-ylboronic acid(cas: 1692-25-7Recommanded Product: 1692-25-7)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Recommanded Product: 1692-25-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Palladium-Catalyzed C-H Alkynylation of Unactivated Alkenes》 was written by Schreib, Benedikt S.; Fadel, Marlene; Carreira, Erick M.. Name: Picolinic acid And the article was included in Angewandte Chemie, International Edition in 2020. The article conveys some information:

Palladium-catalyzed regio- and diastereoselective C-H functionalization with bromoalkynes and electronically unbiased olefins is reported. The picolinamide directing group enables the formation of putative 5 and 6-exo-metallacycles as intermediates to afford monoalkynylated products in up to 91% yield in a stereospecific fashion. The systematic study reveals that substrates with a wide range of substituents on the olefin and bromoalkyne coupling partners are tolerated. Chemoselective transformations were demonstrated for the obtained amides, olefins, and alkynes. In the experiment, the researchers used Picolinic acid(cas: 98-98-6Name: Picolinic acid)

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Name: Picolinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《The synthesis of a hexameric expanded hemiporphyrazine》 was written by Schrage, Briana R.; Chanawanno, Kullapa; Crandall, Laura A.; Ziegler, Christopher J.. Computed Properties of C5H7N3 And the article was included in Journal of Porphyrins and Phthalocyanines in 2020. The article conveys some information:

In this report the synthesis and characterization of a new hexameric expanded hemiporphyrazine which refer to as hexahemiporphyrazine were presented. The synthesis incorporated bis(6-amino-2-pyridyl)amine as a starting material, which could be produced from 2,6-diaminopyridine using melt reaction conditions. Bis(6-amino-2-pyridyl)amine can adopt three different conformations, two of which are observed in the free base and protonated form, and the third in the backbone of hexahemiporphyrazine. Reaction of bis(6-amino-2-pyridyl)amine and diiminoisoindoline in the presence of a catalytic amount of BF3 produces the hexihemiporphyrazine macrocycle, which was characterized spectroscopically and by X-ray crystallog. Structure elucidation reveals two inverted pyridine rings in a configuration reminiscent of that seen in hexaphyrin, however hexahemiporphyrazine lacks cross conjugation across the macrocycle. After reading the article, we found that the author used 2,6-Diaminopyridine(cas: 141-86-6Computed Properties of C5H7N3)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Computed Properties of C5H7N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《The effects of chromium picolinate on glucose and lipid metabolism in running rats》 was published in Journal of Trace Elements in Medicine and Biology in 2020. These research results belong to Pala, Ragip; Sari, Mehmet Akif; Erten, Fusun; Er, Besir; Tuzcu, Mehmet; Orhan, Cemal; Deeh, Patrick Brice Defo; Sahin, Nurhan; Cinar, Vedat; Komorowski, James R.; Sahin, Kazim. COA of Formula: C6H5NO2 The article mentions the following:

We aimed to elucidate the effects of CrPic on glucose and lipid metabolism and the expression of glucose transporters in exercised rats. Forty-two male Wistar rats (8-wk-old) were distributed into six groups (n = 7) as follows: Control, CrPic, Chronic Exercise (CEx), CEx + CrPic, Acute Exercise (AEx), and AEx + CrPic. CrPic was supplemented at 400μg elemental Cr/kg of diet for 6 wk. In the AEx groups, animals were run on the treadmill at 30 m/min until exhaustion. CEx significantly lowered blood glucose (BG), total cholesterol (TC) and triglyceride (TG) levels, but elevated insulin concentration (IC), compared with control (P < 0.05). CEx significantly decreased the level of malondialdehyde (MDA) in the serum, liver, and muscle while AEx elevated it (P < 0.001 for all). CrPic also significantly reduced serum, liver, and muscle MDA levels (P < 0.001). Both AEx and CEx increased the expression of liver glucose transporter 2 (GLUT-2) and muscle GLUT-4 with the highest level in CEx rats (P < 0.05). Moreover, CrPic supplementation significantly elevated GLUT-2 and GLUT-4 expressions in the liver and muscle of sedentary and exercise-treated rats (P < 0.05). CrPic improves various metabolic parameters and reduces oxidative stress in CEx and AEx rats by decreasing BG, TC, TG, MDA levels in serum and elevating GLUT-2 and GLUT-4 expression in the liver and muscle samples. The efficacy of CrPic was more pronounced in CEx rats. In the experimental materials used by the author, we found Picolinic acid(cas: 98-98-6COA of Formula: C6H5NO2)

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.COA of Formula: C6H5NO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Palladium-Catalyzed Regioselective C-H Iodination of Unactivated Alkenes》 were Schreib, Benedikt S.; Carreira, Erick M.. And the article was published in Journal of the American Chemical Society in 2019. Quality Control of Picolinic acid The author mentioned the following in the article:

A palladium-catalyzed C-H iodination of unactivated alkenes is reported. A picolinamide directing group enables the regioselective functionalization of a wide array of olefins to furnish iodination products as single stereoisomers. Mechanistic studies suggest the reversible formation of a six-membered alkenyl palladacycle intermediate through a turnover-limiting C-H activation. In the part of experimental materials, we found many familiar compounds, such as Picolinic acid(cas: 98-98-6Quality Control of Picolinic acid)

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Quality Control of Picolinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Fast Oxygen Reduction Catalyzed by a Copper(II) Tris(2-pyridylmethyl)amine Complex through a Stepwise Mechanism》 were Langerman, Michiel; Hetterscheid, Dennis G. H.. And the article was published in Angewandte Chemie, International Edition in 2019. Formula: C12H13N3 The author mentioned the following in the article:

Catalytic pathways for the reduction of dioxygen can either give H2O or peroxide as the reaction product. The electrocatalytic reduction of O2 by the pyridylalkylamine Cu complex [Cu(tmpa)(L)]2+ in a neutral aqueous solution follows a stepwise 4 e-/4 H+ pathway, in which H2O2 is formed as a detectable intermediate and subsequently reduced to H2O in two sep. catalytic reactions. These homogeneous catalytic reactions are 1st order in catalyst. Coordination of O2 to CuI is the rate-determining step in the formation of the peroxide intermediate. Also, electrochem. studies of the reaction kinetics revealed a high turnover frequency of 1.5 × 105 s-1, the highest reported for any mol. Cu catalyst. The experimental part of the paper was very detailed, including the reaction process of Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Formula: C12H13N3)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Formula: C12H13N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Catalytic enantioselective pyridine N-oxidation》 were Hsieh, Sheng-Ying; Tang, Yu; Crotti, Simone; Stone, Elizabeth A.; Miller, Scott J.. And the article was published in Journal of the American Chemical Society in 2019. COA of Formula: C5H3BrClN The author mentioned the following in the article:

The catalytic, enantioselective N-oxidation of substituted pyridines is described. The approach is predicated on a biomol.-inspired catalytic cycle wherein high levels of asym. induction are provided by aspartic-acid-containing peptides as the aspartyl side chain shuttles between free acid and peracid forms. Desymmetrizations of bis(pyridine) substrates bearing a remote pro-stereogenic center substituted with a group capable of hydrogen bonding to the catalyst are demonstrated. Our approach presents a new entry into chiral pyridine frameworks in a heterocycle-rich mol. environment. Representative functionalizations of the enantioenriched pyridine N-oxides further document the utility of this approach. Demonstration of the asym. N-oxidation in two venerable drug-like scaffolds, Loratadine and Varenicline, show the likely generality of the method for highly variable and distinct chiral environments, while also revealing that the approach is applicable to both pyridines and 1,4-pyrazines. In the experiment, the researchers used many compounds, for example, 5-Bromo-2-chloropyridine(cas: 53939-30-3COA of Formula: C5H3BrClN)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. COA of Formula: C5H3BrClN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem