Tag: 100-200

In 2018,Indian Journal of Heterocyclic Chemistry included an article by Bhasker, G. Vijaya; Satyanarayana, G. V.; Laxminarayana, E.; Latha, A.; Chary, M. Thirumala. Computed Properties of C5H5BrN2. The article was titled 《Synthesis, antibacterial activity, and docking studies of some new 2-substituted-1,8-naphthyridine derivatives》. The information in the text is summarized as follows:

Two series of novel 2-substituted-1,8-naphthyridine derivatives I (R = quinolin-3-yl, 4-AcC6H4, 2-Br-5-pyridyl, etc.) and II (R = quinolin-3-yl, 4-Cl-2-pyridyl, 2-BrC6H4) were synthesized. These compounds were evaluated for their antibacterial activity. Docking studies for these title compounds are also presented in this communication. In the part of experimental materials, we found many familiar compounds, such as 6-Bromopyridin-3-amine(cas: 13534-97-9Computed Properties of C5H5BrN2)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Computed Properties of C5H5BrN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,Shu, Bing; Cao, Jiaojiao; Kuang, Guotao; Qiu, Jun; Zhang, Meiling; Zhang, Yan; Wang, Mingxue; Li, Xiaoya; Kang, Shuangshuang; Ou, Tian-Miao; Tan, Jia-Heng; Huang, Zhi-Shu; Li, Ding published 《Syntheses and evaluation of new acridone derivatives for selective binding of oncogene c-myc promoter i-motifs in gene transcriptional regulation》.Chemical Communications (Cambridge, United Kingdom) published the findings.Formula: C7H9NO The information in the text is summarized as follows:

We synthesized a series of acridone derivatives for specific binding ligands of i-motifs. Subsequent evaluations showed that B19 (I) could selectively bind to and stabilize the c-myc promoter i-motif without significant binding to the G-quadruplex and duplex DNA. This caused down-regulation of c-myc transcription and expression, resulting in tumor cell apoptosis. In the part of experimental materials, we found many familiar compounds, such as 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Formula: C7H9NO)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Formula: C7H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Van Raden, Jeff M.; Louie, Shayan; Zakharov, Lev N.; Jasti, Ramesh published 《2,2′-Bipyridyl-Embedded Cycloparaphenylenes as a General Strategy To Investigate Nanohoop-Based Coordination Complexes》.Journal of the American Chemical Society published the findings.SDS of cas: 53939-30-3 The information in the text is summarized as follows:

Because of their unique cyclic architectures, tunable electronic properties, and supramol. chemistries, cycloparaphenylenes (CPPs) have the potential to act as a new class of ligands for coordination cages, metal-organic frameworks, and small-mol. transition-metal complexes. However, currently there is no general strategy to coordinate the cyclic framework to a variety of metal centers. The authors report here a general and scalable synthetic strategy to embed 2,2′-bipyridine units into the backbone of CPPs. The authors use this approach to synthesize a 2,2′-bipyridine-embedded [8]CPP (L), which the authors show can successfully coordinate to both Pd(II) and Ru(II) forming [PdLCl2], [PdL2](BF4)2 and [Ru(L)(bipy)2](PF6)2. The resulting coordination complexes, a Pd(II) nanohoop dimer and a bis(bipyridyl)ruthenium(II) functionalized nanohoop, show unique solid-state and photophys. properties. This work provides a proof of concept for a general strategy to use nanohoops and their derivatives as a new class of ligands. The experimental part of the paper was very detailed, including the reaction process of 5-Bromo-2-chloropyridine(cas: 53939-30-3SDS of cas: 53939-30-3)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. SDS of cas: 53939-30-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Double Deprotonation of Pyridinols Generates Potent Organic Electron-Donor Initiators for Haloarene-Arene Coupling》 were Barham, Joshua P.; Coulthard, Graeme; Kane, Ryan G.; Delgado, Nathan; John, Matthew P.; Murphy, John A.. And the article was published in Angewandte Chemie, International Edition in 2016. Reference of Methyl 5-methoxypicolinate The author mentioned the following in the article:

Transition metal-free couplings of haloarenes with arenes, triggered using alkali metal alkoxides in the presence of an organic additive, are receiving significant attention in the literature. Most of the known organic additives effect coupling of iodoarenes, but not bromoarenes, to arenes. Recently it was reported that 2-pyridinecarbinol (11) extends the reaction to aryl bromides. This paper studies the mechanism, and reports evidence for dianions derived from 11 as electron donors to initiate the reaction. It also proposes routes by which electron-poor benzoyl derivatives can be transformed into electron donors to initiate these reactions. In addition to this study using Methyl 5-methoxypicolinate, there are many other studies that have used Methyl 5-methoxypicolinate(cas: 29681-39-8Reference of Methyl 5-methoxypicolinate) was used in this study.

Methyl 5-methoxypicolinate(cas: 29681-39-8) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Reference of Methyl 5-methoxypicolinate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Harper, Kaid C.; Vilardi, Sarah C.; Sigman, Matthew S. published an article on February 20 ,2013. The article was titled 《Prediction of Catalyst and Substrate Performance in the Enantioselective Propargylation of Aliphatic Ketones by a Multidimensional Model of Steric Effects》, and you may find the article in Journal of the American Chemical Society.Computed Properties of C7H11ClN2 The information in the text is summarized as follows:

The effectiveness of a new asym. catalytic methodol. is often weighed by the number of diverse substrates that undergo reaction with high enantioselectivity. Here we report a study that correlates substrate and ligand steric effects to enantioselectivity for the propargylation of aliphatic ketones. The math. model is shown to be highly predictive when applied to substrate/catalyst combinations outside the training set. After reading the article, we found that the author used (6-Methylpyridin-2-yl)methanamine hydrochloride(cas: 1365836-53-8Computed Properties of C7H11ClN2)

(6-Methylpyridin-2-yl)methanamine hydrochloride(cas: 1365836-53-8) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Computed Properties of C7H11ClN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Ligand-free copper-catalyzed regio- and stereoselective 1,1-alkylmonofluoroalkylation of terminal alkynes》 was written by Lv, Yunhe; Pu, Weiya; Wang, Xiaoxing. Category: pyridine-derivatives And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020. The article conveys some information:

The copper-catalyzed highly regio- and stereoselective 1,1-alkylmonofluoroalkylation of terminal alkynes with α-chloroacetamides and dialkyl 2-fluoromalonate or 2-fluoro-N,N-dialkyl-3-oxobutanamide without an external ligand was realized. With this novel methodol., (E)-β-monofluoroalkyl-β,γ-unsaturated amides containing quaternary C-F centers I [R = CH2OMe, 3-thienyl, Ph, etc.] could be easily constructed in good to excellent yields. The experimental part of the paper was very detailed, including the reaction process of 4-Ethynylpyridine(cas: 2510-22-7Category: pyridine-derivatives)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Electrochemical Reduction of the Carbonyl Functional Group: The Importance of Adsorption Geometry, Molecular Structure, and Electrode Surface Structure》 were Bondue, Christoph J.; Koper, Marc T. M.. And the article was published in Journal of the American Chemical Society in 2019. HPLC of Formula: 1122-54-9 The author mentioned the following in the article:

This paper studies the electrochem. hydrogenation of the carbonyl functional group of acetophenone and 4-acetylpyridine at platinum single-crystal electrodes. Comparison with results obtained for the hydrogenation of acetone featuring an isolated carbonyl functional group reveals the influence of the Ph ring and the pyridine ring, resp. Lack of acetone adsorption at Pt(111) and Pt(100) due to a weak interaction between surface and carbonyl functional group renders these surfaces inactive for the hydrogenation of acetone. Adsorption through a strong interaction with the Ph ring of acetophenone activates the Pt(111) and Pt(100) surfaces for hydrogenation of the acetyl substituent. In agreement with previous results for acetone reduction, the Pt(100) surface is specifically active for the hydrogenolysis reaction, breaking the C-O bond, whereas the other surfaces only hydrogenate the carbonyl functionality. In contrast to the Ph ring, the pyridine ring has a very different effect: due to the dominant interaction of the N atom of the pyridine ring with the platinum electrode, a vertical adsorption mode is realized. The resulting large phys. distance between the carbonyl functional group and the electrode surface inhibits the hydrogenation at all platinum surfaces. This also holds for the Pt(110) electrode, which is otherwise active for the electrochem. hydrogenation of the isolated carbonyl functional group of aliphatic ketones. Our results show how the combination of mol. structure of the reactant and surface structure of the catalyst determine the selective electroreduction of functionalized ketones.4-Acetylpyridine(cas: 1122-54-9HPLC of Formula: 1122-54-9) was used in this study.

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. HPLC of Formula: 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Chemical Communications (Cambridge, United Kingdom) included an article by Chen, Jian; Zhu, Shengqing; Qin, Jian; Chu, Lingling. Recommanded Product: 100-48-1. The article was titled 《Intermolecular, redox-neutral azidoarylation of alkenes via photoredox catalysis》. The information in the text is summarized as follows:

An intermol., redox-neutral azidoarylation of alkenes with pyridines and TMSN3 was reported via visible light-induced photoredox catalysis. This protocol utilized a radical addition/radical coupling sequence, allowing for facile and regioselective installation of versatile β-azido pyridines under redox-neutral and mild conditions. In the experiment, the researchers used 4-Cyanopyridine(cas: 100-48-1Recommanded Product: 100-48-1)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Recommanded Product: 100-48-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Chemical Communications (Cambridge, United Kingdom) included an article by Yang, Fei; Liu, Caiping; Yin, Di; Xu, Yanqing; Wu, Mingyan; Wei, Wei. Application of 1692-25-7. The article was titled 《Atropisomer-based construction of macrocyclic hosts that selectively recognize tryptophan from standard amino acids》. The information in the text is summarized as follows:

A syn-atropisomer of naphthalene diimide as a highly preorganized precursor was used to construct a type of trapezoid-shape macrocycle, namely ′trapezoid′ mol. boxes (TBox). As supramol. hosts, TBox can bind electron-rich guests and selectively recognize free tryptophan and tryptophanyl residues from 20 standard amino acids. After reading the article, we found that the author used Pyridin-3-ylboronic acid(cas: 1692-25-7Application of 1692-25-7)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Application of 1692-25-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Keylor, Mitchell H.; Niemeyer, Zachary L.; Sigman, Matthew S.; Tan, Kian L. published 《Inverting Conventional Chemoselectivity in Pd-Catalyzed Amine Arylations with Multiply Halogenated Pyridines》.Journal of the American Chemical Society published the findings.Formula: C5H3BrClN The information in the text is summarized as follows:

A new catalyst system capable of selective chloride functionalization in the Pd-catalyzed amination of 3,2- and 5,2- Br/Cl-pyridines is reported. A reaction optimization strategy employing ligand parametrization led to the identification of 1,1′-bis[bis(dimethylamino)phosphino]ferrocene “”DMAPF””, a readily available yet previously unutilized diphosphine, as a uniquely effective ligand for this transformation. In the part of experimental materials, we found many familiar compounds, such as 5-Bromo-2-chloropyridine(cas: 53939-30-3Formula: C5H3BrClN)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Formula: C5H3BrClN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem