Tag: 100-200

In 2017,Pagire, Santosh K.; Kreitmeier, Peter; Reiser, Oliver published 《Visible-Light-Promoted Generation of α-Ketoradicals from Vinyl-bromides and Molecular Oxygen: Synthesis of Indenones and Dihydroindeno[1,2-c]chromenes》.Angewandte Chemie, International Edition published the findings.Related Products of 128071-75-0 The information in the text is summarized as follows:

Ortho-alkynylated α-bromocinnamates can be converted by a visible-light-mediated photocascade reaction with mol. oxygen into either indenones or dihydroindeno[1,2-c]chromenes. The one-step process features key photochem. steps, i.e., the initial activation of vinyl bromides through energy transfer to give α-ketoradicals in a reaction with mol. oxygen, followed by α-oxidation of an arene moiety by 6-π electrocyclization and subsequent hydroxylation by an electron-transfer process from the same photocatalyst leads to the dihydroindeno[1,2-c]chromenes. In the experiment, the researchers used 2-Bromonicotinaldehyde(cas: 128071-75-0Related Products of 128071-75-0)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Related Products of 128071-75-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2014,Guan, Aiying; Li, Huichao; Li, Zhinian; Yang, Fan; Xie, Yong; Yang, Xiaoping; Liu, Changling published 《N-Phenyl heteroarylamine analogues of fluazinam using the intermediate derivatization methods approach》.Journal of Chemical Sciences (Bangalore, India) published the findings.Recommanded Product: 6-Bromopyridin-3-amine The information in the text is summarized as follows:

Twenty-one N-Ph heteroarylamine analogs of fluazinam were prepared via nucleophilic substitution reaction of 2,6-dichloro-3,5-dinitrotoluene with heteroarylamines using the intermediate derivatization method. 2,6-Dichloro-3,5-dinitrotoluene, the key intermediate, was synthesized by nitration of 2,6-dichlorotoluene. Preliminary bioassays indicated that most of the compounds showed good fungicidal activity against rice blast. The activity of I was equal to that of fluazinam. The relationship between mol. structure and biol. activity suggested that introduction of electron-withdrawing groups in the pyridine ring was important for optimizing fungicidal activity against rice blast. The results came from multiple reactions, including the reaction of 6-Bromopyridin-3-amine(cas: 13534-97-9Recommanded Product: 6-Bromopyridin-3-amine)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Recommanded Product: 6-Bromopyridin-3-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Palladium-catalyzed Heck cyclization/carbonylation with formates: synthesis of azaindoline-3-acetates and furoazaindolines》 were Ye, Hao; Wu, Linhui; Zhang, Minrui; Jiang, Guomin; Dai, Hong; Wu, Xin-Xing. And the article was published in Chemical Communications (Cambridge, United Kingdom) in 2022. Recommanded Product: 39856-58-1 The author mentioned the following in the article:

Herein a palladium-catalyzed domino cyclization/carbonylation to access ester-functionalized azaindolines, e.g., I applying formates, e.g., phenylformate as a convenient carbonyl source was reported. All four azaindoline isomers were constructed, exhibiting good functional group compatibility. On this basis, modifying the starting tether on the aminopyridine led to furoazaindolines, e.g., II via an intramol. reductive cyclization after the palladium-catalyzed process. The experimental part of the paper was very detailed, including the reaction process of 2-Bromopyridin-3-amine(cas: 39856-58-1Recommanded Product: 39856-58-1)

2-Bromopyridin-3-amine(cas: 39856-58-1) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Recommanded Product: 39856-58-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gleave, Robert J.; Beswick, Paul J.; Brown, Andrew J.; Giblin, Gerard M. P.; Haslam, Carl P.; Livermore, David; Moses, Andrew; Nicholson, Neville H.; Page, Lee W.; Slingsby, Brian; Swarbrick, Martin E. published their research in Bioorganic & Medicinal Chemistry Letters on December 1 ,2009. The article was titled 《2-Amino-5-aryl-pyridines as selective CB2 agonists: Synthesis and investigation of structure-activity relationships》.Related Products of 102645-33-0 The article contains the following contents:

2-Amino-5-aryl-pyridines e.g. I, had been identified as a synthetically tractable series of CB2 agonists from a high-throughput screen of the GlaxoSmithKline compound collection. The results of an investigation of the structure-activity relationships (SAR) which led to the identification a number of potent and selective agonists are described. After reading the article, we found that the author used 2,5-Dichloroisonicotinaldehyde(cas: 102645-33-0Related Products of 102645-33-0)

2,5-Dichloroisonicotinaldehyde(cas: 102645-33-0) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Related Products of 102645-33-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Synthesis of novel tetrandrine derivatives and their inhibition against NSCLC A549 cells》 was published in Journal of Asian Natural Products Research in 2018. These research results belong to Yang, Qian-Hao; Jiang, Cheng-Shi; Jin, Tao; Xu, Jin-Fang; Qu, Ting-Li; Guo, Yue-Wei; Zhao, Zheng-Bao. Reference of (6-Chloro-5-methylpyridin-3-yl)boronic acid The article mentions the following:

A series of novel tetrandrine (Tet) derivatives were synthesized through Suzuki -Miyaura reaction and evaluated for their cytotoxicity against human non-small cell lung carcinoma (NSCLC) A549 cells. Interestingly, most of derivatives showed similar cytotoxicity to Tet against NSCLC A549 cells, and particularly, compounds Y5, Y6, Y9 and Y11 showed the most significant cytotoxic effects with IC50 values ranging from 3.87 to 4.66 mM. The present study is expected to contribute to the future design of more effective anticancer agents in lung cancer chemotherapy. The results came from multiple reactions, including the reaction of (6-Chloro-5-methylpyridin-3-yl)boronic acid(cas: 1003043-40-0Reference of (6-Chloro-5-methylpyridin-3-yl)boronic acid)

(6-Chloro-5-methylpyridin-3-yl)boronic acid(cas: 1003043-40-0) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Reference of (6-Chloro-5-methylpyridin-3-yl)boronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Ruthenium-Catalyzed C-H Bond Heteroarylation of Triazoles Enabled by a Deconvolution Strategy》 was written by Gramage-Doria, Rafael; Roisnel, Thierry. Related Products of 53939-30-3This research focused ontriazolyl biaryl teraryl chemoselective regioselective preparation; optimization catalyst base solvent directed arylation phenyltriazole bromoarene; ruthenium catalyst regioselective monoarylation diarylation phenyltriazole bromoarene. The article conveys some information:

The ruthenium-catalyzed regioselective arylation of phenyltriazole I with aryl and heteroaryl bromides was optimized using a convolution strategy in which mixtures of carboxylate salts and bases were used instead of single reagents to minimize the number of experiments required to find optimal conditions. In the presence of [RuCl2(p-cymene)]2 and using potassium acetate and potassium carbonate as reagents in N-methyl-2-pyrrolidinone, I underwent regioselective directed mono- and diarylation reactions with aryl and heteroaryl bromides (depending on stoichiometry) such as 4-bromopyridine to yield triazolyl biaryls and teraryls such as II (R = H, 4-pyridinyl); 3-bromobenzonitrile and 2-bromotoluene (bearing meta and ortho substituents) were effective aryl bromides in the arylation.5-Bromo-2-chloropyridine(cas: 53939-30-3Related Products of 53939-30-3) was used in this study.

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Related Products of 53939-30-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Safety of Bis(pyridin-2-ylmethyl)amineIn 2019 ,《Synthetic Polymers To Promote Cooperative Cu Activity for O2 Activation: Poly vs. Mono》 was published in Journal of the American Chemical Society. The article was written by Thanneeru, Srinivas; Milazzo, Nicholas; Lopes, Aaron; Wei, Zichao; Angeles-Boza, Alfredo M.; He, Jie. The article contains the following contents:

The authors report polymer-promoted cooperative catalysis of Cu for O activation. Random copolymers containing dipicolylamine as binding motifs are designed to coordinate type-3 Cu sites. The Cu-copolymers show a 6-8-fold activity enhancement, compared to the mol. complex of Cu with an identical coordination site. Michaelis-Menten anal. demonstrates that the kinetic enhancement results from flexible polymer-promoted cooperative catalysis among multi-Cu sites despite the imposed thermodn. barrier. These observations provide guidance for the bioinspired design of metallopolymers as soluble catalysts with high activity. In the experiment, the researchers used many compounds, for example, Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Safety of Bis(pyridin-2-ylmethyl)amine)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Safety of Bis(pyridin-2-ylmethyl)amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 98-98-6In 2021 ,《Molecular docking, DFT and antimicrobial studies of Cu(II) complex as topoisomerase I inhibitor》 was published in Journal of Biomolecular Structure and Dynamics. The article was written by Parveen, Shazia; Arjmand, Farukh; Zhang, Qianfan; Ahmad, Musheer; Khan, Arif; Toupet, Loic. The article contains the following contents:

Herein, we report the synthesis and single crystal X-ray structure of Cu(II)-picolinic acid complex, as a potent topoisomerase I inhibitor. The complex crystallized in the triclinic crystal system with space group P-1. Comparative in vitro binding studies of complex with CT DNA and tRNA were carried out revealing an electrostatic binding mode with higher binding propensity towards tRNA. The intrinsic bonding constant value, Kb was calculated to be 4.36 x 104 and 8.78 x 104 M-1 with CT DNA and tRNA resp. DNA cleavage activity was carried out with a pBR322 plasmid DNA substrate to ascertain the cleaving ability. Furthermore, Topo-I inhibition assay of complex , performed via gel electrophoresis revealed a significant inhibitory effect on the enzyme catalytic activity at a min. concentration of 15 muM. The DFT studies were carried out to provide better insight in the electronic transitions observed in the absorption spectrum of the complex . Mol. docking studies were carried out with DNA, RNA and Topo-I to determine the specific binding preferences at the target site and complement the spectroscopic studies. The antimicrobial potential of complex was screened against E. coli, S. aureus, P. aeruginosa, B. subtilis and C. albicans; and compared with doxycycline, exhibiting an excellent maximum zone of inhibition of 28 mm against E. coli. The results came from multiple reactions, including the reaction of Picolinic acid(cas: 98-98-6Related Products of 98-98-6)

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Related Products of 98-98-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: 128071-75-0In 2019 ,《Functionalization of 4-bromobenzo[c][2,7]naphthyridine via regioselective direct ring metalation. A novel approach to analogs of pyridoacridine alkaloids》 appeared in Beilstein Journal of Organic Chemistry. The author of the article were Melzer, Benedikt C.; Plodek, Alois; Bracher, Franz. The article conveys some information:

Readily available 4-bromobenzo[c][2,7]naphthyridine undergoes regioselective direct ring metalation at C-5 with TMPMgCl·LiCl at -40°. Quenching with various electrophiles gives a broad range of 5-substituted products, which are building blocks for the synthesis of heterocyclic natural products and analogs thereof. In combination with a Parham-type cyclization a novel approach to pyrido[4,3,2-mn]acridones has been worked out. The experimental process involved the reaction of 2-Bromonicotinaldehyde(cas: 128071-75-0Recommanded Product: 128071-75-0)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Recommanded Product: 128071-75-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Product Details of 53939-30-3In 2014 ,《Continuous flow magnesiation of functionalized heterocycles and acrylates with TMPMgCl.LiCl》 appeared in Angewandte Chemie, International Edition. The author of the article were Petersen, Trine P.; Becker, Matthias R.; Knochel, Paul. The article conveys some information:

The metalation of functionalized heterocycles (pyridines, pyrimidines, thiophenes, and thiazoles) and various acrylates using the strong, non-nucleophilic base TMPMgCl.LiCl was carried out. The flow conditions allow the magnesiations to be performed under more convenient conditions than the comparable batch reactions, which often require cryogenic temperatures and long reaction times. Moreover, the flow reactions are directly scalable without further optimization. Metalation under flow conditions also allows magnesiations that did not produce the desired products under batch conditions, such as the magnesiation of sensitive acrylic derivatives The magnesiated species are subsequently quenched with various electrophiles, thereby introducing a broad range of functionalities. © 2014 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. The results came from multiple reactions, including the reaction of 5-Bromo-2-chloropyridine(cas: 53939-30-3Product Details of 53939-30-3)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Product Details of 53939-30-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem