Tag: 100-200

Impregnated copper on magnetite as catalyst for the O-arylation of phenols with aryl halides was written by Zhang, Ying-Peng;Shi, Ai-Hong;Yang, Yun-Shang;Li, Chun-Lei. And the article was included in Chinese Chemical Letters in 2014.HPLC of Formula: 4783-68-0 This article mentions the following:

Nanoparticle Fe₃O₄ encapsulated CuO, as a heterogeneous catalyst, is a facile system for the synthesis of diaryl ethers by the cross-coupling reaction of aryl halides with phenols, which avoids expensive ligands and can be recovered from the reaction mixture by using a simple magnet. Moreover, this catalyst can be reused 3 times with high catalytic activity. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0HPLC of Formula: 4783-68-0).

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. HPLC of Formula: 4783-68-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pd-catalyzed cross-coupling reactions with carbonyls: application in a very efficient synthesis of 4-aryltetrahydropyridines was written by Barluenga, Jose;Tomas-Gamasa, Maria;Moriel, Patricia;Aznar, Fernando;Valdes, Carlos. And the article was included in Chemistry – A European Journal in 2008.Computed Properties of C10H17NO2 This article mentions the following:

Readily available 4-piperidones are directly employed in a very efficient Pd-catalyzed synthesis of 4-aryltetrahydropyridines, which are important scaffolds in medicinal chem. The actual coupling partner, a tosylhydrazone, is generated in situ from the piperidone and tosylhydrazine. The reaction can be applied to other ketones and aldehydes, providing polysubstituted olefins directly from carbonyls by a very simple and efficient procedure. In the experiment, the researchers used many compounds, for example, tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4Computed Properties of C10H17NO2).

tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Computed Properties of C10H17NO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Fluorine-19 nuclear magnetic resonance study of tin tetrafluoride diadducts of various aromatic amine oxides was written by Ragsdale, Ronald O.;Michelson, C. E.. And the article was included in Inorganic Chemistry in 1970.SDS of cas: 3718-65-8 This article mentions the following:

An 19F NMR study of diadducts of SnF4 with 19 aromatic amine oxides is reported. The results indicate that the steric nature of the ligand is probably more important than the base strength in determining the relative chem. shifts. The trans isomer is identified in all of the complexes whereas the cis isomer is present only with the less bulky ligands. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8SDS of cas: 3718-65-8).

3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.SDS of cas: 3718-65-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Assessment and prediction of joint algal toxicity of binary mixtures of graphene and ionic liquids was written by Wang, Zhuang;Zhang, Fan;Wang, Se;Peijnenburg, Willie J. G. M.. And the article was included in Chemosphere in 2017.Product Details of 125652-55-3 This article mentions the following:

Graphene and ionic liquids (ILs) released into the environment will interact with each other. So far however, the risks associated with the concurrent exposure of biota to graphene and ILs in the environment have received little attention. The research reported here focused on observing and predicting the joint toxicity effects in the green alga Scenedesmus obliquus exposed to binary mixtures of intrinsic graphene (iG)/graphene oxide (GO) and five ILs of varying anionic and cationic types. The isolated ILs in the binary mixtures were the main contributors to toxicity. The binary GO-IL mixtures resulted in more severe joint toxicity than the binary iG-IL mixtures, irresp. of mixture ratios. The mechanism of the joint toxicity may be associated with the adsorption capability of the graphenes for the ILs, the dispersion stability of the graphenes in aquatic media, and modulation of the binary mixtures-induced oxidative stress. A toxic unit assessment showed that the graphene and IL toxicities were additive at low concentration of the mixtures but antagonistic at high concentration of the mixtures Predictions made using the concentration addition and independent action models were close to the observed joint toxicities regardless of mixture types and mixture ratios. These findings provide new insights that are of use in the risk assessment of mixtures of engineered nanoparticles and other environmentally relevant contaminants. In the experiment, the researchers used many compounds, for example, 1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3Product Details of 125652-55-3).

1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Product Details of 125652-55-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Iridium-Catalyzed Regio- and Enantioselective Hydroarylation of Alkenyl Ethers by Olefin Isomerization was written by Ebe, Yusuke;Onoda, Mitsuki;Nishimura, Takahiro;Yorimitsu, Hideki. And the article was included in Angewandte Chemie, International Edition in 2017.HPLC of Formula: 4373-61-9 This article mentions the following:

Iridium-catalyzed hydroarylation of alkenyl ethers, such as allylic and homoallylic ethers, by C-H bond activation gave high yields of the corresponding addition products, where the aryl groups were selectively installed at the α-carbon atom to the alkoxy group. The reaction involves an isomerization of the alkenyl ethers into the corresponding 1-alkenyl ethers, which then undergo the regio- and enantioselective hydroarylation. Thus, e.g., cinnamyl Me ether + 2-phenylpyridine → I (85% yield, 92% ee) in presence of [IrCl(cod)]₂, (R)-binap* and NaBAr^F₄ in toluene. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9HPLC of Formula: 4373-61-9).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.HPLC of Formula: 4373-61-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

A three-step synthesis of 4-(4-iodo-1H-pyrazol-1-yl)piperidine, a key intermediate in the synthesis of Crizotinib was written by Fussell, Steven J.;Luan, Amy;Peach, Philip;Scotney, Gemma. And the article was included in Tetrahedron Letters in 2012.Safety of tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate This article mentions the following:

4-(4-Iodo-1H-pyrazol-1-yl)piperidine is a key intermediate in the synthesis of Crizotinib. We report a robust three-step synthesis that has successfully delivered multi-kilogram quantities of the key intermediate. The process includes nucleophilic aromatic substitution of 4-chloropyridine with pyrazole, followed by hydrogenation of the pyridine moiety and subsequent iodination of the pyrazole which all required optimization to ensure successful scale-up. In the experiment, the researchers used many compounds, for example, tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4Safety of tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate).

tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Safety of tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Thioether-Assisted Cu-Catalyzed C5-H Arylation of Imidazo[1,5-a]pyridines was written by Wang, Linhua;Zheng, Xuesong;Zheng, Qinze;Li, Zhenlong;Wu, Jian;Gao, Ge. And the article was included in Organic Letters in 2022.Application In Synthesis of 4-Methylpicolinonitrile This article mentions the following:

A series of ethylthio (hetero)arylimidazo[1,5-a]pyridine derivatives I (R = 4-methylphenyl, pyridin-4-yl, 1-methyl-1H-indol-5-yl, etc.; R¹ = H, Cl, Br, Me, Ph, 4-methoxyphenyl, 4-trifluoromethylphenyl; R² = H, 6-Cl, 7-Me) was prepared via Cu-catalyzed regioselective C5-H arylation of imidazo[1,5-a]pyridines I (R = H) with aryl iodides RI with the assistance of an ethylthio group at the C3 position. This directing group could be easily removed to furnish a range of 5-(hetero)arylimidazo[1,5-a]pyridine derivatives e.g., II. The reaction tolerates a variety of functionalities and is compatible with sterically hindered substrates. In the experiment, the researchers used many compounds, for example, 4-Methylpicolinonitrile (cas: 1620-76-4Application In Synthesis of 4-Methylpicolinonitrile).

4-Methylpicolinonitrile (cas: 1620-76-4) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Application In Synthesis of 4-Methylpicolinonitrile

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

[CN̂]-Alkenyl Gold(III) Complexes by Proximal Ring-Opening of (2-Pyridyl)alkylidenecyclopropanes: Mechanistic Insights was written by Gonzalez, Jorge A.;Verdugo, Felipe;Mascarenas, Jose Luis;Lopez, Fernando;Nevado, Cristina. And the article was included in Angewandte Chemie, International Edition in 2020.Electric Literature of C12H9NO This article mentions the following:

Pyridine-substituted alkylidenecyclopropanes (Py-ACPs) react with gold(III) salts under mild reaction conditions through an unprecedented, proximal ring-opening pathway, to generate highly appealing, catalytically active pyridine alkenyl [CN̂]-gold(III) species. Mechanistic studies reveal that the activation of the C-C bond of the ACP takes place through an unusual concerted, σ-bond metathesis type-process. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Electric Literature of C12H9NO).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Electric Literature of C12H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Nickel-Catalyzed Suzuki-Miyaura Coupling of Heteroaryl Ethers with Arylboronic Acids was written by Li, Xiao-Jian;Zhang, Jin-Ling;Geng, Yu;Jin, Zhong. And the article was included in Journal of Organic Chemistry in 2013.Quality Control of 2-Phenoxypyridine This article mentions the following:

Nickel-catalyzed Suzuki-Miyaura coupling of heteroaryl ethers with arylboronic acids was described. Selective activation of the phenol C-O bonds was achieved by converting them into the corresponding aryl 2,4-dimethoxy-1,3,5-triazin-6-yl ethers, in which the aryl C-O bond could be selectively cleaved with inexpensive, air-stable NiCl₂(dppf) as a catalyst. Coupling of these readily accessible heteroaryl ethers proved tolerant of extensive functional groups. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0Quality Control of 2-Phenoxypyridine).

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Quality Control of 2-Phenoxypyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Decarboxylation of orotic acid analogues: Comparison of solution and gas-phase reactivity was written by Wong, Amy;Vikse, Krista;Wu, Weiming. And the article was included in Tetrahedron Letters in 2020.Recommanded Product: 59864-31-2 This article mentions the following:

The decarboxylation of orotic acid and analogs have been investigated as a model for enzymic decarboxylation catalyzed by orotidine-5′-monophosphate decarboxylase (ODCase). The rate of decarboxylation of 1-methyl-4-pyridone-2-carboxylic acid in solution has been reported to be three orders of magnitude greater than those of 1,3-dimethylorotic acid and 1-methyl-2-pyridone-6-carboxylic acid in solution Here, the gas-phase decarboxylation of the three corresponding carboxylates were investigated. The carboxylate of 1,3-dimethylorotic acid decarboxylates at a faster rate and thus the relative rates of decarboxylation are different from those observed in solution The relative rates of decarboxylation correlate well with the stability of the corresponding carbanions and the calculated activation energies for gas-phase decarboxylation. Therefore, the reactions in the gas phase seem to go through the direct decarboxylation mechanism whereas the reactions in solution likely go through zwitterionic intermediates as previously proposed. In the experiment, the researchers used many compounds, for example, 1-Methyl-6-oxo-1,6-dihydropyridine-2-carboxylic acid (cas: 59864-31-2Recommanded Product: 59864-31-2).

1-Methyl-6-oxo-1,6-dihydropyridine-2-carboxylic acid (cas: 59864-31-2) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Recommanded Product: 59864-31-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem