Tag: 100-200

The author of 《Boronic acid derivatized lanthanide-polyoxometalates with novel B-OH-Ln and B-O-Nb bridges》 were Li, Shujun; Zhao, Yue; Qi, Huihui; Zhou, Yanfang; Liu, Shuxia; Ma, Xiaoming; Zhang, Jie; Chen, Xuenian. And the article was published in Chemical Communications (Cambridge, United Kingdom) in 2019. Application In Synthesis of Pyridin-3-ylboronic acid The author mentioned the following in the article:

Three new boronic acid derivatized lanthanide-polyoxometalates (BA-Ln-POMs) were synthesized, in which boronic acids served as bi- or tri-dentate ligands and exhibited interesting coordination ability towards POMs and LnIII. The pH is crucial in controlling the coordination modes of boronic acid and the formation of B-O-Ln and B-O-Nb bridges. Compared with the boronic acid-free Ln-POM, a longer lifetime was observed for compound 2Eu due to the coordination of boronic acids to the EuIII center. The results came from multiple reactions, including the reaction of Pyridin-3-ylboronic acid(cas: 1692-25-7Application In Synthesis of Pyridin-3-ylboronic acid)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Application In Synthesis of Pyridin-3-ylboronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2013,El Abidine Chamas, Zein; Marchi, Enrico; Modelli, Alberto; Fort, Yves; Ceroni, Paola; Mamane, Victor published 《Highly Fluorescent, π-Extended Indenopyrido[2,1-a]isoindolone Derivatives Prepared by a Palladium-Catalysed Cascade Reaction》.European Journal of Organic Chemistry published the findings.Electric Literature of C5H3BrClN The information in the text is summarized as follows:

A new family of heterocyclic pentacyclic compounds were prepared by a cascade reaction involving 2,5-dihalopyridines and (2-formylphenyl)boronic acids. Most of the compounds exhibit high quantum yields of fluorescence in dichloromethane. In some cases, small changes in the substitution pattern caused fluorescence quenching. To rationalize this effect, a detailed photophys. study combined with electrochem. and computational studies was performed on four representative derivatives It appears that the fluorescence quenching is caused by a thermally activated nonradiative deactivation process that can be prevented in a rigid matrix such as ethanol at 77 °K or PMMA. In the experiment, the researchers used many compounds, for example, 5-Bromo-2-chloropyridine(cas: 53939-30-3Electric Literature of C5H3BrClN)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Electric Literature of C5H3BrClN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Honnanayakanavar, Jyoti M.; Nanubolu, Jagadeesh Babu; Suresh, Surisetti published an article in 2021. The article was titled 《Tandem copper catalyzed regioselective N-arylation-amidation: synthesis of angularly fused dihydroimidazoquinazolinones and the anticancer agent TIC10/ONC201》, and you may find the article in Organic & Biomolecular Chemistry.Name: 2-Bromonicotinaldehyde The information in the text is summarized as follows:

Herein, a copper-catalyzed tandem reaction of 2-aminoimidazolines I (R = n-Bu, Ph, furan-2-ylmethyl, pyridin-4-ylmethyl, etc.) and ortho-halo(hetero)aryl carboxylic acids R1C(O)OH (R1 = 2-bromophenyl, 2-bromo-4,5-difluorophenyl, 2-bromopyridin-3-yl, 4-chloropyridin-3-yl, etc.) that causes the regioselective formation of angularly fused tricyclic 1,2-dihydroimidazo[1,2-a]quinazolin-5(4H)-one derivs II (R2 = H, OMe, F; R3 = H, OMe, Cl, Br, F, NO2; R4 = H, F), III and IV was presented. The reaction involved in the construction of the core six-membered pyrimidone moiety proceeded via regioselective N-arylation-condensation. The presented protocol has been successfully applied to accomplish the total synthesis of TIC10/ONC201 V, which is an active angular isomer acting as a tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL): a sought after anticancer clin. agent. In addition to this study using 2-Bromonicotinaldehyde, there are many other studies that have used 2-Bromonicotinaldehyde(cas: 128071-75-0Name: 2-Bromonicotinaldehyde) was used in this study.

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Name: 2-Bromonicotinaldehyde

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gil-Martinez, Jon; Macias, Iratxe; Unione, Luca; Bernardo-Seisdedos, Ganeko; Lopitz-Otsoa, Fernando; Fernandez-Ramos, David; Lain, Ana; Sanz-Parra, Arantza; Mato, Jose M.; Millet, Oscar published an article in 2021. The article was titled 《Therapeutic targeting of fumaryl acetoacetate hydrolase in hereditary tyrosinemia type I》, and you may find the article in International Journal of Molecular Sciences.Electric Literature of C7H5N The information in the text is summarized as follows:

Fumarylacetoacetate hydrolase (FAH) is the fifth enzyme in the tyrosine catabolism pathway. A deficiency in human FAH leads to hereditary tyrosinemia type I (HT1), an autosomal recessive disorder that results in the accumulation of toxic metabolites such as succinylacetone, maleylacetoacetate, and fumarylacetoacetate in the liver and kidney, among other tissues. The disease is severe and, when untreated, it can lead to death. A low tyrosine diet combined with the herbicidal nitisinone constitutes the only available therapy, but this treatment is not devoid of secondary effects and long-term complications. In this study, we targeted FAH for the first-time to discover new chem. modulators that act as pharmacol. chaperones, directly associating with this enzyme. After screening several thousand compounds and subsequent chem. redesign, we found a set of reversible inhibitors that associate with FAH close to the active site and stabilize the (active) dimeric species, as demonstrated by NMR spectroscopy. Importantly, the inhibitors are also able to partially restore the normal phenotype in a newly developed cellular model of HT1. The results came from multiple reactions, including the reaction of 4-Ethynylpyridine(cas: 2510-22-7Electric Literature of C7H5N)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Electric Literature of C7H5N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Xia, Dong; Duan, Xin-Fang published their research in Chemical Communications (Cambridge, United Kingdom) in 2021. The article was titled 《Tandem vinyl radical Minisci-type annulation on pyridines: one-pot expeditious access to azaindenones》.Category: pyridine-derivatives The article contains the following contents:

A new regiospecific alkylative/alkenylative cascade annulation of pyridines e.g., I has been achieved while the corresponding classic Minisci alkylative annulation failed. This protocol provides a novel and expeditious access to azaindenones and related compounds e.g., II via cross-dehydrogenative coupling with the long-standing problem of C2/C4 regioselectivity of pyridines being well addressed. In addition to this study using Pyridin-3-ylboronic acid, there are many other studies that have used Pyridin-3-ylboronic acid(cas: 1692-25-7Category: pyridine-derivatives) was used in this study.

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Martinez-Vollbert, Emiliano; Philouze, Christian; Gautier-Luneau, Isabelle; Moreau, Yohann; Lanoe, Pierre-Henri; Loiseau, Frederique published an article in 2021. The article was titled 《Study of a phosphorescent cationic iridium(III) complex displaying a blue-shift in crystals》, and you may find the article in Physical Chemistry Chemical Physics.Related Products of 1134-35-6 The information in the text is summarized as follows:

We report the synthesis and the characterization of a new cationic iridium(III) complex featuring two 1-(p-methoxyphenyl)-5-methoxybenzimidazole cyclometallating ligands and a dimethylbipyridine ancillary ligand. The complex has been fully characterized by 1D and 2D NMR (1H, 13C, 19F and 31P), elemental anal. and high-resolution mass spectrometry (HRMS). The photoluminescence studies performed in a solution, on amorphous powder and on crystals revealed an unexpected behavior. Indeed, the emission spectra observed in both solution (CH2Cl2) and amorphous powder samples are centered at around 580 nm, whereas in crystals the emission displays a large hypsochromic shift of ~800 cm-1 (λem = 558 nm). X-ray diffraction experiments, photophys. studies and DFT calculations allow for rationalizing the hypsochromic shift. After reading the article, we found that the author used 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Related Products of 1134-35-6)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.Related Products of 1134-35-6 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lin, Simin; Chang, Xingmao; Wang, Zhaolong; Zhang, Jing; Ding, Nannan; Xu, Wenjun; Liu, Ke; Liu, Zhongshan; Fang, Yu published an article in 2021. The article was titled 《High-Performance NMHC Detection Enabled by a Perylene Bisimide-Cored Metallacycle Complex-Based Fluorescent Film Sensor》, and you may find the article in Analytical Chemistry (Washington, DC, United States).Application In Synthesis of 4-Ethynylpyridine The information in the text is summarized as follows:

Non-methane hydrocarbons (NMHCs) can serve as precursors of ozone and photochem. smog, and hence their highly efficient detection is of great importance for air quality monitoring. Here, we synthesized a new fluorescent perylene bisimide (PBI)-cored metallacycle complex through coordination-driven self-assembly and used it for the production of a fluorescent film sensor. The unique rectangular structure of the developed fluorophore endows the sensor with enhanced sensing performance and discriminability to n-alkanes (C5-10). Specifically, the exptl. detection limits for n-pentane, n-hexane, and n-decane are 39, 7, and 1.4 mg/m3, resp., and the corresponding linear ranges are from 39 to 2546, 7 to 1745, and 1.4 to 85 mg/m3, resp. Moreover, the sensing is fully reversible. In tandem with a gas chromatog. separation system, the film sensor showed comparable detection ability for the n-alkanes with a com. flame ionization detector (FID), while the film sensor needs no hydrogen; it occupies a much smaller size (30 x 30 x 44 mm3) and consumes less energy (0.215 W). Further studies demonstrated that the developed sensor can be used for on-site and real-time quantification of NHMCs, laying the foundation for developing into a portable detector. In addition to this study using 4-Ethynylpyridine, there are many other studies that have used 4-Ethynylpyridine(cas: 2510-22-7Application In Synthesis of 4-Ethynylpyridine) was used in this study.

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Application In Synthesis of 4-Ethynylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Harenberg, Johannes H.; Weidmann, Niels; Wiegand, Alexander J.; Hoefer, Carla A.; Annapureddy, Rajasekar Reddy; Knochel, Paul published an article in 2021. The article was titled 《(2-Ethylhexyl)sodium: A Hexane-Soluble Reagent for Br/Na-Exchanges and Directed Metalations in Continuous Flow》, and you may find the article in Angewandte Chemie, International Edition.Application of 3510-66-5 The information in the text is summarized as follows:

We report the on-demand generation of hexane-soluble (2-ethylhexyl)sodium (1) from 3-(chloromethyl)heptane (2) using a sodium-packed-bed reactor under continuous flow conditions. Thus, the resulting solution of 1 is free of elemental sodium and therefore suited for a range of synthetic applications. This new procedure avoids the storage of an alkylsodium and limits the handling of metallic sodium to a min. (2-Ethylhexyl)sodium (1) proved to be a very useful reagent and undergoes in-line Br/Na-exchanges as well as directed sodiations. The resulting arylsodium intermediates are subsequently trapped in batch with various electrophiles such as ketones, aldehydes, Weinreb-amides, imines, allyl bromides, disulfides and alkyl iodides. A reaction scale-up of the Br/Na-exchange using an in-line electrophile quench was also reported. The experimental part of the paper was very detailed, including the reaction process of 2-Bromo-5-methylpyridine(cas: 3510-66-5Application of 3510-66-5)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Application of 3510-66-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Imaging and therapeutic applications of Zn(II)-cryptolepine-curcumin molecular probes in cell apoptosis detection and photodynamic therapy》 was written by Qin, Qi-Pin; Wei, Zu-Zhuang; Wang, Zhen-Feng; Huang, Xiao-Ling; Tan, Ming-Xiong; Zou, Hua-Hong; Liang, Hong. Electric Literature of C12H13N3 And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020. The article conveys some information:

Novel red Zn(II) complex-based fluorescent probes featuring cryptolepine-curcumin derivatives, namely, [Zn(BQ)Cl2] (BQ-Zn) and [Zn(BQ)(Cur)]Cl (BQCur-Zn), were developed for the simple and fluorescent label-free detection of apoptosis, an important biol. process. The probes could synergistically promote mitochondrion-mediated apoptosis and enhance tumor therapeutic effects in vitro and vivo. The experimental part of the paper was very detailed, including the reaction process of Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Electric Literature of C12H13N3)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Electric Literature of C12H13N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Efficient Transfer Hydrogenation of Ketones Catalyzed by a Phosphine-Free Cobalt-NHC Complex》 was written by Ibrahim, Jessica Juweriah; Reddy, C. Bal; Fang, Xiaolong; Yang, Yong. Computed Properties of C7H7NO And the article was included in European Journal of Organic Chemistry in 2020. The article conveys some information:

A simple phosphine-free cobalt-NHC pincer complex was synthesized and used for the transfer hydrogenation of ketones with 2-propanol as hydrogen donor. A broad range of ketones varying from aromatic, aliphatic and heterocyclic were effectively reduced to their corresponding alcs. in moderate to excellent yields with good tolerance of functional groups. In the part of experimental materials, we found many familiar compounds, such as 4-Acetylpyridine(cas: 1122-54-9Computed Properties of C7H7NO)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Computed Properties of C7H7NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem