Tag: 100-200

Electric Literature of C7H7NOIn 2021 ,《Divergent, Strain-Release Reactions of Azabicyclo[1.1.0]butyl Carbinols: Semipinacol or Spiroepoxy Azetidine Formation》 was published in Angewandte Chemie, International Edition. The article was written by Gregson, Charlotte H. U.; Noble, Adam; Aggarwal, Varinder K.. The article contains the following contents:

The azetidine moiety is a privileged motif in medicinal chem. and new methods that access them efficiently are highly sought after. Towards this goal, we have found that azabicyclo[1.1.0]butyl carbinols, readily obtained from the highly strained azabicyclo[1.1.0]butane (ABB), can undergo divergent strain-release reactions upon N-activation. Treatment with trifluoroacetic anhydride or triflic anhydride triggered a semipinacol rearrangement to give keto 1,3,3-substituted azetidines. More than 20 examples were explored, enabling us to evaluate selectivity and the migratory aptitude of different groups. Alternatively, treatment of the same alcs. with benzyl chloroformate in the presence of NaI led to iodohydrin intermediates which gave spiroepoxy azetidines upon treatment with base. The electronic nature of the activating agent dictates which pathway operates. In addition to this study using 4-Acetylpyridine, there are many other studies that have used 4-Acetylpyridine(cas: 1122-54-9Electric Literature of C7H7NO) was used in this study.

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Electric Literature of C7H7NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application In Synthesis of Pyridin-3-ylboronic acidIn 2020 ,《Recyclable Cu@C3N4-Catalyzed Hydroxylation of Aryl Boronic Acids in Water under Visible Light: Synthesis of Phenols under Ambient Conditions and Room Temperature》 appeared in ACS Sustainable Chemistry & Engineering. The author of the article were Muhammad, Mehwish Hussain; Chen, Xiao-Lan; Liu, Yan; Shi, Tao; Peng, Yuyu; Qu, Lingbo; Yu, Bing. The article conveys some information:

A heterogeneous photocatalyst based on copper-doped g-C3N4 was developed for the oxidative hydroxylation of aryl boronic acids into phenols at room temperature under the irradiation of blue light (460 nm). The reaction proceeded efficiently in water as a green solvent and air as a green oxidant, giving various phenols as products with high yields in a short reaction time. Importantly, this heterogeneous catalyst can be used at least 5 times with the reactivities maintained. A copper-doped g-C3N4 was developed as a heterogeneous photocatalyst for the hydroxylation of aryl boronic acids toward phenols in water under room temperature with the irradiation of blue light. The results came from multiple reactions, including the reaction of Pyridin-3-ylboronic acid(cas: 1692-25-7Application In Synthesis of Pyridin-3-ylboronic acid)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Application In Synthesis of Pyridin-3-ylboronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Yao, Tuanli; Zhao, Shuaijing; Liu, Tao; Wu, Yuting; Ma, Yanhui; Li, Tao; Qin, Xiangyang published an article in 2022. The article was titled 《Transition-metal-free approaches to 2,3-diarylated indenones from 2-alkynylbenzaldehydes and phenols with tunable selectivity》, and you may find the article in Chemical Communications (Cambridge, United Kingdom).Safety of 2-Bromonicotinaldehyde The information in the text is summarized as follows:

The first transition-metal-free regioselective synthesis of 2,3-diarylindenones via tandem annulation of 2-alkynylbenzaldehydes with phenols was described. Two different modes of reaction controlled by electronic effects and temperature furnished either “”non-rearranged”” or “”rearranged”” indenones in high selectivity. The experimental process involved the reaction of 2-Bromonicotinaldehyde(cas: 128071-75-0Safety of 2-Bromonicotinaldehyde)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Safety of 2-Bromonicotinaldehyde

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Highly efficient and selective photocatalytic CO2 to CO conversion in aqueous solution》 was written by Chai, Xiaomin; Huang, Hai-Hua; Liu, Huiping; Ke, Zhuofeng; Yong, Wen-Wen; Zhang, Ming-Tian; Cheng, Yuan-Sheng; Wei, Xian-Wen; Zhang, Liyan; Yuan, Guozan. Reference of Bis(pyridin-2-ylmethyl)amine And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020. The article conveys some information:

Five mol. complexes with different non-noble metal centers were synthesized. The Co-based complex displays the highest photocatalytic performance for CO2 to CO conversion in aqueous media. It achieves high activity (TON = 41 017 and TOF = 3.80 s-1) and selectivity (87%) for the production of CO. In the part of experimental materials, we found many familiar compounds, such as Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Reference of Bis(pyridin-2-ylmethyl)amine)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Reference of Bis(pyridin-2-ylmethyl)amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《A highly sensitive “”ON-OFF”” optical sensor for the selective detection of cyanide ions in 100% aqueous solutions based on hydrogen bonding and water assisted aggregation induced emission》 was written by Nazarian, Ramo; Darabi, Hossein Reza; Aghapoor, Kioumars; Firouzi, Rohoullah; Sayahi, Hani. Reference of 2,6-Diaminopyridine And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020. The article conveys some information:

Nanoparticles N,N’-(pyridine-2,6-diyl)bis(2-(2,4-dichlorophenoxy)acetamide) exhibited an “”on-off”” emission response toward cyanide (CN-) ions in 100% aqueous solutions based on AIE features. AIEgen 1 is an easy-to-use probe that exhibits rapid response (5 s), extremely high sensitivity (limit of detection = 8.2 nM) and excellent selectivity. The sensing performance of CN- through a test kit and bitter seed solutions was good. The exptl. results show that compound 1 is planar and can self-assemble into a supramol. system and show blue emission. Then, CN- destroys both hydrogen bonds and the aggregates of 1 and quenches the emission. This process is reversible upon the addition of HCl solution In addition to this study using 2,6-Diaminopyridine, there are many other studies that have used 2,6-Diaminopyridine(cas: 141-86-6Reference of 2,6-Diaminopyridine) was used in this study.

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Reference of 2,6-Diaminopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《New α-hydroxy-1,2,3-triazoles and 9H-fluorenes-1,2,3-triazoles: synthesis and evaluation as glycine transporter 1 inhibitors》 was published in Journal of the Brazilian Chemical Society in 2020. These research results belong to Da Silva, Veronica D.; Silva, Rafaela R.; Neto, Joao Goncalves; Lopez-Corcuera, Beatriz; Guimaraes, Marilia Z.; Noeel, Francois; Buarque, Camilla D.. HPLC of Formula: 128071-75-0 The article mentions the following:

Two series of new compounds containing 1,2,3-triazole moiety were designed as putative GlyT1 inhibitors aiming the discovery of new hits with activity in cognitive disorders. 1,4-disubstituted α-hydroxy-1,2,3-triazoles I [Ar = Ph, 4-BrC6H4, 4-C(O)MeC6H4, etc.; X = H, Br, Ph, etc.; Y = CH, N; Z = H, Br] were obtained as racemates in moderate to good yields by the copper-catalyzed azide-alkyne cycloaddition reaction (click chem.) as the key step between propargyl alcs. and aryl azides, previously prepared from anilines or boronic acids. Benzo[c]chromene-triazoles were planned to be obtained by palladium-catalyzed C-H activation using [bis(trifluoroacetoxy)iodobenzene] of some compounds I, since benzo[c]chromenes were also privileged groups with several biol. activities, including to the central nervous system. Unexpectedly, 9H-fluorenes-1,2,3-triazoles II [R = F, OMe, C(O)Me] instead of benzo[c]chromene-triazoles, were obtained by Friedel-Crafts alkylation reaction of compounds I [Ar = 4-MeOC6H4, 4-FC6H4, 4-C(O)MeC6H4; X = Ph; Y = CH; Z = H]. Two series of compounds I and II were tested for inhibition of the glycine transporter (rat GlyT1 isoform) but only compound I [Ar = 4-BrC6H4; X = Br; Y = CH; Z = H] was active (half maximal inhibitory concentration (IC50) = 8.0μM). The experimental part of the paper was very detailed, including the reaction process of 2-Bromonicotinaldehyde(cas: 128071-75-0HPLC of Formula: 128071-75-0)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.HPLC of Formula: 128071-75-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Stress associated protein from Lobularia maritima: Heterologous expression, antioxidant and antimicrobial activities with its preservative effect against Listeria monocytogenes inoculated in beef meat》 were Ben Hsouna, Anis; Ben Saad, Rania; Zouari, Nabil; Ben Romdhane, Walid; Brini, Faical; Ben Salah, Riadh. And the article was published in International Journal of Biological Macromolecules in 2019. Formula: C6H5NO2 The author mentioned the following in the article:

Stress associated Protein from Lobularia maritima (LmSAP) transcripts showed up-regulation in response to wounding, Methyl-jasmonate acid, Picolinic acid, and ethephon treatments. The antioxidant activities of the purified LmSAP protein were evaluated using various in vitro and in vivo assays. LmSAP has an excellent DPPH scavenging ability and exhibits notable reducing power capacity and led to a decrease in TBARS values. The LmSAP showed an important antimicrobial activity against different pathogenic strains tested. In fact, the Inhibition Zone (IZ), Minimal Inhibitory Concentration (MIC) and The Min. Bactericidal Concentration (MCB) recorded were in the range of 14-22 mm, 62-250 μg/mL and 125-250 μg/mL, resp. The LmSAP protein successfully inhibited the growth of L. monocytogenes in minced beef meat. Furthermore, the LmSAP enhanced the sensory acceptability extending the shelf life of minced beef meat. Overall, the finding demonstrates that the application of LmSAP may open new promising opportunities for the prevention of bacterial contamination, particularly L. monocytogenes, during minced beef meat storage. In addition to this study using Picolinic acid, there are many other studies that have used Picolinic acid(cas: 98-98-6Formula: C6H5NO2) was used in this study.

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Formula: C6H5NO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Anion-π and H-Bonding Interactions Supporting Encapsulation of [Ln(NO3)6/5]3-/2- (Ln = Nd, Er) with a Triazine-Based Ligand》 were de Bettencourt-Dias, Ana; Beeler, Rose M.; Zimmerman, Joshua R.. And the article was published in Journal of the American Chemical Society in 2019. Related Products of 1539-42-0 The author mentioned the following in the article:

Reaction of NdIII and ErIII nitrate salts with a 1,3,5-tris(dipicolylamine)-triazine (dpat) ligand yielded two unprecedented examples of [Ln(NO3)6/5]3-/2- (Ln = Nd, Er) moieties completely encapsulated by the ligands. They are found in the two new complexes, [(H3dpat)2][(Nd(NO3)6)2]·2CH3CN (1), and the related [(H3dpat)2][(Er(NO3)5)3]·3CH3CN·2H2O (2). The structures of the complexes are similar and they crystallize in the triclinic P-1 space group with a 12.1630(3), b 12.2694(3), c 17.6357(5) Å, and a 14.3372(4), b 17.1271(4), c 25.2207(7) Å, resp. Anion-π interactions, which are reported here for the first time for LnIII ion complexes, hydrogen bonding interactions and π-π stacking support the formation of the encapsulated species. Evidence of the protonated dpat ligand in 1 and 2 was found through isolation of (H2dpat)(NO3)2. Finally, the pH-dependent ability of the ligand to extract LaIII and nitrate ions from aqueous into toluene solution is demonstrated. In the experiment, the researchers used Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Related Products of 1539-42-0)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Related Products of 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Journal of Biomolecular Structure and Dynamics included an article by Anjomshoa, Marzieh; Torkzadeh-Mahani, Masoud; Sahihi, Mehdi; Rizzoli, Corrado; Ansari, Mehdi; Janczak, Jan; Sherafat Esfahani, Sheila; Ataei, Farangis; Dehkhodaei, Monireh; Amirheidari, Bagher. Synthetic Route of C12H12N2. The article was titled 《Tris-chelated complexes of nickel(II) with bipyridine derivatives: DNA binding and cleavage, BSA binding, molecular docking, and cytotoxicity》. The information in the text is summarized as follows:

Two nickel(II) complexes with substituted bipyridine ligand of the type [Ni(NN)3](ClO4)2, where NN is 4,4′-dimethyl-2,2′-bipyridine (dimethylbpy) () and 4,4′-dimethoxy-2,2′-bipyridine (dimethoxybpy) (), have been synthesized, characterized, and their interaction with DNA and bovine serum albumin (BSA) studied by different phys. methods. X-ray crystal structure of shows a six-coordinate complex in a distorted octahedral geometry. DNA-binding studies of and reveal that both complexes sit in DNA groove and then interact with neighboring nucleotides differently; undergoes a partial intercalation. This is supported by mol.-docking studies, where hydrophobic interactions are apparent between and DNA as compared to hydrogen bonding, hydrophobic, and p-p interactions between and DNA minor groove. Moreover, the two complexes exhibit oxidative cleavage of supercoiled plasmid DNA in the presence of hydrogen peroxide as an activator in the order of >. In terms of interaction with BSA, the results of spectroscopic methods and mol. docking show that binds with BSA only via hydrophobic contacts while interacts through hydrophobic and hydrogen bonding. It has been extensively demonstrated that the nature of the methyl- and methoxy-groups in ligands is a strong determinant of the bioactivity of nickel(II) complexes. This may justify the above differences in biomol. interactions. The experimental process involved the reaction of 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Synthetic Route of C12H12N2)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.Synthetic Route of C12H12N2 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Fluorine-substituted tetracationic ABAB-phthalocyanines for efficient photodynamic inactivation of Gram-positive and Gram-negative bacteria》 was written by Revuelta-Maza, Miguel A.; Gonzalez-Jimenez, Patricia; Hally, Cormac; Agut, Montserrat; Nonell, Santi; de la Torre, Gema; Torres, Tomas. Recommanded Product: 4-EthynylpyridineThis research focused onzinc fluorine substituted phthalocyanine complex preparation fluorescence; antibacterial activity photodynamic therapy zinc phthalocyanine; Amphiphile; Bacteria; Cationic; Photodynamic inactivation; Phthalocyanine. The article conveys some information:

Herein, the authors report the synthesis and characterization of new amphiphilic phthalocyanines (Pcs), the study of their singlet oxygen generation capabilities, and biol. assays to determine their potential as photosensitizers for photodynamic inactivation of bacteria. In particular, Pcs with an ABAB geometry (A and B refer to differently substituted isoindole constituents) have been synthesized. These mols. are endowed with bulky bis(trifluoromethylphenyl) groups in two facing isoindoles, which hinder aggregation and favor singlet oxygen generation, and pyridinium or alkylammonium moieties in the other two isoindoles. In particular, two water-soluble Pc derivatives (PS-1 and PS-2) proved to be efficient in the photoinactivation of S. aureus and E. coli, selected as models of Gram-pos. and Gram-neg. bacteria. After reading the article, we found that the author used 4-Ethynylpyridine(cas: 2510-22-7Recommanded Product: 4-Ethynylpyridine)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Recommanded Product: 4-Ethynylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem