Tag: 100-200

In 2022,Peng, Sasa; Wang, Huaxin; Ding, Haichang; Fan, Congbin; Liu, Gang; Pu, Shouzhi published an article in Journal of Photochemistry and Photobiology, A: Chemistry. The title of the article was 《A high selective chemosensor for detection of Al3+ based on diarylethene with a hydrazide unit》.Recommanded Product: 2510-22-7 The author mentioned the following in the article:

Al3+ plays an indispensable role in different physiol. processes. However, excess Al3+ is destructive to health. Here, a diarylethene-based fluorescent sensor (1O) was synthesized by attaching a hydrazide group to diarylethene moiety through Schiff base structure. In acetonitrile, 1O displayed excellent selectivity and sensitivity to Al3+. The fluorescence intensity increased by 70-fold and accompanied by the color of the solution changed from dark to blue with the addition of Al3+. Further, the potential response mechanism of 1O toward Al3+ was proposed and verified by 1H NMR titrations and mass spectrometry anal., the stoichiometric ratios of the sensor with Al3+ appeared to be 1:1 with the detection limit of 0.073 μM. In addition, 1O has been successfully applied to the detection of Al3+ in real water samples, and it also has successfully designed as mol. logic circuit and test strips. In the experiment, the researchers used many compounds, for example, 4-Ethynylpyridine(cas: 2510-22-7Recommanded Product: 2510-22-7)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Recommanded Product: 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Crystal structure of 5-((bis(pyridin-2-ylmethyl)amino)methyl)quinolin-8-ol, C22H20N4O》 was published in Zeitschrift fuer Kristallographie – New Crystal Structures in 2020. These research results belong to Liu, Jia; Nie, Xu-Liang; Yin, Zhong-Ping; Peng, Da-Yong; Shi, Xu-Gen. Synthetic Route of C12H13N3 The article mentions the following:

C22H20N4O, monoclinic, P21/n (number 14), a = 11.1861(14) Å, b = 8.1418(10) Å, c = 20.461(3) Å, β = 97.433(1)°, V = 1847.8(4) Å3, Z = 4, Rgt(F) = 0.0357, wRref(F2) = 0.1002, T = 296(2) K. CCDC number: 1967398. To a mixture of 8-hydroxyquinoline-5-carbaldehyde (1.04 g, 6 mmol) and bis(pyridin-2-ylmethyl)amine (1.22 g, 6 mmol) in CH2Cl2 (50 mL) was added sodium triacetoxyborohydride (1.4 g, 6.6 mmol) at 0 °C. The mixture was stirred for 24 h at room temperature Dichloromethane was removed by evaporation and the residue was purified by chromatog. on silica gel (eluent: Et acetate) to give the yellow solid [5, 6]. m.p. 102 °C-106 0C; 1H NMR (400 MHz, CDCl3) δ [ppm] 8.78-8.73 (m, 1H), 8.65-8.57 (m, 1H), 8.56-8.51 (m, 2H), 7.67- 7.60 (m, 2H), 7.55-7.49 (m, 1H), 7.48-7.42 (m, 1H), 7.41-7.35 (m, 2H), 7.21-7.13 (m, 2H), 7.06 (d, j = 7.8 Hz, 1H), 4.25-4.14 (m, 2H), 4.06-3.95 (m, 4H); 13C NMR (100 MHz, CDCl3) δ [ppm] 158.07, 152.08, 148.51, 147.48, 138.48, 136.81, 133.99, 129.86, 127.77,124.02,123.65,122.31,121.53,108.94, 59.681, 56.29. After reading the article, we found that the author used Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Synthetic Route of C12H13N3)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Synthetic Route of C12H13N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Synthesis of ethyl 4-(4-nitrophenoxy) picolinate》 were Xiong, Hehua; Gao, Yanli; Yang, Qi; Tang, Qidong; Zheng, Pengwu. And the article was published in IOP Conference Series: Materials Science and Engineering in 2019. Category: pyridine-derivatives The author mentioned the following in the article:

Et 4-(4-nitrophenoxy) picolinate 4 is an important intermediate for the synthesis of many biol. active compounds The compound Et 4-(4- nitrophenoxy) picolinate was obtained by three simple steps to synthesis from 2- picoliniacid. In this paper, three novel chloropicolinoyl chloride derivatives were prepared The structure was confirmed by MS and 1H NMR. Furthermore, the synthetic method was optimized. The total yield of the target product was 78.57%. The experimental part of the paper was very detailed, including the reaction process of Picolinic acid(cas: 98-98-6Category: pyridine-derivatives)

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,Chemical Communications (Cambridge, United Kingdom) included an article by Fieser, Megan E.; Schimler, Sydonie D.; Mitchell, Lauren A.; Wilborn, Emily G.; John, Alex; Hogan, Levi T.; Benson, Brooke; LaPointe, Anne M.; Tolman, William B.. Application In Synthesis of 2-(2-Hydroxyethyl)pyridine. The article was titled 《Dual-catalytic decarbonylation of fatty acid methyl esters to form olefins》. The information in the text is summarized as follows:

The homogeneous dehydrative decarbonylation of fatty acid Me esters (FAMEs) to form olefins was reported. In order to facilitate cleavage of the unactivated acyl C-O bond of the alkyl ester, a one pot dual-catalytic directing group strategy was developed through optimization of the individual transesterification and decarbonylation reaction steps. The experimental part of the paper was very detailed, including the reaction process of 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Application In Synthesis of 2-(2-Hydroxyethyl)pyridine)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Application In Synthesis of 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Wang, Xin; Lv, Huichao; Yang, Liguo; Dai, Yuqiang published 《Crystal structure of bis(μ2-azido-κ2N:N)-dichlorido-bis(μ2-2-(pyridin-2-yl)ethan-1-ol-κ2O,N)dicopper(II), C14H18Cl2Cu2N8O2》.Zeitschrift fuer Kristallographie – New Crystal Structures published the findings.Quality Control of 2-(2-Hydroxyethyl)pyridine The information in the text is summarized as follows:

C14H18Cl2Cu2N8O2, monoclinic, P21/n (number 14), a = 6.0166(6) Å, b = 15.2792(14) Å, c = 11.5833(12) Å, β = 100.295(1)°, V = 1047.70(18) Å3, Z = 2, Rgt(F) = 0.0412, wRref(F2) = 0.0884, T = 298 K. In the experiment, the researchers used 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Quality Control of 2-(2-Hydroxyethyl)pyridine)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Quality Control of 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Safety of 2-(2-Hydroxyethyl)pyridineIn 2018 ,《Polydentate 4-Pyridyl-terpyridine Containing Discrete Cobalt Phosphonate and Polymeric Cobalt Phosphate as Catalysts for Alcohol Oxidation》 appeared in Zeitschrift fuer Anorganische und Allgemeine Chemie. The author of the article were Bhat, Gulzar A.; Rajendran, Antony; Murugavel, Ramaswamy. The article conveys some information:

Mononuclear discrete cobalt phosphonate [Co(pytpy)(tBuPO3H)2(H2O)]·H2O (1) and 1D zigzag polymeric cobalt phosphate [Co(pytpy)2(dipp)(MeOH)·2MeOH]n (2) were prepared from the reactions of tert-Bu phosphonic acid (tBuPO3H2) and organic-soluble 2,6-diisopropylphenyl phosphate (dippH2) ligands with Co(OAc)2·4H2O in the presence of 4-pyridyl 2,2:6,2-terpyridine in MeOH/CHCl3(1:1 volume/volume) solvent mixture at 25 °C. The new compounds were characterized by anal., thermo-anal., and spectroscopic techniques. Further, the mol. structures were established by single-crystal X-ray diffraction studies. Mass spectrometry anal. reveal that both the compounds exist in the solution phase as dimers. Compound 1 was employed as homogeneous catalysts for alc. oxidation reactions using tert-Bu hydroperoxide (TBHP) as the oxidant. In addition to this study using 2-(2-Hydroxyethyl)pyridine, there are many other studies that have used 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Safety of 2-(2-Hydroxyethyl)pyridine) was used in this study.

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Safety of 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application In Synthesis of 4-CyanopyridineIn 2020 ,《Benzylic C-H heteroarylation of N-(benzyloxy)phthalimides with cyanopyridines enabled by photoredox 1,2-hydrogen atom transfer》 appeared in Chemical Communications (Cambridge, United Kingdom). The author of the article were Zhong, Long-Jin; Wang, Hong-Yu; Ouyang, Xuan-Hui; Li, Jin-Heng; An, De-Lie. The article conveys some information:

A visible light initiated α-C(sp3)-H arylation of N-(benzyloxy)phthalimides with cyanopyridines for the construction of highly valuable pyridinyl-containing diarylmethanols, including bioactive motif-based analogs, is reported. This method enables arylation of the C(sp3)-H bonds adjacent to an oxygen atom through alkoxy radical formation by O-N bond cleavage, 1,2-hydrogen atom transfer (HAT), arylation and C-CN bond cleavage cascades, and offers a means to exploit 1,2-HAT modes to incorporate functional groups for constructing functionalized alcs. In the experimental materials used by the author, we found 4-Cyanopyridine(cas: 100-48-1Application In Synthesis of 4-Cyanopyridine)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Application In Synthesis of 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Guo, Yuanqiang; Cao, Yunpeng; Song, Hongjian; Liu, Yuxiu; Wang, Qingmin published an article in 2021. The article was titled 《Photoredox relay-catalyzed gem-difluoroallylation of alkyl iodides》, and you may find the article in Chemical Communications (Cambridge, United Kingdom).Reference of Pyridin-3-ylboronic acid The information in the text is summarized as follows:

Herein, a new example of relay catalysis, using a combination of Mn2(CO)10 and an iridium-based photocatalyst, is reported. In this relay catalytic reaction, the Mn catalyst and iridium-based photocatalyst catalyze the reaction at different stages in the desired sequence under the same reaction conditions, and do not inhibit each other. This convenient method transforms a broad scope of alkyl iodides RI (R = iso-Pr, cyclopentyl, 4-methoxyphenethyl, morpholino, etc.) into the corresponding gem-difluoroalkenes R1C(=CF2)CH2R (R1 = Ph, 2-naphthyl, pyridin-3-yl, etc.) via C(sp3)-C(sp3) bond construction. The protocol has good functional group tolerance and is suitable for the late-stage modification of multifunctional complex mols. In the experiment, the researchers used many compounds, for example, Pyridin-3-ylboronic acid(cas: 1692-25-7Reference of Pyridin-3-ylboronic acid)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Reference of Pyridin-3-ylboronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《A directing group-assisted ruthenium-catalyzed approach to access meta-nitrated phenols》 was written by Sasmal, Sheuli; Sinha, Soumya Kumar; Lahiri, Goutam Kumar; Maiti, Debabrata. Name: 2-Bromo-5-methylpyridine And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020. The article conveys some information:

Meta-Selective C-H nitration of phenol derivatives RC6H4OR1 (R = H, 4-Me, 2-MeO, 4-Ph, etc.; R1 = pyridin-2-yl, 5-methylpyridin-2-yl, pyrimidin-2-yl) was developed using a Ru-catalyzed σ-activation strategy. Cu(NO3)2.3H2O was employed as the nitrating source, whereas Ru2(CO)12 was found to be the most suitable metal catalyst for the protocol. Mechanistic studies suggested involvement of an ortho-CAr-H metal intermediate, which promoted meta-electrophilic aromatic substitution and silver-assisted free-radical pathway. The experimental process involved the reaction of 2-Bromo-5-methylpyridine(cas: 3510-66-5Name: 2-Bromo-5-methylpyridine)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Name: 2-Bromo-5-methylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Immobilization of Mn(I) and Ru(II) polypyridyl complexes on TiO2 nanoparticles for selective photoreduction of CO2 to formic acid》 were Le-Quang, Long; Stanbury, Matthew; Chardon-Noblat, Sylvie; Mouesca, Jean-Marie; Maurel, Vincent; Chauvin, Jerome. And the article was published in Chemical Communications (Cambridge, United Kingdom) in 2019. Formula: C12H12N2 The author mentioned the following in the article:

TiO2 nanoparticles are successively functionalized with [Mn(κ2N1,N2-ttpy)(CO)3Br] as catalyst and [Ru(bpy)3]2+ as photosensitizer to yield RuII/TiO2/MnI. Under continuous irradiation at 470 nm and in the presence of a sacrificial electron donor, this triad reduces CO2 to HCOOH (TONmax = 27) with 100% selectivity. The experimental process involved the reaction of 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Formula: C12H12N2)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.Formula: C12H12N2 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem