Tag: 100-200

The author of 《Microwave-assisted synthesis and sublimation enthalpies of hemiporphyrazines》 were Kuznetsova, Aleksandra S.; Pechnikova, Nadezhda L.; Zhabanov, Yuriy A.; Khochenkov, Aleksey E.; Koifman, Oscar I.; Aleksandriiskii, Victor V.; Islyaikin, Mikhail K.. And the article was published in Journal of Porphyrins and Phthalocyanines in 2019. Recommanded Product: 141-86-6 The author mentioned the following in the article:

It was established that microwave irradiation solvent-free processing of 2,6-diaminopyridine or 1,3-phenylenediamine with phthalonitrile or 4-tert-butylphthalonitrile led to corresponding hemiporphyrazines I (X = N, CH; Y = H, t-Bu; X = CH, Y = t-Bu, Z = H; X = CH, Y = H, Z = t-Bu) with sufficiently high yields and a huge reduction in the time required for synthesis, from 8-12 h to 20 min. The Knudsen effusion method with mass spectrometric control of vapor composition was applied. The mass spectrometric investigations established that the macrocyclic compounds I give a stable stream of particles and their enthalpies of sublimation were estimated by the second law of thermodn. The results came from multiple reactions, including the reaction of 2,6-Diaminopyridine(cas: 141-86-6Recommanded Product: 141-86-6)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Recommanded Product: 141-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《LMCT transition-based red-light photochemotherapy using a tumour-selective ferrocenyl iron(III) coumarin conjugate》 was written by Sarkar, Tukki; Bhattacharyya, Arnab; Banerjee, Samya; Hussain, Akhtar. HPLC of Formula: 1539-42-0This research focused ontumor ferrocenyl iron coumarin conjugate preparation. The article conveys some information:

A rationally designed iron(III) complex (2a) with pendant ferrocene and naturally occurring coumarin (esculetin) shows LMCT transition-based mitochondria-targeted red-light (600-720 nm) induced apoptotic toxicity against cancer cells but remains innocuous in the dark and to normal cells. In the experimental materials used by the author, we found Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0HPLC of Formula: 1539-42-0)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.HPLC of Formula: 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《A mesoporous NNN-pincer-based metal-organic framework scaffold for the preparation of noble-metal-free catalysts》 was written by Zhang, Yingmu; Li, Jialuo; Yang, Xinyu; Zhang, Peng; Pang, Jiandong; Li, Bao; Zhou, Hong-Cai. Formula: C6H6BrNThis research focused onzirconium terpyridinephenylcarboxylate MOF preparation gas adsorption isotherm epoxidation catalyst; borylation catalyst zirconium terpyridinephenylcarboxylate MOF; surface area pore size distribution thermal stability zirconium terpyridinephenylcarboxylate. The article conveys some information:

Through topol.-guided synthesis, a Zr-based mesoporous MOF was successfully constructed, adopting a β-cristobalite-type structure. The MOF is embedded with well-arranged terpyridine coordination sites for facile post-synthetic metalation, and can be effectively used as a general scaffold for the preparation of noble-metal-free catalysts. For instance, the scaffolded metal@MOF material exhibits highly efficient catalytic activity for alkene epoxidation and arene borylation. After reading the article, we found that the author used 2-Bromo-5-methylpyridine(cas: 3510-66-5Formula: C6H6BrN)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Formula: C6H6BrN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Cao, Bing-Jun; Li, Ran; Huang, Xi-He published their research in Acta Crystallographica, Section C: Structural Chemistry in 2021. The article was titled 《Synthesis, structure and photophysical properties of two tetranuclear copper(I) iodide complexes based on acetylpyridine and diphosphine mixed ligands》.Product Details of 1122-54-9 The article contains the following contents:

Two copper(I) iodide tetramers, namely, [μ2-1,3-bis(diphenylphosphanyl)propane-κ2P:P′]di-μ3-iodido-di-μ2-iodido-[1-(pyridin-3-yl)ethan-1-one-κN]tetracopper(I) dichloromethane disolvate, [Cu4I4(C6H7NO)2(C27H26P2)2]·2CH2Cl2 (CuL3), and [μ2-1,3-bis(diphenylphosphanyl)propane-κ2P:P′]di-μ3-iodido-di-μ2-iodido-[1-(pyridin-4-yl)ethan-1-one-κN]tetracopper(I), [Cu4I4(C6H7NO)2(C27H26P2)2] (CuL4), have been synthesized from reactions of CuI, 1,3-bis(diphenylphosphanyl)propane (dppp) and 3- or 4-acetylpyridine (3/4-acepy). The complexes were characterized by elemental anal., IR spectroscopy, single-crystal X-ray diffraction (XRD), powder XRD and photoluminescence spectroscopy. Both complexes possess a stair-step [Cu4I4] cluster structure with a crystallog. inversion center located in the middle of a Cu2I2 ring (Z′ = 1/2). The dppp ligands each adopt a bidentate coordination mode that bridges two CuI centers on one side of the [Cu4I4] cluster and the acepy ligands act as terminal ligands. The solid-state samples of similar complexes show highly efficiency thermally activated delayed fluorescence (TADF) at room temperature At ambient temperature, both CuL3 and CuL4 exhibit photoluminescence, with a maximum emission in the region 560-580 nm and with short emissive decay times, but only phosphorescence was observed at 77 K. The narrow gaps between the higher lying singlet state and the triplet state, ΔE(S1 – T1), also confirm the presence of TADF. Structure anal. and consideration of photoluminescence indicates that the position of the acetyl group on the heterocyclic ligand has an obvious influence on the structural arrangement, on intermol. interactions and on the observed photophys. properties. In the experimental materials used by the author, we found 4-Acetylpyridine(cas: 1122-54-9Product Details of 1122-54-9)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Product Details of 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《The conformational analyses of 2-amino-N-[2-(dimethylphenoxy)ethyl]propan-1-ol derivatives in different environments》 was published in Acta Crystallographica, Section C: Structural Chemistry in 2020. These research results belong to Nitek, Wojciech; Kania, Agnieszka; Marona, Henryk; Waszkielewicz, Anna M.; Zeslawska, Ewa. Application of 98-98-6 The article mentions the following:

Four crystal structures of 2-amino-N-(dimethylphenoxyethyl)propan-1-ol derivatives, characterized by X-ray diffraction anal., are reported. The free base (R,S)-2-amino-N-[2-(2,3-dimethylphenoxy)ethyl]propan-1-ol, C13H21NO2, 1, crystallizes in the space group P21/n, with two independent mols. in the asym. unit. The hydrochloride, (S)-N-[2-(2,6-dimethylphenoxy)ethyl]-1-hydroxypropan-2-aminium chloride, C13H21NO2+Cl-, 2c, crystallizes in the space group P21, with one cation and one chloride anion in the asym. unit. The asym. unit of two salts of 2-picolinic acid, namely, (R,S)-N-[2-(2,3-dimethylphenoxy)ethyl]-1-hydroxypropan-2-aminium pyridine-2-carboxylate, C13H22NO2+·C6H4NO2-, 1p, and (R)-N-[2-(2,6-dimethylphenoxy)ethyl]-1-hydroxypropan-2-aminium pyridine-2-carboxylate, C13H22NO2+·C6H4NO2-, 2p, consists of one cation and one 2-picolinate anion. Salt 1p crystallizes in the triclinic centrosym. space group P [inline formula omitted] , while salt 2p crystallizes in the space group P41212. The conformations of the amine fragments are contrasted and that of 2p is found to have an unusual antiperiplanar arrangement about the ether group. The crystal packing of 1 and 2c is dominated by hydrogen-bonded chains, while the structures of the 2-picolinate salts have hydrogen-bonded rings as the major features. In both salts with 2-picolinic acid, the specific R12(5) hydrogen-bonding motif is observed Structural studies have been enriched by the generation of fingerprint plots derived from Hirshfeld surfaces. In the experiment, the researchers used Picolinic acid(cas: 98-98-6Application of 98-98-6)

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Application of 98-98-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Journal of Enzyme Inhibition and Medicinal Chemistry included an article by Elie, Jonathan; Vercouillie, Johnny; Arlicot, Nicolas; Lemaire, Lucas; Bidault, Rudy; Bodard, Sylvie; Hosselet, Christel; Deloye, Jean-Bernard; Chalon, Sylvie; Emond, Patrick; Guilloteau, Denis; Buron, Frederic; Routier, Sylvain. Related Products of 128071-75-0. The article was titled 《Design of selective COX-2 inhibitors in the (aza)indazole series. Chemistry, in vitro studies, radiochemistry and evaluations in rats of a [18F] PET tracer》. The information in the text is summarized as follows:

A series of novel derivatives exhibiting high affinity and selectivity towards the COX-2 enzyme in the (aza) indazole series was developed. A short synthetic route involving a bromination/arylation sequence under microwave irradiation and direct C-H activation were established in the indazole and azaindazole series resp. In vitro assays were conducted and structural modifications were carried out on these scaffolds to furnish compound which exhibited effective COX-2 inhibitory activity, with IC50 values of 0.409 μM and an excellent selectivity vs. COX-1. Radiolabeling of this most potent derivative [18F] was achieved after boron ester release and the tracer was evaluated in vivo in a rat model of neuroinflammation. All chem., radiochem. and biol. exptl. data are discussed. The experimental part of the paper was very detailed, including the reaction process of 2-Bromonicotinaldehyde(cas: 128071-75-0Related Products of 128071-75-0)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Related Products of 128071-75-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,Gibson, Maya Z.; Nguyen, Minh A.; Zingales, Sarah K. published 《Design, Synthesis, and Evaluation of (2-(Pyridinyl)methylene)-1-tetralone Chalcones for Anticancer and Antimicrobial Activity》.Medicinal Chemistry (Sharjah, United Arab Emirates) published the findings.Category: pyridine-derivatives The information in the text is summarized as follows:

Background: Chalcones, natural products produced by plants as a natural defense mechanisms against various pathogens, are mols. with structures that include two aromatic rings joined by an α, β unsaturated carbonyl system. Previous research has demonstrated that chalcones exhibit a wide variety of biol. activities, including anticancer, antifungal, and antibiotic properties. Objective: Our goal is to synthesize novel heterocyclic-containing chalcones and have their biol. activities evaluated. Methods Sixteen chalcones were synthesized by the crossed aldol condensation of substituted tetralones with substituted pyridinylaldehydes. The products were purified by recrystallization in MeOH/H2O and characterized by 1H NMR, 13C NMR, and HRMS. Anticancer assays were performed by NCI (National Cancer Institute) against the NCI-60 panel of 60 different human cancer cell lines, including leukemia, non-small-cell lung cancer, colon, central nervous system, melanoma, ovarian, renal, prostate, and breast cancer. Antimicrobial assays were performed by COADD (Community for Open Antimicrobial Drug Discovery) against Escherichia coli, Klebsiella pneumonia, Acinetobacter baumannii, Pseudomonas aeruginosa, Staphylococcus aureus, Cryptococcus neoformans var. grubii, and Candida albicans. Result: Chalcone 3d had demonstrated growth inhibition greater than 60% against a variety of cancers: leukemia (MOLT-4, SR), non-small cell lung cancer (NCI-H522), colon cancer (HCT- 116), prostate cancer (DU-145), and breast cancer (MCF7, MDA-MB-468) and was also cytotoxic to three different cell lines (CCRF-CEM, RPMI-8226, and KM12). 5c was active against leukemia (CCRF-CEM, RPMI-8226, SR) and breast cancer (MCF7) and 5e was active only against leukemia (RPMI-8226, SR). 5h was partially active and the best compound with growth inhibition of MRSA by 75%. 3b was the best compound against EC, KP, and PA and 3f had the greatest activity against AB. For fungi, 3f and 3e demonstrated the best growth inhibition. Conclusion: A small library of heterocyclic-containing chalcones was developed and initial screening demonstrates modest activity against cancers, bacteria, and fungi. In the experiment, the researchers used many compounds, for example, 2-Bromonicotinaldehyde(cas: 128071-75-0Category: pyridine-derivatives)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Colak, Alper Tolga; Gunay, Handan; Temel, Ersin; Buyukgungor, Orhan; Colak, Ferdag published 《Synthesis, crystal structures, characterization and antimicrobial activities of 5-hydroxyisophthalate complexes》.Transition Metal Chemistry (Dordrecht, Netherlands) published the findings.Quality Control of 2-(2-Hydroxyethyl)pyridine The information in the text is summarized as follows:

Two 5-hydroxyisophthalate complexes of nickel(II), formulated as [Ni(μ-Hhip)(2-hepy)2]n (1) and [Ni2(μ-Hhip)2(dap)4]n (2) (H3hip = 5-hydroxyisophthalic acid, 2-hepy = 2-(2-hydroxyethyl)pyridine, dap = 1,3-diaminopropane), have been synthesized and characterized by chem. and spectroscopic methods. The mol. structures of the complexes have been determined by single-crystal x-ray diffraction anal. The Ni(II) centers have distorted octahedral geometries in both crystals. Furthermore, both complexes have 1D chain structures in which the individual chains are linked together via hydrogen bonds to give 3D frameworks. Evaluation of the complexes by the agar diffusion method showed that they have weak antibiotic activities against the tested microorganisms. In the part of experimental materials, we found many familiar compounds, such as 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Quality Control of 2-(2-Hydroxyethyl)pyridine)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Quality Control of 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Al-Sayed, Emir; Tanuhadi, Elias; Giester, Gerald; Rompel, Annette published an article in Acta Crystallographica, Section C: Structural Chemistry. The title of the article was 《Synthesis and characterization of the ′Japanese rice-ball′-shaped Molybdenum Blue Na4-[Mo2O2(OH)4(C6H4NO2)2]2[Mo120Ce6O366H12(OH)2(H2O)76]-200H2O》.Recommanded Product: 98-98-6 The author mentioned the following in the article:

The hybridized lanthanide-containing molybdenum blue (Ln-MB) wheel Na4[Mo2O2(OH)4(C6H4NO2)2]2[Mo120Ce6O366H12(OH)2(H2O)76]∼200H2O ({Mo2(C6H4NO2)2}2{Mo120Ce6}) was assembled in an aqueous one-pot synthesis. The Ln-MB was hybridized with 2-picolinic acid through the generation of the organometallic counter-ion [Mo2O2(OH)4(C6H4NO2)2]2+. Control experiments demonstrated that the position of the carboxylic acid group (2-position to the N atom) in the hybridization component is critical in yielding single crystals of Ln-MB. In addition to single-crystal X-ray diffraction (XRD) anal., which revealed a ′Japanese rice-ball′-shaped Ln-MB as the anion, elemental analyses, IR spectroscopy, and thermogravimetric anal. (TGA) were performed to confirm its structure and composition Bond-valence-sum calculations (BVS) revealed that ({Mo2(C6H4NO2)2}2{Mo120Ce6}) is composed of a 24-electron reduced anionic ring, which was confirmed by Vis-NIR spectroscopy. The results came from multiple reactions, including the reaction of Picolinic acid(cas: 98-98-6Recommanded Product: 98-98-6)

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Recommanded Product: 98-98-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Meena, Priyanka; Ayushee; Patel, Monika; Verma, Akhilesh K. published an article in Chemical Communications (Cambridge, United Kingdom). The title of the article was 《Transition-metal-free regioselective hydroamination of styrenes with amino-heteroarenes》.Safety of 6-Bromopyridin-3-amine The author mentioned the following in the article:

The base-mediated anti-Markovnikov hydroamination of functionally varied styrenes with amino-substituted pyridines, quinoline, pyrimidine, pyrazine with excellent regioselectivity to afford arylalkyl nitrogen heterocycles I [R1 = H, 4-Me, 6-Me, 4-CF3, etc; R2 = H, 4-Me, 4-Cl, etc.] and II [R3 = Ph, 4-MeC6H4, 1-naphthyl, 4-tBuC6H4; X = N; Y = N] was described. Double hydroamination was observed chemoselectively on the secondary amine, leaving the primary amine intact. The results came from multiple reactions, including the reaction of 6-Bromopyridin-3-amine(cas: 13534-97-9Safety of 6-Bromopyridin-3-amine)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Safety of 6-Bromopyridin-3-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem