Tag: 100-200

Yang, Weixiang; Tang, Shuihua; Huang, Qiankuan; Zhang, Qian; Tang, Zhen; Yang, Shuang published their research in Journal of Materials Science: Materials in Electronics in 2021. The article was titled 《Highly effective Fe-N-C electrocatalysts toward oxygen reduction reaction originated from 2,6-diaminopyridine》.Quality Control of 2,6-Diaminopyridine The article contains the following contents:

Fe-N-C electrocatalysts have been intensively studied due to their extraordinary catalytic activity toward oxygen reduction reaction (ORR). Here we prepare a Fe-N-C electrocatalyst through cost-effective and nontoxic precursors of 2,6-diaminopyridine (DAP) and FeCl3, where iron ions react with DAP to formed Fe-Nx species first, followed by polymerization and pyrolysis. X-ray diffraction patterns display no obvious Fe2O3 peaks observed in the catalyst as the nominal content of iron addition is less than 10 wt%. XPS spectra indicate that the catalyst has rich pyridinic nitrogen, graphitic nitrogen and Fe-Nx species, which are considered as active sites for ORR. Therefore the catalyst demonstrates an excellent catalytic activity with an onset potential of about 0.96 V, half-wave potential of about 0.84 V, and a limiting c.d. of 5.8 mA cm-2, better than com. Pt/C catalyst in an alk. medium. Furthermore its stability is also much more excellent than that of Pt/C. This work provides a strategy to synthesize universal M-N-C catalysts.2,6-Diaminopyridine(cas: 141-86-6Quality Control of 2,6-Diaminopyridine) was used in this study.

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Quality Control of 2,6-Diaminopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Expanding the repertoire of nitrilases with broad substrate specificity and high substrate tolerance for biocatalytic applications》 was written by Sunder, Avinash Vellore; Shah, Shikha; Rayavarapu, Pratima; Wangikar, Pramod P.. Computed Properties of C6H4N2 And the article was included in Process Biochemistry (Oxford, United Kingdom) in 2020. The article conveys some information:

Enzymic conversion of nitriles to carboxylic acids by nitrilases has gained significance in the green synthesis of several pharmaceutical precursors and fine chems. Although nitrilases from several sources have been characterized, there exists a scope for identifying broad spectrum nitrilases exhibiting higher substrate tolerance and better thermostability to develop industrially relevant biocatalytic processes. Through genome mining, we have identified nine novel nitrilase sequences from bacteria and evaluated their activity on a broad spectrum of 23 industrially relevant nitrile substrates. Nitrilases from Zobellia galactanivorans, Achromobacter insolitus and Cupriavidus necator were highly active on varying classes of nitriles and applied as whole cell biocatalysts in lab scale processes. Z. galactanivorans nitrilase could convert 4-cyanopyridine to achieve yields of 1.79 M isonicotinic acid within 3 h via fed-batch substrate addition The nitrilase from A. insolitus could hydrolyze 630 mM iminodiacetonitrile at a fast rate, effecting 86% conversion to iminodiacetic acid within 1 h. The arylaliph. nitrilase from C. necator catalyzed enantioselective hydrolysis of 740 mM mandelonitrile to (R)-mandelic acid in 4 h. Significantly high product yields suggest that these enzymes would be promising additions to the suite of nitrilases for upscale biocatalytic application. In the experiment, the researchers used 4-Cyanopyridine(cas: 100-48-1Computed Properties of C6H4N2)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Computed Properties of C6H4N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Chemical Communications (Cambridge, United Kingdom) included an article by Larpent, Patrick; Jouaiti, Abdelaziz; Kyritsakas, Nathalie; Hosseini, Mir Wais. COA of Formula: C7H5N. The article was titled 《Molecular tectonics: from a rigid achiral organic tecton to 3D chiral Co and Fe coordination networks》. The information in the text is summarized as follows:

An achiral organic tecton bearing four coordinating sites of the pyridyl type gives iso-structural 3D helical coordination polymers when combined with Co(SCN)2 and Fe(SCN)2 achiral neutral complexes. Their formation occurs during the self-assembly process in the solid state, which leads to crystals composed of homochiral coordination polymers. The experimental part of the paper was very detailed, including the reaction process of 4-Ethynylpyridine(cas: 2510-22-7COA of Formula: C7H5N)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. COA of Formula: C7H5N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《An activity-based two-photon fluorescent probe for real-time and reversible imaging of oxidative stress in the rat brain》 was written by Liang, Chunjing; Chen, Xianghan; Tang, Qiao; Ji, Wenliang; Jiang, Ying; Mao, Lanqun; Wang, Ming. Computed Properties of C7H7NOThis research focused ontwo photon fluorescent probe imaging oxidative stress brain. The article conveys some information:

The real-time and reversible detection of cellular glutathione and oxidative stress challenges the study of the redox homeostasis of biol. systems. The authors report herein a modular approach to design the Michael addition between glutathione and coumarin derivatives for fluorescence imaging of the reversible and dynamic change of oxidative stress in living cells and the rat brain. The results came from multiple reactions, including the reaction of 4-Acetylpyridine(cas: 1122-54-9Computed Properties of C7H7NO)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Computed Properties of C7H7NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Activity and electrochemical properties: iron complexes of the anticancer drug triapine and its analogs》 was written by Plamthottam, Sheba; Sun, Daniel; Van Valkenburgh, Juno; Valenzuela, Jeffrey; Ruehle, Bastian; Steele, Dalton; Poddar, Soumya; Marshalik, Maxim; Hernandez, Selena; Radu, Caius Gabriel; Zink, Jeffrey I.. HPLC of Formula: 39856-58-1 And the article was included in JBIC, Journal of Biological Inorganic Chemistry on August 31 ,2019. The article conveys some information:

Abstract: Triapine (3-AP), is an iron-binding ligand and anticancer drug that is an inhibitor of human ribonucleotide reductase (RNR). Inhibition of RNR by 3-AP results in the depletion of dNTP precursors of DNA, thereby selectively starving fast-replicating cancer cells of nucleotides for survival. The redox-active form of 3-AP directly responsible for inhibition of RNR is the Fe(II)(3-AP)2 complex. In this work, we synthesize 12 analogs of 3-AP, test their inhibition of RNR in vitro, and study the electronic properties of their iron complexes. The reduction and oxidation events of 3-AP iron complexes that are crucial for the inhibition of RNR are modeled with solution studies. We monitor the pH necessary to induce reduction in iron complexes of 3-AP analogs in a reducing environment, as well as the kinetics of oxidation in an oxidizing environment. The oxidation state of the complex is monitored using UV-Vis spectroscopy. Isoquinoline analogs of 3-AP favor the maintenance of the biol. active reduced complex and possess oxidation kinetics that allow redox cycling, consistent with their effective inhibition of RNR seen in our in vitro experiments In contrast, methylation on the thiosemicarbazone secondary amine moiety of 3-AP produces analogs that form iron complexes with much higher redox potentials, that do not redox cycle, and are inactive against RNR in vitro. Graphic abstract: The catalytic subunit of human Ribonucleotide Reductase (RNR), contains a tyrosyl radical in the enzyme active site. Fe(II) complexes of 3-AP and its analogs can quench the radical and, subsequently, inactivate RNR. The potency of RNR inhibitors is highly dependent on the redox properties of the iron complexes, which can be tuned by ligand modifications. Complexes are found to be active within a narrow redox window imposed by the cellular environment.[Figure not available: see fulltext.]. In the experimental materials used by the author, we found 2-Bromopyridin-3-amine(cas: 39856-58-1HPLC of Formula: 39856-58-1)

2-Bromopyridin-3-amine(cas: 39856-58-1) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.HPLC of Formula: 39856-58-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

SDS of cas: 2510-22-7In 2019 ,《Copper-catalyzed aminothiolation of terminal alkynes with tunable regioselectivity》 was published in Chemical Communications (Cambridge, United Kingdom). The article was written by Kuang, Jinqiang; Xia, Yuanzhi; Yang, An; Zhang, Heng; Su, Chenliang; Lee, Daesung. The article contains the following contents:

A simple, mild, and efficient copper(I)-catalyzed aminothiolation of terminal alkynes R1CCH (R1 = HOCH2CH2, Me3Si, cyclohexen-1-yl, Ph, pyridin-2-yl, etc.) with 5-R2-substituted 2-mercaptobenzimidazoles (R2 = H, Me, MeO, O2N) gave both 2- and 3-substituted thiazolo[3,2-a]benzimidazoles I, where complementary regioselectivities could be achieved by using sterically different phenanthroline-based ligands, such as 1,10-phenanthroline and 2,9-diisopropyl-1,10-phenanthroline. In addition to this study using 4-Ethynylpyridine, there are many other studies that have used 4-Ethynylpyridine(cas: 2510-22-7SDS of cas: 2510-22-7) was used in this study.

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. SDS of cas: 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application In Synthesis of 4-CyanopyridineIn 2019 ,《Three AgI, CuI and CdII coordination polymers based on the new asymmetrical ligand 2-{4-[(1H-imidazol-1-yl)methyl]phenyl}-5-(pyridin-4-yl)-1,3,4-oxadiazole: syntheses, characterization and emission properties》 was published in Acta Crystallographica, Section C: Structural Chemistry. The article was written by Jin, Guo-Xia; You, Tian-Chao; Ma, Jian-Ping. The article contains the following contents:

The new asym. organic ligand 2-{4-[(1H-imidazol-1-yl)methyl]phenyl}-5-(pyridin-4-yl)-1,3,4-oxadiazole (L, C17H13N5O), containing pyridine and imidazole terminal groups, as well as potential oxdiazole coordination sites, was designed and synthesized. The coordination chem. of L with soft AgI, CuI and CdII metal ions was investigated and three new coordination polymers (CPs), namely, catena-poly[[silver(I)-μ-2-{4-[(1H-imidazol-1-yl)methyl]phenyl}-5-(pyridin-4-yl)-1,3,4-oxadiazole] hexafluoridophosphate], {[Ag(L)]PF6}n, catena-poly[[copper(I)-di-μ-iodido-copper(I)-bis(μ-2-{4-[(1H-imidazol-1-yl)methyl]phenyl}-5-(pyridin-4-yl)-1,3,4-oxadiazole)] 1,4-dioxane monosolvate], {[Cu2I2(L)2]·C4H8O2}n, and catena-poly[[[dinitratocopper(II)]-bis(μ-2-{4-[(1H-imidazol-1-yl)methyl]phenyl}-5-(pyridin-4-yl)-1,3,4-oxadiazole)]-methanol-water (1/1/0.65)], {[Cd(L)2(NO3)2]·2CH4O·0.65H2O}n, were obtained. The exptl. results show that ligand L coordinates easily with linear AgI, tetrahedral CuI and octahedral CdII metal atoms to form one-dimensional polymeric structures. The intermediate oxadiazole ring does not participate in the coordination interactions with the metal ions. In all three CPs, weak π-π interactions between the nearly coplanar pyridine, oxadiazole and benzene rings play an important role in the packing of the polymeric chains. In the experiment, the researchers used many compounds, for example, 4-Cyanopyridine(cas: 100-48-1Application In Synthesis of 4-Cyanopyridine)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Application In Synthesis of 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Name: 2-(2-Hydroxyethyl)pyridineIn 2020 ,《Synthesis and antimicrobial activities of Schiff base from nitrogen containing heterocycles》 was published in Journal of Applicable Chemistry (Lumami, India). The article was written by Maisuriya, Pratik K.; Soni, Hetal I.; Patel, Jaydeep A.; Patel, Navin B.. The article contains the following contents:

This article dealt with microwave assisted synthesis of Schiff bases N-(aryl)(((pyridinyl)ethoxy)phenyl)methanimines I [R = Ph, 4-MeC6H4, 4-ClC6H4, etc.] from (2-(pyridinyl)ethoxy)benzaldehyde using catalytically amount of concentrateH2SO4 at room temperature MW stimulated synthetic route provided diverse advantages such as reaction rate acceleration, less byproduct, higher yield and reproducibility of final product. The structure of final compounds was established by elemental anal. such as IR, 1H NMR, 13C NMR, mass spectroscopy and also evaluated for their antibacterial, antifungal potency. The biol. potent Schiff base I [R = benzothiazol-2-yl] was found most active against S. aureus (MIC=25μg mL-1) with subjected to reference drug chloramphenicol and ciprofloxacin. The final compounds I [R = 3-ClC6H4, 4-ClC6H4, benzothiazol-2-yl] displayed good antibacterial activity (MIC=50μg mL-1) with reference drug. In the experiment, the researchers used many compounds, for example, 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Name: 2-(2-Hydroxyethyl)pyridine)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Name: 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

SDS of cas: 1134-35-6In 2020 ,《Unexpected disruption of the dimensionality-driven two-photon absorption enhancement within a multipolar polypyridyl ruthenium complex series》 was published in Chemical Communications (Cambridge, United Kingdom). The article was written by Durand, Nicolas; Mhanna, Rana; Savel, Paul; Akdas-Kilic, Huriye; Malval, Jean-Pierre; Soppera, Olivier; Fillaut, Jean-Luc. The article contains the following contents:

The dimensionality-driven 2-photon absorption (2PA) enhancement effect is studied in functionalized bipyridyl Ru complexes. The design strategy leads to very high 2PA responses up to ~1500 GM. The 2PA performance vs. dimensionality correlation reaches an unexpected limit stemming from anti-cooperative interchromophoric couplings. The experimental process involved the reaction of 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6SDS of cas: 1134-35-6)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.SDS of cas: 1134-35-6 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Quality Control of 4,4′-Dimethyl-2,2′-bipyridineIn 2020 ,《Identification of descriptors for structure-activity relationship in ruthenium (II) mixed compounds with antiparasitic activity》 appeared in European Journal of Medicinal Chemistry. The author of the article were Cedillo-Gutierrez, Erika Lorena; Hernandez-Ayala, Luis Felipe; Torres-Gutierrez, Carolina; Reina, Miguel; Flores-Alamo, Marcos; Carrero, Julio C.; Ugalde-Saldivar, Victor M.; Ruiz-Azuara, Lena. The article conveys some information:

Herein is presented the synthesis, characterization, electrochem. studies, DFT calculations and in vitro evaluation of amoebicidal activity in trophozoites of Entamoeba histolytica of twenty ruthenium(II) mixed compounds with general formulas: [Ru(pdto)(E-E)]Clx (E-E bidentate, either neutral or neg. charged ligands). For compounds under study, O-O, N-O and N-N auxiliary donor ligands demonstrate to have a crucial impact on the electronic properties and that it is possible to modulate the antiparasitic activity. Among analyzed complexes, only four present a better performance compared to typically used metronidazole drug (IC50 < 6.80μmol/L) to treat amebiasis disease. For studied compounds, structure-activity relations are strongly determined by either the redox potential (E1/2) of RuII/RuIII and calculated molar volume (V) of the complexes. The experimental part of the paper was very detailed, including the reaction process of 4,4'-Dimethyl-2,2'-bipyridine(cas: 1134-35-6Quality Control of 4,4′-Dimethyl-2,2′-bipyridine)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.Quality Control of 4,4′-Dimethyl-2,2′-bipyridine Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem