Tag: 100-200

In 2022,Ryan, Christopher A.; Baskevics, Vladislavs; Katkevics, Martins; Rozners, Eriks published an article in Chemical Communications (Cambridge, United Kingdom). The title of the article was 《2-Guanidyl pyridine PNA nucleobase for triple-helical Hoogsteen recognition of cytosine in double-stranded RNA》.Related Products of 141-86-6 The author mentioned the following in the article:

In triplex-forming peptide nucleic acid, a novel 2-guanidyl pyridine nucleobase (V) enables recognition of up to two cytosine interruptions in polypurine tracts of dsRNA by engaging the entire Hoogsteen face of C-G base pair. Ab initio and mol. dynamics simulations provided insights into H-bonding interactions that stabilized V·C-G triplets. Our results provided insights for future design of improved nucleobases, which is an important step towards the ultimate goal of recognition of any sequence of dsRNA. In the experiment, the researchers used many compounds, for example, 2,6-Diaminopyridine(cas: 141-86-6Related Products of 141-86-6)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Related Products of 141-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Rapid development of a bromochloropyridine regioisomer purity method enabled by strategic LC screening》 was published in Journal of Pharmaceutical and Biomedical Analysis in 2020. These research results belong to Borges-Munoz, Amaris; Li, Li; Tattersall, Peter. Product Details of 53939-30-3 The article mentions the following:

With the intent to provide aligned, impactful, and efficient strategies for liquid chromatog. method development, tier-based stationary/mobile phase screening workflows have been implemented in the Chem. Process Development department at Bristol Myers Squibb. These workflows are utilized as tools that enable more rapid method generation for early to mid-stage clin. development programs. An illustrative example of applying this approach was the method development for 3-bromo-2-chloropyridine and six of its positional isomeric impurities. Several parameters (gradient time, flow rate, column geometry, particle size, temperature, and solvent effects) were evaluated to achieve a baseline resolved separation for this challenging mixture The impact that the screening workflows have regarding timesavings, effort, and resourcing to develop and optimize this LC method will be discussed. In the experiment, the researchers used 5-Bromo-2-chloropyridine(cas: 53939-30-3Product Details of 53939-30-3)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Product Details of 53939-30-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Safety of 2,6-DiaminopyridineIn 2019 ,《Secondary Electrostatic Interaction Model Revised: Prediction Comes Mainly from Measuring Charge Accumulation in Hydrogen-Bonded Monomers》 was published in Journal of the American Chemical Society. The article was written by van der Lubbe, Stephanie C. C.; Zaccaria, Francesco; Sun, Xiaobo; Guerra, Celia Fonseca. The article contains the following contents:

The secondary electrostatic interaction (SEI) model is often used to predict and explain relative hydrogen bond strengths of self-assembled systems. The SEI model oversimplifies the hydrogen-bonding mechanisms by viewing them as interacting point charges, but nevertheless exptl. binding strengths are often in line with the model’s predictions. To understand how this rudimentary model can be predictive, we computationally studied two tautomeric quadruple hydrogen-bonded systems, DDAA-AADD and DADA-ADAD. Our results reveal that when the proton donors D (which are electron-donating) and the proton acceptors A (which are electron-withdrawing) are grouped together as in DDAA, there is a larger accumulation of charge around the frontier atoms than when the proton donor and acceptor groups are alternating as in DADA. This accumulation of charge makes the proton donors more pos. and the proton acceptors more neg., which enhances both the electrostatic and covalent interactions in the DDAA dimer. The SEI model is thus predictive because it provides a measure for the charge accumulation in hydrogen-bonded monomers. Our findings can be understood from simple phys. organic chem. principles and provide supramol. chemists with meaningful understanding for tuning hydrogen bond strengths and thus for controlling the properties of self-assembled systems. The results came from multiple reactions, including the reaction of 2,6-Diaminopyridine(cas: 141-86-6Safety of 2,6-Diaminopyridine)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Safety of 2,6-Diaminopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Shoair, Abdel Ghany F.; Shanab, Mai M. A. H.; Mahmoud, Mohamed H. H. published an article in 2021. The article was titled 《Electrochemical and catalytic properties of oxo-ruthenate(VI) in aqueous alkaline medium》, and you may find the article in International Journal of Electrochemical Science.HPLC of Formula: 100-48-1 The information in the text is summarized as follows:

The complex K2[Ru(III)Cl5(H2O)] has been prepared and characterized by different spectroscopic techniques (IR and UV-VIS). The electrochem. properties of this complex were investigated at different pH′s using Robinson buffer solutions The cyclic voltammograms exhibited three redox different oxidation and potential peaks due to generation of Ru(III), Ru(IV), Ru(V) and Ru(VI) ions. The catalytic activity of K2[Ru(III)Cl5(H2O)] towards the hydration of some aromatic and three heterocyclic nitriles to their corresponding amides was investigated with excess of three co-oxidants K2S2O8, NaOCl and KBrO3. A number of factors have been investigated and the best yields were obtained with K2S2O8 as a co-oxidant in a 1.0 M KOH at 80 °C. Both spectroscopic and electrochem. techniques were used to establish the nature of active species in this catalytic reaction and the active catalyst was found to be K2[Ru(VI)O3(OH)2], as well as to explain the possible reaction mechanism. The suggested mechanism included the coordination of nitrile to ruthenium center followed by liberation of the corresponding amide and the active complex again. In the part of experimental materials, we found many familiar compounds, such as 4-Cyanopyridine(cas: 100-48-1HPLC of Formula: 100-48-1)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.HPLC of Formula: 100-48-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Richardson, Keith; Brown, Jeffery published an article in 2021. The article was titled 《in silico reagent design for electron-transfer dissociation on a Q-TOF》, and you may find the article in Journal of the American Society for Mass Spectrometry.HPLC of Formula: 100-48-1 The information in the text is summarized as follows:

Electron-transfer dissociation is an important technique capable of probing the primary and higher order structure of a wide variety of biomols. and yielding information that is often inaccessible using other common MS methods. The source of the electron used to initiate the fragmentation event is a radical anion, and the fragmentation process therefore depends intimately on the electronic properties of both the reagent and analyte ions. A good reagent must ionize easily and be sufficiently robust to survive transport to the reaction location, but must also be capable of donating an electron to analyte cations efficiently enough to overcome competition with other ion-ion reaction channels. Inspired by the work of Gunawardena et al. (), an in silico workflow to allow prescreening of potential electron-transfer reagents for use in glow-discharge sources is described. Approx. 150 candidate mols. have been characterized using this workflow. We discuss in detail the properties of a selected subset of singly and doubly substituted benzenes and introduce five effective new reagents that have been identified as a result of this work.4-Cyanopyridine(cas: 100-48-1HPLC of Formula: 100-48-1) was used in this study.

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. HPLC of Formula: 100-48-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adak, Laksmikanta; Jin, Masayoshi; Saito, Shota; Kawabata, Tatsuya; Itoh, Takuma; Ito, Shingo; Sharma, Akhilesh K.; Gower, Nicholas J.; Cogswell, Paul; Geldsetzer, Jan; Takaya, Hikaru; Isozaki, Katsuhiro; Nakamura, Masaharu published their research in Chemical Communications (Cambridge, United Kingdom) in 2021. The article was titled 《Iron-catalyzed enantioselective carbometalation of azabicycloalkenes》.Application In Synthesis of 5-Bromo-2-chloropyridine The article contains the following contents:

The first enantioselective carbometalation reaction of azabicycloalkenes has been achieved by iron catalysis to in situ form optically active organozinc intermediates, which are amenable to further synthetic elaborations. The observed chiral induction, along with the DFT and XAS analyses, reveals the direct coordination of the chiral phosphine ligand to the iron center during the carbon-carbon and carbon-metal bond forming step. This new class of iron-catalyzed asym. reaction will contribute to the synthesis and production of bioactive mols. The results came from multiple reactions, including the reaction of 5-Bromo-2-chloropyridine(cas: 53939-30-3Application In Synthesis of 5-Bromo-2-chloropyridine)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Application In Synthesis of 5-Bromo-2-chloropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Jmai, Momtez; Efrit, Mohamed Lotfi; Dubreuil, Didier; Blot, Virginie; Lebreton, Jacques; M’rabet, Hedi published their research in Phosphorus, Sulfur and Silicon and the Related Elements in 2021. The article was titled 《An efficient and simple strategy toward the synthesis of highly functionalized compounds》.Reference of 2-Bromonicotinaldehyde The article contains the following contents:

The expedient syntheses of small libraries of ((β-ethoxycarbonyl, -cyano and -acetyl)propyloxy) methylphosphonate scaffolds bearing olefin, sulfanyl, or amine functions are described. All these new derivatives are readily produced from easily available starting reagents (aldehydes, electron-poor olefins, and dialkylphosphites) following a three steps reaction sequence of condensations, SN2′-type reaction and a conjugated thia- or aza-Michael 1,4-addition with aromatic and aliphatic thiol or amine nucleophiles. The experimental part of the paper was very detailed, including the reaction process of 2-Bromonicotinaldehyde(cas: 128071-75-0Reference of 2-Bromonicotinaldehyde)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Reference of 2-Bromonicotinaldehyde

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Synthesis, structure and magnetic property of a tricapped trigonal prismatic TbIII -based 3d-4f complex》 was written by Zhuang, Jia-Jia; Chen, Ming-Guang; Sun, Yan-Bing; Hang, Pei; Sui, Yang; Tong, Jia-Ping. Safety of Picolinic acid And the article was included in IOP Conference Series: Materials Science and Engineering in 2020. The article conveys some information:

A novel 3d-4f CoII/TbIII cluster [Co6Tb(Pic)6O3Cl3](H2O)6 (1) (Pic = 2-Picolinic acid) has been synthesized and characterized via X-ray crystallog. and magnetic measurements. X-ray crystallog. and continued shape measurements anal. revealed that the central Terbium (III) is coordinated in TbO9 geometry with D3h symmetry. Magnetic studies indicated the complex presents a magnetic anisotropy with ferrimagnetic interactions. The results came from multiple reactions, including the reaction of Picolinic acid(cas: 98-98-6Safety of Picolinic acid)

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Safety of Picolinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Optical detection of cyanide by palladium(II)-dithiazolopyridine probe at the parts per billion level》 was written by Ebadinia, Leila; Darabi, Hossein Reza; Ramazani, Ali. Quality Control of 2,6-Diaminopyridine And the article was included in Phosphorus, Sulfur and Silicon and the Related Elements in 2020. The article conveys some information:

The ensemble of 2,6-bis(2-chlorophenyl)dithiazolo[4,5-b:5′,4′-e]pyridine with Pd2+ ions (•Pd2+) was prepared for the detection of cyanide ions (CN-) in 50% aqueous methanol. Among the tested metal ions, only Pd2+ sensitively induced the red shift of the absorption bands and the complete decrease of fluorescence emission. The detection limit toward Pd2+ was 2 ppb. The ensemble •Pd2+ selectively and rapidly detected a low concentration of cyanide ions by a colorimetric change (40 ppb) as well as a “”turn-on”” fluorescent response (5 ppb). Job’s plot revealed the complex formation with 1:1 stoichiometry. The binding and replacement mode of •Pd2+ and CN- were also confirmed by 1H NMR titrations and IR anal. In general, a fast and selective recognition of CN- is reported. In the experiment, the researchers used 2,6-Diaminopyridine(cas: 141-86-6Quality Control of 2,6-Diaminopyridine)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Quality Control of 2,6-Diaminopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Hexagonal array formation by intermolecular halogen bonding using a binary blend of linear building blocks: STM study》 were Kikkawa, Yoshihiro; Nagasaki, Mayumi; Koyama, Emiko; Tsuzuki, Seiji; Hiratani, Kazuhisa. And the article was published in Chemical Communications (Cambridge, United Kingdom) in 2019. SDS of cas: 2510-22-7 The author mentioned the following in the article:

Hexagonal arrays were fabricated via intermol. halogen bonding between two linear mol. building blocks in a bicomponent blend. The substitution position of the pyridine N atom involved in the halogen bond plays an important role in the formation of the hexagonal structures. The results came from multiple reactions, including the reaction of 4-Ethynylpyridine(cas: 2510-22-7SDS of cas: 2510-22-7)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. SDS of cas: 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem