Tag: 100-200

In 2019,Austin Journal of Analytical and Pharmaceutical Chemistry included an article by Looga, A. M.; Ambassa, P.; Kamga, J.; Hortense, GK.; Ngadjui, B. T.; Ngameni, B.. COA of Formula: C7H7NO. The article was titled 《Synthesis and evaluation of antimicrobial properties of some novel indole pyridine based chalcones》. The information in the text is summarized as follows:

A series of novel substituted indolylchalcone derivatives (E)-I (R = H, Me, Ar = pyridin-3-yl, pyridin-4-yl) were synthesized via Claisen-Schmidt condensation between indole-3-carbaldehyde and N-methylindole-3-carbaldehyde and 3- and 4-pyridinylacetophenones. All the compounds were screened for their antibacterial and antifungal activity against six different bacterial strains – Escherichia coli ATCC 25922, Klebsiella pneumonia ATCC 700603, Staphylococcus aureus ATCC 25923, Proteus mirabilis, Salmonella typhi, Pseudomonas aeruginosa – and against one fungal strain, Candida albicans. The results reveal that all the compounds exhibited moderate to good antibacterial and antifungal activities. In the part of experimental materials, we found many familiar compounds, such as 4-Acetylpyridine(cas: 1122-54-9COA of Formula: C7H7NO)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. COA of Formula: C7H7NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,Wang, Yanfei; Liu, Nana; Liu, Qingyun; Yang, Liguo; Wei, Aimin published 《Crystal structure of tris(μ2-2-(pyridin-2-yl)ethan-1-olato-κ3N,O:O)-trithiocyanato-κN-dicobalt(III), C24H24Co2N6O3S3》.Zeitschrift fuer Kristallographie – New Crystal Structures published the findings.Quality Control of 2-(2-Hydroxyethyl)pyridine The information in the text is summarized as follows:

C24H24Co2N6O3S3, triclinic, P1[n.773] (number 2), a = 10.5658(9) Å, b = 11.1693(11) Å, c = 11.7054(14) Å, α = 79.200(1)°, β = 84.714(1)°, γ = 89.519(2)°, V = 1351.1(2) Å3, Z = 2, Rgt(F) = 0.0482, wRref(F2) = 0.1213, T = 298 K. In addition to this study using 2-(2-Hydroxyethyl)pyridine, there are many other studies that have used 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Quality Control of 2-(2-Hydroxyethyl)pyridine) was used in this study.

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Quality Control of 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

van Veldhoven, Jacobus P. D.; Campostrini, Giulia; van Gessel, Constantijn J. E.; Ward-van Oostwaard, Dorien; Liu, Rongfang; Mummery, Christine L.; Bellin, Milena; IJzerman, Adriaan P. published an article on February 15 ,2021. The article was titled 《Targeting the Kv11.1 (hERG) channel with allosteric modulators. Synthesis and biological evaluation of three novel series of LUF7346 derivatives》, and you may find the article in European Journal of Medicinal Chemistry.Computed Properties of C6H8N2 The information in the text is summarized as follows:

Three novel series of substituted benzophenones for their allosteric modulation of the human Kv11.1 (hERG) channel were synthesized and evaluated. Effects of this is compared with reference compound LUF7346 previously shown to shorten the action potential of cardiomyocytes derived from human stem cells. Most compounds behaved as neg. allosteric modulators (NAMs) of [3H]dofetilide binding to the channel. Compound III [R = 2-Cl; R1 = CH2cPr; X= Y = C] was the most potent amongst all ligands, remarkably reducing the affinity of dofetilide in competitive displacement assays. One of the other II [R = H; X = N] tested in a second radioligand binding set-up, displayed unusual displacement characteristics with a pseudo-Hill coefficient significantly distinct from unity, further indicative of its allosteric effects on the channel. Some compounds were evaluated in a more physiol. relevant context in beating cardiomyocytes derived from human induced pluripotent stem cells. Surprisingly, the compounds tested showed effects quite different from the reference NAM LUF7346. For instance, compound I [R = 3-Me] prolonged, rather than shortened, the field potential duration, while it did not influence this parameter when the field potential was already prolonged by dofetilide. In subsequent patch clamp studies on HEK293 cells expressing the hERG channel the compounds behaved as channel blockers. In conclusion, new allosteric modulators of the hERG channel were successfully synthesized and identified . Unexpectedly, their effects differed from the reference compound in functional assays on hERG-HEK293 cells and human cardiomyocytes, to the extent that the compounds behaved as stand-alone channel blockers.4-Amino-2-picoline(cas: 18437-58-6Computed Properties of C6H8N2) was used in this study.

4-Amino-2-picoline(cas: 18437-58-6) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Computed Properties of C6H8N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Structural characterization of a hybrid terpyridine-pyrazine ligand and its one-dimensional ZnII coordination polymer: a computational approach to conventional and nonconventional intermolecular interactions》 was written by Granifo, Juan; Gavino, Ruben; Suarez, Sebastian; Baggio, Ricardo. Product Details of 1122-54-9This research focused onzinc terpyridine pyrazine coordination polymer crystal structure intermol interaction; Hirshfeld surface; computational chemistry; crystal structure; energy framework; enrichment ratio; interaction strength hierarchy; one-dimensional coordination polymer; terpyridine-pyrazine. The article conveys some information:

The structures of a new hybrid terpyridine-pyrazine ligand, namely 4′-[4-(pyrazin-2-yl)phenyl]-4,2′:6′,4′′-terpyridine (L2), C25H17N5, and its one-dimensional coordination polymer catena-poly[[bis(acetylacetonato-κ2O,O′)zinc]-μ-4′-[4-(pyrazin-2-yl-κN4)phenyl]-4,2′:6′,4′′-terpyridine-κN1], [Zn(C5H7O2)2(C25H17N5)]n or [Zn(acac)2(L2)]n (Hacac is acetylacetone), are reported. Packing interactions in both crystal structures are analyzed using Hirshfeld surface and enrichment ratio techniques. For the simpler structure of the monomeric ligand, further studies on the interaction hierarchy using the energy framework approach were made. The result was a complete picture of the intermol. interaction landscape, which revealed some subtle details, for example, that some weak (at first sight negligible) C-H···N interactions in the structure of free L2 play a relevant role in the crystal stabilization. After reading the article, we found that the author used 4-Acetylpyridine(cas: 1122-54-9Product Details of 1122-54-9)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Product Details of 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhang, Yuanyuan; Xie, Chuan; Liu, Yang; Shang, Feng; Shao, Rushiya; Yu, Jing; Wu, Chunxia; Yao, Xinghui; Liu, Dongfang; Wang, Zhouyu published an article in 2021. The article was titled 《Synthesis, biological activities and docking studies of pleuromutilin derivatives with piperazinyl urea linkage》, and you may find the article in Journal of Enzyme Inhibition and Medicinal Chemistry.Product Details of 13534-97-9 The information in the text is summarized as follows:

Antibiotics resistance is becoming increasingly common, involving almost all antibiotics on the market. Diseases caused by drug resistant bacteria, such as MRSA, have high mortality and neg. affect public health. The development of new drugs would be an effective means of solving this problem. Modifications based on bioactive natural products could greatly shorten drug development time and improve success rate. Pleuromutilin, a natural product from the basidiomycete bacterial species, is a promising antibiotic candidate. In this study, a series of novel pleuromutilin derivatives possessing piperazinyl urea linkage were efficiently synthesized, and their antibacterial activities and bactericidal properties were evaluated via MIC, MBC and Time-kill kinetics assays. The results showed that all compounds exhibited potent activities against tested strains, especially MRSA strains with MIC values as low as 0.125μg/mL; 8 times lower than that of marketed antibiotic Tiamulin. Docking studies indicate substituted piperazinyl urea derivatives could provide hydrogen bonds and initiate π-π stacking between mols. and surrounding residues. The experimental part of the paper was very detailed, including the reaction process of 6-Bromopyridin-3-amine(cas: 13534-97-9Product Details of 13534-97-9)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Product Details of 13534-97-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Synthesis and structural study of tris(2,6-diaminopyridinium) bis(oxalato)dioxidovanadate(V) 2.5-hydrate》 was written by Sehimi, Hiba; Akitsu, Takashiro; Zid, Mohamed Faouzi. Application In Synthesis of 2,6-DiaminopyridineThis research focused ontrisdiaminopyridinium bis oxalatodioxidovanadatehydrate crystal structure; 2,6-di­amino­pyridine; bis­(oxalato) complexes; crystal structure; dioxovanadate(V); vanadium. The article conveys some information:

Crystals of the title compound, (C5H8N3)3[VO2(C2O4)2]·2.5H2O, a mononuclear VV complex, were obtained by slow evaporation at room temperature of an aqueous solution containing vanadium pentoxide, oxalic acid and 2,6-diaminopyridine. The asym. unit contains one bis(oxalato)dioxovanadate(V) anionic complex, three 2,6-diaminopyridinium cations and two and a half uncoordinated water mols. The mononuclear vanadium(V) anions are connected to the organic cations and water mols. through a strong N-H···O and O-H···O hydrogen-bond network, consolidated by π-π stacking interactions, to form a three-dimensional structure. In the experiment, the researchers used many compounds, for example, 2,6-Diaminopyridine(cas: 141-86-6Application In Synthesis of 2,6-Diaminopyridine)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Application In Synthesis of 2,6-Diaminopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Product Details of 1539-42-0In 2020 ,《A 4,5-quinolimide-based fluorescent sensor for sequential detection of Cu2+ and cysteine in water and living cells with application in a memorized device》 appeared in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy. The author of the article were Zhang, Yu; Li, Lan; Wang, Jinping; Jia, Lihua; Yang, Rui; Guo, Xiangfeng. The article conveys some information:

A new 4,5-quinolimide-based fluorescent sensor BNC was synthesized and characterized. BNC showed single selectivity for Cu2+via the “”turn-off”” fluorescence among various common metal ions. After forming a 1:1 stoichiometric complex with Cu2+, the detection limit (LOD) of BNC for Cu2+ is 0.44μM. Subsequently, the in situ generated BNC-Cu2+ complex had been used for sensing Cys with the LOD of 1.5μM through the displacement strategy, resulting in the revivable emission of BNC. According to the “”off-on-off”” fluorescence cycle of BNC generated by the alternate addition of Cu2+ and Cys, a reversible memorized device with “”read-write-read-erase”” behavior was constructed at the mol. level. Furthermore, the recoveries of Cu2+ in lake water with BNC were at 95.0-105%. And sequential fluorescence imagings of BNC for Cu2+ and Cys were successfully applied in living yeast cells.Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Product Details of 1539-42-0) was used in this study.

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Product Details of 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 98-98-6In 2021 ,《Concentration effects on optical properties, DFT, crystal characterization and α-glucosidase activity studies: Novel Zn(II) complex》 appeared in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy. The author of the article were Dege, Necmi; Ozge, Ozgen; Avci, Davut; Basoglu, Adil; Sonmez, Fatih; Yaman, Mavise; Tamer, Omer; Atalay, Yusuf; Zengin Kurt, Belma. The article conveys some information:

A novel Zn(II) complex of 6-ClpicH and picH was synthesized and its structure was determined by XRD technique. The detailed exptl. optical susceptibility and band gap, refractive index, linear polarizability, optical and elec. conductivity parameters in various concentrations were studied by the UV-visible spectroscopic data. The optical band gap, refractive index (n), linear optical susceptibility (χ(1)), third-order nonlinear optical susceptibility (χ(3)), second- and third-order nonlinear optical (β and γ) parameters were examined by using DFT/M06-L and ωB97XD/6-311++G(d,p) levels. The IC50 value of Zn(II) complex against α-glucosidase was also obtained at 0.44 mM. The exptl. band gap of the Zn(II) complex at 13, 33, 44 and 94μM concentrations in ethanol are 4.38, 4.37, 4.35 and 4.28 eV, resp. The third-order NLO susceptibility χ(3) parameter at 94μM concentration corresponding to the photon energies of 4.6 and 5.7 eV in the UV-visible region were observed at 206.6 x 10-13 and 294.3 x 10-13 esu, resp. Besides, the theor. χ(3) values were obtained at 50.58 x 10-13 and 20.37 x 10-13 esu by using M06-L level. Zn(II) complex could be an effective third-order NLO candidate material. In brief, the detailed theor. and exptl. structural, spectral and optical properties of the Zn(II) complex were presented comparatively. In addition to this study using Picolinic acid, there are many other studies that have used Picolinic acid(cas: 98-98-6Related Products of 98-98-6) was used in this study.

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Related Products of 98-98-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Study Protocol for a Randomized Controlled Trial Evaluating the Effectof Chromium Picolinate Supplementation on Gene Expression of TumorNecrosis Factor-α and DNA Damage in Metabolic Syndrome Patients.》 was written by Mozaffari-Khosravi, Hassan; Jambarsan, Sara; Karimpour, Fazad; Hosseini, Seyyed Ebrahim; Kour, Behrooz Ebrahimzadeh. Application In Synthesis of Picolinic acid And the article was included in Saudi journal of kidney diseases and transplantation in 2021. The article conveys some information:

Metabolic syndrome (MS) is caused by environmental factors as well as genetic. Human studies of efficacy of chromium for glucose and lipid metabolism and insulin function is not still definitive. Furthermore, the effect of chromium supplementation on the expression of inflammatory genes in patients with MS has not been studied. We will assess effects of chromium picolinate supplementation on gene expression of tumor necrosis factor-α (TNF-α) and DNA damage in MS patients. In this triple-blind randomized placebo-controlled clinical trial, 48 MS patients will be randomly assigned into two groups to receive daily 400 μg chromium picolinate supplement or placebo for 12 weeks. The outcome measures include of change in fasting blood sugar, glycosylated hemoglobin A1C, inflammatory biomarkers, lipid profile, blood pressure, gene expression of TNF-α, and 8-hydroxy-deoxyguanosine concentration as DNA damage biomarker, will be quantified at baseline and end of intervention. This protocol was approved by Institutional Research Ethics Committee School of Public Health Shahid Sadoughi University of Medical Sciences (Approval ID: IR.SSU.SPH.REC.1399.141). In addition to this study using Picolinic acid, there are many other studies that have used Picolinic acid(cas: 98-98-6Application In Synthesis of Picolinic acid) was used in this study.

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Application In Synthesis of Picolinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《A binding hotspot in Trypanosoma cruzi histidyl-tRNA synthetase revealed by fragment-based crystallographic cocktail screens》 was written by Koh, Cho Yeow; Kallur Siddaramaiah, Latha; Ranade, Ranae M.; Nguyen, Jasmine; Jian, Tengyue; Zhang, Zhongsheng; Gillespie, J. Robert; Buckner, Frederick S.; Verlinde, Christophe L. M. J.; Fan, Erkang; Hol, Wim G. J.. Category: pyridine-derivativesThis research focused onTrypanosoma histidyl tRNA synthetase crystal structure inhibitor Chagas antiparasitics; fragment-based crystallographic cocktail screening; inhibitor of histidyl-tRNA synthetase; reactive fragment; structure-guided drug discovery; trypanosomiasis. The article conveys some information:

American trypanosomiasis, commonly known as Chagas disease, is a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi. The chronic form of the infection often causes debilitating morbidity and mortality. However, the current treatment for the disease is typically inadequate owing to drug toxicity and poor efficacy, necessitating a continual effort to discover and develop new antiparasitic therapeutic agents. The structure of T. cruzi histidyl-tRNA synthetase (HisRS), a validated drug target, has previously been reported. Based on this structure and those of human cytosolic HisRS, opportunities for the development of specific inhibitors were identified. Here, efforts are reported to identify small mols. that bind to T. cruzi HisRS through fragment-based crystallog. screening in order to arrive at chem. starting points for the development of specific inhibitors. T. cruzi HisRS was soaked into 68 different cocktails from the Medical Structural Genomics of Pathogenic Protozoa (MSGPP) fragment library and diffraction data were collected to identify bound fragments after soaking. A total of 15 fragments were identified, all bound to the same site on the protein, revealing a fragment-binding hotspot adjacent to the ATP-binding pocket. On the basis of the initial hits, the design of reactive fragments targeting the hotspot which would be simultaneously covalently linked to a cysteine residue present only in trypanosomatid HisRS was initiated. Inhibition of T. cruzi HisRS was observed with the resultant reactive fragments and the anticipated binding mode was confirmed crystallog. These results form a platform for the development of future generations of selective inhibitors for trypanosomatid HisRS.6-Bromopyridin-3-amine(cas: 13534-97-9Category: pyridine-derivatives) was used in this study.

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem