Tag: 100-200

Li, Zheng; Xu, Yanqi; Xu, Huandi; Cui, Mengyuan; Liu, Tianguang; Ren, Xiangyu; Sun, Jianfei; Deng, Dawei; Gu, Yueqing; Wang, Peng published their research in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy in 2021. The article was titled 《A dicyanomethylene-4H-pyran-based fluorescence probe with high selectivity and sensitivity for detecting copper (II) and its bioimaging in living cells and tissue》.Computed Properties of C6H5NO2 The article contains the following contents:

Copper (Cu) plays a significant role in the process of oxygenic photosynthesis in living systems. The detection of copper ion (Cu2+) is valuable and meaningful for further studying the functions of Cu2+ under physiol. and pathol. conditions. A novel fluorescence probe DCM-Cu (I) based on the near-IR (NIR) fluorophore dicyanomethylene-4H-pyran (DCM) was designed for Cu2+ detection. The probe DCM-Cu possessed characteristic of “”turn-on”” fluorescent signal in the presence of Cu2+ through the enhanced ICT process. It exhibited satisfactory sensitivity and selectivity toward Cu2+. A good linear correlation was observed between the concentrations of Cu2+ and the fluorescence intensities at 700 nm. The detection limit (LOD) of DCM-Cu toward Cu2+ is 2.54 × 10-8 M. Importantly, DCM-Cu was successfully applied in the detection of Cu2+ in living MCF-7 cells and tumor tissue with low cytotoxicity. Therefore, this probe would have the potential to monitor cellular Cu2+ in the living system and be applied to the diagnosis of related diseases. In addition to this study using Picolinic acid, there are many other studies that have used Picolinic acid(cas: 98-98-6Computed Properties of C6H5NO2) was used in this study.

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Computed Properties of C6H5NO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Satpathi, Bishnupada; Wagulde, Siddhant V.; Ramasastry, S. S. V. published 《An enantioselective organocatalytic intramolecular Morita-Baylis-Hillman (IMBH) reaction of dienones, and elaboration of the IMBH adducts to fluorenones》.Chemical Communications (Cambridge, United Kingdom) published the findings.Recommanded Product: 128071-75-0 The information in the text is summarized as follows:

An enantioselective organocatalytic intramol. Morita-Baylis-Hillman (IMBH) reaction of dienones is reported for the first time. This has been achieved by incorporating entropy and synergy considerations during the substrate design. The reaction conditions are thoroughly verified for an efficient synthesis of highly functionalized cyclopenta-fused arenes and heteroarenes in excellent yields and enantioselectivities. The synthetic utility of the IMBH-adducts has been demonstrated by transforming them into 3,4-disubstituted fluorenones in a serendipitous manner. In the experiment, the researchers used 2-Bromonicotinaldehyde(cas: 128071-75-0Recommanded Product: 128071-75-0)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Recommanded Product: 128071-75-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of C5H6BNO2In 2020 ,《Synthesis and characterization of high affinity fluorogenic α-synuclein probes》 was published in Chemical Communications (Cambridge, United Kingdom). The article was written by Lengyel-Zhand, Zsofia; Ferrie, John J.; Janssen, Bieneke; Hsieh, Chia-Ju; Graham, Thomas; Xu, Kui-ying; Haney, Conor M.; Lee, Virginia M.-Y.; Trojanowski, John Q.; Petersson, E. James; Mach, Robert H.. The article contains the following contents:

Fluorescent small mols. are powerful tools for imaging α-synuclein pathol. in vitro and in vivo. In this work, we explore benzofuranone as a potential scaffold for the design of fluorescent α-synuclein probes. These compounds have high affinity for α-synuclein, show fluorescent turn-on upon binding to fibrils, and display different binding to Lewy bodies, Lewy neurites and glial cytoplasmic inclusion pathologies in post-mortem brain tissue. These studies not only reveal the potential of benzofuranone compounds as α-synuclein specific fluorescent probes, but also have implications for the ways in which α-synucleinopathies are conformationally different and display distinct small mol. binding sites. The experimental process involved the reaction of Pyridin-3-ylboronic acid(cas: 1692-25-7Synthetic Route of C5H6BNO2)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Synthetic Route of C5H6BNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Margonis, Caroline M.; Ho, Marissa; Travis, Benjamin D.; Brennessel, William W.; McNamara, William R. published an article in 2021. The article was titled 《Iron polypyridyl complex adsorbed on carbon surfaces for hydrogen generation》, and you may find the article in Chemical Communications (Cambridge, United Kingdom).Product Details of 1539-42-0 The information in the text is summarized as follows:

A series of homogeneous Fe(III) complexes were recently reported that are active for electrocatalytic hydrogen generation. Herein we report a naphthalene-terminated Fe(III) complex for use in the functionalization of glassy carbon surfaces for electrocatalytic hydrogen generation with retention of catalytic activity. In the part of experimental materials, we found many familiar compounds, such as Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Product Details of 1539-42-0)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Product Details of 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Superstructural diversity in salt-cocrystals: higher-order hydrogen-bonded assemblies formed using U-shaped dications and with assistance of π–π stacking》 was published in Chemical Communications (Cambridge, United Kingdom) in 2020. These research results belong to Yelgaonkar, Shweta P.; Kiani, Daniyal; Baltrusaitis, Jonas; MacGillivray, Leonard R.. COA of Formula: C7H5N The article mentions the following:

Salt cocrystals with components that assemble by hydrogen bonds and aromatic anion-mol. stacks (π–π stacks) are reported. U-shaped bipyridines and an isocoumarin carboxylic acid self-assemble to form 5-, 6-, and 10-component aggregates with components in double and quadruple face-to-face stacks. DFT calculations support the π–π stacks to help stabilize the salt cocrystals. The experimental part of the paper was very detailed, including the reaction process of 4-Ethynylpyridine(cas: 2510-22-7COA of Formula: C7H5N)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.COA of Formula: C7H5N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Chemical Communications (Cambridge, United Kingdom) included an article by Sanchez, Monica L. K.; Wu, Chang-Hao; Adams, Michael W. W.; Dyer, R. Brian. Reference of 4,4′-Dimethyl-2,2′-bipyridine. The article was titled 《Optimizing electron transfer from CdSe QDs to hydrogenase for photocatalytic H2 production》. The information in the text is summarized as follows:

A series of viologen related redox mediators of varying reduction potential has been characterized and their utility as electron shuttles between CdSe quantum dots and hydrogenase enzyme has been demonstrated. Tuning the mediator LUMO energy optimizes the performance of this hybrid photocatalytic system by balancing electron transfer rates of the shuttle. In the experimental materials used by the author, we found 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Reference of 4,4′-Dimethyl-2,2′-bipyridine)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.Reference of 4,4′-Dimethyl-2,2′-bipyridine Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Chemical Communications (Cambridge, United Kingdom) included an article by Ragupathi, Ayyakkannu; Sagadevan, Arunachalam; Charpe, Vaibhav Pramod; Lin, Chun-Cheng; Hwu, Jih-Ru; Hwang, Kuo Chu. Reference of 4-Ethynylpyridine. The article was titled 《Visible-light-driven copper-catalyzed aerobic oxidative cascade cyclization of N-tosylhydrazones and terminal alkynes: regioselective synthesis of 3-arylcoumarins》. The information in the text is summarized as follows:

Regioselective green synthesis of 3-arylcoumarins I [R1 = H, 6-Me, 6-Br, etc.; R2 = H, 3-MeOC6H4, 4-Py, etc.; R3 = H, Me, Ph] as sustainable process was carried out via visible-light-driven copper catalyzed aerobic oxidative cascade cyclization of N-tosylhydrazones with terminal alkynes. This operationally simple methodol. was successfully proceeded well to afford biol. active compounds, such as monoamine oxidase B inhibitor I [R1 = 6-Me; R2 = 3-MeOC6H4; R3 = H] and horseradish peroxidase inhibitor I [R1 = 6-OH; R2 = 2-HOC6H4; R3 = H] in satisfactory yields under mild conditions. In the experiment, the researchers used many compounds, for example, 4-Ethynylpyridine(cas: 2510-22-7Reference of 4-Ethynylpyridine)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Reference of 4-Ethynylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,Fang, Xiangqing; Xu, Jiajia; Qi, Wu; Yang, Liguo; Ya, Li published 《Crystal structure of catena-poly[(μ2-dicyanamido-κ2N:N’)-(μ2-2-(pyridin-2-yl)ethan-1-olato-κ3N,O:O’)copper(II)], C9H8CuN4O》.Zeitschrift fuer Kristallographie – New Crystal Structures published the findings.Formula: C7H9NO The information in the text is summarized as follows:

C9H8CuN4O, triclinic, P1̅ (number 2), a = 7.6740(6) Å, b = 8.6401(8) Å, c = 8.8869(9) Å, α = 109.201(2)°, β = 106.629(1)°, γ = 105.410(1)°, V = 489.21(8) Å3, Z = 2, Rgt(F) = 0.0406, wRref(F2) = 0.0993, T = 298(2) K. After reading the article, we found that the author used 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Formula: C7H9NO)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Formula: C7H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Boiledieu, William; De Abreu, Maxime; Cuyamendous, Claire; Lamaa, Diana; Belmont, Philippe; Brachet, Etienne published an article in Chemical Communications (Cambridge, United Kingdom). The title of the article was 《Photoredox synthesis of 6- and 7-membered ring scaffolds via N-centered radicals》.Electric Literature of C6H4BrNO The author mentioned the following in the article:

N-Containing heterocycles are important scaffolds due to their ubiquitous presence in bioactive compounds Their synthesis has been considered as an important research field. In this work authors report the access to 6- and 7-membered rings via a photoinduced strategy. To authors knowledge, this work represents the first example of photo-induced 7-endo-trig cyclization with N-centered radicals. The experimental process involved the reaction of 2-Bromonicotinaldehyde(cas: 128071-75-0Electric Literature of C6H4BrNO)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Electric Literature of C6H4BrNO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Hydrothermal syntheses, structures and properties of a series of new hybrid iodometallates containing rare cross-shaped spirobifluorene derivatives》 was written by Yang, Lili; Zhou, Jian; An, Litao; Cao, Shumei. Formula: C5H6BNO2 And the article was included in Materials Science & Engineering, B: Advanced Functional Solid-State Materials in 2020. The article conveys some information:

A series of new hybrid iodometallates [H4Spiro-4-py]n[Cu7I10]n(I3-)n·0.5(I2)n·nH2O (1), [Cu2I2(Spiro-3-py)]n·0.75n(DMF)·0.25nH2O (2), [H2Spiro-4-py][H3Spiro-4-py][Ag10I20]0.5·H2O (3) and [H2Spiro-4-py]n[H3Spiro-4-py]n[Ag8I13]n·2.5H2O (4) were hydrothermal synthesized. 1 Contains 1-D chain [Cu7I10]n based on new [Cu7I12] cluster, free I3- anions and I2 mols., which are interconnected by weak I···I interactions to generate a novel polyiodide {[Cu7I10](I3-)·(I2)}n framework. 2 Features a neutral sql layer [Cu2I2(Spiro-3-py)]n constructed by the interconnection of the {Cu2I2} dimers and Spiro-3-py ligands. The anionic [Ag10I20]10- framework of 3 can be described as an aggregation of two tetrameric [Ag4I8] clusters and one dimeric [Ag2I6] unit via sharing corner. The 1-D anionic chain [Ag8I5-13]n of 4 is built up from the alternate connection of tetrameric [Ag4I8] units and rare larger [Ag12I20] clusters, which offers the only example of 1-D iodoargentates based on two types of iodoargentate clusters. The optical and photoelectronic properties of all compounds were also studied. In the experiment, the researchers used Pyridin-3-ylboronic acid(cas: 1692-25-7Formula: C5H6BNO2)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Formula: C5H6BNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem