Tag: 100-200

Lecroq, William;Schleinitz, Jules;Billoue, Mallaury;Perfetto, Anna;Gaumont, Annie-Claude;Lalevee, Jacques;Ciofini, Ilaria;Grimaud, Laurence;Lakhdar, Sami published 《Metal-Free Deoxygenation of Amine N-Oxides: Synthetic and Mechanistic Studies》. The research results were published in《ChemPhysChem》 in 2021.Computed Properties of C6H4N2 The article conveys some information:

An unprecedented combination of light and P(III)/P(V) redox cycling for the efficient deoxygenation of aromatic amine N-oxides was reported. Moreover, a large variety of aliphatic amine N-oxides was easily deoxygenated by using only phenylsilane. These practically simple approaches proceeded well under metal-free conditions, tolerated many functionalities and were highly chemoselective. Combined exptl. and computational studies enabled a deep understanding of factors controlling the reactivity of both aromatic and aliphatic amine N-oxides. To complete the study, the researchers used 3-Cyanopyridine (cas: 100-54-9) .

3-Cyanopyridine(cas: 100-54-9) has been shown to have a number of pharmacological effects: it inhibits the production of prostaglandin E2 and nitric oxide in congestive heart failure patients; it prevents the formation of diazonium salt from benzene and nitrogen dioxide; it inhibits the growth of tumor cell lines; and it protects mice from radiation injury by scavenging reactive oxygen species. Computed Properties of C6H4N2

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of C6H4N2《Silver-Promoted (4 + 1) Annulation of Isocyanoacetates with Alkylpyridinium Salts: Divergent Regioselective Synthesis of 1,2-Disubstituted Indolizines》 was published in 2021. The authors were Chen, Yan;Shatskiy, Andrey;Liu, Jian-Quan;Karkas, Markus D.;Wang, Xiang-Shan, and the article was included in《Organic Letters》. The author mentioned the following in the article:

An unprecedented silver-promoted regioselective (4 + 1) annulation of isocyanoacetates CNCH₂C(O)₂R (R = Me, Et) with pyridinium salts, e.g., 2-(2-oxo-2-phenylethyl)-isoquinolinium bromide is reported. The established protocol provides controlled, facile, and modular access to a range of synthetically useful N-fused heterocyclic scaffolds, e.g., I. A mechanistic pathway involving nucleophilic addition/protonation/elimination/cycloisomerization is proposed. The experimental procedure involved many compounds, such as 3-Cyanopyridine (cas: 100-54-9) .

3-Cyanopyridine(cas: 100-54-9) has been shown to have a number of pharmacological effects: it inhibits the production of prostaglandin E2 and nitric oxide in congestive heart failure patients; it prevents the formation of diazonium salt from benzene and nitrogen dioxide; it inhibits the growth of tumor cell lines; and it protects mice from radiation injury by scavenging reactive oxygen species. Electric Literature of C6H4N2

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

SDS of cas: 100-54-9In 2021, Yuan, Feixiang;Xie, Shihua;Zhuo, Liang;Wang, Lei;Zhu, Hongjun published 《Metal-Free Synthesis of 2-Aryl Quinazolines via Tandem C-H/N-H Bond Functionalization》. 《ChemistrySelect》published the findings. The article contains the following contents:

The present work provides a facile and highly efficient strategy (ca. ∼92%) for the synthesis of quinazoline compounds e.g., I, which involves tandem C-H/N-H bond functionalization using metal-free conditions without the need for an external oxidant. Meanwhile, the reaction system exhibits good functional group tolerance and a wide substrate scope. Furthermore, corresponding isotope tracking experiments have shown that DMSO acts as a carbon source. Finally, this work affords a new strategy toward the further design and synthesis of heteroaromatic rings.3-Cyanopyridine (cas: 100-54-9) were involved in the experimental procedure.

3-Cyanopyridine(cas: 100-54-9) also shows biological activity against autoimmune diseases, such as murine hepatitis, by inhibiting the proliferation of B cells and T cells.SDS of cas: 100-54-9 This drug is not effective against cancer cells because it does not inhibit DNA synthesis or protein synthesis.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 3-Cyanopyridine《Recyclable and Reusable Pd(OAc)₂/XPhos-SO₃Na/PEG-400/H₂O System for Cyanation of Aryl Chlorides with Potassium Ferrocyanide》 was published in 2022. The authors were Cai, Mingzhong;Liu, Rong;Xu, Caifeng;Huang, Bin, and the article was included in《Catalysis Letters》. The author mentioned the following in the article:

Pd(OAc)₂/XPhos-SO₃Na in a mixture of poly(ethylene glycol) (PEG-400) and water is shown to be a highly efficient catalyst for the cyanation of aryl chlorides with potassium ferrocyanide. The reaction proceeded smoothly at 100 or 120°C with K₂CO₃ or KOAc as base, delivering a variety of aromatic nitriles in good to excellent yields. The isolation of the crude products is facilely performed by extraction with cyclohexane and more importantly, both expensive Pd(OAc)₂ and XPhos-SO₃Na in PEG-400/H₂O system could be easily recycled and reused at least six times without any apparent loss of catalytic efficiency. To complete the study, the researchers used 3-Cyanopyridine (cas: 100-54-9) .

3-Cyanopyridine(cas: 100-54-9) also shows biological activity against autoimmune diseases, such as murine hepatitis, by inhibiting the proliferation of B cells and T cells.Reference of 3-Cyanopyridine This drug is not effective against cancer cells because it does not inhibit DNA synthesis or protein synthesis.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of C6H4N2《Blue LED induced solvent-free multicomponent reactions among aryl diazoacetates, pyridine derivatives and maleimides: direct eco-friendly synthesis of densely functionalized itaconimides》 was published in 2022. The authors were Maiti, Debajit;Das, Ranajit;Prabakar, Tejas;Sen, Subhabrata, and the article was included in《Green Chemistry》. The author mentioned the following in the article:

Herein a hitherto novel multicomponent reaction involving pyridine and its derivatives I (R¹ = H, 4-Me, 4-CN) aryl diazoesters ArC(=N₂)C(O)OR² (Ar = Ph, thiophen-3-yl, 4-bromophenyl, etc.; R² = Me, Et) and N-methyl/ethylmaleimide (2 equiv), using a blue LED under neat (solvent-free) conditions and in the absence of any metal catalysts or bases at r. t. to generate densely substituted itaconimides was reported. This environmentally sustainable strategy generated the desired products II (R³ = Me, Et) in excellent yields. The reaction involved the carbene formation of aryl diazoesters from a blue LED and a subsequent generation of pyridine ylides. The pyridine ylides underwent [3 + 2] cycloaddition with N-alkyl maleimides followed by oxidation, subsequent ring opening of the [3 + 2] adducts and finally reaction with another mol. of N-alkyl maleimides to afford the desired itaconimide derivatives The reaction has wide functional group tolerance at the aryl moiety of the diazoesters and also on pyridine. Control experiments and DFT studies were used to elucidate the reaction mechanism. The experimental procedure involved many compounds, such as 3-Cyanopyridine (cas: 100-54-9) .

3-Cyanopyridine(cas: 100-54-9) has been shown to have a number of pharmacological effects: it inhibits the production of prostaglandin E2 and nitric oxide in congestive heart failure patients; it prevents the formation of diazonium salt from benzene and nitrogen dioxide; it inhibits the growth of tumor cell lines; and it protects mice from radiation injury by scavenging reactive oxygen species. Electric Literature of C6H4N2

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhang, Xuan;Nottingham, Kyle G.;Patel, Chirag;Alegre-Requena, Juan V.;Levy, Jeffrey N.;Paton, Robert S.;McNally, Andrew published 《Phosphorus-mediated sp²-sp³ couplings for C-H fluoroalkylation of azines》. The research results were published in《Nature (London, United Kingdom)》 in 2021.Category: pyridine-derivatives The article conveys some information:

Fluoroalkyl groups profoundly affect the phys. properties of pharmaceuticals and influence almost all metrics associated with their pharmacokinetic and pharmacodynamic profile. Drug candidates increasingly contain trifluoromethyl (CF₃) and difluoromethyl (CF₂H) groups, and the same trend in agrochem. development shows that the effect of fluoroalkylation translates across human, insect and plant life. New fluoroalkylation reactions have undoubtedly stimulated this shift; however, methods that directly convert C-H bonds into C-CF₂X groups (where X is F or H) in complex drug-like mols. are rare. Pyridines are the most common aromatic heterocycles in pharmaceuticals, but only one approach – via fluoroalkyl radicals – is viable for achieving pyridyl C-H fluoroalkylation in the elaborate structures encountered during drug development. Here we develop a set of bench-stable fluoroalkylphosphines that directly convert the C-H bonds in pyridine building blocks, drug-like fragments and pharmaceuticals into fluoroalkyl derivatives No preinstalled functional groups or directing groups are required. The reaction tolerates a variety of sterically and electronically distinct pyridines, and is exclusively selective for the 4-position in most cases. The reaction proceeds through initial formation of phosphonium salts followed by sp²-sp³ coupling of phosphorus ligands – an underdeveloped manifold for forming C-C bonds. Thus, e.g., treatment of 2-phenylpyridine with (fluoroalkyl)phosphine I, Tf₂O and DBU afforded intermediate phosphonium salt (not isolated) which, upon treatment with TfOH, MeOH and water afforded II (89%). And 3-Cyanopyridine (cas: 100-54-9) was used in the research process.

3-Cyanopyridine(cas: 100-54-9) has been shown to have a number of pharmacological effects: it inhibits the production of prostaglandin E2 and nitric oxide in congestive heart failure patients; it prevents the formation of diazonium salt from benzene and nitrogen dioxide; it inhibits the growth of tumor cell lines; and it protects mice from radiation injury by scavenging reactive oxygen species. Category: pyridine-derivatives

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hou, Yanggao;Zhu, Limeng;He, Kang;Yang, Ze;Ma, Sicai;Lei, Jiaheng published 《Synthesis of three imidazole derivatives and corrosion inhibition performance for copper》. The research results were published in《Journal of Molecular Liquids》 in 2022.Synthetic Route of C6H4N2 The article conveys some information:

Three imidazole derivatives I [X = 3-pyridyl, 2-pyrazinyl, 2-pyrimidinyl], were synthesized. The structure of these compounds was confirmed by LC-MS, ¹H NMR, ¹³C NMR and FTIR spectra. The inhibition performance in 3.5 wt% NaCl was investigated by electrochem. measurement and surface anal. Results showed that the corrosion efficiency of I [X = 3-pyridyl] (95.93%) was higher than I [X = 2-pyrazinyl] (69.61%) and I [X = 2-pyrimidinyl] (20.46%), which was consistent with the adsorption energy calculated by mol. dynamics simulation. The corrosion inhibition mechanism could be explained by the metal-organic polymer film formed on the copper surface: on the one hand, the π-system formed by aromatic rings is tightly adsorbed on the copper substrates; on the other hand, the nitrogen atoms in the imidazole ring are coordinated with the metal ions in solution to form metal-organic polymer which could improve the compactness of the hydrophobic film.3-Cyanopyridine (cas: 100-54-9) were involved in the experimental procedure.

3-Cyanopyridine(cas: 100-54-9) is an antimicrobial agent that can be used in the treatment of infectious diseases.Synthetic Route of C6H4N2 It has been shown to be effective against a variety of bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus pneumoniae.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Mougeot, Romain;Oger, Samuel;Auvray, Marie;Gallavardin, Thibault;Leleu, Stephane;Mahuteau-Betzer, Florence;Franck, Xavier published 《Convergent and Practical Synthesis of Fluorescent Triphenylamine Derivatives and Their Localization in Living Cells》 in 2022. The article was appeared in 《European Journal of Organic Chemistry》. They have made some progress in their research.Application of 100-54-9 The article mentions the following:

In the search for new fluorescent triphenylamine (TP) derivatives, authors studied the influence of the position and substitution of diverse heterocyclic substituents. A library of 10 fluorescent triphenylamines bearing either oxazoles or thiazoles and pyridiniums, substituted at different positions has been developed. The approach is based on a convergent C-H activation reaction between pyridine-oxazoles or pyridine-thiazoles and di-iodo triphenylamine. Author’s showed that the nature and substitution pattern of the 5-membered- (oxazole, thiazole) or 6-membered heterocycle (pyridine) has a strong influence on their fluorescence properties and on their localization in living cells as they stain either the nucleus or mitochondria. The experimental procedure involved many compounds, such as 3-Cyanopyridine (cas: 100-54-9) .

3-Cyanopyridine(cas: 100-54-9) has been shown to have a number of pharmacological effects: it inhibits the production of prostaglandin E2 and nitric oxide in congestive heart failure patients; it prevents the formation of diazonium salt from benzene and nitrogen dioxide; it inhibits the growth of tumor cell lines; and it protects mice from radiation injury by scavenging reactive oxygen species. Application of 100-54-9

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Today I want to share an article with you. The article is 《Transition-Metal-Free Regioselective Direct C2, C4 Difunctionalization and C2, C4, C6 Trifunctionalization of Pyridines》,you can find this article in 《Advanced Synthesis & Catalysis》. The following contents are mentioned:

This study reports the invention of di- or trifunctionalization of readily available pyridines (including all the pyridine substrates utilized in this paper, such as 3-cyanopyridine and 3-chloropyridine) through dearomative functionalization-oxidative rearomatization under transition-metal- and reductant-free conditions. Although a two-step operation is required, the crude product of the first step could be used in the next step directly. Typically, 3-π-EWG pyridines underwent difunctionalization, whereas 3-σ-EWG pyridines participate in trifunctionalization, affording multisubstituted piperidines. Computational studies provide detailed insights for their distinct reactivity in the title reaction. To complete the study, the researchers used 3-Cyanopyridine (cas: 100-54-9) .

3-Cyanopyridine(cas: 100-54-9) has been shown to have a number of pharmacological effects: it inhibits the production of prostaglandin E2 and nitric oxide in congestive heart failure patients; it prevents the formation of diazonium salt from benzene and nitrogen dioxide; it inhibits the growth of tumor cell lines; and it protects mice from radiation injury by scavenging reactive oxygen species. Electric Literature of C6H4N2

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Efe, Sevval;Schauerte, Carsten;Merz, Klaus published 《Crystal Engineering under Hydrothermal Conditions: Cocrystals and Reactions of 3-Cyanopyridine with Glutaric Acid》 in 2022. The article was appeared in 《Crystal Growth & Design》. They have made some progress in their research.COA of Formula: C6H4N2 The article mentions the following:

Crystallization under hydrothermal conditions is an interesting method to selectively influence crystallization pathways and processes. Crystallization of 3-cyanopyridine and glutaric acid from aqueous solutions under ambient conditions leads to the 2:1 cocryst. entity 1 of 3-cyanopyridine and glutaric acid. Crystallizations under thermal and hydrothermal conditions lead, depending on the amounts of water used, to both the polymorphic forms 1 and 2 of the 2:1 cocryst. entity of 3-cyanopyridine and glutaric acid and furthermore to the cocryst. entity nicotinamide and glutaric acid. To complete the study, the researchers used 3-Cyanopyridine (cas: 100-54-9) .

3-Cyanopyridine(cas: 100-54-9) has been shown to have a number of pharmacological effects: it inhibits the production of prostaglandin E2 and nitric oxide in congestive heart failure patients; it prevents the formation of diazonium salt from benzene and nitrogen dioxide; it inhibits the growth of tumor cell lines; and it protects mice from radiation injury by scavenging reactive oxygen species. COA of Formula: C6H4N2

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem