Tag: 100-200

Synthetic Route of C6H4N2In 2021, Harmange Magnani, Claire S.;Maimone, Thomas J. published 《Dearomative Synthetic Entry into the Altemicidin Alkaloids》. 《Journal of the American Chemical Society》published the findings. The article contains the following contents:

Altemicidin and related Streptomyces-derived monoterpene alkaloids possess dense, highly polar azaindane cores as well as potent cytotoxic and tRNA synthetase inhibitory properties. The congested α-amino acid motif decorating their presumed iridoid-like core structure has proven to be both a synthetic challenge and a biosynthetic mystery to date. Herein, we report a distinct, abiotic strategy to these alkaloids resulting in a concise synthesis of altemicidin from simple chem. feedstocks. Key chem. findings include the exploitation of a dearomative pyridinium addition and dipolar cycloaddition sequence to stereospecifically install the quaternary amine moiety, and a chemoselective molybdenum-mediated double reduction to establish the fully functionalized azaindane nucleus with minimal redox manipulations.3-Cyanopyridine (cas: 100-54-9) were involved in the experimental procedure.

3-Cyanopyridine(cas: 100-54-9) is an antimicrobial agent that can be used in the treatment of infectious diseases.Synthetic Route of C6H4N2 It has been shown to be effective against a variety of bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus pneumoniae.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

COA of Formula: C6H4N2In 2022, Puzari, Amlan;Borah, Debajit;Das, Pankaj published 《Binuclear Pd(II) complexes with multidentate Schiff base ligands: synthesis, catalysis, and antibacterial properties》. 《Monatshefte fuer Chemie》published the findings. The article contains the following contents:

Abstract: Three new binuclear palladium(II) complexes with multidentate Schiff base ligands were synthesized and characterized by FTIR, UV-visible, ¹H-NMR, ESI-MS, and CHN anal. The complexes were successfully applied as catalysts for hydration of nitriles to amides. Using one of the complexes, a wide range of aryl/heteroaryl nitriles were efficiently converted to corresponding amides in moderate-to-excellent yields with low catalyst loading (0.8 mol%). In addition, the complexes were also tested for antibacterial activity against two gram-pos. and two gram-neg. bacteria using Kirby Bauer’s disk diffusion method. However, to the authors’ surprise, among the three complexes, only one complex showed growth inhibitory effect against gram-pos. bacteria, Bacillus subtilis, for which min. inhibitory concentration (MIC) is 30μg cm^-3. The experimental procedure involved many compounds, such as 3-Cyanopyridine (cas: 100-54-9) .

3-Cyanopyridine(cas: 100-54-9) has been shown to have a number of pharmacological effects: it inhibits the production of prostaglandin E2 and nitric oxide in congestive heart failure patients; it prevents the formation of diazonium salt from benzene and nitrogen dioxide; it inhibits the growth of tumor cell lines; and it protects mice from radiation injury by scavenging reactive oxygen species. COA of Formula: C6H4N2

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

HPLC of Formula: 100-54-9《Two-Dimensional Anisotropic Flexibility of Mechanically Responsive Crystalline Cadmium(II) Coordination Polymers》 was published in 2022. The authors were Pisacic, Mateja;Kodrin, Ivan;Trninic, Amanda;Djakovic, Marijana, and the article was included in《Chemistry of Materials》. The author mentioned the following in the article:

Crystals of a family of six one-dimensional (1D) coordination polymers of cadmium(II) with cyanopyridines ([CdX₂L₂]_n; X = Cl, Br, I; L = 3-cyanopyridine, 3-CNpy, 4-cyanopyridine, 4-CNpy) presented a variety of morphologies and mech. responses with dominant 2D-anisotropic flexibility, which has not been previously reported. All mech. adaptable crystals were 2D flexible and they displayed a variety of direction-dependent responses; in addition to 2D-isotropic flexibility observed for solely elastic materials, 2D-anisotropic flexibility was noticed for both elastic and elastic → plastic crystals. The consequences of fine and controlled structural variations on mech. behavior were addnl. explored via microfocus SCXRD and complementary theor. studies, revealing that the relative strength and direction of the hydrogen bonding interactions were the key parameters in delivering a specific mech. response. The experimental procedure involved many compounds, such as 3-Cyanopyridine (cas: 100-54-9) .

3-Cyanopyridine(cas: 100-54-9) is an antimicrobial agent that can be used in the treatment of infectious diseases.HPLC of Formula: 100-54-9 It has been shown to be effective against a variety of bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus pneumoniae.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Quality Control of 3-CyanopyridineIn 2021, Wasfy, Nour;Doan, Brian;Rasheed, Faizan;Fishlock, Dan;Orellana, Arturo published 《Palladium-Catalyzed, Mild Dehydrogenation of 4-Alkylpyridines》. 《ACS Catalysis》published the findings. The article contains the following contents:

A mild palladium-catalyzed selective dehydrogenation of 4-alkylpyridines e.g., I that exploits their soft enolization to alkylidene dihydropyridines e.g., II using allyl chloroformate under metal-free conditions was reported. Treatment of these intermediates with a palladium catalyst liberates an alkylpyridylic anion and an allylpalladium(II) intermediate, which combine and undergo β-hydride elimination to install a double bond. Importantly, the formation of gas byproducts makes the process very practical. Furthermore, the reaction tolerates a broad range of functional groups, including many that can be dehydrogenated using similar palladium-catalyzed reactions, and is selective for 4-alkylpyridines e.g., I even in substrates bearing multiple pyridylic positions. To complete the study, the researchers used 3-Cyanopyridine (cas: 100-54-9) .

3-Cyanopyridine(cas: 100-54-9) has been shown to have a number of pharmacological effects: it inhibits the production of prostaglandin E2 and nitric oxide in congestive heart failure patients; it prevents the formation of diazonium salt from benzene and nitrogen dioxide; it inhibits the growth of tumor cell lines; and it protects mice from radiation injury by scavenging reactive oxygen species. Quality Control of 3-Cyanopyridine

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sarvi, Iraj;Zahedi, Ehsan published 《Zinc Oxide/Graphene Oxide as a Robust Active Catalyst for Direct Oxidative Synthesis of Nitriles from Alcohols in Water》 in 2022. The article was appeared in 《Catalysis Letters》. They have made some progress in their research.Quality Control of 3-Cyanopyridine The article mentions the following:

In this work, without using any linker or chem. modification of graphene oxide, a zinc oxide immobilized graphene oxide-based catalyst was used for the direct aerobic oxidative conversion of alcs. to the nitriles in water. In the first step, graphene oxide was prepared and then zinc ions were electrostatically adsorbed onto the surface of graphene oxide. In the following step, zinc oxide nanoparticles were generated via in-situ growth in presence of NaOH. It was illustrated that graphene oxide layers can control the size of in-situ generated zinc oxide nanoparticles. Various aromatic/aliphatic/heteroaromatic primary alcs. converted to the nitriles in high yields under O₂ balloon with ZnO/GO catalyst. This catalyst can be used for 7 successful consecutive runs without significant loss of activity.3-Cyanopyridine (cas: 100-54-9) were involved in the experimental procedure.

3-Cyanopyridine(cas: 100-54-9) has been shown to have a number of pharmacological effects: it inhibits the production of prostaglandin E2 and nitric oxide in congestive heart failure patients; it prevents the formation of diazonium salt from benzene and nitrogen dioxide; it inhibits the growth of tumor cell lines; and it protects mice from radiation injury by scavenging reactive oxygen species. Quality Control of 3-Cyanopyridine

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application In Synthesis of 3-Cyanopyridine《Synthesis, X-ray structure, Hirshfeld, and antimicrobial studies of new Ag(I) complexes based on pyridine-type ligands》 was published in 2022. The authors were El-Naggar, Mostafa A.;Abu-Youssef, Morsy A. M.;Soliman, Saied M.;Haukka, Matti;Al-Majid, Abdullah Mohammed;Barakat, Assem;Badr, Ahmed M. A., and the article was included in《Journal of Molecular Structure》. The author mentioned the following in the article:

The two silver(I) complexes [Ag(3CNPy)₂(CF₃COO)]_n (1) and [Ag(4BzPy)₂]₂(CF₃COO)₂ (2) where 3CNPy and 4BzPy are 3-cyanopyridine and 4-benzoylpyridine, resp., were synthesized and characterized using elemental anal., FTIR spectra and single crystal x-ray diffraction. Complex 1 is a 1D coordination polymer through the bridging and the highly sym. CF₃COO group while 2 is a dinuclear complex through strong argentophilic interaction connecting the two [Ag(4BzPy)₂] cationic units. In both complexes, the pyridine ligands are acting as monodentate N-donor. Hirshfeld surface anal. revealed the importance of the polar N···H (29.9%) and H···F (10.3%) hydrogen bonds in the mol. packing of 1. For 2, the nonpolar C···H (26.2%) and the polar O···H (15.6%) interactions dominate the crystal packing. Furthermore, both complexes showed π-π stacking interactions. Antimicrobial screening revealed that 3CNPy has no activity against all tested pathogens, while 1 has good antibacterial activity. Both Ag(I) complexes and 4BzPy showed remarkable antifungal activities against A. fumigatus and C. albicans compared to Ketoconazole as control. To complete the study, the researchers used 3-Cyanopyridine (cas: 100-54-9) .

3-Cyanopyridine(cas: 100-54-9) is an antimicrobial agent that can be used in the treatment of infectious diseases.Application In Synthesis of 3-Cyanopyridine It has been shown to be effective against a variety of bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus pneumoniae.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Luo, Lan;Liu, Hongqiang;Zeng, Wei;Hu, Wenkang;Wang, Dawei published 《BTP-Rh@g-C₃N₄ as an efficient recyclable catalyst for dehydrogenation and borrowing hydrogen reactions》 in 2022. The article was appeared in 《Applied Organometallic Chemistry》. They have made some progress in their research.SDS of cas: 100-54-9 The article mentions the following:

Highly active catalysts play an important role in modern catalysis. A novel and efficient ligand benzotriazole-pyrimidine (BTP) and the corresponding rhodium composite on C₃N₄ were successfully synthesized. The resulting rhodium composite was fully characterized by SEM (SEM), transmission electron microscopy (TEM), x-ray diffraction (XRD), thermogravimetric anal. (TGA), and XPS. The obtained composite exhibited good catalytic activity and good recovery performance in the synthesis of quinoxaline from 2-aminobenzyl alc. and benzonitrile, and more than 20 quinoxalines were obtained in good yields. Addnl., it also showed that rhodium composite could achieved good catalytic performance in the synthesis of functionalized ketone through borrowing hydrogen strategy. And 3-Cyanopyridine (cas: 100-54-9) was used in the research process.

3-Cyanopyridine(cas: 100-54-9) also shows biological activity against autoimmune diseases, such as murine hepatitis, by inhibiting the proliferation of B cells and T cells.SDS of cas: 100-54-9 This drug is not effective against cancer cells because it does not inhibit DNA synthesis or protein synthesis.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Xu, Chanchan;Lv, Le;Zhang, Zhijuan;Liu, Wei published 《Inorganic-Organic Hybrid Molecular Clusters with Cu₂I₂ Rhomboid Dimer Core as Light-Emitting Coating Materials》. The research results were published in《Journal of Cluster Science》 in 2021.COA of Formula: C6H4N2 The article conveys some information:

In this paper, a series of light-emitting copper(I) iodide inorganic-organic hybrid clusters has been synthesized, and they are 0D-Cu₂I₂(fmp)₄ (1, fmp = 3-fluoro-5-methyl-pyridine), 0D-Cu₂I₂(iq)₄ (2, iq = isoquinoline), 0D-Cu₂I₂(ni)₄ (3, ni = nicotinonitrile). They are all mol. clusters with Cu₂I₂ rhomboid dimer core which is the result of steric hindrance of organic ligands. The emissions of these compounds range from green to red in the solid state. The band gaps and emission energies of these compounds could be tuned by selecting different organic ligands. These compounds are solution processable and could be coated onto various substrates as luminescent inorganic-organic hybrid coating materials. To complete the study, the researchers used 3-Cyanopyridine (cas: 100-54-9) .

3-Cyanopyridine(cas: 100-54-9) has been shown to have a number of pharmacological effects: it inhibits the production of prostaglandin E2 and nitric oxide in congestive heart failure patients; it prevents the formation of diazonium salt from benzene and nitrogen dioxide; it inhibits the growth of tumor cell lines; and it protects mice from radiation injury by scavenging reactive oxygen species. COA of Formula: C6H4N2

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Xue, Gaijun;Xie, Fukai;Liang, Hongliang;Chen, Guoliang;Dai, Wen published 《Copper-Catalyzed Oxidative C-C Bond Cleavage of Alkyl-(Hetero)arenes Enabling Direct Access to Nitriles》. The research results were published in《Organic Letters》 in 2022.Safety of 3-Cyanopyridine The article conveys some information:

The cleavage and functionalization of C-C bonds has emerged as a powerful tool for discovery of new transformations. Herein, authors report a protocol that enables direct synthesis of nitriles via copper-catalyzed oxidative cleavage and cyanation of C-C bonds in a wide variety of multicarbon alkyl-substituted (hetero)arenes. Detailed mechanistic studies reveal that a tandem oxidative process is involved in this transformation. To complete the study, the researchers used 3-Cyanopyridine (cas: 100-54-9) .

3-Cyanopyridine(cas: 100-54-9) has been shown to have a number of pharmacological effects: it inhibits the production of prostaglandin E2 and nitric oxide in congestive heart failure patients; it prevents the formation of diazonium salt from benzene and nitrogen dioxide; it inhibits the growth of tumor cell lines; and it protects mice from radiation injury by scavenging reactive oxygen species. Safety of 3-Cyanopyridine

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Xia, Yu-Yan;Lv, Qing-Yang;Yuan, Hua;Wang, Jia-Yi published 《Selective oxidation of alcohols to nitriles with high-efficient Co-[Bmim]Br/C catalyst system》. The research results were published in《Chemical Papers》 in 2021.Category: pyridine-derivatives The article conveys some information:

An efficient method for catalyzing the ammoxidation of aromatic alcs. to aromatic nitriles was developed, in which a new heterogeneous catalyst based on transition metal elements was employed, the new catalyst was named Co-[Bmim]Br/C-700 and then characterized by X-ray photo-electronic spectroscopy, transmission electron microscope and X-ray diffraction. The reaction was carried out by two consecutive dehydrogenations under the catalysis of Co-[Bmim]Br/C-700, which catalytically oxidized the alc. to the aldehyde, and then the aldehyde was subjected to ammoxidation to the nitrile. The catalyst system was suitable for a wide range of substrates and nitriles obtained in high yields, especially, the conversion rate of benzyl alc., 4-methoxybenzyl alc., 4-chlorobenzyl alc. and 4-nitrobenzyl alc. reached 100%. The substitution of ammonia and oxygen for toxic cyanide to participate in the reaction accords with the theory of green chem. And 3-Cyanopyridine (cas: 100-54-9) was used in the research process.

3-Cyanopyridine(cas: 100-54-9) has been shown to have a number of pharmacological effects: it inhibits the production of prostaglandin E2 and nitric oxide in congestive heart failure patients; it prevents the formation of diazonium salt from benzene and nitrogen dioxide; it inhibits the growth of tumor cell lines; and it protects mice from radiation injury by scavenging reactive oxygen species. Category: pyridine-derivatives

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem