Tag: 100-200

Metal-free isotactic-specific radical polymerization of N-isopropylacrylamide with pyridine N-oxide derivatives: The effect of methyl substituents of pyridine N-oxide on the isotactic specificity and the proposed mechanism for the isotactic-specific radical polymerization was written by Hirano, Tomohiro;Ishizu, Hideaki;Sato, Tsuneyuki. And the article was included in Polymer in 2008.Category: pyridine-derivatives This article mentions the following:

The radical polymerizations of N-isopropylacrylamide (NIPAAm) in chloroform at low temperatures in the presence of pyridine N-oxide (PNO) derivatives were investigated. It was found that the methylation at meta-positions of PNO improved the isotactic specificity induced by PNO, whereas the methylation at ortho-positions prevented the induction of the isotactic specificity. NMR anal. revealed that NIPAAm and PNO derivatives formed predominantly 2:1 complex through a hydrogen-bonding interaction. Furthermore, the induction of the isotactic specificity was attributed to the conformationally limited propagating radicals. Based on these findings, the mechanism of the isotactic-specific radical polymerization was discussed. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Category: pyridine-derivatives).

3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Fluorenone Schiff base derivative complexes of ruthenium, rhodium and iridium exhibiting efficient antibacterial activity and DNA-binding affinity was written by Kollipara, Mohan Rao;Shadap, Lathewdeipor;Banothu, Venkanna;Agarwal, Nipanshu;Poluri, Krishna Mohan;Kaminsky, Werner. And the article was included in Journal of Organometallic Chemistry in 2020.Computed Properties of C12H9NO This article mentions the following:

Half-sandwich ruthenium, rhodium and iridium pyridyl fluorenylidene azine Schiff base complexes [LMCl(2-pyCR:NN:Fl)] (1–9; M = Ru, L = p-cymene; M = Rh, Ir, L = C₅Me₅; R = Ph, Me, H; py = pyridyl, Fl = 9-fluorenylidene) were prepared and examined for their antibacterial activity. Metal precursors [(arene)MCl₂]₂ (arene = p-cymene, Cp*; M = Ru, Rh and Ir) on reacting with 9-fluorenone derivative ligands L1, L2 and L3 resulted in the formation of mononuclear bidentate cationic N-N bonded complexes. The biol. studies of these complexes such as antibacterial activity studies (against Gram-pos. and Gram-neg. bacteria) revealed significant antibacterial activity with complexes 4, 7 and 9 having the highest activity potency (in-vitro). While for DNA-binding studies, the results revealed that complexes 4 and 5 displayed significant changes in their spectral features upon addition of SM-DNA, thus, indicating that these complexes bind to DNA with a significant affinity. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Computed Properties of C12H9NO).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Computed Properties of C12H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Regiospecific Three-Component Aminofluorination of Olefins via Photoredox Catalysis was written by Mo, Jia-Nan;Yu, Wan-Lei;Chen, Jian-Qiang;Hu, Xiu-Qin;Xu, Peng-Fei. And the article was included in Organic Letters in 2018.Quality Control of Pyridinehydrochloride This article mentions the following:

Direct visible-light-mediated aminofluorination of styrenes has been developed with high regioselectivity. Shelf-stable N-Ts-protected 1-aminopyridine salt was used as the nitrogen-radical precursor, and the com. available hydrogen fluoride-pyridine was used as the nucleophilic fluoride source. The synthesis of an analog of LY503430 was performed to demonstrate the synthetic value of this strategy. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Quality Control of Pyridinehydrochloride).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Quality Control of Pyridinehydrochloride

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Self-aggregation of ionic liquids in aqueous media: A thermodynamic study was written by Singh, Tejwant;Kumar, Arvind. And the article was included in Colloids and Surfaces, A: Physicochemical and Engineering Aspects in 2008.Quality Control of 1-Butyl-3-methylpyridinium Chloride This article mentions the following:

Aggregation process of the ionic liquids (ILs), 1-butyl-3-methylimidazolium tetrafluoroborate [C₄mim][BF₄], 3-methyl-1-octylimidazolium tetrafluoroborate [C₈mim][BF₄], 3-methyl-1-octylimidazolium chloride [C₈mim][Cl], and N-butyl-3-methylpyridinium chloride [C₄mpy][Cl], in the aqueous solutions was characterized by elec. conductivity, d., and speed of sound measurements at 298.15 K. The critical aggregation concentration (CAC), the standard Gibbs energy of aggregation ΔG_agg, isentropic compressibility κ_s, and changes in the isentropic compressibility upon aggregation Δκ _s,agg for the ionic liquids were derived from the exptl. data. The dependence of the CAC, ΔG_agg and Δκ_s,agg on the nature of the cations and anions was examined The aggregation number n for various ILs was determined by applying the mass action theory to the concentration dependence of elec. conductivity and compressibility. Aggregation properties showed fairly good agreement with the authors’ previously reported results of ¹H NMR and fluorescence spectroscopy. In the experiment, the researchers used many compounds, for example, 1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3Quality Control of 1-Butyl-3-methylpyridinium Chloride).

1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Quality Control of 1-Butyl-3-methylpyridinium Chloride

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

One-Step Conversion of Azine N-Oxides to α-1,2,4-Triazolo-, 1,2,3-Triazolo, Imidazolo-, and Pyrazoloheteroarenes was written by Keith, John M.. And the article was included in Journal of Organic Chemistry in 2010.Product Details of 3718-65-8 This article mentions the following:

Pyridine, quinoline, isoquinoline, azaindole, and pyrimidine N-oxides, e.g. I, were converted to their α-triazole and α-diazole derivatives, e.g. II, by treatment with the corresponding p-toluenesulfonylazoles and Hunig’s base at elevated temperatures In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Product Details of 3718-65-8).

3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Product Details of 3718-65-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reaction-Based Europium Complex for Specific Detection of Cysteine Over Homocysteine and Glutathione with Variable-Temperature Kinetic Studies was written by Yip, Yuk-Wang;Yan, Zhiyuan;Law, Ga-Lai;Wong, Wing-Tak. And the article was included in European Journal of Inorganic Chemistry in 2019.Reference of 131747-45-0 This article mentions the following:

A water-soluble europium(III)-based probe, EuL, has been designed and synthesized for selective recognition of cysteine (Cys) over other structurally similar thiols and amino derivatives due to formation of a more stable and preferable seven-membered ring. Addition of Cys shows a significant response with quenching of over 90% of the initial signal (Hcys: 10.5%, GSH: 3.6% resp.). A good linear correlation between the emission intensities and concentrations of Cys has been established. In the experiment, the researchers used many compounds, for example, (4-Bromopyridin-2-yl)methanol (cas: 131747-45-0Reference of 131747-45-0).

(4-Bromopyridin-2-yl)methanol (cas: 131747-45-0) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Reference of 131747-45-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Two-step solid-state synthesis of PEPPSI-type compounds was written by Adams, Christopher J.;Lusi, Matteo;Mutambi, Emily M.;Guy Orpen, A.. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2015.Formula: C5H6ClN This article mentions the following:

The two-step mechanochem. preparation of carbene-pyridine complexes of palladium and platinum is reported. The organometallic products, which represent a class of com. available catalysts, are rapidly formed in excellent yield proving solvent-free synthesis to be a viable synthetic alternative even in the case of NHC-containing compounds In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Formula: C5H6ClN).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Formula: C5H6ClN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sulfur(IV)-Mediated Unsymmetrical Heterocycle Cross-Couplings was written by Zhou, Min;Tsien, Jet;Qin, Tian. And the article was included in Angewandte Chemie, International Edition in 2020.Synthetic Route of C8H11N This article mentions the following:

Despite the tremendous utilities of metal-mediated cross-couplings in modern organic chem., coupling reactions involving nitrogenous heteroarenes remain a challenging undertaking – coordination of Lewis basic atoms into metal centers often necessitate elevated temperature, high catalyst loading, etc. Herein, the authors report a sulfur (IV) mediated cross-coupling amendable for the efficient synthesis of heteroaromatic substrates. Addition of heteroaryl nucleophiles to a simple, readily-accessible alkyl sulfinyl (IV) chloride gave a trigonal bipyramidal sulfurane intermediate. Reductive elimination therefrom provides bis-heteroaryl products in a practical and efficient fashion. In the experiment, the researchers used many compounds, for example, 2-Isopropylpyridine (cas: 644-98-4Synthetic Route of C8H11N).

2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Synthetic Route of C8H11N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Protonation Studies of Molybdenum(VI) Nitride Complexes That Contain the [2,6-(ArNCH₂)₂NC₅H₃]^2- Ligand (Ar = 2,6-Diisopropylphenyl) was written by Hickey, Anne K.;Wickramasinghe, Lasantha A.;Schrock, Richard R.;Tsay, Charlene;Muller, Peter. And the article was included in Inorganic Chemistry in 2019.Safety of Pyridinehydrochloride This article mentions the following:

[Ar₂N₃]Mo(N)(O-t-Bu) (1), which contains the conformationally rigid pyridine-based diamido ligand [2,6-(ArNCH₂)₂NC₅H₃]^2- (Ar = 2,6-diisopropylphenyl), is a catalyst for the reduction of dinitrogen with protons and electrons. Various acids have been added in order to explore where and how the first proton adds to the complex. The addition of adamantol to 1 produces a five-coordinate bis(adamantoxide), [HAr₂N₃]Mo(N)(OAd)₂ (2a), in which one of the amido nitrogens in the ligand has been protonated and the resulting aniline nitrogen in the [HAr₂N₃]^– ligand is not bound to the metal. The addition of [Ph₂NH₂][OTf] to 1 produces {[HAr₂N₃]Mo(N)(O-t-Bu)}(OTf) (3), in which an amido nitrogen has been protonated, but the aniline in the [HAr₂N₃]^– ligand remains bound to the metal. Last, the addition of (2,6-lutidinium)BAr^F₄ (BAr^F₄ = {B(3,5-(CF₃)₂C₆H₃)₄}^–) to 1 yields {[Ar₂N₃]Mo(N)(LutH)(O-t-Bu)}BAr^F₄, in which LutH⁺ is hydrogen-bonded to the nitride in the solid state and in dichloromethane with K_eq = 412 ± 94 and ΔG = -3.6 ± 0.8 kcal at 22 °C. A similar hydrogen-bonded adduct was formed through the addition of (2-methylpyridinium)BAr^F₄ to 1, but the addition of (pyridinium)BAr^F₄ to 1 leads to the formation of (inter alia) {[HAr₂N₃]Mo(N)(O-t-Bu)}(BAr^F₄), in which the amide nitrogen has been protonated. The addition of cobaltocene to 3 or {[Ar₂N₃]Mo(N)(LutH)(O-t-Bu)}(BAr^F₄) leads only to the re-formation of 1. X-ray structural studies were carried out on 2a, 3, and {[Ar₂N₃]Mo(N)(LutH)(O-t-Bu)}(BAr^F₄). In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Safety of Pyridinehydrochloride).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Safety of Pyridinehydrochloride

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Cytotoxicity estimation of ionic liquids based on their effective structural features was written by Fatemi, Mohammad H.;Izadiyan, Parisa. And the article was included in Chemosphere in 2011.Application of 125652-55-3 This article mentions the following:

Cytotoxicity of a diverse set of 227 ionic liquids (taken from UFT/Merck Ionic Liquids Biol. Effects Database) containing 94 imidazolium, 53 pyridinium, 23 pyrrolidinium, 22 ammonium, 15 piperidinium, 10 morpholinium, 5 phosphanium, and 5 quinolinium cations in combination with 25 different types of anions to Leukemia Rat Cell Line (IPC-81) was estimated from their structural parameters using quant. structure – toxicity relationship “QSTR” methodol. Linear and nonlinear models were developed using genetic algorithm (GA), multiple linear regressions (MLR) and multilayer perceptron neural network (MLP NN) approaches. Robustness and reliability of the constructed models were evaluated through internal and external validation methods. Furthermore, chem. applicability domain was determined via leverage approach. In this work, it was revealed that the cationic moieties make the major contribution to cytotoxicity and the anionic parts play a secondary role in cytotoxicity of the ionic liquids studied here. Structural information represented in this work, can be used for a rational design of safer ILs. In the experiment, the researchers used many compounds, for example, 1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3Application of 125652-55-3).

1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Application of 125652-55-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem