Tag: 100-200

Understanding the role of Dimethylformamide as co-solvents in the dissolution of cellulose in ionic liquids: Experimental and theoretical approach was written by Phadagi, R.;Singh, S.;Hashemi, H.;Kaya, S.;Venkatesu, P.;Ramjugernath, D.;Ebenso, E. E.;Bahadur, I.. And the article was included in Journal of Molecular Liquids in 2021.Quality Control of 1-Butyl-3-methylpyridinium Chloride This article mentions the following:

Cellulose has been identified as the most abundant renewable material but however utilization of cellulose is still limited, it does not dissolve in most convectional solvents. This study focusses on cellulose dissolution using ionic liquids namely: 1-butyl-3-methylimidazolium chloride ([BMIM][Cl]), 1-allyl-3-methylimidazolium chloride ([AMIM][Cl]) and 1-butyl-3-methylpyridinium chloride ([BMPy][Cl]) with N, N-dimethylformamide co-solvent. The solubility of the cellulose was tested in pure ILs as well as in solution of ILs/DMF. Results showed that solubility of the cellulose in ILs greatly enhanced in the presence of DMF. The complete dissolution of cellulose in both the systems such as pure ILs and ILs/DMF was also evident by d. (ρ), sound velocity (μ) and refractive index (n_D) measurements. Furthermore, COSMO-RS anal. was also performed in order to achieve a better understanding of the mol. interactions between the ILs and the co-solvent. In addition to the above theor. chem. tools, natural bond orbital (NBO), fragment MO (FMO) and chem. reactivity analyzes for cellulose mol. was investigated. Theor. data obtained proved that cellulose mol. is more reactive than glucose. In addition, this study also deals with the regeneration of the cellulose from dissolved solution using deionized water. The regenerated cellulose was characterized by fourier transform IR spectroscopy, X-ray diffraction, SEM, thermogravimetric anal. and differential scanning calorimetry techniques. It was observed that the cellulose regenerated cellulose from both solvent systems hold excellent mech. properties. In the experiment, the researchers used many compounds, for example, 1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3Quality Control of 1-Butyl-3-methylpyridinium Chloride).

1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Quality Control of 1-Butyl-3-methylpyridinium Chloride

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Asymmetric Transfer Hydrogenative Amination of Benzylic Ketones Catalyzed by Cp*Ir(III) Complexes Bearing a Chiral N-(2-Picolyl)sulfonamidato Ligand was written by Kawada, Takuma;Yabushita, Kenya;Yasuda, Toshihisa;Ohta, Takeshi;Yajima, Takaaki;Tanaka, Kouichi;Utsumi, Noriyuki;Watanabe, Masahito;Murata, Kunihiko;Kayaki, Yoshihito;Kuwata, Shigeki;Katayama, Takeaki. And the article was included in Journal of Organic Chemistry in 2022.Name: Phenyl(pyridin-2-yl)methanone This article mentions the following:

A convenient asym. reductive amination of benzylic ketones (α-arylated ketones) catalyzed by newly designed Cp*Ir complexes bearing a chiral N-(2-picolyl)sulfonamidato ligand was developed. Using readily available β-amino alcs. as chiral aminating agents, a range of benzo-fused and acyclic ketones were successfully reduced with formic acid in methanol at 40°C to afford amines with favorable chemo- and diastereoselectivities. The amino alc.-derived chiral auxiliary was easily removed by mild periodic oxidants, leading to optically active primary β-arylamines without erosion of the optical purity (up to 97% ee). The excellent catalytic performance was retained even upon lowering the amount of catalyst to a substrate/catalyst (S/C) ratio of 20,000, and the amination could be performed on a large scale exceeding 100 g. The precise hydride transfer to iminium species generated from the ketonic substrate and the chiral amine counterpart was suggested by the mechanistic studies on stoichiometric reactions of isolable hydridoiridium complexes and model intermediates such as N,O-acetal, enamine, and iminium compounds In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Name: Phenyl(pyridin-2-yl)methanone).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Name: Phenyl(pyridin-2-yl)methanone

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Scalable Rhodium(III)-Catalyzed Aryl C-H Phosphorylation Enabled by Anodic Oxidation Induced Reductive Elimination was written by Wu, Zheng-Jian;Su, Feng;Lin, Weidong;Song, Jinshuai;Wen, Ting-Bin;Zhang, Hui-Jun;Xu, Hai-Chao. And the article was included in Angewandte Chemie, International Edition in 2019.HPLC of Formula: 4783-68-0 This article mentions the following:

Transition metal catalyzed C-H phosphorylation remains an unsolved challenge. Reported methods are generally limited in scope and require stoichiometric silver salts as oxidants. Reported here is an electrochem. driven Rh^III-catalyzed aryl C-H phosphorylation reaction that proceeds through H₂ evolution, obviating the need for stoichiometric metal oxidants. The method is compatible with a variety of aryl C-H and P-H coupling partners and particularly useful for synthesizing triarylphosphine oxides from diarylphosphine oxides, which are often difficult coupling partners for transition metal catalyzed C-H phosphorylation reactions. Exptl. results suggest that the mechanism responsible for the C-P bond formation involves an oxidation-induced reductive elimination process. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0HPLC of Formula: 4783-68-0).

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.HPLC of Formula: 4783-68-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Novel 1,4-dihydropyridine calcium antagonists. I. Synthesis and hypotensive activity of 4-(substituted pyridyl)-1,4-dihydropyridine derivatives was written by Ashimori, Atsuyuki;Ono, Taizo;Uchida, Takeshi;Ohtaki, Yutaka;Fukaya, Chikara;Watanabe, Masahiro;Yokoyama, Kazumasa. And the article was included in Chemical & Pharmaceutical Bulletin in 1990.Recommanded Product: (4-Bromopyridin-2-yl)methanol This article mentions the following:

A series of 4-(substituted pyridyl)-1,4-dihydropyridine derivatives I (R = H, halo, CF₃, etc.) were synthesized and their hypotensive effects examined Several compounds have a hypotensive activity parallel to that of nicardipine; the 4-(3-trifluoromethyl-2-pyridyl) and 4-(2-trifluoromethyl-3-pyridyl) derivatives, in particular, had approx. twice the duration of nicardipine, and the 4-(4-cyano-2-pyridyl) derivative had the most potent hypotensive activity of all the derivatives synthesized. In the experiment, the researchers used many compounds, for example, (4-Bromopyridin-2-yl)methanol (cas: 131747-45-0Recommanded Product: (4-Bromopyridin-2-yl)methanol).

(4-Bromopyridin-2-yl)methanol (cas: 131747-45-0) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Recommanded Product: (4-Bromopyridin-2-yl)methanol

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Discovery of PIPE-359, a Brain-Penetrant, Selective M₁ Receptor Antagonist with Robust Efficacy in Murine MOG-EAE was written by Schrader, Thomas O.;Xiong, Yifeng;Lorenzana, Ariana O.;Broadhead, Alexander;Stebbins, Karin J.;Poon, Michael M.;Baccei, Christopher;Lorrain, Daniel S.. And the article was included in ACS Medicinal Chemistry Letters in 2021.Product Details of 38186-85-5 This article mentions the following:

The discovery of PIPE-359, a brain-penetrant and selective antagonist of the muscarinic acetylcholine receptor subtype 1 is described. Starting from a literature-reported M₁ antagonist, linker replacement and structure-activity relationship investigations of the eastern 1-(pyridinyl)piperazine led to the identification of a novel, potent, and selective antagonist with good MDCKII-MDR1 permeability. Continued semi-iterative positional scanning facilitated improvements in the metabolic and hERG profiles, which ultimately delivered PIPE-359. This advanced drug candidate exhibited robust efficacy in mouse myelin oligodendrocyte glycoprotein (MOG)-induced exptl. autoimmune encephalitis (EAE), a preclin. model for multiple sclerosis. In the experiment, the researchers used many compounds, for example, 2-Bromo-5-fluoro-3-methylpyridine (cas: 38186-85-5Product Details of 38186-85-5).

2-Bromo-5-fluoro-3-methylpyridine (cas: 38186-85-5) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Product Details of 38186-85-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Palladium-Catalyzed Decarboxylative Coupling of α- Oxocarboxylic Acids with C(sp²)-H of 2-Aryloxypyridines was written by Yao, Jinzhong;Feng, Ruokun;Wu, Zaihong;Liu, Zhanxiang;Zhang, Yuhong. And the article was included in Advanced Synthesis & Catalysis in 2013.Product Details of 4783-68-0 This article mentions the following:

An efficient palladium-catalyzed decarboxylative ortho-acylation of 2-aryloxypyridines with α-oxocarboxylic acids is described. In this new transformation, the aromatic C(sp²)-H bond was successfully acylated to give diverse aromatic ketones regioselectively in moderate to good yields. The pyridine group can be removed easily after the acylation to give the corresponding 2-hydroxy aromatic ketones. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0Product Details of 4783-68-0).

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Product Details of 4783-68-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Improved synthesis of 4-substituted pyridines from nitriles was written by Chelucci, Giorgio;Giacomelli, Giampaolo;Scano, Gianfranco. And the article was included in Gazzetta Chimica Italiana in 1991.Application In Synthesis of 4-Hexylpyridine This article mentions the following:

4-Substituted pyridines I ( R = n-hexyl, iso-Bu, sec-Bu, Ph) were prepared by a 4-step sequence in 23-27% overall yield starting from RCH₂CN. The synthesis involves alkylation of RCH₂CN with BrCH₂CH(OEt)₂, then with 2-iodomethyl-1,3-dioxolane, removal of the CN group and reaction of the glutaraldehyde acetals II, thus obtained, with NH₂OH.HCl in AcOH to give I. In the experiment, the researchers used many compounds, for example, 4-Hexylpyridine (cas: 27876-24-0Application In Synthesis of 4-Hexylpyridine).

4-Hexylpyridine (cas: 27876-24-0) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Application In Synthesis of 4-Hexylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Scandium(III) Triflate Catalyzed Direct Synthesis of N-Unprotected Ketimines was written by Kondo, Yuta;Kadota, Tetsuya;Hirazawa, Yoshinobu;Morisaki, Kazuhiro;Morimoto, Hiroyuki;Ohshima, Takashi. And the article was included in Organic Letters in 2020.Product Details of 91-02-1 This article mentions the following:

N-Unprotected ketimines are useful substrates and intermediates for synthesizing valuable nitrogen-containing compounds, but their potential applicability is limited by the available synthetic methods. To address this issue, we report a scandium(III) triflate catalyzed direct synthesis of N-unprotected ketimines. Using com. available reagents and Lewis acid catalysts, ketones were directly transformed into the corresponding N-unprotected ketimines in high yields with broad functional group tolerance, even in multigram scales. The reactions were readily applicable for one-pot synthesis of important compounds such as a glycine Schiff base without isolation of N-unprotected ketimine intermediates. Preliminary mechanistic studies to clarify the reaction mechanism are also described. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Product Details of 91-02-1).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Product Details of 91-02-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Tetracyclic spirooxindole blockers of hNa_V1.7: activity in vitro and in CFA-induced inflammatory pain model was written by Chowdhury, Sultan;Liu, Shifeng;Cadieux, Jay A.;Hsieh, Tom;Chafeev, Mikhail;Sun, Shaoyi;Jia, Qi;Sun, Jianyu;Wood, Mark;Langille, Jonathan;Sviridov, Serguei;Fu, Jianmin;Zhang, Zaihui;Chui, Ray;Wang, Audrey;Cheng, Xing;Zhong, Jing;Hossain, Sazzad;Khakh, Kuldip;Rajlic, Ivana;Verschoof, Henry;Kwan, Rainbow;Young, Wendy. And the article was included in Medicinal Chemistry Research in 2013.Recommanded Product: 5-Hydroxy-2-methoxylpyridine This article mentions the following:

The structure-activity relationship of a new series of tetracyclic spirooxindoles led to the discovery of compound 25a, a potent hNa_V1.7 blocker with improved ADME properties and in vivo efficacy in the CFA-induced inflammatory pain model. In the experiment, the researchers used many compounds, for example, 5-Hydroxy-2-methoxylpyridine (cas: 51834-97-0Recommanded Product: 5-Hydroxy-2-methoxylpyridine).

5-Hydroxy-2-methoxylpyridine (cas: 51834-97-0) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Recommanded Product: 5-Hydroxy-2-methoxylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Discovery of thiosemicarbazone derivatives as effective New Delhi metallo-β-lactamase-1 (NDM-1) inhibitors against NDM-1 producing clinical isolates was written by Zhao, Bing;Zhang, Xinhui;Yu, Tingting;Liu, Ying;Zhang, Xiaoling;Yao, Yongfang;Feng, Xuejian;Liu, Hongmin;Yu, Dequan;Ma, Liying;Qin, Shangshang. And the article was included in Acta Pharmaceutica Sinica B in 2021.Recommanded Product: Phenyl(pyridin-2-yl)methanone This article mentions the following:

In this study, structure-activity relationship based on thiosemicarbazone derivatives (E)-R¹C(S)NHN=C(R²)(R³) (I) (R¹ = phenylamino, Ph, cyclohexylamino, morpholin-4-yl, etc.; R² = H, Me; R³ = Ph, pyridin-2-yl, 3,4,5-trimethoxyphenyl, etc.) was systematically characterized and their potential activities combined with meropenem (MEM) were evaluated. Compounds (I).HCl [R¹ = piperazin-1-yl, R² = H, R³ = 2-hydroxyphenyl (II); R¹ = 4-methylpiperazin-1-yl, R² = H, R³ = 2-hydroxyphenyl (III)] exhibited excellent activity against 10 NDM-pos. isolate clin. isolates in reversing MEM resistance. Further studies demonstrated that compounds II and III were uncompetitive NDM-1 inhibitors with Ki = 0.63 and 0.44μmol/L, resp. Mol. docking speculated that compounds II and III were most likely to bind in the allosteric pocket which would affect the catalytic effect of NDM-1 on the substrate meropenem. Toxicity evaluation experiment showed that no hemolysis activities were found even at concentrations of 1000 mg/mL against red blood cells. In vivo exptl. results showed that a combination of MEM and compound III was markedly effective in treating infections caused by NDM-1 pos. strain and prolonging the survival time of sepsis mice. The finding showed that compound III might be a promising lead in developing new inhibitor to treat NDM-1 producing superbug. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Recommanded Product: Phenyl(pyridin-2-yl)methanone).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Recommanded Product: Phenyl(pyridin-2-yl)methanone

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem