Tag: 100-200

Dimensional Reduction of Eu-Based Metal-Organic Framework as Catalysts for Oxidation Catalysis of C(sp³)-H Bond was written by Zhang, Yin;Yu, Wei-Dong;Zhao, Cai-Feng;Yan, Jun. And the article was included in Chinese Journal of Chemistry in 2022.SDS of cas: 91-02-1 This article mentions the following:

Developing new catalysts for highly selectivity and conversion of saturated C(sp³)-H bonds is of great significance. In order to obtain catalysts with high catalytic performance, six Eu-based MOFs with different structural characteristics were obtained by using europium ions and different organic acid ligands, namely Eu-1∼Eu-6. Eu-1, Eu-2 and Eu-3 featured three-dimensional structures, while Eu-4 and Eu-5 featured two-dimensional structures. Differently, a one-dimensional chain structure of Eu-6 was obtained by changing the ligand. All the six MOFs were applied to the catalytic reaction of C(sp³)-H bond, and it was found that the catalytic effect was gradually enhanced with the decrease of dimension and the increase of the size of channels. As expected, Eu-6 showed the highest selectivity (∼99%) and conversion (∼99%). Moreover, catalytic cycling and stability tests showed Eu-6 can be a reliable catalyst. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1SDS of cas: 91-02-1).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.SDS of cas: 91-02-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Discovery of a tricyclic farnesoid X receptor agonist HEC96719, a clinical candidate for treatment of non-alcoholic steatohepatitis was written by Cao, Shengtian;Yang, Xinye;Zhang, Zheng;Wu, Junwen;Chi, Bo;Chen, Hong;Yu, Jianghong;Feng, Shanshan;Xu, Yulin;Li, Jing;Zhang, Yingjun;Wang, Xiaojun;Wang, Yan. And the article was included in European Journal of Medicinal Chemistry in 2022.SDS of cas: 51834-97-0 This article mentions the following:

Synthesis and characterization of compound HEC96719 I a novel tricyclic FXR agonist based on a prior high-affinity nonsteroidal mol. GW4064 was reported. HEC96719 I exhibited excellent potency superior to GW4064 and obeticholic acid in in vitro and in vivo assays of FXR activation. It also showed higher FXR selectivity and more favorable tissue distribution dominantly in liver and intestine. Preclin. data on pharmacokinetic properties, efficacy, and safety profiles overall indicate that HEC96719 I was a promising drug candidate for NASH treatment. In the experiment, the researchers used many compounds, for example, 5-Hydroxy-2-methoxylpyridine (cas: 51834-97-0SDS of cas: 51834-97-0).

5-Hydroxy-2-methoxylpyridine (cas: 51834-97-0) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.SDS of cas: 51834-97-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Catalytic activity of sterically hindered heterocyclic tertiary amines in thiosemicarbazide formation was written by Yanchuk, N. I.. And the article was included in Russian Journal of General Chemistry (Translation of Zhurnal Obshchei Khimii) in 1998.SDS of cas: 644-98-4 This article mentions the following:

Kinetics of the reaction of diphenylphosphinic hydrazide with Ph isothiocyanate in benzene at 25° in the presence of 2-alkyl-substituted pyridines and N-methylbenzimidazoles were studied. Steric and inductive components of the nucleophilicity of these tertiary amines were determined The catalytic activity of pyridines was more sensitive to steric demand of the catalytic center compared with that of benzimidazoles. In the experiment, the researchers used many compounds, for example, 2-Isopropylpyridine (cas: 644-98-4SDS of cas: 644-98-4).

2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. SDS of cas: 644-98-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Photoarylation of Pyridines Using Aryldiazonium Salts and Visible Light: An EDA Approach was written by Bartolomeu, Aloisio de A.;Silva, Rodrigo C.;Brocksom, Timothy J.;Noel, Timothy;de Oliveira, Kleber T.. And the article was included in Journal of Organic Chemistry in 2019.Recommanded Product: Pyridinehydrochloride This article mentions the following:

A metal-free methodol. for the photoarylation of pyridines, in water, is described giving 2 and 4-arylated-pyridines in yields up to 96%. The scope of the aryldiazonium salts is presented showing important results depending on the nature and position of the substituent group in the diazonium salt, i.e., electron-donating or electron-withdrawing in the ortho, meta, or para positions. Further heteroaromatics were also successfully photoarylated. Mechanistic studies and comparison between our methodol. and similar metal-catalyzed procedures are presented, suggesting the occurrence of a visible-light EDA complex which generates the aryl radical with no need for an addnl. photocatalyst. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Recommanded Product: Pyridinehydrochloride).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Recommanded Product: Pyridinehydrochloride

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

α-Halo carbonyls enable meta selective primary, secondary and tertiary C-H alkylations by ruthenium catalysis was written by Paterson, Andrew J.;Heron, Callum J.;McMullin, Claire L.;Mahon, Mary F.;Press, Neil J.;Frost, Christopher G.. And the article was included in Organic & Biomolecular Chemistry in 2017.Recommanded Product: 2-(m-Tolyl)pyridine This article mentions the following:

A catalytic meta selective C-H alkylation of arenes is described using a wide range of α-halo carbonyls as coupling partners. Previously unreported primary alkylations with high meta selectivity have been enabled by this methodol. whereas using straight chain alkyl halides affords ortho substituted products. Mechanistic anal. reveals an activation pathway whereby cyclometalation with a ruthenium(II) complex activates the substrate mol. and is responsible for the meta selectivity observed A distinct second activation of the coupling partner allows site selective reaction between both components. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Recommanded Product: 2-(m-Tolyl)pyridine).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Recommanded Product: 2-(m-Tolyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Phase diagrams of ionic liquids-based aqueous biphasic systems as a platform for extraction processes was written by Sintra, Tania E.;Cruz, Rafaela;Ventura, Sonia P. M.;Coutinho, Joao A. P.. And the article was included in Journal of Chemical Thermodynamics in 2014.Electric Literature of C10H16ClN This article mentions the following:

In the past few years, ionic liquid-based aqueous biphasic systems have become the subject of considerable interest as a promising technique for the extraction and purification of several macro/biomols. Aiming at developing guidelines for more benign and efficient extraction processes, phase diagrams for aqueous biphasic systems composed of ionic liquids and inorganic/organic salts are here reported. Several combinations of ionic liquid families (imidazolium, pyridinium, phosphonium, quaternary ammonium and cholinium) and salts [potassium phosphate buffer (KH₂PO₄/K₂HPO₄ at pH 7), potassium citrate buffer (C₆H₅K₃O₇/C₆H₈O₇ at pH 5, 6, 7 and 8) and potassium carbonate (K₂CO₃ at pH ∼13)] were evaluated to highlight the influence of the ionic liquid structure (cation core, anion and alkyl chain length), the pH and the salt nature on the formation of aqueous biphasic systems. The binodal curves and resp. tie-lines reported for these systems were exptl. determined at (298 ± 1) K. In general, the ability to promote the aqueous biphasic systems formation increases with the pH and alkyl chain length. While the influence of the cation core and anion nature of the ionic liquids on their ability to form aqueous biphasic systems closely correlates with ionic liquids capacity to be hydrated by water, the effect of the different salts depends of the ionic liquid nature and salt valency. In the experiment, the researchers used many compounds, for example, 1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3Electric Literature of C10H16ClN).

1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Electric Literature of C10H16ClN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

A highly selective on-off-on responsive lanthanide(III) based probe for recognition of copper and hydrogen sulfide was written by Yip, Yuk-Wang;Law, Ga-Lai;Wong, Wing-Tak. And the article was included in Dalton Transactions in 2016.Application In Synthesis of (4-Bromopyridin-2-yl)methanol This article mentions the following:

The development of a europium(III) based probe (EuL1) for the detection of Cu(II) ions and hydrogen sulfide is presented. With the addition of Cu(II) ions, EuL1 displayed the greatest quenching among the other cations examined The binding constant was 74 026 ± 2899 M^-1. Once combined with Cu(II) ions, EuL1Cu demonstrated high specificity for hydrogen sulfide compared to other organic and inorganic sulfur compounds EuL1Cu exhibited an on-off-on type luminescence change with the alternate addition of Cu(II) ions and H₂S along with reversible forming-separating of the complex. In the experiment, the researchers used many compounds, for example, (4-Bromopyridin-2-yl)methanol (cas: 131747-45-0Application In Synthesis of (4-Bromopyridin-2-yl)methanol).

(4-Bromopyridin-2-yl)methanol (cas: 131747-45-0) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Application In Synthesis of (4-Bromopyridin-2-yl)methanol

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reaction of 3-substituted and 3,5-disubstituted pyridine N-oxides with phenyl isocyanate was written by Hisano, Takuzo;Matsuoka, Toshikazu;Ichikawa, Masataka. And the article was included in Organic Preparations and Procedures International in 1974.Electric Literature of C7H9NO This article mentions the following:

3,5-Dimethylpyridine N-oxide was treated with PhNCO to give I, which was hydrolyzed to give 2-anilino-3,5-dimethylpyridine. 3-Bromopyridine and PhNCO gave 46% oxazolopyridinone II, 3% 2-anilino-3-bromopyridine, and 3% 6-anilino-3-bromopyridine. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Electric Literature of C7H9NO).

3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Electric Literature of C7H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Water-mediated C-H activation of arenes with secure carbene precursors: the reaction and its application was written by Nie, Ruifang;Lai, Ruizhi;Lv, Songyang;Xu, Yingying;Guo, Li;Wang, Qiantao;Wu, Yong. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2019.SDS of cas: 4373-61-9 This article mentions the following:

A water-mediated C-H activation using sulfoxonium ylides was reported, providing a general, green and step-economic approach to construct a C-C bond and varieties of useful N-heterocycle scaffolds. Three series of aryl-alkylketones RCOCH²R¹ [R = t-Bu, 1-adamantanyl, Ph; R¹ = 2-(2-pyridyl)phenyl, 2-(2-pyridyl)-3-thienyl, 2-pyrazol-1-ylphenyl, etc.], benzothiazines I [R² = Me, i-Pr, Ph, Bn; R³ = i-Pr, t-Bu, Ph; R⁴ = H, 6-Me, 6-OMe, 6-F, 8-OMe] and isoquinolines II [R⁵ = H, 8-F, 6-Br, etc.; R⁶ = H, Me; R⁷ = 2,6-di-MeOC₆H₃, 2-naphthyl, 2-thienyl, etc.] were synthesized via rhodium-catalyzed coupling of arenes/sulfoximines/benzylamines with sulfoxonium ylides. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9SDS of cas: 4373-61-9).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. SDS of cas: 4373-61-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Polynuclear zinc(II) complexes of thiosemicarbazone: Synthesis, X-ray structure and biological evaluation was written by Saswati;Mohanty, Monalisa;Banerjee, Atanu;Biswal, Sonaleen;Horn, Adolfo Jr.;Schenk, Gerhard;Brzezinski, Krzysztof;Sinn, Ekkehard;Reuter, Hans;Dinda, Rupam. And the article was included in Journal of Inorganic Biochemistry in 2020.Quality Control of Phenyl(pyridin-2-yl)methanone This article mentions the following:

Two new dimeric Zn(II) ([{ZnL¹(DMSO₂)}₂]·DMSO (1), [{ZnL²Cl}₂] (2)) and a novel tetrameric Zn(II) complex ([(Zn₂L³)₂(μ-OAc)₂(μ₃-O)₂] (3)), where H₂L¹ = 4-(p-methoxyphenyl)thiosemicarbazone of o-hydroxynaphthaldehyde, HL² = 4-(p-methoxyphenyl)thiosemicarbazone of benzoyl pyridine and H₂L³ = 4-(p-chlorophenyl)thiosemicarbazone of o-vanillin are reported. Ligands and their complexes were characterized by spectroscopic and single crystal x-ray diffraction techniques. In addition, the complexes exhibited good binding affinity towards HSA (10¹² M^-1), which is supported by their ability to quench the tryptophan fluorescence emission spectra of HSA. The complexes were also screened for their DNA binding propensity through UV-vis absorption titration, CD and fluorescence spectral studies. Results show that they effectively interact with CT-DNA through an intercalative mode of binding, with binding constants ranging from 10³ to 10⁴ M^-1. Among the three complexes 1 has the highest binding affinity towards CT-DNA. Further, the phosphatase activity was evaluated using bis(2,4-dinitrophenyl)phosphate (BDNPP) as substrate, however, the complexes did not yield any measurable catalytic activity. Nevertheless the complexes showed significant cytotoxic potential against HeLa and HT-29 cancer cell lines that was assessed through MTT assay and DAPI staining. Remarkably, complex 1 showed better activity than cisplatin against HT-29 cell line. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Quality Control of Phenyl(pyridin-2-yl)methanone).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Quality Control of Phenyl(pyridin-2-yl)methanone

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem