Tag: 100-200

Pd₂dba₃/P(t-Bu)₃H.BF₄/Cy₂NMe Catalyzed Heck Coupling in Synthesis of 3-Alkenyl-1H-Isochromen-1-Ones was written by Dasaradhan, Changalaraya;Nawaz Khan, Fazlur-Rahman. And the article was included in Polycyclic Aromatic Compounds in 2022.Application of 85838-94-4 This article mentions the following:

An efficient catalytic system comprising Pd₂dba₃/P(t-Bu)₃H.BF₄/Cy₂NMe -for the Heck coupling in the synthesis of 3-alkenyl isochromen-1-ones, I (R = H, 6,7-(OMe)₂; R¹ = Ph, benzyl, pyridin-2-yl), II (R² = OH, OMe, NH₂, butoxy) and III (R³ = 3,6-dihydro-2H-pyran-4-yl, 1-[(tert-butoxy)(oxo)methane]-1,2,5,6-tetrahydropyridin-3-yl) has been developed. Air stable alkyl phosphonium salt, [(t-Bu)₃Ph]BF₄ was found to be vital for the activation of 3- chloroisochromen-1-one and 3-chloro-6,7-dimethoxy-1H-isochromen-1-one, in regio-selective Heck coupling reactions. The technique has addnl. been reached out to typharin I, penicilisorin II and artemidin analogs III. In the experiment, the researchers used many compounds, for example, tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4Application of 85838-94-4).

tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Application of 85838-94-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

High-throughput screening for ionic liquids dissolving (ligno-)cellulose was written by Zavrel, Michael;Bross, Daniela;Funke, Matthias;Buechs, Jochen;Spiess, Antje C.. And the article was included in Bioresource Technology in 2009.Synthetic Route of C10H16ClN This article mentions the following:

The recalcitrance of lignocellulosic biomass poses a major challenge for its sustainable and cost-effective utilization. Therefore, an efficient pretreatment is decisive for processes based on lignocellulose. A green and energy-efficient pretreatment could be the dissolution of lignocellulose in ionic liquids Several ionic liquids were identified earlier which are capable to dissolve (ligno-)cellulose. However, due to their multitude and high costs, a high-throughput screening on small scale is essential for the determination of the most efficient ionic liquid In this contribution two high-throughput systems are presented based on extinction or scattered light measurements. Quasi-continuous dissolution profiles allow a direct comparison of up to 96 ionic liquids per experiment in terms of their dissolution kinetics. The screening results indicate that among the ionic liquids tested EMIM Ac is the most efficient for dissolving cellulose. Moreover, it was observed that AMIM Cl is the most effective ionic liquid for dissolving wood chips. In the experiment, the researchers used many compounds, for example, 1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3Synthetic Route of C10H16ClN).

1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Synthetic Route of C10H16ClN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Functional Supramolecular Polypeptides Involving π-π Stacking and Strong Hydrogen-Bonding Interactions: A Conformation Study toward Carbon Nanotubes (CNTs) Dispersion was written by Huang, Cheng-Wei;Mohamed, Mohamed Gamal;Zhu, Chao-Yuan;Kuo, Shiao-Wei. And the article was included in Macromolecules (Washington, DC, United States) in 2016.Recommanded Product: 1075-62-3 This article mentions the following:

New supramol. polypeptides have been prepared through simple ring-opening polymerization and “click” reactions. Postfunctionalization with diaminopyridine (DAP) moieties, capable of multiple hydrogen bonding, was an efficient approach toward forming α-helical-dominant polypeptides. The phys. crosslinked networks produced upon self-organization of the DAP units increased the glass transition temperature (T_g) of the polymers and sustained the secondary structures of the polypeptides. Addnl. thermal responsivity resulted from dynamic noncovalent bonding on the polymer side chains. Mol. recognition through heterocomplementary DAP···thymine (T) base pairs was revealed spectroscopically and then used to construct poly(γ-propargyl-L-glutamate)-g-N-(6-acetamidopyridin-2-yl)-11-undecanamide/thyminylpyrene (PPLG-DAP/Py-T) supramol. complexes. Transmission electron microscopy images revealed that this complex was an efficient dispersant of carbon nanotubes (CNTs). Indeed, it could disperse CNTs in both polar and nonpolar media, the direct result of combining two modes of secondary noncovalent bonding: multiple hydrogen bonding and π-π interactions. Furthermore, CNT composites fabricated with biocompatible polymers and high value of T_g should enable the development of bio-inspired carbon nanostructures and lead the way toward their biomedical applications. In the experiment, the researchers used many compounds, for example, N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3Recommanded Product: 1075-62-3).

N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Recommanded Product: 1075-62-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

α-Halo carbonyls enable meta selective primary, secondary and tertiary C-H alkylations by ruthenium catalysis was written by Paterson, Andrew J.;Heron, Callum J.;McMullin, Claire L.;Mahon, Mary F.;Press, Neil J.;Frost, Christopher G.. And the article was included in Organic & Biomolecular Chemistry in 2017.Recommanded Product: 2-(m-Tolyl)pyridine This article mentions the following:

A catalytic meta selective C-H alkylation of arenes is described using a wide range of α-halo carbonyls as coupling partners. Previously unreported primary alkylations with high meta selectivity have been enabled by this methodol. whereas using straight chain alkyl halides affords ortho substituted products. Mechanistic anal. reveals an activation pathway whereby cyclometalation with a ruthenium(II) complex activates the substrate mol. and is responsible for the meta selectivity observed A distinct second activation of the coupling partner allows site selective reaction between both components. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Recommanded Product: 2-(m-Tolyl)pyridine).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Recommanded Product: 2-(m-Tolyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Phase diagrams of ionic liquids-based aqueous biphasic systems as a platform for extraction processes was written by Sintra, Tania E.;Cruz, Rafaela;Ventura, Sonia P. M.;Coutinho, Joao A. P.. And the article was included in Journal of Chemical Thermodynamics in 2014.Electric Literature of C10H16ClN This article mentions the following:

In the past few years, ionic liquid-based aqueous biphasic systems have become the subject of considerable interest as a promising technique for the extraction and purification of several macro/biomols. Aiming at developing guidelines for more benign and efficient extraction processes, phase diagrams for aqueous biphasic systems composed of ionic liquids and inorganic/organic salts are here reported. Several combinations of ionic liquid families (imidazolium, pyridinium, phosphonium, quaternary ammonium and cholinium) and salts [potassium phosphate buffer (KH₂PO₄/K₂HPO₄ at pH 7), potassium citrate buffer (C₆H₅K₃O₇/C₆H₈O₇ at pH 5, 6, 7 and 8) and potassium carbonate (K₂CO₃ at pH ∼13)] were evaluated to highlight the influence of the ionic liquid structure (cation core, anion and alkyl chain length), the pH and the salt nature on the formation of aqueous biphasic systems. The binodal curves and resp. tie-lines reported for these systems were exptl. determined at (298 ± 1) K. In general, the ability to promote the aqueous biphasic systems formation increases with the pH and alkyl chain length. While the influence of the cation core and anion nature of the ionic liquids on their ability to form aqueous biphasic systems closely correlates with ionic liquids capacity to be hydrated by water, the effect of the different salts depends of the ionic liquid nature and salt valency. In the experiment, the researchers used many compounds, for example, 1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3Electric Literature of C10H16ClN).

1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Electric Literature of C10H16ClN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

A highly selective on-off-on responsive lanthanide(III) based probe for recognition of copper and hydrogen sulfide was written by Yip, Yuk-Wang;Law, Ga-Lai;Wong, Wing-Tak. And the article was included in Dalton Transactions in 2016.Application In Synthesis of (4-Bromopyridin-2-yl)methanol This article mentions the following:

The development of a europium(III) based probe (EuL1) for the detection of Cu(II) ions and hydrogen sulfide is presented. With the addition of Cu(II) ions, EuL1 displayed the greatest quenching among the other cations examined The binding constant was 74 026 ± 2899 M^-1. Once combined with Cu(II) ions, EuL1Cu demonstrated high specificity for hydrogen sulfide compared to other organic and inorganic sulfur compounds EuL1Cu exhibited an on-off-on type luminescence change with the alternate addition of Cu(II) ions and H₂S along with reversible forming-separating of the complex. In the experiment, the researchers used many compounds, for example, (4-Bromopyridin-2-yl)methanol (cas: 131747-45-0Application In Synthesis of (4-Bromopyridin-2-yl)methanol).

(4-Bromopyridin-2-yl)methanol (cas: 131747-45-0) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Application In Synthesis of (4-Bromopyridin-2-yl)methanol

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reaction of 3-substituted and 3,5-disubstituted pyridine N-oxides with phenyl isocyanate was written by Hisano, Takuzo;Matsuoka, Toshikazu;Ichikawa, Masataka. And the article was included in Organic Preparations and Procedures International in 1974.Electric Literature of C7H9NO This article mentions the following:

3,5-Dimethylpyridine N-oxide was treated with PhNCO to give I, which was hydrolyzed to give 2-anilino-3,5-dimethylpyridine. 3-Bromopyridine and PhNCO gave 46% oxazolopyridinone II, 3% 2-anilino-3-bromopyridine, and 3% 6-anilino-3-bromopyridine. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Electric Literature of C7H9NO).

3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Electric Literature of C7H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Water-mediated C-H activation of arenes with secure carbene precursors: the reaction and its application was written by Nie, Ruifang;Lai, Ruizhi;Lv, Songyang;Xu, Yingying;Guo, Li;Wang, Qiantao;Wu, Yong. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2019.SDS of cas: 4373-61-9 This article mentions the following:

A water-mediated C-H activation using sulfoxonium ylides was reported, providing a general, green and step-economic approach to construct a C-C bond and varieties of useful N-heterocycle scaffolds. Three series of aryl-alkylketones RCOCH²R¹ [R = t-Bu, 1-adamantanyl, Ph; R¹ = 2-(2-pyridyl)phenyl, 2-(2-pyridyl)-3-thienyl, 2-pyrazol-1-ylphenyl, etc.], benzothiazines I [R² = Me, i-Pr, Ph, Bn; R³ = i-Pr, t-Bu, Ph; R⁴ = H, 6-Me, 6-OMe, 6-F, 8-OMe] and isoquinolines II [R⁵ = H, 8-F, 6-Br, etc.; R⁶ = H, Me; R⁷ = 2,6-di-MeOC₆H₃, 2-naphthyl, 2-thienyl, etc.] were synthesized via rhodium-catalyzed coupling of arenes/sulfoximines/benzylamines with sulfoxonium ylides. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9SDS of cas: 4373-61-9).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. SDS of cas: 4373-61-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Polynuclear zinc(II) complexes of thiosemicarbazone: Synthesis, X-ray structure and biological evaluation was written by Saswati;Mohanty, Monalisa;Banerjee, Atanu;Biswal, Sonaleen;Horn, Adolfo Jr.;Schenk, Gerhard;Brzezinski, Krzysztof;Sinn, Ekkehard;Reuter, Hans;Dinda, Rupam. And the article was included in Journal of Inorganic Biochemistry in 2020.Quality Control of Phenyl(pyridin-2-yl)methanone This article mentions the following:

Two new dimeric Zn(II) ([{ZnL¹(DMSO₂)}₂]·DMSO (1), [{ZnL²Cl}₂] (2)) and a novel tetrameric Zn(II) complex ([(Zn₂L³)₂(μ-OAc)₂(μ₃-O)₂] (3)), where H₂L¹ = 4-(p-methoxyphenyl)thiosemicarbazone of o-hydroxynaphthaldehyde, HL² = 4-(p-methoxyphenyl)thiosemicarbazone of benzoyl pyridine and H₂L³ = 4-(p-chlorophenyl)thiosemicarbazone of o-vanillin are reported. Ligands and their complexes were characterized by spectroscopic and single crystal x-ray diffraction techniques. In addition, the complexes exhibited good binding affinity towards HSA (10¹² M^-1), which is supported by their ability to quench the tryptophan fluorescence emission spectra of HSA. The complexes were also screened for their DNA binding propensity through UV-vis absorption titration, CD and fluorescence spectral studies. Results show that they effectively interact with CT-DNA through an intercalative mode of binding, with binding constants ranging from 10³ to 10⁴ M^-1. Among the three complexes 1 has the highest binding affinity towards CT-DNA. Further, the phosphatase activity was evaluated using bis(2,4-dinitrophenyl)phosphate (BDNPP) as substrate, however, the complexes did not yield any measurable catalytic activity. Nevertheless the complexes showed significant cytotoxic potential against HeLa and HT-29 cancer cell lines that was assessed through MTT assay and DAPI staining. Remarkably, complex 1 showed better activity than cisplatin against HT-29 cell line. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Quality Control of Phenyl(pyridin-2-yl)methanone).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Quality Control of Phenyl(pyridin-2-yl)methanone

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Anticancer gold(III)-bisphosphine complex alters the mitochondrial electron transport chain to induce in vivo tumor inhibition was written by Kim, Jong Hyun;Ofori, Samuel;Parkin, Sean;Vekaria, Hemendra;Sullivan, Patrick G.;Awuah, Samuel G.. And the article was included in Chemical Science in 2021.Electric Literature of C11H9NO This article mentions the following:

Expanding the chem. diversity of metal complexes provides a robust platform to generate functional bioactive reagents. To access an excellent repository of metal-based compounds for probe/drug discovery, we capitalized on the rich chem. of gold to create organometallic gold(III) compounds by ligand tuning. We obtained novel organogold(III) compounds bearing a 1,2-bis(diphenylphosphino)benzene ligand, providing structural diversity with optimal physiol. stability. Biol. evaluation of the lead compound AuPhos-89 demonstrates mitochondrial complex I-mediated alteration of the mitochondrial electron transport chain (ETC) to drive respiration and diminish cellular energy in the form of ATP (ATP). Mechanism-of-action efforts, RNA-Seq, quant. proteomics, and NCI-60 screening reveal a highly potent anticancer agent that modulates mitochondrial ETC. AuPhos-89 inhibits the tumor growth of metastatic triple neg. breast cancer and represents a new strategy to study the modulation of mitochondrial respiration for the treatment of aggressive cancer and other disease states where mitochondria play a pivotal role in the pathobiol. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0Electric Literature of C11H9NO).

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Electric Literature of C11H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem