Tag: 100-200

Anthranil: An Aminating Reagent Leading to Bifunctionality for Both C(sp³)-H and C(sp²)-H under Rhodium(III) Catalysis was written by Yu, Songjie;Tang, Guodong;Li, Yingzi;Zhou, Xukai;Lan, Yu;Li, Xingwei. And the article was included in Angewandte Chemie, International Edition in 2016.Reference of 644-98-4 This article mentions the following:

Previous direct C-H nitrogenation suffered from simple amidation/amination with limited atom-economy and is mostly limited to C(sp²)-H substrates. In this work, anthranil was designed as a novel bifunctional aminating reagent for both C(sp²)-H and C(sp³)-H bonds under rhodium(III) catalysis, thus affording a nucleophilic aniline tethered to an electrophilic carbonyl, e. g., I. A tridendate rhodium(III) complex has been isolated as the resting state of the catalyst, and DFT studies established the intermediacy of a nitrene species. In the experiment, the researchers used many compounds, for example, 2-Isopropylpyridine (cas: 644-98-4Reference of 644-98-4).

2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Reference of 644-98-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Steric activation in prototropic reactions of pyrazine derivatives. II. The Broensted relation was written by Nagarajan, K.;Lee, T. W. S.;Perkins, R. R.;Stewart, Ross. And the article was included in Canadian Journal of Chemistry in 1986.Recommanded Product: 644-98-4 This article mentions the following:

The rate of deprotonation of the 2-Me group in 1,2,3-trimethylpyrazinium ion by RCO₂^–, aniline, and pyridine bases are determined in D₂O. RCO₂^– containing bulky groups near the reaction center (e.g., o-benzoates) react faster than predicted by the Broensted equation that correlates the reactions of unhindered RCO₂^–. Anilines and pyridines, on the other hand, show conventional steric effects. A tentative explanation for the activation engendered by groups adjacent to the carboxylate center is based on the known effect that high concentrations of organic electrolytes have on the strengths of RCO₂H but not of amines. Since ortho carboxylate ions have their relative basicities increased by an alkyl-rich environment, it is argued that the reactive Me groups of the substrate might provide such an interaction in the transition state. In the experiment, the researchers used many compounds, for example, 2-Isopropylpyridine (cas: 644-98-4Recommanded Product: 644-98-4).

2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Recommanded Product: 644-98-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Rhodium(III)-Catalyzed Selective C-H Acetoxylation and Hydroxylation Reactions was written by Wu, Yunxiang;Zhou, Bing. And the article was included in Organic Letters in 2017.Safety of 2-(m-Tolyl)pyridine This article mentions the following:

An efficient Cp^*Rh(III)-catalyzed, chelation-assisted C(sp²)-H acetoxylation and hydroxylation reaction has been developed for the first time. The reaction proceeds under mild conditions and allows for selective preparation of C-H acetoxylation and hydroxylation products, thus providing a good complement to previous C-H oxygenation reactions and expanding the field of Cp^*Rh(III)-catalyzed C-H functionalizations. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Safety of 2-(m-Tolyl)pyridine).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Safety of 2-(m-Tolyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

“Pocket dendrimers” as nanoscale receptors for bimolecular guest accommodation was written by Shinoda, Satoshi;Ohashi, Masakazu;Tsukube, Hiroshi. And the article was included in Chemistry – A European Journal in 2007.Application of 1075-62-3 This article mentions the following:

A series of dendrimer receptors was prepared by combining a (tetraphenylporphinato)zinc(II) core and benzyl ether type dendritic substituents. Since one direction of the (tetraphenylporphinato)zinc(II) was not substituted by a dendritic residue, the resulting unsym. dendrimers have “pockets” available for access of external substrates. Mol. modeling, NMR measurements, and zinc-coordination experiments revealed that the third-generation dendrimer of this type exhibited characteristic inclusion of coordinative pyridine guests. When diamidopyridine moiety was introduced into the dendrimer pocket, a thymine derivative was bound through complementary hydrogen bonding. Two different kinds of substrates, pyridine and thymine derivatives, were simultaneously accommodated in the nanoscale pocket and bimol. guest accommodation was realized with the designed dendrimer receptor. In the experiment, the researchers used many compounds, for example, N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3Application of 1075-62-3).

N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Application of 1075-62-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Structure-activity studies related to ABT-594, a potent nonopioid analgesic agent: effect of pyridine and azetidine ring substitutions on nicotinic acetylcholine receptor binding affinity and analgesic activity in mice was written by Holladay, Mark W.;Bai, Hao;Li, Yihong;Lin, Nan-Horng;Daanen, Jerome F.;Ryther, Keith B.;Wasicak, James T.;Kincaid, John F.;He, Yun;Hettinger, Anne-Marie;Huang, Peggy;Anderson, David J.;Bannon, Anthony W.;Buckley, Michael J.;Campbell, Jeffrey E.;Donnelly-Roberts, Diana L.;Gunther, Karen L.;Kim, David J. B.;Kuntzweiler, Theresa A.;Sullivan, James P.;Decker, Michael W.;Arneric, Stephen P.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 1998.COA of Formula: C6H6ClNO This article mentions the following:

Analogs of A-98593 (I) and its enantiomer ABT-594 (II) with diverse substituents on the pyridine ring were prepared and tested for affinity to nicotinic acetylcholine receptor binding sites in rat brain and for analgesic activity in the mouse hot plate assay. Numerous types of modifications were consistent with high affinity for [³H]cytisine binding sites. By contrast, only selected modifications resulted in retention of analgesic potency in the same range as I and II. Analogs of II with one or two Me substituents at the 3-position of the azetidine ring also were prepared and substantially less active in both assays. In the experiment, the researchers used many compounds, for example, 6-Chloro-2-methylpyridin-3-ol (cas: 218770-02-6COA of Formula: C6H6ClNO).

6-Chloro-2-methylpyridin-3-ol (cas: 218770-02-6) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.COA of Formula: C6H6ClNO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ligand-Enabled Regioselectivity in the Oxidative Cross-coupling of Arenes with Toluenes and Cycloalkanes Using Ruthenium Catalysts: Tuning the Site-Selectivity from the ortho to meta Positions was written by Li, Guobao;Li, Dongze;Zhang, Jingyu;Shi, Da-Qing;Zhao, Yingsheng. And the article was included in ACS Catalysis in 2017.SDS of cas: 4373-61-9 This article mentions the following:

A Ru-catalyzed 1,1′-binaphthyl-2,2′-diyl hydrogen phosphate (BNDHP)-enabled meta C-H benzylation under the assistance of ferrocene using less sterically hindered toluene derivatives as the coupling partners has been developed. Various arenes bearing pyridyl, pyridmidyl, and pyrazolyl directing groups can be selectively coupled with toluenes at the meta positions in moderate to good yield. A mechanistic study clearly showed the site selectivity at the ortho or meta position is completely controlled by the ligand of BNDHP and the catalyst precursor. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9SDS of cas: 4373-61-9).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.SDS of cas: 4373-61-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Aryl and Arylalkyl Substituted 3-Hydroxypyridin-2(1H)-ones: Synthesis and Evaluation as Inhibitors of Influenza A Endonuclease was written by Sagong, Hye Yeon;Bauman, Joseph D.;Nogales, Aitor;Martinez-Sobrido, Luis;Arnold, Eddy;LaVoie, Edmond J.. And the article was included in ChemMedChem in 2019.Synthetic Route of C5H4BrNO2 This article mentions the following:

Seasonal influenza infections are associated with an estimated 250,00-500,000 deaths annually. Resistance to the antiviral M2 ion-channel inhibitors has largely invalidated their clin. utility. Resistance to neuraminidase inhibitors has also been observed in several influenza A virus (IAV) strains. These data have prompted research on inhibitors that target the cap-snatching endonuclease activity of the polymerase acidic protein (PA). Baloxavir marboxil (Xofluza), recently approved for clin. use, inhibits cap-snatching endonuclease. Resistance to Xofluza has been reported in both in vitro systems and in the clinic. An x-ray crystallog. screening campaign of a fragment library targeting IAV endonuclease identified 5-chloro-3-hydroxypyridin-2(1H)-one as a bimetal chelating agent at the active site. We have reported the structure-activity relationships for 3-hydroxypyridin-2(1H)-ones and 3-hydroxyquinolin-2(1H)-ones as endonuclease inhibitors. These studies identified two distinct binding modes associated with inhibition of this enzyme that are influenced by the presence of substituents at the 5- and 6-positions of 3-hydroxypyridin-2(1H)-ones. Herein we report the structure-activity relationships associated with various para-substituted 5-Ph derivatives of 6-(p-fluorophenyl)-3-hydroxypyridin-2(1H)-ones (I) and the effect of using naphthyl, benzyl, and naphthylmethyl groups as alternatives to the p-fluorophenyl substituent on their activity as endonuclease inhibitors. In the experiment, the researchers used many compounds, for example, 5-Bromopyridine-2,3-diol (cas: 34206-49-0Synthetic Route of C5H4BrNO2).

5-Bromopyridine-2,3-diol (cas: 34206-49-0) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Synthetic Route of C5H4BrNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Study and comparison of detection methods for prochloraz and its metabolite residue in garlic bolting was written by Chen, Keyun;Li, Ling;Ju, Xiang;Wang, Yanli;Liu, Yanming. And the article was included in Sepu in 2020.Application of 628-13-7 This article mentions the following:

Two anal. methods for the determination of prochloraz and its metabolite residues in garlic bolting were established and compared. In the QuEChERS method, the sample was extracted with acetonitrile and purified in a QuEChERS purification tube, and then, the contents of prochloraz and its metabolite 2,4,6-trichlorophenol were determined by gas chromatog. The hydrolysis method involved extraction of the sample with acetonitrile, hydrolysis by pyridine hydrochloride, purification with sulfuric acid, and determination of the prochloraz content by gas chromatog. The standard curve in the hydrolysis and QuEChERS methods showed a good linear relationship in the concentration range of 0.01-2 mg/L, and the correlation coefficient (r²) was greater than 0.999. The limit of quantitation (LOQ) for prochloraz in the hydrolysis method was 0.005 mg/kg. The LOQ for prochloraz in the QuEChERS method was 0.039 mg/kg, and that for 2,4,6-trichlorophenol was 0.003 mg/kg. At three spiked levels in the sample, the recoveries were 81.5%-105.4%, and the relative standard deviations (RSDs) were between 1.3%-6.8%. In the determination of pos. samples, the hydrolysis method can detect the total amount of prochloraz and its main metabolites. QuEChERS method can detect the presence and contents of prochloraz and its main metabolite 2,4,6-trichlorophenol. These two methods can complement each other for the detection and confirmation of prochloraz and its metabolites in garlic bolting. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Application of 628-13-7).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Application of 628-13-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem