Tag: 100-200

Deoxybenzoin-containing polysulfones and polysulfoxides: Synthesis and thermal properties was written by Mir, Aabid A.;Wagner, Sebastian;Kramer, Roland H.;Deglmann, Peter;Emrick, Todd. And the article was included in Polymer in 2016.Name: Pyridinehydrochloride This article mentions the following:

Novel poly(arylene ether) sulfones, sulfoxides, and sulfides containing deoxybenzoin subunits were synthesized by step growth polymerization involving bishydroxydeoxybenzoin (BHDB) and the corresponding sulfur-containing monomers. The isolated polymers demonstrated good solubility in organic solvents, making them easily processible into transparent, flexible, and creasable films upon solution casting. All of the polymers prepared exhibited exceptionally low flammability characteristics, with total heat release (THR) values as low as 6 J/g-K, and char yield values as high as 54%. Inclusion of deoxybenzoin monomers into polysulfones with 4,4′-biphenyl led to heat release capacity (HRC) values less than half that of com. polysulfones in use today, placing deoxybenzoin-based polysulfones and polysulfoxides into the ultra-low flammability category. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Name: Pyridinehydrochloride).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Name: Pyridinehydrochloride

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Cobalt-Catalyzed Direct C(sp²)-H Alkylation with Unactivated Alkenes was written by Kim, Ye Lim;Park, Sun-a;Kim, Ju Hyun. And the article was included in European Journal of Organic Chemistry in 2020.Quality Control of 2-(m-Tolyl)pyridine This article mentions the following:

A facile and efficient method for Cp*Co^III-catalyzed C(sp²)-H bond alkylation was developed using 2-aryl pyridines and unactivated alkenes. The reaction proceeded atom-economically with readily available styrene derivatives and an abundant cobalt catalyst. This reaction tolerates a broad range of functional groups, directing groups, styrenes and affords mono-diarylethane products with high linear selectivity. To demonstrate the synthetic utility and the potential application in organic synthesis, a gram-scale reaction and further C-H bond functionalizations of the mono-alkylated product were performed. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Quality Control of 2-(m-Tolyl)pyridine).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Quality Control of 2-(m-Tolyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

A one-pot synthesis of substituted pyrido[2,3-b]indolizines was written by Proenca, Fernanda;Costa, Marta. And the article was included in Tetrahedron in 2011.Reference of 17281-59-3 This article mentions the following:

An efficient and novel approach to the synthesis of substituted pyrido[2,3-b]indolizine-10-carbonitriles (I; R¹, R² = Me, aryl) was developed. These structures are practically unavailable through previously described methods. The cascade transformation involves the reaction of α,β-unsaturated carbonyl compounds with a stable dimer prepared from 1-(cyanomethyl)pyridinium chloride. The reaction was performed under reflux conditions in ethanol/water and in the presence of sodium acetate. This procedure represents a eco-friendly regioselective approach to the pyrido[2,3-b]indolizine core structure. In the experiment, the researchers used many compounds, for example, 1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3Reference of 17281-59-3).

1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Reference of 17281-59-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

γ-Bromination of quinoline and pyridine N-oxides was written by Saito, Hirohisa;Hamana, Masatomo. And the article was included in Heterocycles in 1979.Formula: C7H9NO This article mentions the following:

Treatment of quinoline 1-oxide with Br (2 equiv) and Tl(OAc)₃ in HOAc at 50° for 29 h gave 65.8% 4-bromoquinoline 1-oxide. Similarly, quinaldine and 3-bromoquinoline 1-oxide gave the corresponding γ-bromo derivatives in good yields. From 2-cyanoquinoline 1-oxide, 2-cyano-4-bromoquinoline 1-oxide and 2-carbamoyl-4-bromoquinoline 1-oxide were obtained. The reactivity of N-oxides of pyridine series was somewhat lower and pyridine and 2-picoline 1-oxides resist bromination under similar conditions, but 2,6-lutidine, 3-picoline and 3,5-lutidine 1-oxides afforded the corresponding γ-bromo derivatives In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Formula: C7H9NO).

3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Formula: C7H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Transition-Metal-Free Decarboxylative Arylation of 2-Picolinic Acids with Arenes under Air Conditions was written by Zhang, Xitao;Feng, Xiujuan;Zhou, Chuancheng;Yu, Xiaoqiang;Yamamoto, Yoshinori;Bao, Ming. And the article was included in Organic Letters in 2018.Recommanded Product: 4373-61-9 This article mentions the following:

A facile, transition-metal-free, and direct decarboxylative arylation of 2-picolinic acids with simple arenes is described. The oxidative decarboxylative arylation of 2-picolinic acids with arenes proceeds readily via N-chloro carbene intermediates to afford 2-arylpyridines in satisfactory to good yields under transition-metal-free conditions. This new type of decarboxylative arylation is operationally simple and scalable and exhibits high functional-group tolerance. Various synthetically useful functional groups, such as halogen atoms, methoxycarbonyl, and nitro, remain intact during the decarboxylative arylation of 2-picolinic acids. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Recommanded Product: 4373-61-9).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Recommanded Product: 4373-61-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Phosphination of Phenol Derivatives and Applications to Divergent Synthesis of Phosphine Ligands was written by Li, Chenchen;Zhang, Kezhuo;Zhang, Minghao;Zhang, Wu;Zhao, Wanxiang. And the article was included in Organic Letters in 2021.HPLC of Formula: 4783-68-0 This article mentions the following:

The authors describe a general and efficient protocol for the synthesis of organophosphine compounds from phenols and phosphines (R₂PH) via a metal-free C-O bond cleavage and C-P bond formation process. This approach exhibits broad substrate scope and excellent functional group tolerance. The synthetic utilities of this protocol were demonstrated by the synthesis of chiral ligands via the various transformations of cyano groups and their applications in asym. catalysis. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0HPLC of Formula: 4783-68-0).

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.HPLC of Formula: 4783-68-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Mono- and dimethylbenzyls as new protecting groups for no-carrier-added nucleophilic aromatic radiofluorination was written by Malik, Noeen;Zlatopolskiy, Boris D.;Solbach, Christoph;Voelter, Wolfgang;Reske, Sven N.;Machulla, Hans-Juergen. And the article was included in Journal of Radioanalytical and Nuclear Chemistry in 2011.Related Products of 15128-90-2 This article mentions the following:

In this work, we tested the applicability of several Me substituted benzyl groups as an alternative to the Me group for the protection of the hydroxyl groups in the nucleophilic aromatic radiofluorination. As a model synthesis, the no-carrier-added (n.c.a.) preparation of 2-[¹⁸F]fluoro-3-hydroxy-6-methylpyridine from O-protected 3-hydroxy-6-methyl-2-nitropyridine was chosen. Conditions for acidolytic and hydrogenolytic cleavage of heteroaryl esters were studied. Among various protecting groups tested, 4-methylbenzyl and 2,4-dimethylbenzyl groups proved to be the best by resulting in about 70% yields of [¹⁸F]-labeled product after hydrolysis with 32% HCl at 120 °C for 10 min. Furthermore, 4-methylbenzyl ester cleaved readily under catalytic transfer hydrogenation condition using ammonium formate and 10% Pd/C in boiling methanol to give 2-[¹⁸F]fluoro-3-hydroxy-6-methylpyridine in radiochem. yield of 75% within a reaction time of 10 min. Conditions for the cleavage of both 4-methylbenzyl and 2,4-dimethylbenzyl esters are well suited for the implementation into an automated synthesis module. In the experiment, the researchers used many compounds, for example, 3-Hydroxy-6-methyl-2-nitropyridine (cas: 15128-90-2Related Products of 15128-90-2).

3-Hydroxy-6-methyl-2-nitropyridine (cas: 15128-90-2) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Related Products of 15128-90-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Dihydropyrrole[2,3-d]pyridine Derivatives as Novel Corticotropin-Releasing Factor-1 Antagonists: Mapping of the Receptor Binding Pocket by in Silico Docking Studies was written by Di Fabio, Romano;Arban, Roberto;Bernasconi, Giovanni;Braggio, Simone;Blaney, Frank E.;Capelli, Anna M.;Castiglioni, Emiliano;Donati, Daniele;Fazzolari, Elettra;Ratti, Emiliangelo;Feriani, Aldo;Contini, Stefania;Gentile, Gabriella;Ghirlanda, Damiano;Sabbatini, Fabio M.;Andreotti, Daniele;Spada, Simone;Marchioro, Carla;Worby, Angela;St-Denis, Yves. And the article was included in Journal of Medicinal Chemistry in 2008.Application In Synthesis of 3-Amino-2,6-dimethoxypyridine This article mentions the following:

In an effort to discover novel CRF-1 receptor antagonists exhibiting improved physicochem. properties, a dihydropirrole[2,3]pyridine scaffold was designed and explored in terms of the SAR of the substitution at the pendent Ph ring and the nature of the heterocyclic moieties present in the upper region of the mol. Selective and potent compounds have been discovered endowed with reduced ClogP with respect to compounds known in the literature. Of particular relevance was the finding that the in vitro affinity of the series was maintained by reducing the overall lipophilicity. The results achieved by this exploration enabled the formulation of a novel hypothesis on the nature of the receptor binding pocket of this class of CRF-1 receptor antagonists, making use of in silico docking studies of the putative nonpeptidic antagonist binding site set up in house by homol. modeling techniques. In the experiment, the researchers used many compounds, for example, 3-Amino-2,6-dimethoxypyridine (cas: 28020-37-3Application In Synthesis of 3-Amino-2,6-dimethoxypyridine).

3-Amino-2,6-dimethoxypyridine (cas: 28020-37-3) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Application In Synthesis of 3-Amino-2,6-dimethoxypyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Alkylation of 4-cyanopyridine and pyridine was written by Wang, Cheng-Hsia;Horng, Jhy-Ming;Hwang, Fang-Yu. And the article was included in Bulletin of the Institute of Chemistry, Academia Sinica in 1979.Recommanded Product: 644-98-4 This article mentions the following:

Pyridine and 4-cyanopyridine were alkylated with RCO₂H (R = Me, Et, Pr, CHMe₂, Bu) in the presence of (NH₄)₂S₂O₈ and AgNO₃ in aqueous H₂SO₄ at 70-80° to give 51-95% 2- and 4-alkylpyridines and 2-alkyl- and 2,6-dialkyl-4-cyanopyridines. Aromatic compounds were not alkylated under these conditions. In the experiment, the researchers used many compounds, for example, 2-Isopropylpyridine (cas: 644-98-4Recommanded Product: 644-98-4).

2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Recommanded Product: 644-98-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Onium compounds. XVI. Quaternary derivation of pyridyl ethers was written by Renshaw, R. R.;Conn, R. C.. And the article was included in Journal of the American Chemical Society in 1937.Synthetic Route of C11H9NO This article mentions the following:

The following compounds have been prepared for pharmacol. examination The 2-pyridyl ethers were prepared from 2-C₅H₄NBr, PhOH and K₂CO₃ at 200-10° for 3 h. The 4-isomers were obtained by heating 4-pyridylpyridinium dichloride with excess of PhOH and 1.1 mol of its Na salt. 2-PhO, b₁₁ 134-5°, 92% yield; 2-o-cresoxy, b₂₁ 156-8°, 90%; p-isomer, b₂₂ 171.5-2.5°, 92%; m-isomer, b₂₀ 164-6°, 83%; 2-carvacroxy, b₂ 133-4°, 73%; resorcinol di-2-pyridyl ether, b₃ 183-5°, 38%; 2-pyridyl benzyl ether, b₂₀ 162-4°, 65%; 4-BuO, b₂₅ 129-31°, 37%; 4-MeO, b₃₁ 95-6° (picrate, m. 171-2°); 4-PhO, b₂₁ 157-8°; 4-o-, -m- and -p-cresoxy, b₁₉ 161-2°, b₂₂ 166-7°, b₄ 124-6°, resp. The onium derivatives were prepared from the ether and alkyl halide in Et₂O at room or slightly elevated temperature for from 1 to 6 days. Pyridinium iodides.-2-Phenoxymethyl, m. 174-5°, 96% (all m. ps. corrected); 2-phenoxyethyl, m. 150.5-1.5°, 57%; 2-o-cresoxymethyl, m. 186-6.2° (decomposition), 92%; p-isomer, m. 149-50°, 93%; m-isomer, m. 145-6.5°, 90%; 2-o-cresoxyethyl, m. 122-4°, 69%; m-isomer, m. 126-6.5°, 70%; 2-carvacroxymethyl, m. 134-5°, 85%; 3-phenoxymethyl, yellow, m. 82.5-4°, 96%; 3-phenoxyethyl, m. 136-7°, 98%; 4-phenoxymethyl, m. 227.5-8.5°, 68%; 4-phenoxyethyl, m. 110.5-11°, 70%; 4-o-cresoxy, m. 163-4°, 100%; p-isomer, m. 163°, 81%; m-isomer, m. 157-8°, 92%; 4-o-cresoxyethyl, m. 148°, 79%; p-isomer, m. 126-6.5°, 93%; m-isomer, m. 128°, 85%; 4-p-cresoxy-β-phenoxyethyl (as bromide), m. 129-30°, 64%; 4-m-methoxymethyl, m. 145° (decomposition), 100%; 4-butoxymethyl, m. 74-5°, 100%. N-4′-Pyridyl-4-pyridone forms a chloroaurate, yellow, m. 218-19°, and a chloroplatinate, buff, m. above 300°; di-HCl salt, m. 238° (decomposition) methiodide(N-(4′- methylpyridinium iodide)-4-pyridone), yellowish brown, m. 238-8.5°, 95% yield; ethiodide, with 1 mol H₂O, buff m. 134-5°. 3-Phenoxypyridine, b₁₇ 147-9°, results in 27% yield from 3-HOC₅H₄N, 3-KOC₅H₄N and PhBr with Cu bronze at 200° for 6 h., or in 59% yield from 3-IC₅H₄N and PhOK in PhOH with Cu bronze (46% with K₂CO₃). 2-and 4-Phenoxymethylpyridinium iodides are reduced with cleavage of the PhO group, PhOH and N-methylpiperidine being formed. The 3-isomer is readily reduced without the loss of the PhO group (unless in the presence of a large quantity of catalyst); 3-phenoxydimethylpiperidinium iodide, m. 177-8° (corrected). This behavior is general, the stability and aromatic nature of 3-substituted pyridines being quite marked, whereas 2- and 4-pyridyl derivatives are characterized by the lability and often by the anomalous behavior of the substituted groups. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0Synthetic Route of C11H9NO).

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Synthetic Route of C11H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem