Tag: 100-200

Basic matrixes for the matrix-assisted laser desorption/ionization mass spectrometry of proteins and oligonucleotides was written by Fitzgerald, Michael C.;Parr, Gary R.;Smith, Lloyd M.. And the article was included in Analytical Chemistry in 1993.Category: pyridine-derivatives This article mentions the following:

In order to examine the importance of pH in the matrix-assisted laser desorption/ionization (MALDI) anal. of proteins and oligonucleotides, 37 highly substituted pyrimidine, pyridine, and benzene derivatives containing basic amino groups were screened as potential matrixes. Several of these compounds were useful for the preparation and anal. of samples under neutral and basic pH conditions. The matrix, 2-amino-4-methyl-5-nitropyridine, gave good results with small proteins (up to ∼12,000 Da). The best results with oligonucleotides were obtained with 2-amino-5-nitropyridine, which was a useful matrix for the anal. of mixed-base oligonucleotides smaller than 20 nucleotides in length and homopolymers of thymidine. In general, oligonucleotide anal. using basic matrixes was found to be subject to similar constraints of size and base composition that hold when acidic matrixes are used. A major advantage of these newly discovered matrix materials over the more commonly used acidic matrixes is that they extend the utility of MALDI to the anal. of acid-sensitive species. In the experiment, the researchers used many compounds, for example, 3-Amino-2,6-dimethoxypyridine (cas: 28020-37-3Category: pyridine-derivatives).

3-Amino-2,6-dimethoxypyridine (cas: 28020-37-3) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lead(II) compounds with neutral coordination of semicarbazones: Synthesis and characterization was written by Oliveira Araujo, Vinicius;Antonio Casagrande, Gleison;Tirloni, Barbara;Denise Schwade, Vania. And the article was included in Inorganica Chimica Acta in 2022.Safety of Phenyl(pyridin-2-yl)methanone This article mentions the following:

2-Benzoylpyridine semicarbazide/4-phenylsemicarbazide derived ligands as hydrochloride salts, [H₂L]Cl and [H₂L^Ph]Cl·2H₂O, react with Pb²⁺ ions in aqueous and organic milieus. The compounds [Pb₂(HL)₂Cl₄]·2DMF (1a), [Pb₂(HL)₂Cl₄]·5H₂O (1b), [Pb₂(HL)₂Cl₂(NO₃)₂]·4H₂O (2), [Pb₂(HL)₂(SCN)₄] (3), [Pb₄(HL^Ph)₄Cl₈] (4), [Pb(HL^Ph)₂(NO₃)₂] (5) and [Pb(HL^Ph)₂(SCN)₂] (6) were obtained and characterized by powder x-ray diffraction and by IR and UV-visible spectroscopies. Compounds 1–5 were analyzed by single-crystal x-ray diffraction. Tetrel and hydrogen bonds dominate the solid-state arrangements. The aqueous synthetic approach makes the pre-ligands of this work promising for further studies in aqueous coordination chem. with p-block metal ions. [H₂L]Cl and [H₂L^Ph]Cl·2H₂O are suitable for coordination as neutral HL or HL^Ph species. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Safety of Phenyl(pyridin-2-yl)methanone).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Safety of Phenyl(pyridin-2-yl)methanone

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Design, Synthesis, and Biological Evaluation of Potent and Selective Class IIa Histone Deacetylase (HDAC) Inhibitors as a Potential Therapy for Huntington’s Disease was written by Burli, Roland W.;Luckhurst, Christopher A.;Aziz, Omar;Matthews, Kim L.;Yates, Dawn;Lyons, Kathy. A.;Beconi, Maria;McAllister, George;Breccia, Perla;Stott, Andrew J.;Penrose, Stephen D.;Wall, Michael;Lamers, Marieke;Leonard, Philip;Muller, Ilka;Richardson, Christine M.;Jarvis, Rebecca;Stones, Liz;Hughes, Samantha;Wishart, Grant;Haughan, Alan F.;O’Connell, Catherine;Mead, Tania;McNeil, Hannah;Vann, Julie;Mangette, John;Maillard, Michel;Beaumont, Vahri;Munoz-Sanjuan, Ignacio;Dominguez, Celia. And the article was included in Journal of Medicinal Chemistry in 2013.COA of Formula: C8H8BrN This article mentions the following:

Inhibition of class IIa histone deacetylase (HDAC) enzymes have been suggested as a therapeutic strategy for a number of diseases, including Huntington’s disease. Catalytic-site small mol. inhibitors of the class IIa HDAC4, -5, -7, and -9 were developed (e.g., I). These trisubstituted diarylcyclopropanehydroxamic acids were designed to exploit a lower pocket that is characteristic for the class IIa HDACs, not present in other HDAC classes. Selected inhibitors were cocrystd. with the catalytic domain of human HDAC4. We describe the first HDAC4 catalytic domain crystal structure in a “closed-loop” form, which in our view represents the biol. relevant conformation. We have demonstrated that these mols. can differentiate class IIa HDACs from class I and class IIb subtypes. They exhibited pharmacokinetic properties that should enable the assessment of their therapeutic benefit in both peripheral and CNS disorders. These selective inhibitors provide a means for evaluating potential efficacy in preclin. models in vivo. In the experiment, the researchers used many compounds, for example, 4-Bromo-2-cyclopropylpyridine (cas: 1086381-28-3COA of Formula: C8H8BrN).

4-Bromo-2-cyclopropylpyridine (cas: 1086381-28-3) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. COA of Formula: C8H8BrN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

A Practically Unified Electrochemical Strategy for Ni-Catalyzed Decarboxylative Cross-Coupling of Aryl Trimethylammonium Salts was written by Kong, Xianqiang;Chen, Yiyi;Chen, Xiaohui;Lu, Zheng-Xuan;Wang, Wei;Ni, Shao-Fei;Cao, Zhong-Yan. And the article was included in Organic Letters in 2022.Electric Literature of C12H9NO This article mentions the following:

By merging electrocatalysis and nickel catalysis, a unified strategy was successfully applied for preparing aryl ketones ArC(O)Ph [Ar = Ph, 4-ClC₆H₄, 4-MeC₆H₄, etc.], amides ArC(O)NR¹R² [Ar = Ph, 4-ClC₆H₄, 4-MeC₆H₄, etc.; R¹ = R² = Me, Et; R¹R² = CH₂(CH₂)₂CH₂, CH₂CH₂OCH₂CH₂], esters ArC(O)OR [Ar = Ph, 2-MeC₆H₄, 4-FC₆H₄, etc.; R = Me, Et] or aldehydes ArCHO [Ar = Ph, 4-MeC₆H₄, 4-PhC₆H₄, etc.] via decarboxylative cross-coupling of four types of α-oxocarboxylic acids and their derivatives with aryl trimethylammonium salts under mild conditions. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Electric Literature of C12H9NO).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Electric Literature of C12H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chemical microarrays to identify ligands that bind pathogenic cells was written by Barrett, Olivia J.;Childs, Jessica L.;Disney, Matthew D.. And the article was included in ChemBioChem in 2006.Application of 28020-37-3 This article mentions the following:

The use of microarrays to identify new ligands for cells by interrogating their binding to a library of organic ligands is described. The advantages of using microarrays include assay miniaturization and the manner in which ligands are displayed in a small area. This display mimics interactions that occur at cell-cell interfaces and amplifies binding affinities. In addition, a series of array surfaces was tested for resisting nonspecific binding, which includes amine-, BSA, and agarose- (aldehyde-) coated glass, plain glass, and glass coated with ethanolamine prepared in a two-step procedures from amine-coated slides using the pathogenic Pseudomonas aeruginosa, which forms sticky biofilms. The agarose slides offer an alternative as a more general arraying substrate to study the binding of microarray-immobilized ligands to cells. In the experiment, the researchers used many compounds, for example, 3-Amino-2,6-dimethoxypyridine (cas: 28020-37-3Application of 28020-37-3).

3-Amino-2,6-dimethoxypyridine (cas: 28020-37-3) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Application of 28020-37-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

General Copper-Catalyzed Coupling of Alkyl-, Aryl-, and Alkynylaluminum Reagents with Organohalides was written by Shrestha, Bijay;Thapa, Surendra;Gurung, Santosh K.;Pike, Ryan A. S.;Giri, Ramesh. And the article was included in Journal of Organic Chemistry in 2016.Formula: C12H11N This article mentions the following:

We report the first example of a very general Cu-catalyzed cross-coupling of organoaluminum reagents with organohalides. The reactions proceed for the couplings of alkyl-, aryl-, and alkynylaluminum reagents with aryl and heteroaryl halides and vinyl bromides, affording the cross-coupled products in good to excellent yields. Both primary and secondary alkylaluminum reagents can be utilized as organometallic coupling partners. These reactions are not complicated by β-hydride elimination, and as a result rearranged products are not observed with secondary alkylaluminum reagents even for couplings with heteroaryl halides under “ligand-free” conditions. Radical clock experiment with a radical probe and relative reactivity study of Ph₃Al with two haloarenes, 1-bromonaphthalene and 4-chlorobenzonitrile, having two different redox potentials indicates that the reaction does not involve free aryl radicals and radical anions as intermediates. These results combined with the result of the Hammett plot obtained by reacting Ph₃Al with iodoarenes containing p-H, p-Me, p-F, and p-CF₃ substituents, which shows a linear curve (R² = 0.99) with a ρ value of +1.06, suggest that the current transformation follows an oxidative addition-reductive elimination pathway. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Formula: C12H11N).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Formula: C12H11N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Rhodium-Catalyzed Asymmetric Conjugate Pyridylation with Pyridylboronic Acids was written by Ye, Bihai;Yao, Jian;Wu, Changhui;Zhu, Huilong;Yao, Weijun;Jin, Lili;Dou, Xiaowei. And the article was included in ACS Catalysis in 2022.Computed Properties of C5H4BCl2NO2 This article mentions the following:

In this study, the rhodium-catalyzed asym. conjugate pyridylation of α,β-unsaturated carbonyl compounds with pyridylboronic acids was reported. The bifunctional chiral amide-diene ligand, which dramatically accelerated the reaction via possible H-bonding activation, and alc. solvent, which significantly inhibited the competing protodeboronation of pyridylboronic acids under rhodium catalysis, worked in concert to promote the reaction, thus enabling production of the pyridylation products in high yields (up to 99%) with good enantioselectivities (up to >99% ee). In the experiment, the researchers used many compounds, for example, (2,6-Dichloropyridin-4-yl)boronic acid (cas: 1072951-54-2Computed Properties of C5H4BCl2NO2).

(2,6-Dichloropyridin-4-yl)boronic acid (cas: 1072951-54-2) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Computed Properties of C5H4BCl2NO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Condensation of substituted 2-aminopyridine with β-keto carboxylic esters: 4H-pyrido[1,2-a]pyrimidin-4-ones and pyridin-2-ones was written by Ferrarini, Pier Luigi;Mori, Claudio;Manera, Clementina;Mori, Filippo;Calderone, Vincenzo;Martinotti, Enrica. And the article was included in Journal of Heterocyclic Chemistry in 1999.Synthetic Route of C7H9N3O This article mentions the following:

The condensation of substituted 2-aminopyridines 5 with β-keto carboxylic esters in polyphosphoric acid is reported. In addition to the target compounds, 4H-pyrido[1,2-a]pyrimidin-4-ones, 1-(2-pyridinyl)-2-pyridinones were also obtained in this reaction. The latter compounds were tested for their Ca-antagonistic activity but failed to evoke any vasorelaxant response. In the experiment, the researchers used many compounds, for example, N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3Synthetic Route of C7H9N3O).

N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Synthetic Route of C7H9N3O

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Rapid and Efficient Construction of Indolizino[3,4,5-ab]isoindole Skeletons by a Rhodium-Catalyzed Tandem Reaction was written by Liu, Chang;Wu, Shaonan;Sun, Wan;Meng, Haifang;Xing, Siyang;Zhu, Bolin. And the article was included in Asian Journal of Organic Chemistry in 2020.Formula: C12H11N This article mentions the following:

A facile rhodium-catalyzed tandem reaction of two mols. of acrylates with two mols. of 2-phenylpyridines involving sequential C-H activation, Michael addition, [12+2] cycloaddition and oxidative aromatization was described. A series of indolizino[3,4,5-ab]isoindole compounds were efficiently afforded in good yields by the formation of two C-C bonds, two C=C bonds and one C-N bond. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Formula: C12H11N).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Formula: C12H11N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Discovery of isoquinolinone and naphthyridinone-based inhibitors of poly(ADP-ribose) polymerase-1 (PARP1) as anticancer agents: Structure activity relationship and preclinical characterization was written by Karche, Navnath P.;Bhonde, Mandar;Sinha, Neelima;Jana, Gourhari;Kukreja, Gagan;Kurhade, Sanjay P.;Jagdale, Arun R.;Tilekar, Ajay R.;Hajare, Anil K.;Jadhav, Ganesh R.;Gupta, Nishant R.;Limaye, Rohan;Khedkar, Nilesh;Thube, Baban R.;Shaikh, Javed S.;Rao Irlapati, Nageswara;Phukan, Samiron;Gole, Gopal;Bommakanti, Apparao;Khanwalkar, Harshal;Pawar, Yogesh;Kale, Ramesh;Kumar, Rakesh;Gupta, Rajesh;Praveen Kumar, V. R.;Wahid, Saif;Francis, Albi;Bhat, Tariq;Kamble, Nivrutti;Patil, Vinod;Nigade, Prashant B.;Modi, Dipak;Pawar, Shashikant;Naidu, Sneha;Volam, Harish;Pagdala, Vamsi;Mallurwar, Sadanand;Goyal, Hemant;Bora, Pushpak;Ahirrao, Prajakta;Singh, Minakshi;Kamalakannan, Prabhakaran;Naik, Kumar Ram;Kumar, Pradipta;Powar, Rajendra G.;Shankar, Rajesh B.;Bernstein, Peter R.;Gundu, Jayasagar;Nemmani, Kumar;Narasimham, Lakshmi;George, Kochumalayil Shaji;Sharma, Sharad;Bakhle, Dhananjay;Kamboj, Rajender Kumar;Palle, Venkata P.. And the article was included in Bioorganic & Medicinal Chemistry in 2020.Recommanded Product: 3939-12-6 This article mentions the following:

The exploitation of GLU988 and LYS903 residues in PARP1 as targets to design isoquinolinone and naphthyridinone analogs is described. Compounds of structure I have good biochem. and cellular potency but suffered from inferior PK. Constraining the linear propylene linker of structure into a cyclopentene ring offered improved PK parameters, while maintaining potency for PARP1. Finally, to avoid potential issues that may arise from the presence of an anilinic moiety, the nitrogen substituent on the isoquinolinone ring was incorporated as part of the bicyclic ring. This afforded a naphthyridinone scaffold, as shown in structure naphthyridinones. Further optimization of naphthyridinone series led to identification of a novel and highly potent PARP1 inhibitor I, which was further characterized as preclin. candidate mol. Compound I is orally bioavailable and displayed favorable pharmacokinetic (PK) properties. Compound I demonstrated remarkable antitumor efficacy both as a single-agent as well as in combination with chemotherapeutic agents in the BRCA1 mutant MDA-MB-436 breast cancer xenograft model. Addnl., compound I also potentiated the effect of agents such as temozolomide in breast cancer, pancreatic cancer and Ewing’s sarcoma models. In the experiment, the researchers used many compounds, for example, 6-Fluoronicotinonitrile (cas: 3939-12-6Recommanded Product: 3939-12-6).

6-Fluoronicotinonitrile (cas: 3939-12-6) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Recommanded Product: 3939-12-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem