Tag: 100-200

Thermal decomposition of 1-alkyl-3-methylpyridinium based ionic liquids was written by Sashina, E. S.;Kashirskii, D. A.;Chizhova, A. Yu.. And the article was included in Russian Journal of General Chemistry in 2017.Recommanded Product: 125652-55-3 This article mentions the following:

Products of thermal degradation of 1-alkyl-3-methylpyridinium halides are investigated by the method of gas chromatomass spectrometry. The main products of the reaction are 3-methylpyridine and the corresponding alkyl halide. It was supposed that thermal decomposition of pyridinium ionic liquids proceeds similarly to that of imidazolium ionic liquids by dealkylation with elimination of the substituent at the nitrogen atom of the pyridinium ring via S_N2 mechanism. The presence of 5 wt% of cellulose decreases the onset temperature of thermal decomposition by 15-20°C. In the experiment, the researchers used many compounds, for example, 1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3Recommanded Product: 125652-55-3).

1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Recommanded Product: 125652-55-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Manganese-catalyzed asymmetric transfer hydrogenation of hydrazones was written by Wang, Lixian;Lin, Jin;Xia, Chungu;Sun, Wei. And the article was included in Journal of Catalysis in 2022.Recommanded Product: 91-02-1 This article mentions the following:

The enantioselective reduction of C=N bonds constitutes an effective strategy for the production of chiral amines. Herein, manganese-catalyzed asym. transfer hydrogenation of hydrazones by employing a readily available chiral aminobenzimidazole manganese(I) complex under mild conditions was reported. The present protocol allows for the enantioselective transfer hydrogenation of a wide range of arylalkyl, dialkyl and diaryl hydrazones, providing the desired chiral hydrazines in excellent yields and enantioselectivities (65 examples, up to 99.9% ee). Of note, the current method is compatible with the challenging diaryl hydrazones without the requirement of an ortho-substitution on the Ph ring. A preliminary study of the mechanism suggests that a manganese-hydride pathway is involved, and the high enantiocontrol of the reaction is attributed to a π-π stacking interaction between substrate and catalyst. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Recommanded Product: 91-02-1).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Recommanded Product: 91-02-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Discovery and Development of 3-(6-Chloropyridine-3-yloxymethyl)-2-azabicyclo[3.1.0]hexane Hydrochloride (SUVN-911): A Novel, Potent, Selective, and Orally Active Neuronal Nicotinic Acetylcholine α4β2 Receptor Antagonist for the Treatment of Depression was written by Nirogi, Ramakrishna;Mohammed, Abdul Rasheed;Shinde, Anil K.;Ravella, Srinivasa Rao;Bogaraju, Narsimha;Subramanian, Ramkumar;Mekala, Venkat Reddy;Palacharla, Raghava Choudary;Muddana, Nageswararao;Thentu, Jagadeesh Babu;Bhyrapuneni, Gopinadh;Abraham, Renny;Jasti, Venkat. And the article was included in Journal of Medicinal Chemistry in 2020.HPLC of Formula: 51834-97-0 This article mentions the following:

A series of chem. optimizations guided by in vitro affinity at the α4β2 receptor in combination with selectivity against the α3β4 receptor, pharmacokinetic evaluation, and in vivo efficacy in a forced swim test resulted in identification of 3-(6-chloropyridine-3-yloxymethyl)-2-azabicyclo[3.1.0]hexane hydrochloride, I, (SUVN-911) as a clin. candidate. Compound I is a potent α4β2 receptor ligand with a K_i value of 1.5 nM. It showed >10μM binding affinity toward the ganglionic α3β4 receptor apart from showing selectivity over 70 other targets. It is orally bio-available and showed good brain penetration in rats. Marked antidepressant activity and dose-dependent receptor occupancy in rats support its potential therapeutic utility in the treatment of depression. It does not affect the locomotor activity at doses several folds higher than its efficacy dose. It is devoid of cardiovascular and gastrointestinal side effects. Successful long-term safety studies in animals and phase-1 evaluation in healthy humans for safety, tolerability, and pharmacokinetics paved the way for its further development. In the experiment, the researchers used many compounds, for example, 5-Hydroxy-2-methoxylpyridine (cas: 51834-97-0HPLC of Formula: 51834-97-0).

5-Hydroxy-2-methoxylpyridine (cas: 51834-97-0) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.HPLC of Formula: 51834-97-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Natural and transmission line produced positive ions was written by Eisele, F. L.. And the article was included in Journal of Geophysical Research, [Atmospheres] in 1989.COA of Formula: C8H11N This article mentions the following:

Pos. ions were studied at 3 field sites, 2 of which contained ions produced by high-voltage d.c. (HVDC) transmission lines. Natural ions were studied at 2 of the 3 sites. The observed differences between natural and anthropogenic ion spectra near HVDC lines are attributed primarily to a shortening of ion lifetimes by the strong elec. field associated with the HVDC lines. One exception is the production of K and probably Na based ions from the decomposition of insects in transmission line coronas. Several ions which have been observed previously at mass 60 and 130 were identified for the first time, using tandem mass spectrometric techniques, as trimethylamine and quinoline (and isoquinoline), resp. In the experiment, the researchers used many compounds, for example, 2-Isopropylpyridine (cas: 644-98-4COA of Formula: C8H11N).

2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.COA of Formula: C8H11N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Rhodium-Catalyzed Additive-Free C-H Ethoxycarbonylation of (Hetero)Arenes with Diethyl Dicarbonate as a CO Surrogate was written by Suzuki, Hirotsugu;Liao, Yumeng;Kawai, Yuya;Matsuda, Takanori. And the article was included in European Journal of Organic Chemistry in 2021.SDS of cas: 4373-61-9 This article mentions the following:

A rhodium-catalyzed C(sp²)-H ethoxycarbonylation of indoles and arylpyridines using di-Et dicarbonate to form indole-2-carboxylic acid esters such as I [X = CH, N; R¹ = H, 4-Me, 5-Cl, etc.] and isophthalates II [R² = H, 5-Me, 5-Ph, etc.; R³ = H, 5-Me, 4-Me] was developed. The catalytic process featured an additive-free ethoxycarbonylation reaction, in which only ethanol and CO² were produced as byproducts, providing a CO-free and operationally simple protocol. The introduced ethoxycarbonyl group was easily transformed into other ester and amide functionalities in a single step. Moreover, the reaction could be successfully applied on gram scale, and allowed for the efficient synthesis of indole-2-carboxylic acid esters and isophthalates. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9SDS of cas: 4373-61-9).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.SDS of cas: 4373-61-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Copper(II) mediated C-H methylthiolation of 2-phenyl pyridines with dimethyl sulfoxide using an amino acid ligand was written by Xiao, Yan;Wang, Shuo;Liu, Jianyu;Zhang, Hui;Xu, Yongnan. And the article was included in Tetrahedron Letters in 2019.Quality Control of 2-(m-Tolyl)pyridine This article mentions the following:

A novel protocol for the C-H methylthiolation of 2-Ph pyridines using DMSO as the methylthio source and an amino acid ligand was described. This simple procedure doesn’t requires neither an oxidant nor an addnl. solvent. The developed protocol tolerates a wide range of functional groups including Me, methoxy, fluoro, chloro and in particular the formyl group. This new strategy is highly regioselective and provided aryl Me sulfides from 2-Ph pyridines in moderate to good yields. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Quality Control of 2-(m-Tolyl)pyridine).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Quality Control of 2-(m-Tolyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Rapid, chemoselective and mild oxidation protocol for alcohols and ethers with recyclable N-chloro-N-(phenylsulfonyl)benzenesulfonamide was written by Palav, Amey;Misal, Balu;Ganwir, Prerna;Badani, Purav;Chaturbhuj, Ganesh. And the article was included in Tetrahedron Letters in 2021.Reference of 91-02-1 This article mentions the following:

A sulfonimide reagent, N-chloro-N-(phenylsulfonyl)benzenesulfonamide (NCBSI) was identified as a mild and selective oxidant. Without activation, the reagent was proved to oxidize primary and secondary alcs. as well as their sym. and mixed ethers to corresponding aldehydes and ketones. With recoverable PS-TEMPO catalyst, selective oxidation over chlorination of primary and secondary alcs. and their ethers with electron-donating substituents was achieved. The reagent precursor of NCBSI was recovered quant. and can be reused for synthesizing NCBSI. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Reference of 91-02-1).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Reference of 91-02-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis and structure-activity relationships of N ³-pyridylpyrazinones as corticotropin-releasing factor-1 (CRF₁) receptor antagonists was written by Hartz, Richard A.;Ahuja, Vijay T.;Schmitz, William D.;Molski, Thaddeus F.;Mattson, Gail K.;Lodge, Nicholas J.;Bronson, Joanne J.;Macor, John E.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.Safety of 3-Amino-2,6-dimethoxypyridine This article mentions the following:

A series of N ³-pyridylpyrazinones was investigated as corticotropin-releasing factor-1 receptor antagonists. It was observed that the binding affinity of analogs containing a pyridyl group was influenced not only by the substitution pattern on the pyridyl group, but also by the pK _a of the pyridyl nitrogen. Analogs containing a novel 6-(difluoromethoxy)-2,5-dimethylpyridin-3-amine group e. g., I were among the most potent N³-pyridylpyrazinones synthesized. The synthesis and SAR of N ³-pyridylpyrazinones is described herein. In the experiment, the researchers used many compounds, for example, 3-Amino-2,6-dimethoxypyridine (cas: 28020-37-3Safety of 3-Amino-2,6-dimethoxypyridine).

3-Amino-2,6-dimethoxypyridine (cas: 28020-37-3) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Safety of 3-Amino-2,6-dimethoxypyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis and performance of piperidinium-based ionic liquids as catalyst for biomass conversion into 3-acetamido-5-acetylfuran was written by Zang, Hongjun;Feng, Yimo;Lou, Jing;Wang, Kai;Wu, Changchun;Liu, Zhipeng;Zhu, Xi. And the article was included in Journal of Molecular Liquids in 2022.Recommanded Product: 628-13-7 This article mentions the following:

Ionic liquids have shown good catalytic performance and been widely used in the biomass conversion process due to their unique properties, including environmental friendship, low toxicity, and simple preparation In this work, a series of novel piperidinium-based ionic liquids were synthesized under mild conditions via a simple protonation reaction or nucleophilic substitution reaction. Among them, 4,4′-(propane-1,3-diyl)bis(1-(carboxymethyl)piperidin-1-ium) chloride ([PDCMPi]Cl) displayed the best catalytic performance. The highest yield (42.81 %) of 3A5AF from NAG was obtained after reacting in N-methyl-pyrrolidone (NMP) in the presence of piperidinium-based ionic liquids at 180 °C for 20 min under normal atm. conditions. Addnl., ionic liquid [PDCMPi]Cl showed good catalytic activity in six repeated catalytic runs. Meanwhile, a possible reaction pathway was also proposed on the basis of the results of NMR spectra. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Recommanded Product: 628-13-7).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Recommanded Product: 628-13-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Cobalt(III)-catalyzed alkenylation of arenes and 6-arylpurines with terminal alkynes: efficient access to functional dyes was written by Wang, Shan;Hou, Ji-Ting;Feng, Mei-Lin;Zhang, Xiao-Zhuan;Chen, Shan-Yong;Yu, Xiao-Qi. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2016.Product Details of 4373-61-9 This article mentions the following:

Alkenylation of unactivated arenes and 6-arylpurines with terminal alkynes in high yields using Cp*Co(CO)I₂ as catalyst under mild conditions is described. This method shows outstanding functional group compatibility and can be applied in the design of a mitochondria-targeted imaging dye. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Product Details of 4373-61-9).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Product Details of 4373-61-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem