Tag: 100-200

Synthesis of substituted pyridines from 1,2-nucleophilic addition products of functionalized N-acyl-2,3-dihydropyridones was written by Guzel, Mustafa;Watts, Joshua;McGilvary, Matthew;Wright, Marcus;Kiren, Sezgin. And the article was included in Tetrahedron Letters in 2015.Recommanded Product: 24103-75-1 This article mentions the following:

A general and efficient synthetic approach toward substituted pyridines from functionalized N-acyl-2,3-dihydropyridones in two steps; 1,2-addition with organocerium reagents and subsequent oxidative aromatization with chloranil is described. This strategy allows the generation of pyridines with various substitution patterns and introduces a variety of substituents including aryl, alkyl, alkynyl, alkenyl, and heteroaryl groups at the desired positions. In the experiment, the researchers used many compounds, for example, 4-Methoxy-2-methylpyridine (cas: 24103-75-1Recommanded Product: 24103-75-1).

4-Methoxy-2-methylpyridine (cas: 24103-75-1) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Recommanded Product: 24103-75-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis, Antiproliferative and Pro-Apoptotic Effects of Nitrostyrenes and Related Compounds in Burkitt′;s Lymphoma was written by Byrne, Andrew J.;Bright, Sandra A.;Fayne, Darren;McKeown, James P.;McCabe, Thomas;Twamley, Brendan;Williams, Clive;Meegan, Mary J.. And the article was included in Medicinal Chemistry (Sharjah, United Arab Emirates) in 2018.Application In Synthesis of Pyridinehydrochloride This article mentions the following:

Background: Cancers of the lymphatic cells (lymphomas) account for approx. 12% of malignant diseases worldwide. The nitrostyrene scaffold is identified as a lead target structure for the development of particularly effective compounds targeting Burkitt′s lymphoma (BL). Objectives: The aims of the curent study were to synthesize a panel of nitrostyrene compounds and to evaluate their activity in Burkitt′s lymphoma (BL). Methods: A panel of structurally varied compounds were designed and synthesized using Henry Knoevenagel condensation reactions. Single crystal X-Ray anal. confirmed the E configuration for six examples of these novel structures. A number of nitrostyrene-related compounds were also investigated including 1,3-bis(aryl)-2-nitropropenes together with heterocyclic scaffolds containing the nitrovinyl pharmacophore such as 3-nitro-2-phenyl-2H-chromenes. The antiproliferative activities of the compounds were evaluated using the BL cell lines EBV- MUTU-1 and EBV+ DG- 75 (chemoresistant) to establish preliminary structure-activity relationships. Results: Lead compounds with optimized nitrostyrene scaffolds and 3-nitro-2-phenyl-2Hchromene structures were successfully established with typical IC50 values of 0.45 μM and 0.47 μM in MUTU-1 cells and 1.41 μM and 1.92 μM, resp., in DG-75 cells. The mechanism of cell death was identified as apoptotic and the lead compound was found to elicit comparable apoptotic effects to Taxol in Burkitt′s lymphoma cell lines MUTU-1 and DG-75. Conclusion: This class of pharmaceutically active compounds with potential for the treatment of Burkitt′s lymphoma suggest a potential role for nitrostyrene based agents in chemotherapy. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Application In Synthesis of Pyridinehydrochloride).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Application In Synthesis of Pyridinehydrochloride

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine-directed carbon-carbon single bond activation: Rhodium-catalyzed decarbonylation of aryl and heteroaromatic ketones was written by Wagner, Cole J.;Salisbury, Eric A.;Schoonover, Erik J.;VanderRoest, Jacob P.;Johnson, Jeffrey B.. And the article was included in Tetrahedron Letters in 2021.Category: pyridine-derivatives This article mentions the following:

The decarbonylation of 2-pyridyl-substituted ketones via transition metal-catalyzed carbon-carbon bond activation provided ready access to a variety of biaryl compounds The highly efficient and general method provided reliable decarbonylation of benzophenones including a range of functional groups and substitution patterns. The methodol. has also proven highly efficient for heteroaromatic substrates, including those containing thiophenyl, indolyl, quinolinyl and pyridine substitution. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Category: pyridine-derivatives).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis and anti-platelet aggregation activity evaluation of ligustrazine H₂S donor derivatives was written by Luo, Bi-lan;Liu, Zi-bing;Li, Yi;Zhao, Ju-qin;Li, Yong;Zhang, Yi;Tang, Lei;Fan, Ling-ling. And the article was included in Huaxue Shiji in 2020.Application of 628-13-7 This article mentions the following:

Based on the principles of the combination and bioisosterism, three ligustrazine H₂S donor derivatives were designed and synthesized by substitution, cyclation, oxidation, esterification and etherification reactions using 4-hydroxyacetophenone and ligustrazine as the starting materials. The structures were confirmed by ¹HNMR, ¹³CNMR and HR-MS. The in vitro anti-platelet aggregation activities of the target compounds have been preliminarily tested by the Born turbidimetric method, and the exptl. results showed that 4-(3-thioxo-3H-1, 2-dithiol-5-yl) phenyl-3,5,6-trimethylpyrazine-2-carboxylate shown in I (IC₅₀=1.16 mmol/L) had significant inhibitory activity for ADP induced platelet aggregation, which was better than clin. drugs ligustrazine, 3-n-butylphthalide, edaravone and aspirin. Therefore, it may be used as a potential candidate for the treatment of cardiovascular and cerebrovascular disease. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Application of 628-13-7).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Application of 628-13-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Preparation of new nitrogen-bridged heterocycles. 60. Syntheses and conformational analyses of bis(indolizin-1-yl) disulfides was written by Kakehi, Akikazu;Suga, Hiroyuki;Okuno, Hiroko;Okuhara, Masaki;Ohta, Akira. And the article was included in Chemical & Pharmaceutical Bulletin in 2007.COA of Formula: C7H7ClN2 This article mentions the following:

Bis(indolizin-1-yl) disulfides I (R = cyano, CO₂Et, COPh, R¹ = Me, Et, CH₂Ph, etc., R² = H, Me), readily obtainable from the treatment of 1-(benzoylthio)indolizines II with piperidine, were prepared and their conformations were investigated. In comparison with those of 1-(benzoylthio)indolizines, the ¹H-NMR spectra of these disulfides showed considerable high field shifts (δ 0.13-0.82 ppm) on each pyridine ring proton and the UV spectra exhibited significant bathochromic and hyperchromic shifts. These results supported strongly the participation of an intramol. π-π interaction between two indolizine rings in these mols. and, hence, of a particular gauche (cis) conformation. However, the conformational considerations and mol. calculations (Mopac PM3) for some bis(indolizin-1-yl) disulfides showed the presence of four more stable gauche forms in which two are enantiomeric, resulting in three types of gauche structures. These three types of gauche structures were confirmed by X-ray analyses. In the experiment, the researchers used many compounds, for example, 1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3COA of Formula: C7H7ClN2).

1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.COA of Formula: C7H7ClN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Seven-membered ring compounds. XXXVIII. Reaction of troponoid with ylide. III. Reaction of tropone with pyridinium compounds was written by Sugimura, Yukio;Soma, Nobuo;Kishida, Yukichi. And the article was included in Bulletin of the Chemical Society of Japan in 1972.Formula: C7H7ClN2 This article mentions the following:

Phenacylpyridinium ylide (I, R = H, Br) reacted with tropone to afford 2-hydroxy-2-phenyl-3-phenacyl-2H-cyclohepta[b]furan (II) which was converted into 2-(1,2-dibenzoylethyl)tropone. The reactions of tropone with several kinds of pyridinium bromides yielded 2-substituted tropones in the presence of amines and 1-azaazulene derivatives including III in a one-step formation in the presence of NH4OAc. In the experiment, the researchers used many compounds, for example, 1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3Formula: C7H7ClN2).

1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Formula: C7H7ClN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ru-Catalyzed Selective C-H Functionalization of Pyridotriazoles with Acrylates was written by Joshi, Abhisek;Semwal, Rashmi;Adimurthy, Subbarayappa. And the article was included in SynOpen in 2021.Formula: C12H9NO This article mentions the following:

Ruthenium-catalyzed efficient and selective C-H alkenylation of pyridotriazoles with acrylates is described. The combination of metals (Ru and Fe) plays a crucial role in achieving quant. yields of the desired products. The reaction is proposed to involve the formation of a ruthenium cyclometalated intermediate. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Formula: C12H9NO).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Formula: C12H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Imidazo[1,5-α]pyridine-based fluorescent probe with a large Stokes shift for specific recognition of sulfite was written by Chen, Song;Hou, Peng;Sun, Jingwen;Wang, Haijun;Liu, Lei. And the article was included in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy in 2020.Name: Phenyl(pyridin-2-yl)methanone This article mentions the following:

By taking advantage of the intramol. charge transfer (ICT) process, we presented a novel fluorescent probe IPY-SO₂ based on imidazo[1,5-α]pyridine derivative for detecting SO^2-₃ with a low detection limit (70 nM). Combining its favorable turn-on fluorescence feature (75-fold), rapid response (5 min), high selectivity, large Stokes shift (174 nm) and low cytotoxicity, IPY-SO₂ was successfully applied to imaging SO²₃ in living MCF-7 cells and zebrafish. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Name: Phenyl(pyridin-2-yl)methanone).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Name: Phenyl(pyridin-2-yl)methanone

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Enabling Catalytic Arene C-H Amidomethylation via Bis(tosylamido)methane as a Sustainable Formaldimine Releaser was written by Li, Zhong-Yuan;Chaminda Lakmal, Hetti Handi;Cui, Xin. And the article was included in Organic Letters in 2019.Application In Synthesis of 2-(m-Tolyl)pyridine This article mentions the following:

2-Arylpyridines and aryl N-heterocycles such as 2-phenylpyridine underwent regioselective directed tosylaminomethylation with bis(tosylamino)methane as the formaldimine source in the presence of [Ru(p-cymene)Cl₂]₂, NaOAc, and Na₂CO₃ in 1,4-dioxane to yield mono(tosylaminomethyl)aryl pyridines such as I. Using the method, a dihydrobenzonaphthyridine and a dihydropyridobenzazepine were prepared In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Application In Synthesis of 2-(m-Tolyl)pyridine).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Application In Synthesis of 2-(m-Tolyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis of substituted pyridines by the reactions of halopyridines with sulfur, oxygen and carbon nucleophiles under focused microwave irradiation was written by Cherng, Yie-Jia. And the article was included in Tetrahedron in 2002.Application of 4783-68-0 This article mentions the following:

The nucleophilic substitution reactions of halopyridines with S, O and C nucleophiles under microwave irradiation was complete within several minutes with yields up to 99%. The method using microwave irradiation is superior to those conducted under conventional heating processes. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0Application of 4783-68-0).

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Application of 4783-68-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem