Tag: 100-200

Singh, Y. et al. published their research in Polyhedron in 2021 | CAS: 91-02-1

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Synthetic Route of C12H9NO

Non-covalent interactions governing the supramolecular assembly of copper(II) complexes with hydrazone-type ligand: Experimental and quantum chemical study was written by Singh, Y.;Patel, Ram N.;Patel, Satish K.;Jadeja, R. N.;Patel, Abhay K.;Patel, Neetu;Roy, H.;Kumar, P.;Butcher, R. J.;Jasinski, Jerry P.;Cortijo, M.;Herrero, S.. And the article was included in Polyhedron in 2021.Synthetic Route of C12H9NO This article mentions the following:

Two new mono- and one binuclear 娓?nitrato bridged Cu(II) complexes [Cu(L)(HL)]ClO4 (1), [Cu(HL)(NO3)(H2O)]2NO3閳ヮ敭2O (2) and [Cu2(L2)(娓?NO3)2] (3), with an unsym. NNO donor Schiff base (HL) were synthesized and characterized by elemental anal., FTIR, CV, UV-visible and EPR spectroscopy. Their mol. structures were also determined by single crystal x-ray crystallog. In the binuclear complex 3, the Cu璺矾璺?Cu distance is 3.494 鑴? In 1, 2 and 3, the Cu(II) centers have distorted square pyramidal geometry (锜?sub>5 = 0.05-0.17). Evidence of weak 锜鸿矾璺矾锜?stacking intermol. interactions along with other noncovalent interactions (H bonding) was observed by analyzing the resp. crystal structures of the complexes. Thus, these H bonds, 锜鸿矾璺矾锜?stacking interactions and other weak intermol. interactions establish as supramol. architectures a crystalline network environment. The noncovalent interactions were also studied by employing Hirshfeld Anal. The room temperature magnetic moments of the mononuclear complexes are less than the spin only values which are indicative of small interactions. Also, significant magnetic interactions were not exhibited by binuclear Cu(II) complex 3 in the variable temperature magnetic measurements. The X-band EPR spectra of all three complexes exhibit Cu(II) hyperfine structures as well as zero-field splitting which are appropriate for the triplet states of dimers. In 1 and 2, the presence of pseudo dipolar interactions is proposed. Quantum chem. calculations (DFT) were carried out on complexes 1–3 to explore the electronic and spectral properties of these newly synthesized complexes. These complexes show significant antiproliferative and SOD activity. The SOD activity measured in terms of kMcCF is in the range 4.94-12.31 (mol L)-1s-1 x 104. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Synthetic Route of C12H9NO).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Synthetic Route of C12H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chihiro, Masatoshi et al. published their research in Journal of Medicinal Chemistry in 1995 | CAS: 122637-39-2

6-Acetylpicolinic acid (cas: 122637-39-2) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Name: 6-Acetylpicolinic acid

Novel Thiazole Derivatives as Inhibitors of Superoxide Production by Human Neutrophils: Synthesis and Structure-Activity Relationships was written by Chihiro, Masatoshi;Nagamoto, Hisashi;Takemura, Isao;Kitano, Kazuyoshi;Komatsu, Hajime;Sekiguchi, Kazuo;Tabusa, Fujio;Mori, Toyoki;Tominaga, Michiaki;Yabuuchi, Youichi. And the article was included in Journal of Medicinal Chemistry in 1995.Name: 6-Acetylpicolinic acid This article mentions the following:

Neutrophils have an important role in the self-defense systems of organisms through the production of superoxide. On the other hand, it has been proposed that abnormal amounts of superoxide produced by neutrophils are a serious factor in tissue injury. A series of novel thiazole derivatives was prepared and evaluated for inhibitory effect on superoxide production by human neutrophils in vitro. Among these compounds, 6-[2-(3,4-diethoxyphenyl)thiazol-4-yl]pyridine-2-carboxylic acid (OPC-6535) was selected as one of the most promising compounds In the experiment, the researchers used many compounds, for example, 6-Acetylpicolinic acid (cas: 122637-39-2Name: 6-Acetylpicolinic acid).

6-Acetylpicolinic acid (cas: 122637-39-2) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Name: 6-Acetylpicolinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Levin, J. I. et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2001 | CAS: 28020-37-3

3-Amino-2,6-dimethoxypyridine (cas: 28020-37-3) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Synthetic Route of C7H10N2O2

Heteroaryl and cycloalkyl sulfonamide hydroxamic acid inhibitors of matrix metalloproteinases was written by Levin, J. I.;Gu, Y.;Nelson, F. C.;Zask, A.;DiJoseph, J. F.;Sharr, M. A.;Sung, A.;Jin, G.;Cowling, R.;Chanda, P.;Cosmi, S.;Hsiao, C.-L.;Edris, W.;Wilhelm, J.;Killar, L. M.;Skotnicki, J. S.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2001.Synthetic Route of C7H10N2O2 This article mentions the following:

Heteroaryl and cycloalkyl sulfonamide-hydroxamic acid MMP inhibitors were investigated. Of these, the pyridyl analog I is the most potent and selective inhibitor of MMP-9 and MMP-13 in vitro. In the experiment, the researchers used many compounds, for example, 3-Amino-2,6-dimethoxypyridine (cas: 28020-37-3Synthetic Route of C7H10N2O2).

3-Amino-2,6-dimethoxypyridine (cas: 28020-37-3) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Synthetic Route of C7H10N2O2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wahyudiono et al. published their research in Journal of Chemistry and Chemical Engineering in 2012 | CAS: 644-98-4

2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ璺痬ol閳? in pyridine vs. 150 kJ璺痬ol閳? in benzene). Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Synthetic Route of C8H11N

Supercritical water as a reaction medium for nitrogen-containing heterocycles was written by Wahyudiono;Matsunaga, Yui;Machmudah, Siti;Sasaki, Mitsuru;Goto, Motonobu. And the article was included in Journal of Chemistry and Chemical Engineering in 2012.Synthetic Route of C8H11N This article mentions the following:

Supercritical water has been focused on as an environmentally attractive reaction media, in which organic materials can be decomposed into smaller mols. The reaction behavior of pyrrole as a simple model compound of nonbasic nitrogen compounds found in petroleum residua was studied in supercritical water with a batch type reactor. The reaction was carried out at temperatures of 698-748 K and at various pressures under an argon atm. The chem. species in the aqueous products were identified by GCMS (gas chromatog. mass spectrometry) and quantified using GC-FID (gas chromatog. flame ionization detector). The effect of temperature and reaction time on the conversion process of pyrrole is presented. Under supercritical water conditions, pyrrole underwent successful decomposition in water into its derived compounds The conversion of pyrrole could approach 81.12 wt% at 723 K and 40 MPa within 240 min of reaction time. The decomposition process was accelerated with the existence of water at the same temperature Ultimate anal. of solid products was also conducted using a CHN analyzer. The process investigated in this study may form the basis for an efficient method of nitrogen compound decomposition in future. In the experiment, the researchers used many compounds, for example, 2-Isopropylpyridine (cas: 644-98-4Synthetic Route of C8H11N).

2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ璺痬ol閳? in pyridine vs. 150 kJ璺痬ol閳? in benzene). Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Synthetic Route of C8H11N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Jin, Seongho et al. published their research in ACS Catalysis in 2021 | CAS: 4373-61-9

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridine has a conjugated system of six 锜?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H鐪塩kel criteria for aromatic systems. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Application In Synthesis of 2-(m-Tolyl)pyridine

Electrolytic C-H Oxygenation via Oxidatively Induced Reductive Elimination in Rh Catalysis was written by Jin, Seongho;Kim, Jinwoo;Kim, Dongwook;Park, Jung-Woo;Chang, Sukbok. And the article was included in ACS Catalysis in 2021.Application In Synthesis of 2-(m-Tolyl)pyridine This article mentions the following:

Herein, the development of a Rh-catalyzed C-H acyloxylation under mild electrolytic conditions is described. Anodic oxidation of a key rhodacyclic carboxylate intermediate was found to enable the product-releasing C-O bond-forming reductive elimination process. An accumulation of carboxylate near the electrode surface was rationalized to further induce the desired C-O bond formation, allowing an ambient catalytic C-H oxygenation using stoichiometric amounts of readily accessible carboxylic acid coupling partners. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Application In Synthesis of 2-(m-Tolyl)pyridine).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridine has a conjugated system of six 锜?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H鐪塩kel criteria for aromatic systems. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Application In Synthesis of 2-(m-Tolyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sashina, Elena S. et al. published their research in Cellulose Chemistry and Technology in 2016 | CAS: 125652-55-3

1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Product Details of 125652-55-3

Dissolution of cellulose with pyridinium-based ionic liquids: effect of chemical structure and interaction mechanism was written by Sashina, Elena S.;Kashirskii, Dmitrii A.;Busygin, Konstantin N.. And the article was included in Cellulose Chemistry and Technology in 2016.Product Details of 125652-55-3 This article mentions the following:

The results of theor. and exptl. studies of 1-alkyl-3-methylpyridinium cation-based ionic liquids (ILs) and their solutions with cellulose are presented. The obtained results show a correlation between the chem. structure of the ILs and their ability to dissolve cellulose. The mechanism of natural polymer solvation in these solvents is discussed. Our results allow us to conclude that pyridinium-based ILs are extremely promising for biomass processing. These results can help design solvents with required phys. and chem. properties. In the experiment, the researchers used many compounds, for example, 1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3Product Details of 125652-55-3).

1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Product Details of 125652-55-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

de Geest, Duncan J. et al. published their research in Journal of Organometallic Chemistry in 1999 | CAS: 4783-68-0

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the 锜?bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the 锜?bonds. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Name: 2-Phenoxypyridine

Cyclometallated compounds. XIII. Cyclopalladation of 2-phenoxypyridine and structurally-related compounds was written by de Geest, Duncan J.;O’Keefe, Brendan J.;Steel, Peter J.. And the article was included in Journal of Organometallic Chemistry in 1999.Name: 2-Phenoxypyridine This article mentions the following:

2-Phenoxypyridine and 2-phenylsulfanylpyridine are cyclopalladated readily by Pd acetate to give six-membered metallocycles. Extension to the three isomeric bis(2-pyridyloxy)benzenes leads to doubly-cyclopalladated compounds In contrast, 3,6-diphenoxypyridazine and 4,6-diphenoxypyrimidine only undergo monopalladation, while their S analogs are resistant to cyclopalladation. All cyclometalated compounds are converted to their acetylacetonate derivatives and the x-ray crystal structure of one of these is described. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0Name: 2-Phenoxypyridine).

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the 锜?bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the 锜?bonds. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Name: 2-Phenoxypyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Petel, Brittney E. et al. published their research in Synlett in 2018 | CAS: 644-98-4

2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the 锜?bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the 锜?bonds. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Recommanded Product: 644-98-4

Manganese-Catalyzed Kumada Cross-Coupling Reactions of Aliphatic Grignard Reagents with N-Heterocyclic Chlorides was written by Petel, Brittney E.;Purak, Merjema;Matson, Ellen M.. And the article was included in Synlett in 2018.Recommanded Product: 644-98-4 This article mentions the following:

The use of manganese(II) chloride for the catalytic generation of C(sp2)-C(sp3) bonds via Kumada cross-coupling is reported. Rapid and selective formation of 2-alkylated N-heterocyclic complexes was observed in high yields with use of 3 mol% MnCl2THF1.6and under ambient reaction conditions (21 鎺矯, 15 min to 20 h). Manganese-catalyzed cross-coupling is tolerant toward both electron-donating and electron-withdrawing functional groups in the 5-position of the pyridine ring, with the latter resulting in an increased reaction rate and a decrease in the amount of nucleophile required. The use of this biol. and environmentally benign metal salt as a catalyst for C-C bond formation highlights its potential as a catalyst for the late-stage functionalization of pharmaceutically active N-heterocyclic mols. (e.g., pyridine, pyrazine). In the experiment, the researchers used many compounds, for example, 2-Isopropylpyridine (cas: 644-98-4Recommanded Product: 644-98-4).

2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the 锜?bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the 锜?bonds. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Recommanded Product: 644-98-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Huang, Sheng et al. published their research in ACS Omega in 2020 | CAS: 628-13-7

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. Pyridine has a conjugated system of six 锜?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H鐪塩kel criteria for aromatic systems. Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Safety of Pyridinehydrochloride

Synthesis, Characterization, and In Vivo Evaluation of Desmethyl Anethole Trithione Phosphate Prodrug for Ameliorating Cerebral Ischemia-Reperfusion Injury in Rats was written by Huang, Sheng;Dong, Renhan;Xu, Gaojie;Liu, Jin;Gao, Xiaofang;Yu, Siqi;Qie, Pengfan;Gou, Gang;Hu, Min;Wang, Yu;Peng, Jian;Guang, Bing;Xu, Ying;Yang, Tai. And the article was included in ACS Omega in 2020.Safety of Pyridinehydrochloride This article mentions the following:

Anethole trithione (ATT) has a wide range of physiol. activities, but its use is limited due to its poor water solubility To improve the solubility of ATT, we synthesized and characterized a novel phosphate prodrug (ATXP) relying on the availability of the hydroxy group in 5-(4-hydroxyphenyl)-3H-1,2-dithiole3-thione (ATX), which was transformed from ATT rapidly and extensively in vivo. Our results showed that ATXP significantly improved drug solubility ATXP was rapidly converted to ATX and reached a maximum plasma concentration with a Tmax of approx. 5 min after i.v. (iv) administration. Furthermore, after the oral administration of ATXP, the Cmax was 3326.30 鍗?566.50 ng/mL, which was approx. 5-fold greater than that of the parent drug form, indicating that ATXP has greater absorption than that of ATT. Addnl., the oral phosphate prodrug ATXP increased the ATX in the area under the plasma concentration vs time curves (AUC0-t = 3927.40 鍗?321.50 and AUC0-閳?/sub> = 4579.0 鍗?756.30), making its use in practical applications more meaningful. Finally, compared to the vehicle, ATXP was confirmed to maintain the bioactivity of the parent drug for a significant reduction in infarct volume 24 h after reperfusion. Based on these findings, the phosphate prodrug ATXP is a potentially useful water-soluble prodrug with improved pharmacokinetic properties. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Safety of Pyridinehydrochloride).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. Pyridine has a conjugated system of six 锜?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H鐪塩kel criteria for aromatic systems. Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Safety of Pyridinehydrochloride

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sutherland, Hamish S. et al. published their research in Bioorganic & Medicinal Chemistry in 2019 | CAS: 51834-97-0

5-Hydroxy-2-methoxylpyridine (cas: 51834-97-0) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ璺痬ol閳? in pyridine vs. 150 kJ璺痬ol閳? in benzene). Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Electric Literature of C6H7NO2

3,5-Dialkoxypyridine analogues of bedaquiline are potent antituberculosis agents with minimal inhibition of the hERG channel was written by Sutherland, Hamish S.;Tong, Amy S. T.;Choi, Peter J.;Blaser, Adrian;Conole, Daniel;Franzblau, Scott G.;Lotlikar, Manisha U.;Cooper, Christopher B.;Upton, Anna M.;Denny, William A.;Palmer, Brian D.. And the article was included in Bioorganic & Medicinal Chemistry in 2019.Electric Literature of C6H7NO2 This article mentions the following:

Bedaquiline is a new drug of the diarylquinoline class that has proven to be clin. effective against drug-resistant tuberculosis, but has a cardiac liability (prolongation of the QT interval) due to its potent inhibition of the cardiac potassium channel protein hERG. Bedaquiline is highly lipophilic and has an extremely long terminal half-life, so has the potential for more-than-desired accumulation in tissues during the relatively long treatment durations required to cure TB. The present work is part of a program that seeks to identify a diarylquinoline that is as potent as bedaquiline against Mycobacterium tuberculosis, with lower lipophilicity, higher clearance, and lower risk for QT prolongation. Previous work led to the identification of compounds with greatly-reduced lipophilicity compounds that retain good anti-tubercular activity in vitro and in mouse models of TB, but has not addressed the hERG blockade. We now present compounds where the C-unit naphthalene is replaced by a 3,5-dialkoxy-4-pyridyl, demonstrate more potent in vitro and in vivo anti-tubercular activity, with greatly attenuated hERG blockade. Two examples of this series are in preclin. development. In the experiment, the researchers used many compounds, for example, 5-Hydroxy-2-methoxylpyridine (cas: 51834-97-0Electric Literature of C6H7NO2).

5-Hydroxy-2-methoxylpyridine (cas: 51834-97-0) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ璺痬ol閳? in pyridine vs. 150 kJ璺痬ol閳? in benzene). Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Electric Literature of C6H7NO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem